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Why should I be an academic pathologist ? 10.10-10.40. Phil Quirke Royal College of Pathologists YCR Centenary Professor of Pathology University of Leeds. Contents. Why do research Careers Academic clinical fellows Clinical lecturers Future. Why do research?. You can make a difference - PowerPoint PPT Presentation
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Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why should I be an academic pathologist ?
10.10-10.40
Phil QuirkeRoyal College of Pathologists
YCR Centenary Professor of Pathology
University of Leeds
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Contents
• Why do research
• Careers– Academic clinical fellows
– Clinical lecturers
• Future
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why do research?
• You can make a difference
–Prevent a disease
–Cure it
–Reduce its effects
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why
• Service career– Reports 2,000 surgicals a year– 35 year career– 70,000 patients– 50 colorectal cancers a year :1,750– GI biopsies: 17,500 each
• Variable private practice• Increasing management interference• Decreasing independence• Increasing commercialisation
– USA, Australia, SERCO…….
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Academic impact - Research
•Research•Helicobacter pylori observation •50% of the worlds population?
– Duodenal ulcer – 4 x106
• Gastric ulcer• Gastric cancer• Gastric lymphoma
Warren 2005
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Leeds - Research
• Bowel cancer 1.2M worldwide– Observations on surgery
• Total mesorectal Excision
• Abdominoperineal excision
• Colon cancer
– Screening – Implementation
– Change
– Flexisigmoidoscopy
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Leeds research
• Can we prevent bowel cancer ?
• Abnormal microbiome• Faecal transplants?
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Academic impact - Teaching
• Teaching– Undergraduates
• Influence 230 students per year • 8,050 doctors over 35 years• Create the next generation of pathologists
– Postgraduates• FRCPath
– 10 years training committee 300• PhD’s/ MD’s
– 40
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why?
• Patient benefit• Excitement• Challenges• Independence• Consultant for 35 years• Technology changes• Cutting edge• Self interest - jobs• Self confidence• Self satisfaction
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why?
• Variety• Influence policy• Change practice• Travel• Opportunities• Reward
– Building your own team– Seeing the success of others– Following their achievements– Pay progression/patent/startups/consultancies
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Lecturing/training/influencing
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Why do research?
• The thrill of discovery• You work in a worldwide community• Similar aims• Competition/friendship
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Academic careers
• Never a better time• Major shortage• Ageing population• Council Heads of Medical schools
– Worst Pathology/Anaesthetics
• 5x the chance of holding a Platinum award• International market• Freedom to explore your ideas
NIHR Trainees Coordinating Centre www.nihrtcc.nhs.uk
Integrated Clinical Academic Training Pathway
NIHR Trainees Coordinating Centre www.nihrtcc.nhs.uk
NIHR Academic Clinical Fellowships
• Academic and clinical training • For entrants to Specialist Training• 25% is academic component• Support in making application for training fellowship or
educational programme leading to higher degree• Up to 3 years (4 for GPs)• All ACFs except medical education are run-through• 250 posts each year
£4,500 over 3 years to fund research training and conferences
NIHR Trainees Coordinating Centre www.nihrtcc.nhs.uk
Opens Closes
ACFs Round 1 Early November End January
ACFs Round 2 Early February End March (following year)
ACF Recruitment Timetable
NIHR Trainees Coordinating Centre www.nihrtcc.nhs.uk
NIHR Clinical Lectureships
• Academic and clinical training for those with a higher degree• Available to qualified GPs and GDPs with higher degree• 50% is academic component• Support in making application for Clinician Scientist Scheme or
similar• Up to 4 years• End point marked by CCT and substantial piece of post-doctoral
research or educational work• 100 posts each year
£1000 for travel per year
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Pathways
• Service Consultant• ST1• ST2• ST3• ST4• ST5• Consultant
• Academic and service• ST1-3 / Academic
Clinical Fellow• Out of programme
experience PhD/MD• Lecturer• Senior Lecturer• Reader• Professor
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Out of programme experience
• 3 years funded by fellowship– NIHR– MRC– CRUK/ARC/BHF– College
– PhD/Publications – Presentations
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Senior positions
• Senior Lecturer 5 years
• Reader 2-3 years
• Professor – established Chair/personal Chair – career position
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
What happens
• All– Understand the literature– Undertake a research
project– Present their work at
national meetings
• Some– Publish papers– MD/PhD– Awarded grants– International meetings– Specialist reputation
• Few– Professional academic– Own research
programme– International reputation
• Fewer– Head academic grouping
within University
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
What is the connection between Black and Decker and Pathologists
InformationWhat do we do?
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Threats
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Opportunities
• Digital world 3D and digital pathology• Integration of genotype and phenotype• Stratified/personalised medicine
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Opportunities – Digital pathology
• Integration of the microscope and computer
• Efficiency
• Breaks the limitations of the microscope
• Anytime/anywhere
• International opinions
• Learning/teaching/quality
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Stratified/personalised medicine
• Prognosis – aggressive/benign outcomes– Her-2 amplification – Mismatch repair
• Prediction – which drugs– Her-2 breast and gastric cancers– Ki ras EGFr antibodies– Focus 4
• Toxicity– DPD deficiency– UGT1A1
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Future medicine
• Whole genome • Now £5000• 2 years £500• Association of genotype
with phenotype• Deep sequencing for
rare events• Copy number variation
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Next generation sequencing
TPD52
Copy number variation
In house 1-50Fluidigm 144Haloplex 4,000
Mutation detection
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Maldi-Tof imaging
• Protein visualisation without antibodies
• 30um resolution• EGFR• Amphiregulin• Epiregulin
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Leeds
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Programme
• LURE• iBSc• aFY2• ACF• Clinical lecturers
• ACF position to be advertised November start August 2013 Lecturer position
Leeds Institute of Molecular Medicine
Pathology and Tumour Biology
Questions?
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