Who’s Developing What in Drug Delivery? · 2013. 6. 3. · World Leaders in Health Industry...

World Leaders in Health Industry Analysis

Who’s Developing What in Drug Delivery?

Part 1

©Espicom Business Intelligence October 2008ii

Who’s Developing What in Drug Delivery?

October 2008

ISBN: 978-1-85822-331-5

© Copyright 2008 Espicom Business Intelligence

All rights reserved. No part of this publication may be reproduced or used in any form or by any means graphic, electronic or mechanical, including photocopying, recording, taping or storage in information retrieval systems without the express permission of

the publisher.

Every care has been taken to ensure that the information contained in this report is correct. The publisher accepts no liability for decisions made on the basis of information contained herein.

British Library Cataloguing in Publication Data.

A catalogue record for this report is available from the British Library.

©Espicom Business Intelligence iiiOctober 2008

Who’s Developing What in Drug Delivery? Table of Contents

Contents3M DRUG DELIVERY SYSTEMS ...................................................................................................................... 1

KEY PERSONNEL ........................................................................................................................................................................ 1COMPANY OVERVIEW .............................................................................................................................................................. 1KEY MILESTONES ...................................................................................................................................................................... 1PRODUCTS / TECHNOLOGIES .................................................................................................................................................. 2RESEARCH ACTIVITIES .............................................................................................................................................................. 6AGREEMENTS ............................................................................................................................................................................. 6KEY FINANCIAL DATA................................................................................................................................................................ 7COMPETITION ............................................................................................................................................................................ 7

ABRAXIS BIOSCIENCE INC ............................................................................................................................. 9KEY PERSONNEL ........................................................................................................................................................................ 9COMPANY OVERVIEW .............................................................................................................................................................. 9KEY MILESTONES ...................................................................................................................................................................... 9PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 10RESEARCH STRATEGY ............................................................................................................................................................. 11AGREEMENTS ........................................................................................................................................................................... 12KEY FINANCIAL DATA.............................................................................................................................................................. 13RELATED COMPANIES ............................................................................................................................................................. 14

ACCESS PHARMACEUTICALS INC ............................................................................................................... 15KEY PERSONNEL ...................................................................................................................................................................... 15COMPANY OVERVIEW ............................................................................................................................................................ 15KEY MILESTONES .................................................................................................................................................................... 15PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 16RESEARCH ACTIVITIES ............................................................................................................................................................ 18AGREEMENTS ........................................................................................................................................................................... 20KEY FINANCIAL DATA.............................................................................................................................................................. 21COMPETITION .......................................................................................................................................................................... 21

ACUSPHERE INC .......................................................................................................................................... 23KEY PERSONNEL ......................................................................................................................................................................23COMPANY OVERVIEW ............................................................................................................................................................23KEY MILESTONES ....................................................................................................................................................................23PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 24RESEARCH ACTIVITIES ............................................................................................................................................................ 26AGREEMENTS ........................................................................................................................................................................... 26KEY FINANCIAL DATA.............................................................................................................................................................. 27COMPETITION .......................................................................................................................................................................... 27

ACRUX LTD ................................................................................................................................................... 29KEY PERSONNEL ...................................................................................................................................................................... 29COMPANY OVERVIEW ............................................................................................................................................................ 29KEY MILESTONES .................................................................................................................................................................... 29PRODUCTS / TECHNOLOGIES ................................................................................................................................................30RESEARCH ACTIVITIES ............................................................................................................................................................ 31AGREEMENTS ........................................................................................................................................................................... 31KEY FINANCIAL DATA.............................................................................................................................................................. 33

AKELA PHARMA .......................................................................................................................................... 35KEY PERSONNEL ...................................................................................................................................................................... 35COMPANY OVERVIEW ............................................................................................................................................................ 35KEY MILESTONES .................................................................................................................................................................... 35R&D ACTIVITIES ....................................................................................................................................................................... 35

©Espicom Business Intelligence October 2008iv

Who’s Developing What in Drug Delivery?

TECHNOLOGIES/PRODUCTS.................................................................................................................................................. 36AGREEMENTS ...........................................................................................................................................................................38KEY FINANCIAL DATA..............................................................................................................................................................38

ALIZYME PLC ............................................................................................................................................... 39KEY PERSONNEL ...................................................................................................................................................................... 39COMPANY OVERVIEW ............................................................................................................................................................ 39KEY MILESTONES .................................................................................................................................................................... 39PRODUCTS / TECHNOLOGIES ................................................................................................................................................40RESEARCH ACTIVITIES ............................................................................................................................................................ 42AGREEMENTS ........................................................................................................................................................................... 42KEY FINANCIAL DATA.............................................................................................................................................................. 43COMPETITION .......................................................................................................................................................................... 43

ALKERMES INC ............................................................................................................................................ 45KEY PERSONNEL ...................................................................................................................................................................... 45COMPANY OVERVIEW ............................................................................................................................................................ 45KEY MILESTONES .................................................................................................................................................................... 45PRODUCTS / TECHNOLOGIES ...............................................................................................................................................46RESEARCH ACTIVITIES ........................................................................................................................................................... 49AGREEMENTS ...........................................................................................................................................................................50KEY FINANCIAL DATA.............................................................................................................................................................. 51COMPETITION .......................................................................................................................................................................... 51

ALPHARX INC ............................................................................................................................................... 53KEY PERSONNEL ...................................................................................................................................................................... 53COMPANY OVERVIEW ............................................................................................................................................................ 53KEY MILESTONES .................................................................................................................................................................... 53PRODUCTS / TECHNOLOGIES ................................................................................................................................................54RESEARCH ACTIVITIES ............................................................................................................................................................ 57AGREEMENTS ........................................................................................................................................................................... 57KEY FINANCIAL DATA..............................................................................................................................................................58ASSOCIATED COMPANIES ......................................................................................................................................................58COMPETITION ..........................................................................................................................................................................58

ALPHAVAX INC ............................................................................................................................................ 61KEY PERSONNEL ..................................................................................................................................................................... 61COMPANY OVERVIEW ............................................................................................................................................................ 61KEY MILESTONES .................................................................................................................................................................... 61PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 62RESEARCH ACTIVITIES ............................................................................................................................................................ 63AGREEMENTS ...........................................................................................................................................................................64KEY FINANCIAL DATA..............................................................................................................................................................64

ALTEA THERAPEUTICS ................................................................................................................................ 65KEY PERSONNEL ...................................................................................................................................................................... 65COMPANY OVERVIEW ............................................................................................................................................................ 65PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 65RESEARCH ACTIVITIES ............................................................................................................................................................66AGREEMENTS ........................................................................................................................................................................... 67KEY FINANCIAL DATA..............................................................................................................................................................68

ALZA CORPORATION .................................................................................................................................. 69KEY PERSONNEL ...................................................................................................................................................................... 69COMPANY OVERVIEW ............................................................................................................................................................ 69KEY MILESTONES .................................................................................................................................................................... 69PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 70

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©Espicom Business Intelligence vOctober 2008

Who’s Developing What in Drug Delivery?

RESEARCH ACTIVITIES ............................................................................................................................................................ 73AGREEMENTS ........................................................................................................................................................................... 74KEY FINANCIAL DATA.............................................................................................................................................................. 75

ANTARES PHARMA INC ............................................................................................................................... 77KEY PERSONNEL ......................................................................................................................................................................77COMPANY OVERVIEW ............................................................................................................................................................77KEY MILESTONES ....................................................................................................................................................................77PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 78RESEARCH ACTIVITIES ............................................................................................................................................................80AGREEMENTS ...........................................................................................................................................................................82KEY FINANCIAL DATA..............................................................................................................................................................84COMPETITION ..........................................................................................................................................................................84

AP PHARMA INC .......................................................................................................................................... 85KEY PERSONNEL .....................................................................................................................................................................85COMPANY OVERVIEW ............................................................................................................................................................85KEY MILESTONES ....................................................................................................................................................................85PRODUCTS / TECHNOLOGIES ................................................................................................................................................86RESEARCH ACTIVITIES ............................................................................................................................................................88AGREEMENTS ...........................................................................................................................................................................89KEY FINANCIAL DATA..............................................................................................................................................................89COMPETITION ..........................................................................................................................................................................90

ARADIGM CORPORATION ........................................................................................................................... 91KEY PERSONNEL ...................................................................................................................................................................... 91COMPANY OVERVIEW ............................................................................................................................................................ 91KEY MILESTONES .................................................................................................................................................................... 91PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 92RESEARCH ACTIVITIES ............................................................................................................................................................ 93AGREEMENTS ...........................................................................................................................................................................94KEY FINANCIAL DATA.............................................................................................................................................................. 95COMPETITION .......................................................................................................................................................................... 95

AVIDIMER THERAPEUTICS INC ................................................................................................................... 97KEY PERSONNEL ...................................................................................................................................................................... 97COMPANY OVERVIEW ............................................................................................................................................................ 97PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 97RESEARCH ACTIVITIES ............................................................................................................................................................ 97KEY FINANCIAL DATA..............................................................................................................................................................98

BAXA CORPORATION .................................................................................................................................. 99KEY PERSONNEL ......................................................................................................................................................................99COMPANY OVERVIEW ............................................................................................................................................................99KEY MILESTONES ....................................................................................................................................................................99PRODUCTS / TECHNOLOGIES ..............................................................................................................................................100AGREEMENTS .........................................................................................................................................................................102KEY FINANCIAL DATA............................................................................................................................................................103

BAXTER INTERNATIONAL INC ................................................................................................................... 105KEY PERSONNEL ....................................................................................................................................................................105COMPANY OVERVIEW ..........................................................................................................................................................105KEY MILESTONES ..................................................................................................................................................................105PRODUCTS / TECHNOLOGIES ..............................................................................................................................................106AGREEMENTS ..........................................................................................................................................................................111KEY FINANCIAL DATA............................................................................................................................................................ 113COMPETITION ........................................................................................................................................................................ 114

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©Espicom Business Intelligence October 2008vi

Who’s Developing What in Drug Delivery?

BIODELIVERY SCIENCES INTERNATIONAL ................................................................................................115KEY PERSONNEL .................................................................................................................................................................... 115COMPANY OVERVIEW .......................................................................................................................................................... 115KEY MILESTONES .................................................................................................................................................................. 115PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 116RESEARCH ACTIVITIES .......................................................................................................................................................... 118AGREEMENTS ......................................................................................................................................................................... 119KEY FINANCIAL DATA............................................................................................................................................................ 120KEY FINANCIAL DATA............................................................................................................................................................ 120ASSOCIATED COMPANIES .................................................................................................................................................... 120COMPETITION ........................................................................................................................................................................ 121

BIOJECT MEDICAL TECHNOLOGIES INC ................................................................................................... 123KEY PERSONNEL .................................................................................................................................................................... 123COMPANY OVERVIEW .......................................................................................................................................................... 123KEY MILESTONES .................................................................................................................................................................. 123PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 123RESEARCH ACTIVITIES .......................................................................................................................................................... 125AGREEMENTS ......................................................................................................................................................................... 126KEY FINANCIAL DATA............................................................................................................................................................ 127COMPETITION ........................................................................................................................................................................ 127

BIOSANTE PHARMACEUTICALS INC ......................................................................................................... 129KEY PERSONNEL .................................................................................................................................................................... 129COMPANY OVERVIEW .......................................................................................................................................................... 129KEY MILESTONES .................................................................................................................................................................. 129PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 129RESEARCH ACTIVITIES .......................................................................................................................................................... 131AGREEMENTS ......................................................................................................................................................................... 132KEY FINANCIAL DATA............................................................................................................................................................ 133COMPETITION ........................................................................................................................................................................ 133

BIOVAIL CORPORATION ............................................................................................................................ 135KEY PERSONNEL .................................................................................................................................................................... 135COMPANY OVERVIEW .......................................................................................................................................................... 135KEY MILESTONES .................................................................................................................................................................. 135PRODUCTS / TECHNOLOGIES ..............................................................................................................................................136RESEARCH ACTIVITIES .......................................................................................................................................................... 139AGREEMENTS ......................................................................................................................................................................... 139KEY FINANCIAL DATA............................................................................................................................................................ 141ASSOCIATED COMPANIES .................................................................................................................................................... 141COMPETITION ........................................................................................................................................................................ 142

CALANDO PHARMACEUTICALS ................................................................................................................ 143KEY PERSONNEL .................................................................................................................................................................... 143COMPANY OVERVIEW .......................................................................................................................................................... 143MILESTONES .......................................................................................................................................................................... 143PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 143RESEARCH ACTIVITIES ..........................................................................................................................................................145AGREEMENTS .........................................................................................................................................................................145KEY FINANCIAL DATA............................................................................................................................................................146

CAMURUS AB ............................................................................................................................................ 147KEY PERSONNEL .................................................................................................................................................................... 147COMPANY OVERVIEW .......................................................................................................................................................... 147KEY MILESTONES .................................................................................................................................................................. 147

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©Espicom Business Intelligence viiOctober 2008

Who’s Developing What in Drug Delivery?

PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 147RESEARCH ACTIVITIES ..........................................................................................................................................................149AGREEMENTS .........................................................................................................................................................................150KEY FINANCIAL DATA............................................................................................................................................................150

CARDINAL HEALTH ....................................................................................................................................151KEY PERSONNEL .................................................................................................................................................................... 151COMPANY OVERVIEW .......................................................................................................................................................... 151KEY MILESTONES .................................................................................................................................................................. 151PRODUCTS ............................................................................................................................................................................. 152AGREEMENTS .........................................................................................................................................................................158KEY FINANCIAL DATA............................................................................................................................................................ 159COMPETITION ........................................................................................................................................................................ 159

CELL THERAPEUTICS INC .......................................................................................................................... 161KEY PERSONNEL .................................................................................................................................................................... 161COMPANY OVERVIEW .......................................................................................................................................................... 161KEY MILESTONES .................................................................................................................................................................. 161PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 161RESEARCH ACTIVITIES ..........................................................................................................................................................162AGREEMENTS .........................................................................................................................................................................162KEY FINANCIAL DATA............................................................................................................................................................163

CEPHALON ................................................................................................................................................. 165KEY PERSONNEL ....................................................................................................................................................................165COMPANY OVERVIEW ..........................................................................................................................................................165KEY MILESTONES ..................................................................................................................................................................165PRODUCTS .............................................................................................................................................................................166R&D ACTIVITIES ..................................................................................................................................................................... 167AGREEMENTS .........................................................................................................................................................................168CIMA agreements .................................................................................................................................................................169KEY FINANCIAL DATA............................................................................................................................................................ 170KEY COMPETITORS ............................................................................................................................................................... 170

CIPHER PHARMACEUTICALS .................................................................................................................... 171KEY PERSONNEL .................................................................................................................................................................... 171COMPANY OVERVIEW .......................................................................................................................................................... 171KEY MILESTONES .................................................................................................................................................................. 171TECHNOLOGIES/PRODUCTS................................................................................................................................................ 172R&D MILESTONES ................................................................................................................................................................. 172AGREEMENTS ......................................................................................................................................................................... 173KEY FINANCIAL DATA............................................................................................................................................................ 173

COLUMBIA LABORATORIES INC ................................................................................................................175KEY PERSONNEL .................................................................................................................................................................... 175COMPANY OVERVIEW .......................................................................................................................................................... 175KEY MILESTONES .................................................................................................................................................................. 175PRODUCTS / TECHNOLOGIES ............................................................................................................................................. 175RESEARCH ACTIVITIES .......................................................................................................................................................... 177AGREEMENTS ......................................................................................................................................................................... 177KEY FINANCIAL DATA............................................................................................................................................................ 178COMPETITION ........................................................................................................................................................................ 179

CONSORT MEDICAL PLC ........................................................................................................................... 181KEY PERSONNEL .................................................................................................................................................................... 181COMPANY OVERVIEW .......................................................................................................................................................... 181KEY MILESTONES .................................................................................................................................................................. 181

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©Espicom Business Intelligence October 2008viii

Who’s Developing What in Drug Delivery?

PRODUCTS / TECHNOLOGIES ..............................................................................................................................................182RESEARCH ACTIVITIES ..........................................................................................................................................................182AGREEMENTS .........................................................................................................................................................................183KEY FINANCIAL DATA............................................................................................................................................................184COMPETITION ........................................................................................................................................................................184

COPERNICUS THERAPEUTICS ................................................................................................................... 185KEY PERSONNEL ....................................................................................................................................................................185COMPANY OVERVIEW ..........................................................................................................................................................185KEY MILESTONES ..................................................................................................................................................................185PRODUCTS / TECHNOLOGIES ..............................................................................................................................................185RESEARCH STRATEGY ...........................................................................................................................................................186AGREEMENTS .........................................................................................................................................................................186KEY FINANCIAL DATA............................................................................................................................................................186

CPEX PHARMACEUTICALS INC ................................................................................................................. 187KEY PERSONNEL ....................................................................................................................................................................187COMPANY OVERVIEW ..........................................................................................................................................................187KEY MILESTONES ..................................................................................................................................................................187PRODUCTS / TECHNOLOGIES ..............................................................................................................................................188RESEARCH ACTIVITIES ..........................................................................................................................................................188AGREEMENTS ........................................................................................................................................................................189KEY FINANCIAL DATA............................................................................................................................................................189COMPETITION ........................................................................................................................................................................190

CRITICAL THERAPEUTICS INC ................................................................................................................... 191KEY PERSONNEL .................................................................................................................................................................... 191COMPANY OVERVIEW .......................................................................................................................................................... 191KEY MILESTONES .................................................................................................................................................................. 191PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 192RESEARCH ACTIVITIES .......................................................................................................................................................... 192AGREEMENTS ......................................................................................................................................................................... 193KEY FINANCIAL DATA............................................................................................................................................................194

CYDEX PHARMACEUTICALS ..................................................................................................................... 195KEY PERSONNEL ....................................................................................................................................................................195COMPANY OVERVIEW ..........................................................................................................................................................195KEY MILESTONES ..................................................................................................................................................................195PRODUCTS / TECHNOLOGIES ..............................................................................................................................................195RESEARCH ACTIVITIES ..........................................................................................................................................................199AGREEMENTS .........................................................................................................................................................................199KEY FINANCIAL DATA............................................................................................................................................................200

DEBIOPHARM SA ....................................................................................................................................... 201KEY PERSONNEL ....................................................................................................................................................................201COMPANY OVERVIEW ..........................................................................................................................................................201KEY MILESTONES ..................................................................................................................................................................201PRODUCTS / TECHNOLOGIES ..............................................................................................................................................201RESEARCH ACTIVITIES ..........................................................................................................................................................203AGREEMENTS .........................................................................................................................................................................204KEY FINANCIAL DATA............................................................................................................................................................205ASSOCIATED COMPANIES ....................................................................................................................................................205

DELCATH SYSTEMS INC ............................................................................................................................. 207KEY PERSONNEL ....................................................................................................................................................................207COMPANY OVERVIEW ..........................................................................................................................................................207KEY MILESTONES ..................................................................................................................................................................207

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©Espicom Business Intelligence ixOctober 2008

Who’s Developing What in Drug Delivery?

PRODUCTS / TECHNOLOGIES ..............................................................................................................................................208RESEARCH ACTIVITIES ..........................................................................................................................................................208AGREEMENTS .........................................................................................................................................................................209KEY FINANCIAL DATA............................................................................................................................................................209COMPETITION ........................................................................................................................................................................ 210

DELSITE BIOTECHNOLOGIES INC ..............................................................................................................211KEY PERSONNEL .................................................................................................................................................................... 211COMPANY OVERVIEW .......................................................................................................................................................... 211KEY MILESTONES .................................................................................................................................................................. 211PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 212AGREEMENTS ......................................................................................................................................................................... 214KEY FINANCIAL DATA............................................................................................................................................................ 215

DEPOMED INC ............................................................................................................................................217KEY PERSONNEL .................................................................................................................................................................... 217COMPANY OVERVIEW .......................................................................................................................................................... 217KEY MILESTONES .................................................................................................................................................................. 217PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 218RESEARCH ACTIVITIES .......................................................................................................................................................... 219AGREEMENTS .........................................................................................................................................................................220KEY FINANCIAL DATA............................................................................................................................................................222COMPETITION ........................................................................................................................................................................222

DIATOS SA .................................................................................................................................................. 223KEY PERSONNEL ....................................................................................................................................................................223COMPANY OVERVIEW ..........................................................................................................................................................223KEY MILESTONES ..................................................................................................................................................................223PRODUCTS / TECHNOLOGIES ..............................................................................................................................................223RESEARCH ACTIVITIES ..........................................................................................................................................................226AGREEMENTS .........................................................................................................................................................................226KEY FINANCIAL DATA............................................................................................................................................................227ASSOCIATED COMPANIES ....................................................................................................................................................227

DOR BIOPHARMA INC ............................................................................................................................... 229KEY PERSONNEL ....................................................................................................................................................................229COMPANY OVERVIEW ..........................................................................................................................................................229KEY MILESTONES ..................................................................................................................................................................229PRODUCTS / TECHNOLOGIES ..............................................................................................................................................230RESEARCH ACTIVITIES ..........................................................................................................................................................233AGREEMENTS .........................................................................................................................................................................234KEY FINANCIAL DATA............................................................................................................................................................235COMPETITION ........................................................................................................................................................................235

DURECT CORPORATION ............................................................................................................................ 237KEY PERSONNEL ....................................................................................................................................................................237COMPANY OVERVIEW ..........................................................................................................................................................237KEY MILESTONES ..................................................................................................................................................................237PRODUCTS / TECHNOLOGIES ..............................................................................................................................................238RESEARCH ACTIVITIES .......................................................................................................................................................... 241AGREEMENTS ......................................................................................................................................................................... 241KEY FINANCIAL DATA............................................................................................................................................................243ASSOCIATED COMPANIES ....................................................................................................................................................243COMPETITION ........................................................................................................................................................................243

DUSA PHARMACEUTICALS INC................................................................................................................. 245KEY PERSONNEL ....................................................................................................................................................................245

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©Espicom Business Intelligence October 2008x

Who’s Developing What in Drug Delivery?

COMPANY OVERVIEW ..........................................................................................................................................................245KEY MILESTONES ..................................................................................................................................................................245PRODUCTS / TECHNOLOGIES ..............................................................................................................................................246RESEARCH ACTIVITIES ..........................................................................................................................................................247AGREEMENTS .........................................................................................................................................................................247KEY FINANCIAL DATA............................................................................................................................................................248COMPETITION ........................................................................................................................................................................249

ECHO THERAPEUTICS ............................................................................................................................... 251KEY PERSONNEL ....................................................................................................................................................................251COMPANY OVERVIEW ..........................................................................................................................................................251KEY MILESTONES ..................................................................................................................................................................251PRODUCTS / TECHNOLOGIES ..............................................................................................................................................252RESEARCH ACTIVITIES ..........................................................................................................................................................253AGREEMENTS .........................................................................................................................................................................254KEY FINANCIAL DATA............................................................................................................................................................255COMPETITION ........................................................................................................................................................................255

ELAN CORPORATION ................................................................................................................................ 257KEY PERSONNEL ....................................................................................................................................................................257COMPANY OVERVIEW ..........................................................................................................................................................257KEY MILESTONES ..................................................................................................................................................................257PRODUCTS / TECHNOLOGIES ..............................................................................................................................................258RESEARCH ACTIVITIES ..........................................................................................................................................................260AGREEMENTS .........................................................................................................................................................................262KEY FINANCIAL DATA............................................................................................................................................................263

ELITE PHARMACEUTICALS INC ................................................................................................................. 265KEY PERSONNEL ....................................................................................................................................................................265COMPANY OVERVIEW ..........................................................................................................................................................265KEY MILESTONES ..................................................................................................................................................................265PRODUCTS / TECHNOLOGIES ..............................................................................................................................................265RESEARCH ACTIVITIES ..........................................................................................................................................................266AGREEMENTS .........................................................................................................................................................................266KEY FINANCIAL DATA............................................................................................................................................................267COMPETITION ........................................................................................................................................................................267

EMISPHERE TECHNOLOGIES INC .............................................................................................................. 269KEY PERSONNEL ....................................................................................................................................................................269COMPANY OVERVIEW ..........................................................................................................................................................269KEY MILESTONES ..................................................................................................................................................................269PRODUCTS / TECHNOLOGIES ..............................................................................................................................................269RESEARCH ACTIVITIES ..........................................................................................................................................................273AGREEMENTS .........................................................................................................................................................................273KEY FINANCIAL DATA............................................................................................................................................................ 274COMPETITION ........................................................................................................................................................................ 274

ENCAP DRUG DELIVERY ............................................................................................................................ 277KEY PERSONNEL ....................................................................................................................................................................277COMPANY OVERVIEW ..........................................................................................................................................................277KEY MILESTONES ..................................................................................................................................................................277PRODUCTS / TECHNOLOGIES ..............................................................................................................................................277AGREEMENTS .........................................................................................................................................................................278KEY FINANCIAL DATA............................................................................................................................................................278

ENDO PHARMACEUTICALS ....................................................................................................................... 279KEY PERSONNEL ....................................................................................................................................................................279

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©Espicom Business Intelligence xiOctober 2008

Who’s Developing What in Drug Delivery?

COMPANY OVERVIEW ..........................................................................................................................................................279KEY MILESTONES ..................................................................................................................................................................279PRODUCTS/TECHNOLOGIES/ ..............................................................................................................................................279R&D MILESTONES .................................................................................................................................................................280AGREEMENTS .........................................................................................................................................................................281KEY COMPETITORS ...............................................................................................................................................................282KEY FINANCIAL DATA............................................................................................................................................................282

ENDOCYTE ................................................................................................................................................. 283KEY PERSONNEL ....................................................................................................................................................................283COMPANY OVERVIEW ..........................................................................................................................................................283KEY MILESTONES ..................................................................................................................................................................283PRODUCTS / TECHNOLOGIES ..............................................................................................................................................283RESEARCH ACTIVITIES ..........................................................................................................................................................284AGREEMENTS .........................................................................................................................................................................285KEY FINANCIAL DATA............................................................................................................................................................286

ENDOVASC INC .......................................................................................................................................... 287KEY PERSONNEL ....................................................................................................................................................................287COMPANY OVERVIEW ..........................................................................................................................................................287KEY MILESTONES ..................................................................................................................................................................287PRODUCTS / TECHNOLOGIES ..............................................................................................................................................287RESEARCH ACTIVITIES ..........................................................................................................................................................289AGREEMENTS .........................................................................................................................................................................289KEY FINANCIAL DATA............................................................................................................................................................290ASSOCIATED COMPANIES ....................................................................................................................................................290COMPETITION ........................................................................................................................................................................290

ENZON INC ................................................................................................................................................. 291KEY PERSONNEL ....................................................................................................................................................................291COMPANY OVERVIEW ..........................................................................................................................................................291KEY MILESTONES ..................................................................................................................................................................291PRODUCTS / TECHNOLOGIES ..............................................................................................................................................292RESEARCH ACTIVITIES ..........................................................................................................................................................294AGREEMENTS .........................................................................................................................................................................295KEY FINANCIAL DATA............................................................................................................................................................297COMPETITION ........................................................................................................................................................................297

ETHYPHARM S/A ....................................................................................................................................... 299KEY PERSONNEL ....................................................................................................................................................................299COMPANY OVERVIEW ..........................................................................................................................................................299KEY MILESTONES ..................................................................................................................................................................299PRODUCTS / TECHNOLOGIES ..............................................................................................................................................299RESEARCH ACTIVITIES ..........................................................................................................................................................303AGREEMENTS .........................................................................................................................................................................304KEY FINANCIAL DATA............................................................................................................................................................305

EURAND ..................................................................................................................................................... 307KEY PERSONNEL ....................................................................................................................................................................307COMPANY OVERVIEW ..........................................................................................................................................................307KEY MILESTONES ..................................................................................................................................................................307PRODUCTS / TECHNOLOGIES ..............................................................................................................................................308RESEARCH ACTIVITIES .......................................................................................................................................................... 311AGREEMENTS ......................................................................................................................................................................... 312KEY FINANCIAL DATA............................................................................................................................................................ 313

EXPRESSION GENETICS INC .......................................................................................................................315

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©Espicom Business Intelligence October 2008xii

Who’s Developing What in Drug Delivery?

KEY PERSONNEL .................................................................................................................................................................... 315COMPANY OVERVIEW .......................................................................................................................................................... 315KEY MILESTONES .................................................................................................................................................................. 315PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 315RESEARCH ACTIVITIES .......................................................................................................................................................... 317KEY FINANCIAL DATA............................................................................................................................................................ 318

FERTIN PHARMA A/S ................................................................................................................................. 319KEY PERSONNEL .................................................................................................................................................................... 319COMPANY OVERVIEW .......................................................................................................................................................... 319KEY MILESTONES .................................................................................................................................................................. 319PRODUCTS / TECHNOLOGIES ..............................................................................................................................................320R&D ACTIVITIES .....................................................................................................................................................................320AGREEMENTS .........................................................................................................................................................................321KEY FINANCIAL DATA............................................................................................................................................................321

FLAMEL TECHNOLOGIES INC .................................................................................................................... 323KEY PERSONNEL ....................................................................................................................................................................323COMPANY OVERVIEW ..........................................................................................................................................................323KEY MILESTONES ..................................................................................................................................................................323PRODUCTS / TECHNOLOGIES ..............................................................................................................................................324AGREEMENTS .........................................................................................................................................................................325KEY FINANCIAL DATA............................................................................................................................................................326COMPETITION ........................................................................................................................................................................326

FZIOMED INC ............................................................................................................................................. 327KEY PERSONNEL ....................................................................................................................................................................327COMPANY OVERVIEW ..........................................................................................................................................................327KEY MILESTONES ..................................................................................................................................................................327PRODUCTS / TECHNOLOGIES ..............................................................................................................................................328RESEARCH ACTIVITIES ..........................................................................................................................................................329AGREEMENTS .........................................................................................................................................................................330KEY FINANCIAL DATA............................................................................................................................................................330

GENEREX BIOTECHNOLOGY CORPORATION ........................................................................................... 331KEY PERSONNEL .................................................................................................................................................................... 331COMPANY OVERVIEW .......................................................................................................................................................... 331KEY MILESTONES .................................................................................................................................................................. 331PRODUCTS / TECHNOLOGIES ..............................................................................................................................................332RESEARCH ACTIVITIES ..........................................................................................................................................................333AGREEMENTS .........................................................................................................................................................................334KEY FINANCIAL DATA............................................................................................................................................................335COMPETITION ........................................................................................................................................................................336

GILEAD SCIENCES ...................................................................................................................................... 337KEY PERSONNEL ....................................................................................................................................................................337COMPANY OVERVIEW ..........................................................................................................................................................337PRODUCTS / TECHNOLOGIES ..............................................................................................................................................337RESEARCH ACTIVITIES ..........................................................................................................................................................340AGREEMENTS .........................................................................................................................................................................342KEY FINANCIAL DATA............................................................................................................................................................343

GLYCOLOGIC LTD ....................................................................................................................................... 345KEY PERSONNEL ....................................................................................................................................................................345COMPANY OVERVIEW ..........................................................................................................................................................345KEY MILESTONES ..................................................................................................................................................................345PRODUCTS / TECHNOLOGIES ..............................................................................................................................................345

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©Espicom Business Intelligence xiiiOctober 2008

Who’s Developing What in Drug Delivery?

RESEARCH STRATEGY ...........................................................................................................................................................348AGREEMENTS .........................................................................................................................................................................348KEY FINANCIAL DATA............................................................................................................................................................348

HOSPIRA .................................................................................................................................................... 349KEY PERSONNEL ....................................................................................................................................................................349COMPANY OVERVIEW ..........................................................................................................................................................349KEY MILESTONES ..................................................................................................................................................................349PRODUCTS / TECHNOLOGIES ..............................................................................................................................................350RESEARCH ACTIVITIES ..........................................................................................................................................................354AGREEMENTS .........................................................................................................................................................................354KEY FINANCIAL DATA............................................................................................................................................................356COMPETITION ........................................................................................................................................................................356

Table of Contents

World Leaders in Health Industry Analysis

Who’s Developing What in Drug Delivery?

Part 2

©Espicom Business Intelligence October 2008ii

Who’s Developing What in Drug Delivery?

October 2008

ISBN: 978-1-85822-331-5

© Copyright 2008 Espicom Business Intelligence

All rights reserved. No part of this publication may be reproduced or used in any form or by any means graphic, electronic or mechanical, including photocopying, recording, taping or storage in information retrieval systems without the express permission of

the publisher.

Every care has been taken to ensure that the information contained in this report is correct. The publisher accepts no liability for decisions made on the basis of information contained herein.

British Library Cataloguing in Publication Data.

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©Espicom Business Intelligence iiiOctober 2008

Who’s Developing What in Drug Delivery? Table of Contents

ContentsImaRx THERaPEUTICS.................................................................................................................................. 1

KEY PERSONNEL ........................................................................................................................................................................ 1COMPANY OVERVIEW .............................................................................................................................................................. 1KEY MILESTONES ...................................................................................................................................................................... 1PRODUCTS / TECHNOLOGIES .................................................................................................................................................. 1RESEARCH ACTIVITIES .............................................................................................................................................................. 2AGREEMENTS ............................................................................................................................................................................. 2KEY FINANCIAL DATA................................................................................................................................................................ 3

ImmUNOGEN ................................................................................................................................................. 5KEY PERSONNEL ........................................................................................................................................................................ 5COMPANY OVERVIEW .............................................................................................................................................................. 5KEY MILESTONES ...................................................................................................................................................................... 5PRODUCTS / TECHNOLOGIES .................................................................................................................................................. 5RESEARCH ACTIVITIES .............................................................................................................................................................. 5AGREEMENTS ............................................................................................................................................................................. 7KEY FINANCIAL DATA................................................................................................................................................................ 8

ImPax LaBORaTORIES ................................................................................................................................. 9KEY PERSONNEL ........................................................................................................................................................................ 9COMPANY OVERVIEW .............................................................................................................................................................. 9KEY MILESTONES ...................................................................................................................................................................... 9PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 10RESEARCH ACTIVITIES ............................................................................................................................................................ 11AGREEMENTS ........................................................................................................................................................................... 11KEY FINANCIAL DATA.............................................................................................................................................................. 12COMPETITION .......................................................................................................................................................................... 13

INDEVUS PHaRmaCEUTICaLS ................................................................................................................... 15KEY PERSONNEL ...................................................................................................................................................................... 15COMPANY OVERVIEW ............................................................................................................................................................ 15KEY MILESTONES .................................................................................................................................................................... 15PRODUCTS ............................................................................................................................................................................... 16RESEARCH ACTIVITIES ............................................................................................................................................................ 18AGREEMENTS .......................................................................................................................................................................... 19KEY FINANCIAL DATA.............................................................................................................................................................. 20

INNOCOLL TECHNOLOGIES ........................................................................................................................ 21KEY PERSONNEL ...................................................................................................................................................................... 21COMPANY OVERVIEW ............................................................................................................................................................ 21KEY MILESTONES .................................................................................................................................................................... 21PRODUCTS / TECHNOLOGIES ................................................................................................................................................22RESEARCH ACTIVITIES ............................................................................................................................................................23AGREEMENTS ...........................................................................................................................................................................25KEY FINANCIAL DATA..............................................................................................................................................................25

INOVIO BIOmEDICaL .................................................................................................................................. 27KEY PERSONNEL ...................................................................................................................................................................... 27COMPANY OVERVIEW ............................................................................................................................................................ 27KEY MILESTONES .................................................................................................................................................................... 27TECHNOLOGIES/PRODUCTS..................................................................................................................................................28RESEARCH ACTIVITIES ...........................................................................................................................................................28AGREEMENTS ...........................................................................................................................................................................30KEY FINANCIAL DATA.............................................................................................................................................................. 31

©Espicom Business Intelligence October 2008iv

Who’s Developing What in Drug Delivery?

KEY COMPETITORS ................................................................................................................................................................. 32INSITE VISION INC ....................................................................................................................................... 33

KEY PERSONNEL ...................................................................................................................................................................... 33COMPANY OVERVIEW ............................................................................................................................................................ 33KEY MILESTONES .................................................................................................................................................................... 33PRODUCTS / TECHNOLOGIES ................................................................................................................................................34RESEARCH ACTIVITIES ............................................................................................................................................................ 35AGREEMENTS ........................................................................................................................................................................... 35KEY FINANCIAL DATA.............................................................................................................................................................. 37COMPETITION .......................................................................................................................................................................... 37

INTERCELL aG .............................................................................................................................................. 39KEY PERSONNEL ...................................................................................................................................................................... 39COMPANY OVERVIEW ............................................................................................................................................................ 39INTERCELL KEY MILESTONES ................................................................................................................................................ 39IOMAI KEY MILESTONES ........................................................................................................................................................40INTERCELL PRODUCTS / TECHNOLOGIES ............................................................................................................................40INTERCELL RESEARCH ACTIVITIES ........................................................................................................................................ 42IOMAI RESEARCH ACTIVITIES ................................................................................................................................................ 42INTERCELL AGREEMENTS ...................................................................................................................................................... 43IOMAI AGREEMENTS .............................................................................................................................................................. 43KEY FINANCIAL DATA..............................................................................................................................................................44COMPETITION ..........................................................................................................................................................................44

INTRaNaSaL THERaPEUTICS INC .............................................................................................................. 45KEY PERSONNEL ...................................................................................................................................................................... 45COMPANY OVERVIEW ............................................................................................................................................................ 45KEY MILESTONES .................................................................................................................................................................... 45PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 45RESEARCH ACTIVITIES ............................................................................................................................................................46AGREEMENTS ...........................................................................................................................................................................48KEY FINANCIAL DATA..............................................................................................................................................................48

KV PHaRmaCEUTICaL COmPaNY .............................................................................................................. 49KEY PERSONNEL ...................................................................................................................................................................... 49COMPANY OVERVIEW ............................................................................................................................................................ 49KEY MILESTONES .................................................................................................................................................................... 49PRODUCTS / TECHNOLOGIES ................................................................................................................................................50AGREEMENTS ........................................................................................................................................................................... 51KEY FINANCIAL DATA.............................................................................................................................................................. 53ASSOCIATED COMPANIES ...................................................................................................................................................... 53COMPETITION ..........................................................................................................................................................................54

LaBOPHaRm INC ........................................................................................................................................ 55KEY PERSONNEL ...................................................................................................................................................................... 55COMPANY OVERVIEW ............................................................................................................................................................ 55KEY MILESTONES .................................................................................................................................................................... 55PRODUCTS / TECHNOLOGIES ................................................................................................................................................56RESEARCH ACTIVITIES ............................................................................................................................................................ 59AGREEMENTS ...........................................................................................................................................................................60KEY FINANCIAL DATA.............................................................................................................................................................. 63ASSOCIATED COMPANIES ...................................................................................................................................................... 63COMPETITION .......................................................................................................................................................................... 63

LaVIPHaRm GROUP .................................................................................................................................... 65KEY PERSONNEL ...................................................................................................................................................................... 65

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©Espicom Business Intelligence vOctober 2008

Who’s Developing What in Drug Delivery?

COMPANY OVERVIEW ............................................................................................................................................................ 65KEY MILESTONES .................................................................................................................................................................... 65PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 65AGREEMENTS ........................................................................................................................................................................... 67KEY FINANCIAL DATA..............................................................................................................................................................68

LIGHT SCIENCES CORPORaTION ................................................................................................................ 69KEY PERSONNEL ...................................................................................................................................................................... 69COMPANY OVERVIEW ............................................................................................................................................................ 69KEY MILESTONES .................................................................................................................................................................... 69PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 69RESEARCH ACTIVITIES ............................................................................................................................................................ 70AGREEMENTS ........................................................................................................................................................................... 71KEY FINANCIAL DATA.............................................................................................................................................................. 71ASSOCIATED COMPANIES ...................................................................................................................................................... 71

maCROCHEm CORPORaTION..................................................................................................................... 73KEY PERSONNEL ...................................................................................................................................................................... 73COMPANY OVERVIEW ............................................................................................................................................................ 73KEY MILESTONES .................................................................................................................................................................... 73PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 74RESEARCH ACTIVITIES ............................................................................................................................................................ 76AGREEMENTS ...........................................................................................................................................................................77KEY FINANCIAL DATA..............................................................................................................................................................77COMPETITION .......................................................................................................................................................................... 78

maxCYTE INC .............................................................................................................................................. 79KEY PERSONNEL ...................................................................................................................................................................... 79COMPANY OVERVIEW ............................................................................................................................................................ 79KEY MILESTONES .................................................................................................................................................................... 79PRODUCTS / TECHNOLOGIES ................................................................................................................................................80AGREEMENTS ........................................................................................................................................................................... 81KEY FINANCIAL DATA..............................................................................................................................................................82

mDRNa ........................................................................................................................................................ 83KEY PERSONNEL ...................................................................................................................................................................... 83COMPANY OVERVIEW ............................................................................................................................................................ 83 KEY MILESTONES .................................................................................................................................................................... 83PRODUCTS / TECHNOLOGIES ................................................................................................................................................84RESEARCH ACTIVITIES ............................................................................................................................................................86AGREEMENTS ........................................................................................................................................................................... 87KEY FINANCIAL DATA..............................................................................................................................................................89COMPETITION ..........................................................................................................................................................................89

mEDImmUNE INC ........................................................................................................................................ 91KEY PERSONNEL ...................................................................................................................................................................... 91COMPANY OVERVIEW ............................................................................................................................................................ 91KEY MILESTONES .................................................................................................................................................................... 91PRODUCTS / TECHNOLOGIES ................................................................................................................................................ 92RESEARCH ACTIVITIES ............................................................................................................................................................ 93AGREEMENTS ...........................................................................................................................................................................94KEY FINANCIAL DATA.............................................................................................................................................................. 95COMPETITION .......................................................................................................................................................................... 95

mELDEx INTERNaTIONaL PLC .................................................................................................................... 97KEY PERSONNEL ...................................................................................................................................................................... 97COMPANY OVERVIEW ............................................................................................................................................................ 97

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Who’s Developing What in Drug Delivery?

KEY MILESTONES .................................................................................................................................................................... 97PRODUCTS / TECHNOLOGIES ................................................................................................................................................98RESEARCH ACTIVITIES ..........................................................................................................................................................100AGREEMENTS .........................................................................................................................................................................105KEY FINANCIAL DATA............................................................................................................................................................106COMPETITION ........................................................................................................................................................................106

mILESTONE SCIENTIFIC ............................................................................................................................. 109KEY PERSONNEL ....................................................................................................................................................................109COMPANY BACKGROUND ....................................................................................................................................................109KEY MILESTONES ..................................................................................................................................................................109PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 110AGREEMENTS ......................................................................................................................................................................... 112KEY FINANCIAL DATA............................................................................................................................................................ 112COMPETITION ........................................................................................................................................................................ 112

mIRUS BIO CORPORaTION ........................................................................................................................113KEY PERSONNEL .................................................................................................................................................................... 113COMPANY OVERVIEW .......................................................................................................................................................... 113KEY MILESTONES .................................................................................................................................................................. 113PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 113RESEARCH STRATEGY ........................................................................................................................................................... 114AGREEMENTS ......................................................................................................................................................................... 116KEY FINANCIAL DATA............................................................................................................................................................ 116

mOOG mEDICaL DEVICES ..........................................................................................................................117KEY PERSONNEL .................................................................................................................................................................... 117COMPANY OVERVIEW .......................................................................................................................................................... 117KEY MILESTONES .................................................................................................................................................................. 117PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 117AGREEMENTS ......................................................................................................................................................................... 119KEY FINANCIAL DATA............................................................................................................................................................ 120

NaNOBIOTIx ...............................................................................................................................................121KEY PERSONNEL .................................................................................................................................................................... 121COMPANY OVERVIEW .......................................................................................................................................................... 121PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 121RESEARCH ACTIVITIES .......................................................................................................................................................... 121AGREEMENTS ......................................................................................................................................................................... 121KEY FINANCIAL DATA............................................................................................................................................................ 122

NaNOmaTERIaLS TECHNOLOGY ............................................................................................................. 123KEY PERSONNEL .................................................................................................................................................................... 123COMPANY OVERVIEW .......................................................................................................................................................... 123KEY MILESTONES .................................................................................................................................................................. 123PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 123RESEARCH .............................................................................................................................................................................. 124AGREEMENTS ......................................................................................................................................................................... 124KEY FINANCIAL DATA............................................................................................................................................................ 124

NaNOBIO CORPORaTION ......................................................................................................................... 125KEY PERSONNEL .................................................................................................................................................................... 125COMPANY OVERVIEW .......................................................................................................................................................... 125KEY MILESTONES .................................................................................................................................................................. 125PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 125RESEARCH ACTIVITIES .......................................................................................................................................................... 126KEY FINANCIAL DATA............................................................................................................................................................ 127

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Who’s Developing What in Drug Delivery?

NaNOBIOmaGNETICS ............................................................................................................................... 129KEY PERSONNEL .................................................................................................................................................................... 129COMPANY OVERVIEW .......................................................................................................................................................... 129PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 129RESEARCH ..............................................................................................................................................................................130KEY FINANCIAL DATA............................................................................................................................................................130

NaNOCaRRIER ...........................................................................................................................................131KEY PERSONNEL .................................................................................................................................................................... 131COMPANY OVERVIEW .......................................................................................................................................................... 131PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 131RESEARCH ACTIVITIES .......................................................................................................................................................... 132AGREEMENTS ......................................................................................................................................................................... 132KEY FINANCIAL DATA............................................................................................................................................................ 133

NaNOTHERaPEUTICS INC ......................................................................................................................... 135KEY PERSONNEL .................................................................................................................................................................... 135COMPANY OVERVIEW .......................................................................................................................................................... 135KEY MILESTONES .................................................................................................................................................................. 135PRODUCTS / TECHNOLOGIES ..............................................................................................................................................136RESEARCH ACTIVITIES ..........................................................................................................................................................138AGREEMENTS .........................................................................................................................................................................138KEY FINANCIAL DATA............................................................................................................................................................ 139

NaNO INTERFaCE TECHNOLOGY ..............................................................................................................141KEY PERSONNEL .................................................................................................................................................................... 141COMPANY OVERVIEW .......................................................................................................................................................... 141PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 141RESEARCH ACTIVITIES .......................................................................................................................................................... 141KEY FINANCIAL DATA............................................................................................................................................................ 141

NaNO S BIOTECHNOLOGY ........................................................................................................................ 143KEY PERSONNEL .................................................................................................................................................................... 143COMPANY OVERVIEW .......................................................................................................................................................... 143KEY MILESTONES .................................................................................................................................................................. 143PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 143RESEARCH .............................................................................................................................................................................. 143AGREEMENTS .........................................................................................................................................................................144KEY FINANCIAL DATA............................................................................................................................................................144

NaNOTECHNOLOGY VICTORIa ................................................................................................................ 145KEY PERSONNEL ....................................................................................................................................................................145COMPANY OVERVIEW ..........................................................................................................................................................145PRODUCTS / TECHNOLOGIES ..............................................................................................................................................145RESEARCH ..............................................................................................................................................................................145AGREEMENTS .........................................................................................................................................................................146KEY FINANCIAL DATA............................................................................................................................................................146

NEKTaR THERaPEUTICS ........................................................................................................................... 147KEY PERSONNEL .................................................................................................................................................................... 147COMPANY OVERVIEW .......................................................................................................................................................... 147KEY MILESTONES .................................................................................................................................................................. 147PRODUCTS / TECHNOLOGIES ..............................................................................................................................................148RESEARCH ACTIVITIES .......................................................................................................................................................... 152AGREEMENTS ......................................................................................................................................................................... 153KEY FINANCIAL DATA............................................................................................................................................................ 155ASSOCIATED COMPANIES .................................................................................................................................................... 155

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Who’s Developing What in Drug Delivery?

COMPETITION ........................................................................................................................................................................ 155NEOPHaRm INC ......................................................................................................................................... 157

KEY PERSONNEL .................................................................................................................................................................... 157COMPANY OVERVIEW .......................................................................................................................................................... 157PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 157AGREEMENTS .........................................................................................................................................................................160KEY FINANCIAL DATA............................................................................................................................................................160

NEUROTECH .............................................................................................................................................. 161KEY PERSONNEL .................................................................................................................................................................... 161COMPANY OVERVIEW .......................................................................................................................................................... 161KEY MILESTONES .................................................................................................................................................................. 161PRODUCTS / TECHNOLOGIES ..............................................................................................................................................162RESEARCH ACTIVITIES ..........................................................................................................................................................163AGREEMENTS .........................................................................................................................................................................164KEY FINANCIAL DATA............................................................................................................................................................165ASSOCIATED COMPANIES ....................................................................................................................................................165

NExmED INC .............................................................................................................................................. 167KEY PERSONNEL .................................................................................................................................................................... 167COMPANY OVERVIEW .......................................................................................................................................................... 167KEY MILESTONES .................................................................................................................................................................. 167PRODUCTS / TECHNOLOGIES ..............................................................................................................................................168RESEARCH ACTIVITIES .......................................................................................................................................................... 170AGREEMENTS ......................................................................................................................................................................... 170KEY FINANCIAL DATA............................................................................................................................................................ 171COMPETITION ........................................................................................................................................................................ 171

NORWOOD aBBEY .................................................................................................................................... 173KEY PERSONNEL .................................................................................................................................................................... 173COMPANY OVERVIEW .......................................................................................................................................................... 173KEY MILESTONES .................................................................................................................................................................. 173PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 174RESEARCH ACTIVITIES .......................................................................................................................................................... 176AGREEMENTS ......................................................................................................................................................................... 176KEY FINANCIAL DATA............................................................................................................................................................ 177ASSOCIATED COMPANIES .................................................................................................................................................... 177

NOVaDEL PHaRma ................................................................................................................................... 179KEY PERSONNEL .................................................................................................................................................................... 179COMPANY OVERVIEW .......................................................................................................................................................... 179KEY MILESTONES .................................................................................................................................................................. 179PRODUCTS / TECHNOLOGIES ..............................................................................................................................................180AGREEMENTS .........................................................................................................................................................................182KEY FINANCIAL DATA............................................................................................................................................................182COMPETITION ........................................................................................................................................................................183

NOVaGaLI PHaRma .................................................................................................................................. 185KEY PERSONNEL ....................................................................................................................................................................185COMPANY OVERVIEW ..........................................................................................................................................................185KEY MILESTONES ..................................................................................................................................................................185PRODUCTS / TECHNOLOGIES ..............................................................................................................................................185RESEARCH ACTIVITIES ..........................................................................................................................................................187AGREEMENTS .........................................................................................................................................................................189KEY FINANCIAL DATA............................................................................................................................................................189

NOVaVax ................................................................................................................................................... 191

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Who’s Developing What in Drug Delivery?

KEY PERSONNEL .................................................................................................................................................................... 191COMPANY OVERVIEW .......................................................................................................................................................... 191KEY MILESTONES .................................................................................................................................................................. 191PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 192RESEARCH ACTIVITIES ..........................................................................................................................................................194AGREEMENTS .........................................................................................................................................................................194KEY FINANCIAL DATA............................................................................................................................................................196COMPETITION ........................................................................................................................................................................196

NOVEN PHaRmaCEUTICaLS .................................................................................................................... 197KEY PERSONNEL .................................................................................................................................................................... 197COMPANY OVERVIEW .......................................................................................................................................................... 197KEY MILESTONES .................................................................................................................................................................. 197PRODUCTS / TECHNOLOGIES ..............................................................................................................................................198RESEARCH ACTIVITIES ..........................................................................................................................................................199AGREEMENTS .........................................................................................................................................................................200KEY FINANCIAL DATA............................................................................................................................................................201ASSOCIATED COMPANIES ....................................................................................................................................................201COMPETITION ........................................................................................................................................................................201

NOVOSOm aG ............................................................................................................................................ 203KEY PERSONNEL ....................................................................................................................................................................203COMPANY OVERVIEW ..........................................................................................................................................................203KEY MILESTONES ..................................................................................................................................................................203PRODUCTS / TECHNOLOGIES ..............................................................................................................................................203RESEARCH ACTIVITIES ..........................................................................................................................................................204AGREEMENTS .........................................................................................................................................................................204KEY FINANCIAL DATA............................................................................................................................................................204

OaKWOOD LaBORaTORIES LLC ............................................................................................................... 205KEY PERSONNEL ....................................................................................................................................................................205COMPANY OVERVIEW ..........................................................................................................................................................205PRODUCTS / TECHNOLOGIES ..............................................................................................................................................205RESEARCH ACTIVITIES ..........................................................................................................................................................207AGREEMENTS .........................................................................................................................................................................207KEY FINANCIAL DATA............................................................................................................................................................207

OCTOPLUS ................................................................................................................................................. 209KEY PERSONNEL ....................................................................................................................................................................209COMPANY OVERVIEW ..........................................................................................................................................................209KEY MILESTONES ..................................................................................................................................................................209PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 210AGREEMENTS ......................................................................................................................................................................... 212KEY FINANCIAL DATA............................................................................................................................................................ 213

ORExO.........................................................................................................................................................215KEY PERSONNEL .................................................................................................................................................................... 215COMPANY OVERVIEW .......................................................................................................................................................... 215KEY MILESTONES .................................................................................................................................................................. 215PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 216RESEARCH ACTIVITIES .......................................................................................................................................................... 217AGREEMENTS ......................................................................................................................................................................... 219KEY FINANCIAL DATA............................................................................................................................................................220COMPETITION .......................................................................................................................................................................220

ORIEL THERaPEUTICS INC ........................................................................................................................ 221KEY PERSONNEL ....................................................................................................................................................................221

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COMPANY OVERVIEW ..........................................................................................................................................................221KEY MILESTONES ..................................................................................................................................................................221PRODUCTS / TECHNOLOGIES ..............................................................................................................................................222AGREEMENTS .........................................................................................................................................................................222KEY FINANCIAL DATA............................................................................................................................................................222

OTSUKa PHaRma ..................................................................................................................................... 223KEY PERSONNEL ....................................................................................................................................................................223COMPANY OVERVIEW ..........................................................................................................................................................223KEY MILESTONES ..................................................................................................................................................................223PRODUCTS / TECHNOLOGIES ..............................................................................................................................................224RESEARCH ACTIVITIES ..........................................................................................................................................................229AGREEMENTS ........................................................................................................................................................................231KEY FINANCIAL DATA............................................................................................................................................................232

PCI BIOTECH .............................................................................................................................................. 233KEY PERSONNEL ....................................................................................................................................................................233COMPANY OVERVIEW ..........................................................................................................................................................233KEY MILESTONES ..................................................................................................................................................................233PRODUCTS / TECHNOLOGIES ..............................................................................................................................................233RESEARCH ACTIVITIES ..........................................................................................................................................................234AGREEMENTS .........................................................................................................................................................................234KEY FINANCIAL DATA............................................................................................................................................................234

PENWEST PHaRmaCEUTICaLS COmPaNY .............................................................................................. 235KEY PERSONNEL ....................................................................................................................................................................235COMPANY OVERVIEW ..........................................................................................................................................................235KEY MILESTONES ..................................................................................................................................................................235PRODUCTS / TECHNOLOGIES ..............................................................................................................................................236RESEARCH ACTIVITIES ..........................................................................................................................................................239AGREEMENTS .........................................................................................................................................................................240FINANCIALS ............................................................................................................................................................................ 241COMPETITION ........................................................................................................................................................................ 241

PHOQUS GROUP PLC ................................................................................................................................ 243KEY PERSONNEL ....................................................................................................................................................................243COMPANY OVERVIEW ..........................................................................................................................................................243KEY MILESTONES ..................................................................................................................................................................243PRODUCTS / TECHNOLOGIES ..............................................................................................................................................244RESEARCH ACTIVITIES ..........................................................................................................................................................245AGREEMENTS .........................................................................................................................................................................246KEY FINANCIAL DATA............................................................................................................................................................246

PHOSPHaGENICS LImITED ....................................................................................................................... 247KEY PERSONNEL ....................................................................................................................................................................247COMPANY OVERVIEW ..........................................................................................................................................................247KEY MILESTONES ..................................................................................................................................................................247TECHNOLOGIES/PRODUCTS................................................................................................................................................248Drug Enhancement .............................................................................................................................................................250R&D ACTIVITIES .....................................................................................................................................................................250AGREEMENTS .........................................................................................................................................................................251FINANCIALS ............................................................................................................................................................................251

PHOTOCURE aSa ...................................................................................................................................... 253KEY PERSONNEL ....................................................................................................................................................................253COMPANY OVERVIEW ..........................................................................................................................................................253KEY MILESTONES ..................................................................................................................................................................253

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Who’s Developing What in Drug Delivery?

PRODUCTS / TECHNOLOGIES ..............................................................................................................................................255RESEARCH ACTIVITIES ..........................................................................................................................................................257AGREEMENTS .........................................................................................................................................................................257KEY FINANCIAL DATA............................................................................................................................................................258ASSOCIATED COMPANIES ....................................................................................................................................................258

POINT BIOmEDICaL CORPORaTION ........................................................................................................ 259KEY PERSONNEL ....................................................................................................................................................................259COMPANY OVERVIEW ..........................................................................................................................................................259PRODUCTS / TECHNOLOGIES ..............................................................................................................................................259RESEARCH ACTIVITIES ..........................................................................................................................................................260KEY FINANCIAL DATA............................................................................................................................................................260

PROTHERICS .............................................................................................................................................. 261KEY PERSONNEL ....................................................................................................................................................................261COMPANY OVERVIEW ..........................................................................................................................................................261KEY MILESTONES ..................................................................................................................................................................261PRODUCTS / TECHNOLOGIES ..............................................................................................................................................261RESEARCH ACTIVITIES ..........................................................................................................................................................264AGREEMENTS .........................................................................................................................................................................267KEY FINANCIAL DATA............................................................................................................................................................269

PSIVIDa ...................................................................................................................................................... 271KEY PERSONNEL ....................................................................................................................................................................271COMPANY OVERVIEW ..........................................................................................................................................................271KEY MILESTONES ..................................................................................................................................................................271TECHNOLOGIES/PRODUCTS................................................................................................................................................273R&D MILESTONES .................................................................................................................................................................273AGREEMENTS .........................................................................................................................................................................275KEY FINANCIAL DATA............................................................................................................................................................277

QLT ............................................................................................................................................................. 279KEY PERSONNEL ....................................................................................................................................................................279COMPANY OVERVIEW ..........................................................................................................................................................279KEY MILESTONES ..................................................................................................................................................................279PRODUCTS / TECHNOLOGIES ..............................................................................................................................................280RESEARCH ACTIVITIES ..........................................................................................................................................................282AGREEMENTS .........................................................................................................................................................................283KEY FINANCIAL DATA............................................................................................................................................................286COMPETITION ........................................................................................................................................................................286

QUEST PHaRmaTECH ............................................................................................................................... 287KEY PERSONNEL ....................................................................................................................................................................287COMPANY OVERVIEW ..........................................................................................................................................................287KEY MILESTONES ..................................................................................................................................................................287PRODUCTS / TECHNOLOGIES ..............................................................................................................................................287RESEARCH ACTIVITIES ..........................................................................................................................................................287AGREEMENTS .........................................................................................................................................................................289KEY FINANCIAL DATA............................................................................................................................................................290

SCOLR PHaRma INC .................................................................................................................................. 291KEY PERSONNEL ....................................................................................................................................................................291COMPANY OVERVIEW ..........................................................................................................................................................291KEY MILESTONES ..................................................................................................................................................................291PRODUCTS / TECHNOLOGIES ..............................................................................................................................................292RESEARCH ACTIVITIES ..........................................................................................................................................................293AGREEMENTS ........................................................................................................................................................................294

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KEY FINANCIAL DATA............................................................................................................................................................295COMPETITION ........................................................................................................................................................................296

SEaTTLE GENETICS .................................................................................................................................... 297KEY PERSONNEL ....................................................................................................................................................................297COMPANY OVERVIEW ..........................................................................................................................................................297PRODUCTS / TECHNOLOGIES ..............................................................................................................................................297RESEARCH ACTIVITIES ..........................................................................................................................................................297AGREEMENTS .........................................................................................................................................................................298KEY FINANCIAL DATA............................................................................................................................................................299

SILENCE THERaPEUTICS ........................................................................................................................... 301KEY PERSONNEL ....................................................................................................................................................................301COMPANY OVERVIEW ..........................................................................................................................................................301KEY MILESTONES ..................................................................................................................................................................301PRODUCTS / TECHNOLOGIES ..............................................................................................................................................301RESEARCH ACTIVITIES ..........................................................................................................................................................302AGREEMENTS .........................................................................................................................................................................303KEY FINANCIAL DATA............................................................................................................................................................304

SKINVISIBLE INC ........................................................................................................................................ 305KEY PERSONNEL ....................................................................................................................................................................305COMPANY OVERVIEW ..........................................................................................................................................................305KEY MILESTONES ..................................................................................................................................................................305PRODUCTS / TECHNOLOGIES ..............................................................................................................................................305RESEARCH STRATEGY ...........................................................................................................................................................306AGREEMENTS .........................................................................................................................................................................307KEY FINANCIAL DATA............................................................................................................................................................308COMPETITION ........................................................................................................................................................................308

SKYEPHaRma PLC .....................................................................................................................................311KEY PERSONNEL .................................................................................................................................................................... 311COMPANY OVERVIEW .......................................................................................................................................................... 311KEY MILESTONES .................................................................................................................................................................. 311PRODUCTS / TECHNOLOGIES .............................................................................................................................................. 312RESEARCH ACTIVITIES .......................................................................................................................................................... 316AGREEMENTS ......................................................................................................................................................................... 316KEY FINANCIAL DATA............................................................................................................................................................ 318ASSOCIATED COMPANIES .................................................................................................................................................... 319COMPETITION ........................................................................................................................................................................ 319

SPHERICS INC ............................................................................................................................................ 321KEY PERSONNEL ....................................................................................................................................................................321COMPANY OVERVIEW ..........................................................................................................................................................321KEY MILESTONES ..................................................................................................................................................................321PRODUCTS / TECHNOLOGIES ..............................................................................................................................................321RESEARCH ACTIVITIES ..........................................................................................................................................................322AGREEMENTS .........................................................................................................................................................................323KEY FINANCIAL DATA............................................................................................................................................................323

STaRPHaRma ............................................................................................................................................ 325KEY PERSONNEL ....................................................................................................................................................................325COMPANY OVERVIEW ..........................................................................................................................................................325KEY MILESTONES ..................................................................................................................................................................325PRODUCTS / TECHNOLOGIES ..............................................................................................................................................325RESEARCH ACTIVITIES ..........................................................................................................................................................326AGREEMENTS .........................................................................................................................................................................327

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Who’s Developing What in Drug Delivery?

KEY FINANCIAL DATA............................................................................................................................................................327SUPRaTEK PHaRma INC ........................................................................................................................... 329

KEY PERSONNEL ....................................................................................................................................................................329COMPANY OVERVIEW ..........................................................................................................................................................329KEY MILESTONES ..................................................................................................................................................................329PRODUCTS / TECHNOLOGIES ..............................................................................................................................................329RESEARCH ACTIVITIES .......................................................................................................................................................... 331AGREEMENTS ......................................................................................................................................................................... 331KEY FINANCIAL DATA............................................................................................................................................................ 331

SYNTONIx PHaRmaCEUTICaLS INC......................................................................................................... 333KEY PERSONNEL ....................................................................................................................................................................333COMPANY OVERVIEW ..........................................................................................................................................................333KEY MILESTONES ..................................................................................................................................................................333PRODUCTS / TECHNOLOGIES ..............................................................................................................................................333RESEARCH ACTIVITIES ..........................................................................................................................................................334AGREEMENTS .........................................................................................................................................................................336KEY FINANCIAL DATA............................................................................................................................................................336

TEKmIRa PHaRmaCEUTICaLS CORPORaTION ....................................................................................... 337KEY PERSONNEL ....................................................................................................................................................................337COMPANY OVERVIEW ..........................................................................................................................................................337KEY MILESTONES ..................................................................................................................................................................337PRODUCTS / TECHNOLOGIES ..............................................................................................................................................338RESEARCH ACTIVITIES ..........................................................................................................................................................339AGREEMENTS .........................................................................................................................................................................340KEY FINANCIAL DATA............................................................................................................................................................341

TELESSO TECHNOLOGIES ......................................................................................................................... 343KEY PERSONNEL ....................................................................................................................................................................343COMPANY OVERVIEW ..........................................................................................................................................................343KEY MILESTONES ..................................................................................................................................................................343PRODUCTS / TECHNOLOGIES ..............................................................................................................................................344RESEARCH ACTIVITIES ..........................................................................................................................................................347AGREEMENTS .........................................................................................................................................................................347KEY FINANCIAL DATA............................................................................................................................................................348ASSOCIATED COMPANIES ....................................................................................................................................................348

TRaNSPHaRma mEDICaL ........................................................................................................................ 349KEY PERSONNEL ...................................................................................................................................................................349COMPANY OVERVIEW ..........................................................................................................................................................349KEY MILESTONES ..................................................................................................................................................................349PRODUCTS / TECHNOLOGIES ..............................................................................................................................................349RESEARCH ACTIVITIES ..........................................................................................................................................................351AGREEMENTS .........................................................................................................................................................................352KEY FINANCIAL DATA............................................................................................................................................................352

URIGEN PHaRmaCEUTICaLS .................................................................................................................... 353KEY PERSONNEL ....................................................................................................................................................................353COMPANY OVERVIEW ..........................................................................................................................................................353KEY MILESTONES ..................................................................................................................................................................353PRODUCTS / TECHNOLOGIES ..............................................................................................................................................353RESEARCH ACTIVITIES ..........................................................................................................................................................355AGREEMENTS .........................................................................................................................................................................356KEY FINANCIAL DATA............................................................................................................................................................357ASSOCIATED COMPANIES ....................................................................................................................................................357

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©Espicom Business Intelligence October 2008xiv

Who’s Developing What in Drug Delivery?

COMPETITION .......................................................................................................................................................................358VECTURa LTD ............................................................................................................................................ 359

KEY PERSONNEL ....................................................................................................................................................................359COMPANY OVERVIEW ..........................................................................................................................................................359KEY MILESTONES ..................................................................................................................................................................359PRODUCTS / TECHNOLOGIES ..............................................................................................................................................360RESEARCH ACTIVITIES ..........................................................................................................................................................361AGREEMENTS .........................................................................................................................................................................364KEY FINANCIAL DATA............................................................................................................................................................365ASSOCIATED COMPANIES ....................................................................................................................................................365

VICaL ......................................................................................................................................................... 367KEY PERSONNEL ....................................................................................................................................................................367COMPANY OVERVIEW ..........................................................................................................................................................367KEY MILESTONES ..................................................................................................................................................................367PRODUCTS / TECHNOLOGIES ..............................................................................................................................................367RESEARCH ACTIVITIES ..........................................................................................................................................................368AGREEMENTS .........................................................................................................................................................................369KEY FINANCIAL DATA............................................................................................................................................................370

VIVUS INC .................................................................................................................................................. 371KEY PERSONNEL ....................................................................................................................................................................371COMPANY OVERVIEW ..........................................................................................................................................................371KEY MILESTONES ..................................................................................................................................................................371PRODUCTS / TECHNOLOGIES ..............................................................................................................................................371RESEARCH ACTIVITIES ..........................................................................................................................................................375AGREEMENTS .........................................................................................................................................................................375KEY FINANCIAL DATA............................................................................................................................................................ 376COMPETITION ........................................................................................................................................................................ 376

ZOGENIx INC ............................................................................................................................................. 377KEY PERSONNEL ....................................................................................................................................................................377COMPANY OVERVIEW ..........................................................................................................................................................377KEY MILESTONES ..................................................................................................................................................................377PRODUCTS / TECHNOLOGIES ..............................................................................................................................................377RESEARCH ACTIVITIES ..........................................................................................................................................................378AGREEMENTS .........................................................................................................................................................................379KEY FINANCIAL DATA............................................................................................................................................................379

ZOSaNO PHaRma ..................................................................................................................................... 381KEY PERSONNEL ....................................................................................................................................................................381COMPANY OVERVIEW ..........................................................................................................................................................381PRODUCTS / TECHNOLOGIES ..............................................................................................................................................381RESEARCH STRATEGY ...........................................................................................................................................................382KEY FINANCIAL DATA............................................................................................................................................................382

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