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7/27/2019 What is cancer-(Nop-2010).ppt
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WHAT IS CANCER ? !
Dairion Gatot
Divisi Hematology -Onkology MedicInternal Departement of Medical Faculty of
North Sumatera University /Haji Adam Malik General Hospital,
Medan 2010
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Definition
Tumor
Neoplasma
Benigna
cancer
( = cancer = lobster)
Maligna
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Group of diseases
Progressif and uncontrol (abnormal)
development to be enlargement tumor(Neoplasma) Tumor benigna and malignant. Benigna tumor : abnormal development, is not
spread.
Malignan tumor : abnormal development,spread, metastase.
Tumor solid = hard cancer, Tumor non solid =liquid cancer
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Mitosis/miosis activity
EUKARIOT CELL (Ex: Human Cell )
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computer
Program
Analysis Data
Instruction
Program
Printer
output
DNA
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PATOGENSIS OF CANCER ?
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Etiology
Uncontrol development
Miosis/mitosis
Gen damage
Radiation
? ?
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Virus
Carsinogen chemistry
Environment
Normal celCancer cel
transformation
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DNA
Mutation = change from instruction program
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CANCER CHARACTERISTIC ?
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Progressif, uncontrol. Metastatic
stadium IV Non infectious
Herediter (?) Genetik !
CancervsNormal
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Cancer :
Uncontrol development and
proliferation
Immortal
To presure normal cell
Cancer vs Normal
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Progresifitas cancer cell
Cancer Cell size :
One milyar cancercell = nail
spuit
One billion cancer
cell =strowberry
230 = 1,073,741,824= 1 milyar cell
2-6 week
Mitosis cancer cell every2-6 week
2-6 week
2-6 week
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METASTASIS CANCER ?
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Stadium / tahap
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SIMPTOM AND SIGN
Bowel and urine disorders
Ulcus Chronic
Bleeding uncontrol
Mass or and calsificatie
Dysphagia
Dyspepsia chronic
Hoarness and cough
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Karsinoma (cancersurface area)
CANCER TYPE AND LOCATION
Lung
Breast
Colon
bladder
Prostat (male)
Leukemia
Limfoma
Sarkoma
(musculo skeletal)
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CANCER DIAGNOSTIC
CYITOLOGIS /HISTOPHATOLOGY
CLINIS
(STAGING)
IMUNOHISTOCHEMISTY
ONCOMARKERRADIOGRAFI
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HEMATOLOGY MALIGNACY
Dr.Dairion Gatot Sp.PD
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Maturasi and Stem cell Diferentiation
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Malignancy Hematology :
From single cel , bone marrow, thymus or lymphoid
perifer system.
- Cel , genetic mutationmalignant
transformation malignant cel.
- Excessive mitosis and uncontrolclone malignant
cel. And or resisten forApoptosis-Progresife mutasi clone malignant celsubclone
maligna cel
(Atul Mechta-Victor Hoffbrand, Hematoloogi at a Glance)
INTRODUCTION
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Classification :
Characteristic malignancy hematology and lymphoid :
3 Characteristic :
Aggressiveness:Acute versus Chronic
Lineage: Lymphoidversus Myeloid
Predominant Site of Involvement: Blood and
Bone Marrowversus Tissue
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De Vita
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DIAGNOSTIC OF ACUTE LEUCAEMIA
SIMPTOM SIGNS
Fatigue,Malaise,Dyspnea Anemia,pallor
hematome , Trombosit Bleeding
Under weight Petechia,ecchymosis,fundusBone pain,abdominal pain hemorrhage
Neurologic symptom Fever and infection
Adenopathy
Hepatosplenomegali
Gum hypertrophy
Skin infiltration
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Blood periferal : Retikulosit
Dif-tel manual Bone Marrow
Aspirasi
Cytomorpholog
Cytogenetic (molecular
genetic) Immunophenotyping
Histologi/Biopsi
Blood chemisty:
. Elektrolit, creatinin, uric acid, Ca,LDH
Serologi Virus
APTT, PT, Fibr.,D-Dimer
SPEP I n MM atau Bcell
malignancy Blood Bank
HLA
L.P. pd ALL
CT Scan (Whole
Body/mediastinum)
DIAGNOSTIC OF ACUTE LEUCAEMIA
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Clasification FAB ,Akut Leukaemia
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Treatment of acute leukemia
Phase 1: INDUCTION Target complete remission Temporary (reversible) aplasia
Phase 2 : POST REMISSION Maintain remission (Last timemaintenance therapy Intensive consolidation therapy Stem cell transplantation
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Criteria for Remission in Acute Myelogenous Leukemia
Less than 5% myeloblasts in the bone marrow
Restoration of normal hematopoieis
Resolution of cytogenetic abnormalities
Resolution of any evidence of extramedullary leukemia (granulocytic sarcomas)
EBM
Criteria for Remission in Acute Leukemia
Hematologic Complete Response:
BM Aspirasi : Normal cellularity dan < 5% Blast dari semua
cell berintiDarah Tepi : Tanpa cell lekemia dan
Lekosit > 3000/mm3
Granulosit > 1500/mm3
Trombosit > 100.000/mm3
Lain lain : tak ada tanda klinik lekemia LUMC
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