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DISCLAIMER
The information provided by speakers in any presentation made as part of the 2012 NAF Annual Membership Meeting is for informational use only.
NAF encourages all attendees to consult with their primary care provider, neurologist, or other health care provider about any advice, exercise, therapies, medication, treatment, nutritional supplement, or regimen that may have been mentioned as part of any presentation.
Products or services mentioned during these presentations does not imply endorsement by NAF.
Clinical MRI Scanners 0.5 - 1.5 Tesla
High field MRI Scanners 3 - 7 Tesla Clearer images, more detailed info
MRI SCANNERSTesla = strength of
magnetic field
Versatility of MRI
• MRI can non-invasively image: anatomy
blood vessels / flow
brain networks
biochemistry:
• chemical levels
• metabolic rates
brain activation
Functional MRI (fMRI)
BOLD (blood oxygenation dependent) effect
Blood flow ↑
Deoxyhemoglobin ↓
Signal ↑
N-acetylaspartate 10.0 mmol/gglutamate 7.6 mmol/gglutamine 1.3 mmol/ginositol 5.4 mmol/g
MR image
MR spectrum
Concentration of metabolites
MR Spectroscopy (MRS)
Use of MRI in ataxias
• MRI is currently used in clinical care of ataxias as..
..diagnostic aid (detection of cerebellar atrophy)
MRI research in ataxias
• Recent focus areas:
anatomy / quantitative morphology
brain networks
brain chemistry
MORPHOLOGIC IMAGING in SCAs
Schulz et al, 2010
Different patterns of atrophy in different ataxias
Degree of tissue loss reflects disease severity
Control
MSA/C
4 3 2 1 ppm
NEUROCHEMICAL CHANGES IN SPORADIC ATAXIA
4 3 2 1 ppm
N-acetylaspartate
myo-inositol
Oz et al, 2011
Chemical changes can be detected & quantified
TREATMENT MONITORING WITH MRS Research with SCA1 mice
Age (weeks)
6
7
8
9
10
11
6 12
[Ta
urin
e] (
μm
ol/g
)
Oz et al, 2011
Chemical levels can be used to monitor disease reversal
healthy mice
mice with ataxia
Treatment
treated mice with ataxia
Future of MRI in ataxias
• Novel MRI technology can help with:
understanding disease processes
differential diagnosis
monitoring drug effects in clinical trials (serial testing no problem – no radioactivity)
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