WELCOME [] · Personalized Medicine - enabling hypothesis driven patient stratification and...

WELCOME

Otmar D. Wiestler, M.D. President of the Helmholtz Association

• Systems solutions for grand challenges based on: • Scientific excellence

• Interdisciplinarity and critical mass

• long term research programs

• Helmholtz provides a highly attractive environment for talents and brilliant brains

• Profound expertise in large scale research infrastructure

• Transfer of knowledge into economy and society

HELMHOLTZ RESEARCH MISSION & STRATEGY

HELMHOLTZ CENTERS

FACTS AND FIGURES

Staff

Budget 2016

EARTH AND ENVIRONMENT

RESEARCH PORTFOLIO of the Helmholtz Association

ENERGY HEALTH

AERONAUTICS, SPACE AND TRANSPORT

MATTER

KEY TECHNOLOGIES

HELMHOLTZ FUTURE CHALLENGES

• Energy research (storage, future energy systems)

• Exploring the system earth

• Future mobility concepts

• Personalized medicine (eHealth, PoC, prevention)

• Helmholtz Incubator Information & Data Science

SEITE 6

Five Disease-related Programs

Cardiovascular and Metabolic Diseases

Infection Research

Cancer Research

DKFZ, MDC, HZDR, GSI MDC, DKFZ

HZI

Diseases of the Nervous System

DZNE, MDC

Genes and Environment in Common Diseases

HMGU, UFZ

Largescale Research Infrastructure

National

Cohort

DKFZ, HMGU, MDC, HZI

HEALTH RESEARCH CENTERS AND PROGRAMS

HELMHOLTZ RESEARCH FIELD HEALTH

PAGE 8

• Basic research: disease mechanisms

• Unravel complex systems

• Translational research

• Focus on major diseases

• Strategic alliances

Grand challenges :

• Preventive medicine

• Personalized medicine

• E – Health

• Psychiatric disease

Helmholtz Cohort / MDC

Drug research, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) / HZI

TRANSLATION CENTERS - Helmholtz & University Medicine

• Close interaction between Helmholtz Research Centers and clinical partners under one roof

• Preclinical research and development

• Early clinical evaluation of innovative tools for diagnosis, therapy and prevention

• Platform for novel PPP alliances Helmholtz Center

Branch of a Helmholtz Center

Helmholtz Head Office

List

Helgoland

Bremerhaven Geesthacht Hamburg

Greifswald

Braunschweig

Wolfenbüttel-Remlingen

Göttingen

Magdeburg

Potsdam

Berlin

Zeuthen

Teltow

Niemegk

Halle

Leipzig Bad

Lauchstädt

Köln

Jülich

Bonn

Darmstadt

Heidelberg

Lampoldshausen

Karlsruhe

Stuttgart

München

Garching Neuherberg

Oberpfaffenhofen

ECRC Berlin

TWINCORE Hannover

CPC Munich

NCT Heidelberg

DZNE Bonn

MARC, Diabetes Study Center Munich

Slide 9

Helmholtz-Centre Pulmonary diseases

Neurodegenerative diseases

Diabetes

Cadio-vascular diseases

Cancer (DKTK)

Infections

GERMAN CENTRES FOR HEALTH RESEARCH

• Focus on translational research and personalized medicine

• Equal and long-term partnership between research institutions, universities, university clinics and clinics

THE NATIONAL COHORT

• Large prospective cohort

• Unique platform: 200,000 adults (20-69 years), follow- up for up to 30 years

• 18 Centers in representative regions

• Close cooperation between Helmholtz Centers (DKFZ, HMGU, MDC, HZI), Universities and Leibniz Institutes

• Start of recruitment October 2014

• Central biorepository for about 20 million samples at HMGU

Slide 11 Biorepository

PERSONALIZED MEDICINE

Personalized Medicine - enabling hypothesis driven patient stratification and

individualized diagnostics, therapies and prevention.

• Joint initiative of Helmholtz Research Field Health in close cooperation with academic medicine

• Common platform for high-throughput and information technologies

• Know-how and Life Science Technologies for molecular characterization of individual patients and application in the clinical setting

• Novel tailored therapies with maximum efficacy and minimum adverse effects

• Potential for personalized early detection and prevention (link to National Cohort)

CROSS-PROGRAM INITIATIVE

Slide 13

HELMHOLTZ INSTITUTE FOR

TRANSLATIONAL ONCOLOGY (HI-TRON)

• German Cancer Research Center, TRON, Mainz University Faculty of Medicine, Johannes Gutenberg University Mainz

• Development of personalized oncology based on cancer immunotherapy at the international forefront

• “The proposed HI-TRON is uniquely positioned to become a world leader in accelerating scientific, technical and clinical advances in this space.”

• “The overall concept and strategy is of outstanding scientific quality in the identification of biomarkers and the development of efficient new cancer therapies.”

DIGITAL HEALTH & DATA SCIENCE

• Incubator on „Information and Data Science “

• Strategic process for linking IT activities within the Helmholtz Association

• Contribution of all centers and research fields

• Program for data scientists

• Links between IT and Medicine

• Program „Decoding the human brain“

• Technologies and research on soft matter and biointerfaces

• Data There House for biomedical resaerch

• Cloud architectures (genome cloud)

INFORMATION AND DATA SCIENCE

Forschungszentrum Jülich

INFORMATION PROCESSING & BIG DATA IN BIOMEDICAL RESEARCH

• Data warehouse structures

• Clinical & research data

• Big data analytics

• Mesh computing

• Simulation, modelling

• Machine learning

• Data exchange

• Data protection

• Alliances between biomedical resaerch, academic medicine and IT industries

Display Data from Various Sources for a Comprehensive Overview of Information Relevant for Personalized Treatment

NCT GOES SAP HANA – NCT DATA THERE HOUSE

FUTURE DEVELOPMENTS IN BIOMEDICAL RESEARCH

POSSIBLE CORE ELEMENTS FOR ADVANCING HEALTH RESEARCH IN GERMANY

• Establishment of a Proof-of-Concept-platform

• Development and implementation of unified / interoperable HealthCare IT-concepts

• Joint initiatives for multi-site infrastructures in biomedical research

• Training programs for physician scientists

• Local centers of excellence for defined diseases entities

THANK YOU

Otmar D. Wiestler, M.D. President of the Helmholtz Association