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Purposeful innovations are alwaysthe result of collaborative vision.
ASMS2013Waters Corporation at
MinneapoLis, MinnesotaJUne 8 –13, 2013
[ COLLABORATE. InnOvATE. SUCCEED. ]
Waters exhibit booth #132
June 9, 7:30 pm to 9:30 pm
June 10 – 12, 9:00 am to 5:00 pm
June 13, 9:00 am to 3:30 pm
Minneapolis Convention Center
exhibit Hall B–C on Level one
1301 2nd ave south, Minneapolis, Mn
Waters hospitalit y suite
June 10 – 12, 8:00 pm to 11:00 pm
Hilton Minneapolis Grand Ballroom D,
third Level 1001 Marquette avenue south,
Minneapolis, Mn
Waters poster presentations
June 10 – 13, 10:30 am to 2:30 pm
Minneapolis Convention Center
poster/exhibit Hall B-C on Level one
1301 2nd ave south, Minneapolis, Mn
Waters oral presentations
June 10 – 13
room locations and times vary
Minneapolis Convention Center
1301 2nd ave south, Minneapolis, Mn
Waters breakfast seminars
June 10 – 12, 7:00 am to 8:00 am
Hilton Minneapolis, Grand Ballroom D
and Minneapolis Convention Center,
room 200i, Level 2
pre-registration is required. space is limited.
speak with your Waters sales representative
today to reserve your seat.
[ experience asms With Waters ]
Learn about the latest innovations and developments in Mass spectrometry from Waters experts throughout your time at asMs. Discover the new dimension of superior performance.
Let’s explore the possibilities together
2
orals: locations and times vary 9:30 am, Monday, Room L100 oral: MoB am - instrumentation: time-of-Flight Mass spectrometry: in Memory of Bob Cotter
Sub-Second Ce-Esi-MS Using Microfluidic Devices and a Novel Method for Acquiring High Speed Tof-MS Data
J. scott Mellors1; nicholas Batz1; Martin Green2; J. Michael ramsey1 1University of North Carolina, Chapel Hill, NC; 2Waters Corporation, Manchester, UK
posters: located in exhibit/poster halls b & c
Museum History Display, all week
From Radio Tube Cathodes to Cells in Mitosis: The Evolution of Secondary Ion Mass Spectrometry (SIMS) Instrumentation and Applications
p. Jane Gale1; Bryan L. Bentz2 1Gale-Bentz Consulting, Southborough, MA; 2Waters Corporation, Milford, MA
MP25 - 496 - protein therapeutics: Quantitative analysis
Quantitative Analysis of Blood Coagulation Factor VIII Therapeutics in Plasma using UPLC/MS
Hiroya Miura1; taiji Kawase2; Kenji Hirose2 1Japanese blood products organization, Tokyo, Japan; 2Nihon Waters K.K., Tokyo, Japan
MP26 -532 - Biomarker Quantitation: proteins and peptides
Ultrasensitive Quantification Assay for Oxytocin in Human Plasma using a LC/MS Microfluidic Platform
Catalin Doneanu; paul rainville Waters Corporation, Milford, MA
MP27-558 - Biomarker Discovery: Cancer
Bladder Cancer Proteome: A Multiplexing Approach using Online 2D Rp-Rp Chromatography Coupled with Data Independent Ion Mobility
Lee a Gethings1; Zhuowei Wang2; Bo Wen3; Ju Zhang3; Quanhui Wang3; Liang Lin3; Chris Hughes1; Johannes p.C. Vissers1; James Langridge1; siqi Liu3 1Waters Corporation, Manchester, UK; 2Waters Corporation(China), Beijing, China; 3BGI, Beijing, China
MP32- 659 - plant”omics”
Application of Sub-2µm Particle CO2-based Chromatography Coupled to Mass Spectrometry for Chemical Profiling of Various Chamomiles
Bharathi avula1; Yan-Hong Wang1; Michael D Jones2; Larry Meeker2; Kate Yu2; troy J. smillie1; ikhlas a. Khan1, 3 1University of Mississippi, NCNPR, University, MS; 2Waters Corporation, Milford, MA; 3Universty of Mississippi, School of Pharmacy, University, MS
MP36 - 736 - polymers
Advantages of Mass Spectrometric Detection for Polymers Separated by UltraPerformance Convergence Chromatography
oliver Burt1; Baiba Cabovska2; Michael o’Leary2; peter Hancock1 1Waters Corporation, Manchester, UK; 2Waters Corporation, Milford, MA
MP36 -741 - polymers
Evaluating the Use of Ion Mobility-Mass Spectrometry for Polymer End Group Characterization Using Polydimethyl Siloxane as a Model
andrew J. Hoteling1; eleanor riches2 1Bausch + Lomb, Rochester, NY; 2Waters Corporation, Manchester, UK
MP36 - 749 - polymers
Characterization Of Trace Organic Impurities in Purified Terephthalic Acid (Pta) by Using UPLC Q-Tof Ms For Process Optimization
Yuhong Zhang1; Chuan Wang1; Zhenlei peng1; Yidan Guo1; Kejun Qian2; Xiaomei Huang2; peter Lee3 1SINOPEC SRIPT, Shanghai, China; 2Waters Technologies (Shanghai) Limited, Shanghai, China; 3Waters Corporation, Milford, MA
MP36 - 723 - polymers
Using Ion Mobility for ‘Shape-Selective’ Characterization of Polymers
Kirsten Craven1; Julien De Winter2; pascal Gerbaux2 1Waters Corporation, Manchester, UK; 2University of Mons, Mons, Belgium
MP34 - 696 - natural products
Quality-by-Design UHPLC Method Development with High Resolution MSE for Biomarker Identification of Phyllanthus Species
amadeu iglesias1; ricardo sprenger2; Fernando de paula1; tiago Campos1; Michael Murgu1; Quezia Cass2 1Waters Corporation, Barueri, Brazil; 2Universidade Federal de São Carlos - UFSCar, São Carlos, SP, Brazil
MP31 - 639 - environmental analysis: General i
Selective and Sensitive Detection and Quantification of Stockholm Convention Pops, Including Dioxins, using Atmospheric Pressure Gas Chromatography MS/MS
Kendon Graham1, 2; Jody Dunstan1, 2; Michael McCullagh1, 2; ingrid ericson Jogsten3; Jessika Hagberg3; Bert van Bavel3 1Waters Corporation, Milford, MA; 2Waters Corporation, Manchester, UK; 3MTM Research Centre, Orebro, Sweden
MP06 - 096 - LC-Ms: Chromatography
High Resolution LC-MS Peptide Separations with Formic Acid Mobile Phases using Charge Surface Modified C18 Columns
Matthew Lauber; stephan Koza; Kenneth Fountain
Waters Corporation, Milford, MA
MP06 - 116 - LC-Ms: Chromatography
Considerations in Combining Mass Spectral Data with Orthogonal Detector Information in LC/MS
thomas e. Wheat; aparna Chavali; patricia McConville
Waters Corporation, Milford, MA
MP06 - 124 - LC-Ms: Chromatography
Considerations in Developing a Prototype Microfluidic Trapping Column to Improve Mass and Volume Capacity in an Integrated LC/MS System
Jay s. Johnson; James Murphy; angela Doneanu; Bob Jencks; robert Collamati
Waters Corporation, Milford, MA
MP16 - 319 - instrumentation: new Developments in Mass analyzers
Electrostatic Gimbal for Correction of Errors in Time-Of-Flight Mass Spectrometers
John B Hoyes; andrew Whatley; David Langridge; anthony Gilbert
Waters Corporation, Manchester, UK
MP24 - 489 - new advances in Quantitative proteomics
Travelling Wave Ion Mobility Assisted Duty Cycle Enhancements for Targeted and Non-Targeted Proteomics Experiments
Christopher J Hughes ; Johannes pC Vissers; James Langridge
Waters Corporation, Manchester, UK
MP25 - 519 - protein therapeutics: Quantitative analysis
Quantification of Biotherapeutics in DMPK Studies using Accurate Mass MS/MS
Joanne Mather1; robert s. plumb2; Gordon Fujimoto1; Jonathan r. Kheller3; Matthew e. szapacs3; Christopher evans3 1Waters Corporation, Milford, MA; 2Imperial College, London, UK; 3GSK, King of Prussia, PA
MP25 - 521 - protein therapeutics: Quantitative analysis
Improved Identification and Quantitation of Host Cell Proteins in Protein Therapeutics using 2D-LC and Ion Mobility
Martha stapels; Catalin Doneanu; Keith Fadgen
Waters Corporation, Milford, MA
MOndAy, June 10
3
orals: locations and times vary
Time: 10:10 am, Tuesday, Room 101
oral: toF am - Metabolomics/Lipidomics: new Ms technologies and applications
The Use Of Ion-Mobility Mass Spectrometry for Separation and Structural Elucidation of Lipids in Human Plasma. Application In Lipidomics Studies
Carola W.n. Damen1, 2; Giorgis isaac3; Jonathan p. Williams4; Johannes p.C. Vissers4; James i. Langridge4; thomas Hankemeier1, 2; rob J. Vreeken1, 2 1Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands; 2Analytical Biosciences, LACDR, Leiden University, Leiden, The Netherlands; 3Waters Corporation, Milford, MA, USA; 4Waters Corporation., Manchester, UK
Time: 9:30 am, Tuesday, Room 101
oral: toF am - Metabolomics/Lipidomics: new Ms technologies and applications
Multi-Omics Profiling of Methionine-Restricted MCF7 Cells in 24 Hours Using a Prototype UPLC-Compatible Microfluidic Device
J. Will thompson1; Jay Johnson2; Giuseppe astarita2; Xiaohu tang1; Giuseppe paglia3; Jim Murphy2; steven Cohen2; Mark Bennett4; Jen-tsan Chi1; James Langdridge2; Geoff Gerhardt2; M. arthur Moseley1 1Duke University School of Medicine, Durham, NC; 2Waters Corporation, Milford, MA; 3Center for Systems Biology, University of Iceland, Reykjavik, Iceland; 4Nonlinear Dynamics, Durham, NC
Time: 8:30 am, Tuesday, Ballroom B
oral: toC am - Functional Foods, phytochemicals, and supplements
Analysis of an Adulterated Herbal Medicinal Product using UPLC-Qtof-MS
Mark powell1; Margaret Maziarz2; Michael D. Jones2; Warren potts2; Kate Yu2 1Quay Pharmaceuticals, Flintshire, UK; 2Waters Corporation, Milford, MA
Time: 3:30 pm, Tuesday, Ballroom B
oral: toC pm - Characterization of product Variants in Biosimilars
Assessing ‘Scrambled’ Disulfide Linkages: A Comprehensive Workflow for Routine Characterization of Biotherapeutics using High-Resolution LCMS and Electron Transfer Dissociation
asish Chakraborty; stephane Houel; Henry shion; scott Berger; Weibin Chen
Waters Corporation, Milford, MA
posters: located in exhibit/poster halls b & c
TP01 - 001 - ion activation/Dissociation
Investigation Into UV Photon Induced Fragmentation in a RF Confined Ion Guide Using A Vacuum UV Ionisation Lamp.
Martin Green; Keith richardson; Jeff Brown; paul Murray
Waters Corporation, Manchester, UK
TP01 - 002 - ion activation/DissociationUV Photodissociation within an Axially Illuminated Stacked Ring Ion Guide of an Ion Mobility Enabled Q-ToF
Jeff Brown1; Mike Morris1; Kevin Giles1; richard Chapman1; paul Murray1; emmy Hoyes1; Christopher Jones1; Jakub Ujma2; Bruno Bellina3; isabelle Compagnon3; perdita Barran2 1Waters Corporation, Manchester, UK; 2The University of Edinburgh, Edinburgh, UK; 3CNRS et Université Lyon, Lyon, France
TP02 - 027 - ion/Molecule, ion/ion, ion/electron interactions
Electrochemical-Assistance for Electron Transfer Dissociation Ion Mobility MS of Peptides and Proteins
Jonathan p. Williams; Christopher Hughes; Jeffery Brown
Waters Corporation, Manchester, UK
TP04 - 065 - instrumentation: new Developments in ionization and sampling
A Closer Look at The Sensitivity Enhancement Observed with Capillary and Nanoflow UPLC for Both Small and Large Molecules.
James Murphy; Jay Johnson; paul rainville
Waters Corporation, Milford, MA
TP04 - 086 - instrumentation: new Developments in ionization and sampling
Construction of an Interventional Mass Spectrometer for Intrasurgical Tissue Identification.
Cristina Guallar-Hoyas1; Laura Muirhead1; Lajos Gödörházy2; Dániel szalay2; tamás Krancsi2; steven pringle3; Mike Morris3; Zoltán takáts1 1Imperial Collegue, London, UK; 2Medimass, Budapest, Hungary; 3Waters Corporation, Manchester, UK
TP05 - 099 - instrumentation: new Concepts
Multiplexed Analysis of Steroid Hormones in Human Serum using Novel Microflow Tile Technology and LC-MS/MS
Carolyn Broccardo1; Kevin schauer1; Wendy Kohrt2; robert schwartz2; James Murphy3; Jessica prenni1 1Colorado State University, Ft Collins, CO; 2University of Colorado Anschutz Medical Campus, Aurora, CO; 3Waters Corporation, Milford, MA
TP08 - 139 - peptides: Quantitative analysis i
High Resolution Pseudo Mrm Peptide Assays on a Qtof Instrument
Dominic Helm1; Benjamin ruprecht1; simone Lemeer1; Christopher J Hughes2; Johannes pC Vissers2; James i Langridge2; Bernhard Kuster1 1Technische Universität München, Freising, Germany; 2Waters Corporation, Manchester, UK
TP10 - 190 - protein Covalent Labeling
A New Label Free Approach for the Determination of Reaction Rates in Oxidative Footprinting Experiments
eduardo pilau1; amadeu iglesias2; Fabio Gozzo3 1University of Maringá, Maringá, Brazil; 2Waters Technology, São Paulo, Brasil; 3University of Campinas, Campinas, Brazil
TP15 - 232 - protein therapeutics: structural Characterization
Characterization And Comparison Of O-Glycosylation Between the Innovator and a Biosimilar of Etanercept
stephane Houel1; Ying Qing Yu1; Jonathan p. Williams2; Weibin Chen1 1Waters Corporation, Milford, MA; 2Waters Corporation, Manchester, UK
TP18 - 262 - Biomarker Discovery: proteins
Application Of Multi-Omic And Functional Network Analysis For Paediatric Patients Diagnosed with Idiopathic Nephrotic Syndrome
Lee a Gethings1; Johannes p.C. Vissers1; John shockcor2; stephen McDonald2; sandra Kraljevic pavelic3; Mirela sedic3; Maja Lemac4; Danica Batinic4; James Langridge1; olga Vasieva5; Keith Compson1 1Waters Corporation, Manchester, UK; 2Waters Corporation, Milford, MA; 3University of Rijeka, Rijeka, Croatia; 4University of Zagreb, Zagreb, Croatia; 5University of Liverpool, Liverpool, UK
TP20 - 301 - new technologies in Biomarker Discovery
Rapid Analysis of Endogenous Steroids using Convergence Chromatography Coupled with Mass Spectrometric Detection
Christopher J. Hudalla1; stuart Chadwick2; Fiona Liddicoat2; andrew peck1; Kenneth J. Fountain1 1Waters Corporation, Milford, MA; 2Waters Corporation, Manchester, UK
TP20 - 304 - new technologies in Biomarker Discovery
Calcyclin Levels Determined by High-Throughput Srm In Serum Samples Of Pre-Eclampsia Patients
Coskun Güzel2; Johannes pC Vissers1; Lennard Dekker2; Gerda G Zeeman3; eric ap steegers3; theo M Luider2 1Waters Corporation, Manchester, UK; 2ErasmusMC, Department of Neurology, Rotterdam, The Netherlands; 3ErasmusMC, Department of Gynaecology, Rotterdam, The Netherlands
TueSdAy, June 11
4
TP23 - 361 - Metabolomics: General
Collision-Cross Sections of Common Cellular Metabolites to Support Metabolomics Applications
Giuseppe paglia1; Giuseppe astarita2, 4; J. Will thompson3; Jonathan p. Williams2, 4; James Langridge2,
4; Bernhard o. palsson1, 5 1Center for Systems Biology, University of Iceland, Reykjavik, Iceland; 2Waters Corporation, Milford, MA; 3Duke Proteomics Core Facility, Durham, NC; 4Waters Corporation, Manchester, UK; 5Systems Biology Research Group, UCSD, San Diego, CA
TP24 - 384 - Metabolomics: Untargeted Metabolite profiling applications
UPLC-MS Metabolic Profiling Reveals Involvement of Novel Biological Pathways in the Progression of Atherosclerosis
panagiotis Vorkas1; Joseph shalhoub2; Giorgis isaac3; elizabeth Want1; Jeremy nicholson1; alun Davies2; elaine Holmes1 1Biomolecular Medicine, Imperial College, London, UK; 2Section of Vascular Surgery, Imperial College, London, UK; 3Waters Corporation, Milford, MA
TP25 - 421 - Drug Metabolism: Quantitative analysis
Analysis of Pharmaceutical Small Molecules using a Prototype Microfluidics Tandem Quadrupole LCMS System
Yun W. alelyunas1; Mark D. Wrona1; Catalin Doneanu1; stephen McDonald1; paul D. rainville1; philip tiller2 1Waters Corporation, Milford, MA; 2RMI laboratories, North Wales, PA
TP25 - 451 - Drug Metabolism: Quantitative analysis
Diastereomeric Separation of Chiral Metabolites Utilizing SFC-MS/MS; A Powerful Tool to Investigate Stereoselective Metabolism?
Chester L Bowen1; Hermes Licea-perez1; tom Dephillipo2; Denise Heyburn2; paul rainville2; robert plumb2; Christopher evans1 1GlaxoSmithKline, King Of Prussia, PA; 2Waters Corporation, Milford, MA
TP27 - 492 - Lipids: Quantitative analysis
Rapid Profiling of Oxylipins for Drug Discovery and Development, Nutritional and Clinical Research
roy Martin1; Katrin strassburg2, 3; thomas Hankemeier3; Giorgis isaac1; James Langridge1; Claude Mallet1; rob Vreeken2, 3; Giuseppe astarita1 1Waters Corporation, Milford, MA; 2Netherlands Metabolomics Centre, Leiden, The Netherlands; 3Analytical BioSciences, LACDR, Leiden, The Netherlands
TP28 - 519 - informatics: Quantification/Validation
A Qualitative and Quantitative Ion Mobility Enabled Data Independent SILAC Workflow
andrew JK Williamson1; steven Ciavarini2; scott J Geromanos2; andrew tudor3; Barry Dyson3; Lee Gethings3; Kelly McMahon3; robert tonge3; James i Langridge3; anthony D Whetton1; Johannes pC Vissers3 1School of Cancer and Imaging Sciences, Manchester, UK; 2Waters Corporation, Milford, MA; 3Waters Corporation UK, Manchester, UK
TP31 - 579 - environmental analysis: pharmaceuticals and pesticides
Screening Environmental Samples for a Diverse Range of Compound Classes/Structures with Accurate Mass LC-MS and an Integrated Scientific Information System
Gareth Cleland; Lauren Mullin; Claude Mallet; Jennifer Burgess
Waters Corporation, Milford, MA
TP33 - 620 - ion Mobility applications
Separation of Isomeric Cationized Diterpene Glycosides from Stevia Rebaudiana Bertoni Leaves by Traveling Wave Ion Mobility Mass Spectrometry (Twim-Ms).
alessandra tata1; Giovana anceski Bataglion1; Gustavo Henrique Martins Ferreira souza2; Marcos nogueira eberlin1 1University of Campinas UNICAMP, Campinas (SP), Brazil; 2MS Applications and Develop Lab, Waters Corporation, São Paulo, Brazil
TP33 - 626 - ion Mobility applications
Determination and Characterization of PFOS in Environmental Samples Using Travelling Wave Ion Mobility Mass Spectrometry
Michael McCullagh1; Kendon Graham1; Dominic roberts1; Kieran J neeson1; Jeff Goshawk1; Leonard Dillon1; Mike Hodgkinson1; ingrid ericson2; Bert van Bavel2 1Waters Corporation, Manchester, UK; 2MTM Research Centre, Örebro University, Örebro, Sweden
TP33 - 627 - ion Mobility applications
A Novel Approach to the Reduction of False Positive and Negative Identifications in Screening of Pesticide Residues in Food Analysis
séverine Goscinny1; Michael McCullagh2; Kieran neeson2; Jeff Goshawk2; David eatough2; sara stead2; ramesh rao2; Dominic roberts2 1Scientific Institute of Public Health, Brussels, BELGIUM; 2Waters Corporation, Manchester, UK
TP35 - 695 - Carbohydrates i
Confident Identification of Isomeric N-Glycan Structures by Combined Ion Mobility Mass Spectrometry and Hydrophilic Interaction Liquid Chromatography
Yoshiki Yamaguchi1; Kenji Hirose2; Wataru nishima1; suyong re1; Yuji sugita1
1RIKEN, Wako-Shi, JAPAN; 2Nihon Waters K.K., Osaka, JAPAN
TP36 - 719 - Glycoproteins i
Rapid N-Linked Glycan Glycopeptide Analysis Of The Biotherapeutic Erythropoietin (Epo) Using Hilic UPLC/Flr And Mass Spectrometry
Mark Hilliard1; pauline rudd1; Jonathan Bones 1; Ying Qing Yu2 1NIBRT, Dublin, Ireland; 2Waters Corporation, Milford, MA
TP37 - 750 - Food safety
Using Ion Mobility Mass Spectrometry to Identify Multiple Protonation Sites and Different Fragmentation Patterns Within the Fluoroquinolone Class of Antibiotics
Michael McCullagh1; sara stead1; David eatough1; Kieran neeson1; Jeff Goshawk1; Wouter de Keizer2; aldert Bergwerff2 1Waters Corporation, Manchester, UK; 2RnAssays BV, Utrecht, The Netherlands
TP37 - 750 - Food Safety
Using Ion Mobility Mass Spectrometry to Identify Multiple Protonation Sites and Different Fragmentation Patterns Within the Fluoroquinolone Class of Antibiotics
Michael McCullagh1; sara stead1; David eatough1; Kieran neeson1; Jeff Goshawk1; Wouter de Keizer2; aldert Bergwerff2 1Waters Corporation, Manchester, UK; 2RnAssays BV, Utrecht, The Netherlands
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5
orals: locations and times vary
Time: 3:10 pm, Wednesday, Ballroom A
oral: WoD pm - Biomarkers of Drug response, efficacy and toxicity: novel Ms approaches
Evaluation of a Novel Microfluidic Device for Robust and Ultrasensitive Quantitative Analysis of Biomarkers and Bio-Therapeutics By LC-MS/MS
Jose Castro-perez1; Haihong Zhou1; Vinit shah1; Kevin Bateman1; David Mclaren1; anita Lee1; stephen previs1; Kitshiri Herath1; James Murphy2; paul rainville2; alan Millar2; angela Doneanu2; Michele Cleary1; thomas roddy1 1Merck, Kenilworth, NJ; 2Waters Corporation, Milford, USA
posters: located in exhibit/poster halls b & c
WP05 - 052 - energy: Hydrocarbons and petrochemical
Comparisons and Characterization of Different Asphaltenes Using Novel Ion Mobility-Mass Spectrometry Comparison Software.
eleanor riches1; Jeremie ponthus2 1Waters Corporation, Manchester, UK; 2IFP Energies Nouvelles, Lyon, France
WP05 - 067 - energy: Hydrocarbons and petrochemical
Petroleum Biomarkers Analyzed by Atmospheric Pressure Gas Chromatography Tandem Mass Spectrometry (APGC/MS/MS)
Douglas stevens1; Quan shi2; Chang samuel Hsu3, 4 1Waters Corporation, Milford, MA; 2China University of Petroleum, Beijing, China; 3Florida State University, Tallahassee, FL; 4Petro Bio Oil Consulting, Tallahassee, FL
WP10 - 167 - imaging Ms: software
Targeted Ion Imaging MS: Evaluation Of New Algorithms to Reduce Acquisition and Processing Time
paul Murray; Keith richardson; emmy Hoyes; Chris Jones; richard Chapman; Jeff Brown
Waters Corporation, Manchester, UK
WP10 - 168 - imaging Ms: software
Investigation of Different Hierarchal Clustering Approaches for Protein Identification Directly from Tissue Section in a Maldi Imaging Experiment.
Mark towers1; Laura M. Cole2; Malcolm r. Clench2; emmanuelle Claude1 1Waters Corporation, Manchester, UK; 2Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
WP12 - 208 - imaging Ms: small Molecules
Spatial Correlation Combined with Hierarchal Clustering Analysis For Reducing Complex Multi-Dimensional Maldi Imaging Dataset
Hernando olivos1, 2; Kieran neeson1, 2; emmanuelle Claude1, 2; Mark towers1, 2 1Waters Corporation, Manchester, UK; 2Waters Corporation, Beverly, US
WP13 - 232 - informatics: small Molecule identification and Characterization
Integrating Datasets from Drug Metabolism and Bioanalytical Studies and Fixing the Missing Link for Quan/Qual
Mark D. Wrona; Craig Dorschel; Yun W. alelyunas; Kevin Cook; stephen McDonald; paul D. rainville
Waters Corporation, Milford, MA
WP15 - 254 - Drug Metabolism: Qualitative analysis
Evaluation of Xevo G2-S Q-Tof And Unifi Software for the Identification and Relative Quantitation of Metabolites
richard Clayton1; richard Lock2; Lucy Fernandes2 1Covance, Harrogate, UK; 2Waters Corporation, Manchester, UK
WP15 - 264 - Drug Metabolism: Qualitative analysis
Utility of Data-Independent LC/MSE with Ion Mobility to Increase Coverage of Nefazodone Metabolites from In-Vivo Matrices
Joseph t. Marini1; andrew G. Baker2; Jie Ding1; Donald L. McKenzie1 1Covance, Madison, WI; 2Waters Corporation, Pleasanton, CA
WP15 - 280 - Drug Metabolism: Qualitative analysis
A Comparison Of LC-MS and a Prototype Microfluidics-MS Device in the Metabolite Identification of In-Vitro and In-Vivo Samples.
philip tiller1; Mark D. Wrona2; Yun W. alelyunas2; Catalin Doneanu2; paul D. rainville2 1RMI laboratories, North Wales, PA; 2Waters Corporation, Milford, MA
WP16 - 286 - Drug and Metabolite analysis: novel approaches for Dried Biological samples
Application of Micro Fluidic LC/MS/MS for the Quantification Rosuvastatin from Dried Blood Spots: a Clinical Study Example
robert plumb2; nicola Gray1; ian Wilson2; paul rainville1 1Waters Corporation, Milford, MA; 2Imperial College, London, UK
WP18 - 313 - Metabolomics: Clinical applications
Application of Metabolomics to Characterize Differences Between Plasma and Nipple Aspirate Fluid, a Potential Source of Novel Breast Cancer Biomarkers.
Jessica Miller1; patricia thompson1; andrew Baker2, 3; steven Lai2, 3; H-H sherry Chow1 1University of Arizona Cancer Center, Tucson, AZ; 2Waters Corporation, Pleasanton, CA; 3Waters Corporation, Milford, MA
WP18 - 318 - Metabolomics: Clinical applications
Evaluation of Home Sampling DBS And Micro Fluidic LC/MS for Monitoring the Effects of Rosuvastatin on Cholesterol and Triglyceride Levels
robert plumb1; ian Wilson1; nicola Gray1; paul rainville2 1Imperial College, London, UK; 2Waters Corporation, Milford, MA
WP19 - 344 - Food “omics” Ms Characterization of Food and nutritional supplements
Characterization And Quantification of Peanut Allergens using Ion Mobility Data Independent Label Free Strategies
philip Johnson2; Lee a Gethings1; Justin Marsh2; James Langridge1; Clare Mills2 1Waters Corporation, Manchester, UK; 2University of Manchester, Manchester, UK
WP21 - 374 - H/D exchange, software and Hardware
Assessing Lab-to-lab Reproducibility of Deuterium Measurement in Hydrogen Deuterium Exchange Mass Spectrometry Analysis
Barbara sullivan
Waters Corporation, Beverly, MA
WP21 - 376 - H/D exchange, software and Hardware
An Improved Hdx Platform Workflow for Enhanced Separation, Digestion, and Data Analysis
Joomi ahn1; Michael eggertson1; Keith Fadgen1; Han Joo Lee1; John engen2 1Waters Corporation, Milford, MA; 2Northeastern University, Boston, MA
WP21 - 378 - H/D exchange, software and Hardware
Overcoming Peak Capacity Limitations Imposed by Hydrogen Exchange Quench Conditions
Bradley B. stocks1; thomas e. Wales1; Martha stapels2; Keith Fadgen2; Michael eggertson2; Geoff Gerhardt2; John r. engen1 1Northeastern University, Boston, MA; 2Waters Corporation, Milford, MA
WP24 - 436 - antibody and antibody Drug Conjugates
Rapid Analysis of Intact Antibody-Drug Conjugates(Adcs) By UPLC Q-Tof MS
Wei Jia1; ChuanFei Yu2; Kai Gao2 1Waters Corporation, ShangHai, Beijing, China; 2China National institutes for Food and Drug Control, Beijing, China
WP25 - 447 - analysis of Biosimilars
Applying Multiple Orthogonal Analytical Methodologies for Comprehensive Biosimilar Comparability Assessment
Henry shion; Vera ivleva; Ying Qing Yu; tom Wheat; Weibin Chen
Waters Corporation, Milford, MA
WP25 - 448 - analysis of Biosimilars
N-linked Glycan Profile Comparison Between the Innovator and a Biosimilar Etanercept
Ying-Qing Yu
Waters Corporation, Milford, MA
WP26 - 475 - Biomarkers: Discovery
Biomarker Screening for Drug-Induced Nephrotoxicity in Rats Using UPLC-MSe
Liuxi Chen1; Brad Williams2; Jonathan phillips1; scott Geromanos2; Vladimir papov1 1Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT; 2Waters Corporation, Milford, MA
WedneSdAy, June 12
6
WP31 - 590 - informatics: peptide identification / Characterization i
Using Orthogonal Techniques For Protein-Peptide Separation to Generate Comprehensive HDMSE Mass Spectral Libraries From an e. Coli Model System
Justin D. topp3; Michael nold5; ezra s. abrams2; Charles L. Farnsworth1; scott Geromanos5; Manor askenazi4; Jeffrey C. silva1 1Cell Signaling Technology, Danvers, MA; 2Sage Science Inc., Beverly, MA; 3Gordon College, Wenham, MA; 4The Ionomix Initiative, Arlington, MA; 5Waters Corporation, Milford, MA
WP33 - 634 - peptides: Quantitative analysis ii
The Analysis Of Human Parathyroid Hormone 1-34 (Teriparatide) by LC-MS/MS: Challenges and Lessons Learned
erin e. Chambers1; Mary Lame1; Jon Bardsley2; eileen Collins2; sally Hannam2; elizabeth thomas2; Kenneth J. Fountain1 1Waters Corporation, Milford, MA; 2ICON PLC, Manchester, UK
WP33 - 641 - peptides: Quantitative analysis ii
Absolute Quantitation of Yeast Kinases by Means of LC-MS/MS Using Qconcat And Srm Technologies
philip J Brownridge1; Victoria Harman1; simon Cubbon2; Johannes pC Vissers2; Craig Lawless3; simon J Hubbard3; robert J Beynon1 1Protein Function Group, University of Liverpool, Liverpool, UK; 2Waters Corporation, Manchester, UK; 3Faculty of Life Sciences, University of Manchester, Manchester, UK
WP35 - 672 - advances in separation techniques for proteomic applications
A Comparison of Proteomic Data Sets Obtained from Varied Experimental Approaches
susan slade1; James Langridge3; nisha patel2; Joanne B. Connolly3; James scrivens1 1University of Warwick, Coventry, UK; 2Department of Chemistry, University of Oxford, Oxford, UK; 3Waters Corporation, Manchester, UK
WP36 - 699 - interactions and pathway analysis
Investigation of Hepatocytes Transfected with Cytochrome P450: Data Independent LC-MS Approach to Identify and Quantify on a Multi-Omic Scale
suzanne Geenen1; Lee a Gethings2; Cristian Cojocariu2; Janet Hammond2; Giorgis isaac3; Lucy Fernandes2; robert tonge2; Johannes p.C. Vissers2; James Langridge2; ian Wilson1; Mark McDowall2 1AstraZeneca, Macclesfield, UK; 2Waters Corporation, Manchester, UK; 3Waters Corporation, Milford, MA
WP37 - 707 - ambient ionization: applications ii
Rapid Screening of Plasticisers in Gaskets for Glass Food Jar Lids using Atmospheric Pressure Solids Analysis Probe-High Resolution Mass Spectrometry
Malcolm Driffield1; Dennis speck1; Mita parmar1; Jennifer Leak1; Liam Lister1; emma Bradley1; Dominic roberts2; sara stead2 1Food and Environmental Research Agency (Fera), York, UK; 2Waters Corporation, Manchester, UK
orals: locations and times vary
Time: 8:50 am, Thursday, Room L100
thoB am - informatics: Metabolomics
A Novel Approach for Processing LC-Ion Mobility-MS Metabolomics Data
Giorgis isaac2; Martin palmer3; Mark Bennett1; James Langridge3; John p. shockcor2; andy Borthwick1 1Nonlinear Dynamics, Newcastle, upon Tyne , UK; 2Waters Corporation, Milford, MA; 3Waters Corporation, Manchester, UK
Time: 10:10 am, Thursday, Exhibit Hall A
thoa am - ambient ionization: instrumentation and applications
Rapid Evaporative Ionization Mass Spectrometry – Mechanism And Applications
Dániel szalay1; Lajos Gödörházy1; tamás Karancsi1; andor rozsnyai1; ottmar Golf2; Karl-Christian schäfer2; steven pringle3; Mike Morris3; Zoltán takáts2 1Medimass Ltd., Budapest, Hungary; 2Imperial College London, London , UK; 3Waters Corporation, Manchester, UK
Time: 4:10 pm, Thursday, Room L100
thoB pm - proteomics: infection Diseases
A Systems Biology Approach for The Discovery of Drug and/or Vaccine Targets In Plasmodium Falciparum using Irradiated Long-Lived Merozoites
Krishan Kumar1; prakash srinivasan2; Michael J. nold3; Dan sturdevant4; J. Kathleen Moch5; Karine reiter1; steve F. porcella4; scott Geromanos3; Julian C. rayner6; J. David Haynes5; David L. narum1 1LMIV,NIAID,NIH, Rockville, MD; 2LMVR,NIAID,NIH, Rockville, MD; 3Waters Corporation, Milford, MA; 4RTB, NIAID, NIH, Hamilton, MT; 5Walter Reed Army Institute of Research, Silver Spring, MD; 6Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
posters: located in exhibit/poster halls b & c
ThP05 - 054 - imaging Ms: instrumentation
Rapid Imaging of Unprocessed Chicken Bone Marrow by LAESI-MS with T-Wave Ion Mobility Separation using a Synapt G2-S
emmanuelle Claude1; Michel W.F nielen2, 3; Brent r. reschke4; Hilary Major1 1Waters Corporation, Manchester, UK; 2RIKILT, Wageningen, The Netherlands; 3Wageningen University, Lab of Organic Chemistry, Wageningen, The Netherlands; 4Protea Biosciences, Morgantown, US
ThP06 - 073 - instrumentation: General
3D Simulation of Quadrupole Mass Filter Performance with Realistic Ion Input Conditions
David Langridge
Waters Corporation, Manchester, UK
ThP06 - 087 - instrumentation: General
Probing the High Mass Transmission Characteristics of a Conjoined Ion Guide Enabled Quadrupole / Ion Mobility /Time-of Flight Instrument
Kevin Giles; Jason Wildgoose; Jonathan Williams; Martin De Cecco
Waters Corporation, Manchester, UK
ThP06 - 089 - instrumentation: General
Novel Acquisition Strategies For Tof And Ims-Tof Mass Spectrometers
Keith richardson1; Jason Wildgoose1; Martin Green1; stephen platt1; Martin palmer1; Mark Wrona2; asish Chakraborty2; arkadiusz Grzyb3 1Waters Corporation, Manchester, UK; 2Waters Corporation, Milford, MA; 3Inquiry Software, Bialogard, Poland
ThP07 - 118 - LC-Ms instrumentation
An Integrated LC/MS Platform for Microscale Applications
angela Doneanu; Jim Murphy; Jay Johnson; steve Cohen; Giusseppe astarita
Waters Corporation, Milford, MA
ThP08 - 131 - LC-Ms sample preparation (proteins & peptides)
Critical Evaluation of The Effects of Various Sample Clean Up Approaches for Micro Fluidic LC/MS In Bioanalysis
paul rainville; Jim Murphy; Catalin Doneanu
Waters Corporation, Milford, MA
ThP11 - 207 - GCMs: instrumentation & applications
Characteristics of Charge Exchange Chemical Ionization (CI) in an Atmospheric Pressure Gas Chromatography (APGC) Source and Applied Uses
steven Lai1; rhys Jones2; David Douce2; Jody Dunstan 2; Douglas stevens3 1Waters Corporation, Beverly, MA; 2Waters Corporation, Manchester, UK; 3Waters Corporation, Milford, MA
THuRSdAy, June 13
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