Visual processing pathways Ungerleider et al., 1998

Visual processing pathways

Ungerleider et al., 1998

Suzuki and Amaral, 1994

Organization and strength of cortical inputsto the hippocampus

VanRullen, 2003

Hierarchical organization of the ventral visual stream

Schematic representation of the ventral visual pathway

Rousselet et al., 2004

Distributed semantic model

Patterson et al., 2007

Semantic hub model

Patterson et al., 2007

Patterson et al., 2007

- stroke- Herpes simplex virus encephalitis- Alzheimer’s disease- fronto-temporal dementia (semantic variant)

Semantic dementia (SD)

Patterson et al., 2007

Patterson et al., 2007

Patterson et al., 2007

Differences between semantic dementia and Alzheimer’s disease inmeasures of semantic memory

1 minute to list as many examples of a semantic category as they can

Pyramids and Palm Trees test of semantic association

Patterson et al., 2007

Differences between semantic dementia and Alzheimer’s disease inmeasures of brain hypometabolism regions

(18F)fluoro‑2- deoxy‑D -glucose positron emission tomography (FDG-PET)

Magnetoencephalography (MEG)

Positron emission tomography (PET)

Functional MRI (fMRI)

Voxel-based morphometry(T1‑weighted MRI)

Rostral temporal lobes are ‘hard-to-get’

“To paraphrase a recently-departedUnited States Secretary of Defense,

Hub model: ATL regions as beingcrucial for semantic processing, or …

we do not believe that the seeming absence of evidence constitutes,in this case, evidence of absence.“

Patterson et al., 2007

ATL activation in functional imaging studies of semantic processing

Patterson et al., 2007

ATL activation in functional imaging studies of semantic processing

Thank you for your attention