Two compartment phantom for modeling hepatic tumors · 2017-01-26 · Two compartment phantom for...

Two compartment phantom for modeling hepatic tumors

Patrick McNeillie, MS2University of North Carolina at Chapel HillSchool of Medicine

March 7, 2008 Patrick McNeillie, MS2 2

Liver Cancer Statistics5th Highest Incidence3rd Highest Mortality

Incidence: (new cases)Hepatocellular Carcinoma

World: 600,000/yearUS: 22,000/year

5-year survival: 7%Cover, Oncology Times Special Supplement on Colorectal Cancer, May 2005

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Treatments-old favorites• Chemotherapy

– Liver cancer tends to be resistant

– Limited use

• Resection– High survival, if all

removed– Invasive,

complications

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Treatments-future• Radiation

– Effective– Harmful to regional organs

• Radiofrequency Ablation– High recurrence rate– Few complications

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How to study treatments?• Computer Simulations- not clinically

relevant, based on ideal models• Animals- OK models, difficult to

correlate, expensive, time consuming• People- IRB nightmare, illegal

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Phantom

• phan·tom (fan·tom) noun– a model of the body or one of its parts

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Properties• Imaging:

– MRI– CT– Ultrasound

• Radiofrequency Ablation

• Radiation Therapy• Resection

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Hypoxia – Tumor Size

Courtesy Hall, E. Radiobiology 1998

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Imaging-MRI

Real PatientPhantom

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Imaging-CT

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Imaging-US

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RFA-Thermal

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RFA- Before and After

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Radiation

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Radiation- Gamma (T99)

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Radiation- Beta (Y-90)

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Shortcomings

• Does not contain live cells, cannot test chemotherapy

• Does not have vascular system, cannot test endovascular therapies

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Summary

• Production of tissue-mimicking liver phantom

• Imaging: MRI, CT, and US

• Radiofrequency Ablation• Radiation

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Shameless Plug• GO UNC Beat Duke

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The University of North Carolina at Chapel Hill

The University of North Carolina at Chapel Hill

Oldest State University in the US: established 1773