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Trisynaptic Circuit
Hippocampal-Cortical Circuitry
AMNESIA……
…………..NOT A SOAP OPERA
Table 2. Anterograde memory test performance
E. P. Control means (n = 8)
Two-choice recognition memory
Words (50) 24 48.4
Faces (50) 28 41.9
Complex design
Copy (36) 27 30.3
Recall (36) 0 20.6
Paired-associate learning
Trial 1 (10) 0 6.0
Trial 2 (10) 0 7.6
Trial 3 (10) 0 8.9
Prose recall
No delay (21) 3 7.6
Delay (21) 0 6.4
The mean scores for control subjects for these tests are from Squire and Shimamura (1986). The two-choice recognition memory scores are based on a 24 hr recognition test of 50 words or 50 faces (modified from Warrington, 1984; maximum score, 50; chance, 25). The complex design test score is based on the copy and delayed (12 min) reproduction of the Rey-Osterrieth figure (Osterrieth, 1944; maximum score, 36; see also Figure 6). The paired-associates scores are the number of word pairs recalled on three successive trials (maximum score, 10/trial). The Prose recall scores are based on the number of segments recalled from a short prose passage that was read to the subjects. Recall was tested immediately and after 12 min. Note that the no-delay test requires recall of more information than can be retained in immediate memory, and amnesic patients often obtain impaired scores on this test.
Hypoxia; hippocampus: Another area of selective vulnerability is the hippocampus. In this slide the hippocampus is shrunken, cavitated and discolored, the result of a severe episode of hypoxia.
• Next Slide will show a damaged hippocampus…..
Korsakoff’s Syndrome –Degeneration of Mammillary Bodies
Recall of famous faces
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Basal Ganglia
Rat hippocampus
Hippocampal place field
‘Cognitive Map’ Dostrovsky & O’Keefe (1971)
Frontal Cortex
Prefrontal cortex neurons(Working memory)
Hippocampal & subicular recording
DNMS- neural recordings
Hampson & Deadwyler, 2003
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