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Transporting Your Skin Through Time. Lori Bush President of Nu Skin. Our Nu Skin Mission. We strive to be a distinctive resource for all who aspire to the physical, emotional, or financial rewards that derive from skin care product leadership. Healthy, beautiful skin. - PowerPoint PPT Presentation
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Transporting Your Skin Through Time
Lori BushPresident of Nu Skin
Our Nu Skin Mission
We strive to be a distinctive resource for all who aspire to the physical, emotional, or financial rewards that derive from skin care product leadership.
Healthy, beautiful skin
On a journey through time
?
How will your skin travel through time?
Zoe Diana Draelos, M.D.
Evolution of Skin Care:The Beginning
• Affordable common soap– Increased hygiene and fewer skin
infections– Soap removed too much sebum and
yielded dry skin
Evolution of Skin Care:The Beginning
• Moisturizers needed to counteract the drying effect of soap– Original moisturizers were
petroleum, lanolin– Greasy substances prevented
moisture from evaporating from the skin
Evolution of Skin Care:The Present
• Refined cleansers that provide excellent hygiene, but do not overdry the skin
• Elegant moisturizers that hydrate and retard moisture loss
• Sunscreens that prevent sunburn and function to counteract the aging effects of UV exposure
Present Skin Care Philosophy
• Add to the skin what is missing
• Sophisticated cosmeceutical moisturizers to add vitamins and antioxidants (skin care maintenance)
• Sunscreens to add additional protection from aging (skin care prevention)
Future Skin Care Philosophy
• Adding and supplementing the skin for prevention and maintenance purposes is important
• The step beyond is removal of substances that retard optimal skin functioning
• Add the good, remove the bad
Critical Questions
• What should you add to the skin and what should you remove?
• How do you know what is good and what is bad?
• How do you remove substances from the skin that promote aging?
Skin Aging Concepts
• Skin ages due to UV damage, oxidation
• Oxidation by products accumulate
• Skin aging progresses as byproducts decrease optimal functioning
Satisfied Oxygen Atom
Crippled “Free Radical”
Free Radical Chain Reaction
Antioxidants lose an electron without initiating a chain reaction.
Antioxidants inhibit lipid bi-layer and cell membrane breakdown.
Future Skin Care: Adapting New Technology to Skin
• Rate of tissue aging is slowed in laboratory by placing tissue in special transport media
• Transport media contains substances to remove byproducts from the tissue
• Tissues age at a slower rate due to optimal functioning
Evolution of Skin Care:The Future
• Important active ingredient in transport media is lactobionic acid
• Minimize the damaging effects of:– Oxygen and other pro-oxidants– Transitional metals, such as
iron
Evolution of Skin Care:The Future
• New skin care products utilize transport media technology to aid in the prevention of aging
• Active ingredients placed in moisturizers to hydrate skin
• Adding the good and removing the bad
The Future is Now
• Add to the skin – sun protection– skin moisturizers– skin antioxidants
• Remove from the skin– sebum and environmental dirt– damaging byproducts
Barbara Green, R.Ph., M.S.
Evolution of Hydroxyacid Skin Care
AHAs (glycolic acid, lactic acid)
PHAs (gluconolactone)
Bionic PHAs (lactobionic acid)
New
AHA vs. PHA
glycolic acid
COOH
C OH
gluconolactone
H
H
OH
OH
H
OHH
OH
CH OH
HO
2
PHA: Gluconolactone
• Polyhydroxy AHA (PHA): full strength anti-aging benefits
• Natural component of skin; cell nutrient
• Natural antioxidant/chelator
• Highly moisturizing
• Strengthens skin barrier (published study)
• Non-stinging, non-burning
• Suitable for all skin types including sensitive skin
• No increase in sun sensitivity
Gluconolactone - Chelator
• Dairy - prevents milk stone
• Brewery - prevents beer stones
• Foodstuffs - coagulant for tofu
• Humans - acidify urine to allow exchange
of Mg++ for Ca++ in kidney stones
Lactobionic Acid(Bionic PHA)
• Anti-aging effects (it is an AHA)
• Gentle to skin
• Plumps the skin
• Provides unique skin feel attributes – gel/film forming property
• Suitable for all skin types, even sensitive skin• Moisturizing/water binding: 8 hydroxyl groups
Lactobionic Acid Gel
Weight (g) of water absorbed per mole of substance*
-5
5
15
25
35
45
55
65
75
lactobionic acidglycerolgluconolactonesorbitolglycolic acidcitric acidpropylene glycollactic acidcontrolsalicylic acid
*After exposure to 100 % relative humidity for four hours.
Lactobionic Acid – Skin Protector!
• Antioxidant – Medical use - preservative for organs during
transplantation procedures – it traps metals
• Inhibitor of metalloproteinase enzymes (MMPs)– MMPs degrade skin collagen
– Leads to wrinkles, laxity, visible capillaries
– UV and aging MMP activity
Cumulative Irritation Study 14 days
0
0.5
1
1.5
2
2.5
3
1 2 3 4 5 6 7 8 9 10 11 12 13 14Day
0.1% SLS
Lactobionic acid 4% +Gluconolactone 8%cream0.9% NaCl
MeanScores
n = 24
Nonirritating!
Atopic Dermatitis with PHA Regimen
Before After
Antioxidant Effects
Most Effective
Very Effective
ANTHRALIN HYDROQUINONE BANANA PEEL
oxalic acid oxalic acid oxalic acidascorbic acidcitric acidgluconolactone
ascorbic acid ascorbic acid lactobionic acid citric acid citric acid tartaric acid gluconolactone gluconolactone lactobionic acid lactobionic acid
Anti-oxidant effects on Banana Peel (72 hours)
Gluconolactone
Lactobionic AcidPHAs
prevent oxidativebrowning
AHAs vs. PHAsAnti-aging Effects
AHA vs. PHA Anti-Aging Study
Mean Relative % Improvement(compared to baseline)
0
10
20
30
40
50
Week 12PHA n=30Week 12AHA n=27
Note: All attributes significantly improved from baseline (p<0.05) X: AHA regimen significantly better than PHA regimen
X
PHA Regimen : 14% daily PHA AHA Regimen : 16% daily AHA
AHA vs. PHA Anti-Aging StudyIrritation Assessment
0
0.25
0.5
0.75
1Ery
them
a-A
HA
Eryth
ema-
PHA
Burni
ng-A
HA
Burni
ng-P
HA
Stin
ging
-AH
A
Stin
ging
-PH
A
Mea
ns (
0-3
Scal
e)
BaselineWeek 6Week 12
n=27 (AHA)n=27 (PHA)
* significant improvement from baseline (p<0.05)+ significant worsening from baseline (p<0.05)X burning, stinging significantly worse than PHA regimen
*
*
+ X
+ X+ X
+ X
*
*
(mild)
(none)
PHA SerumAnti-aging Effects
Facial Clinical Evaluation - PHA SerumMean Relative % Improvement
(compared to baseline)
0
20
40
60
80
100
Fine L
ines
Wrin
kles
Pore S
ize
Laxity
Rough
ness
Sallow
ness
Mot
tled P
igm
nt
Per
cent
% Week 6
Week 12
All attributes significantly improved at Weeks 6 and 12 from baseline (p<0.05)
Facial Clinical EvaluationMean Relative % Improvement
(compared to baseline)
200
220
240
260
280
Clarity
Per
cent
% Week 12PHAserum
Significantly improved at Weeks 6 and 12 from baseline (p<0.05)
Total Skin Thickness (Plumping) Mean Relative % Improvement
(compared to baseline)
0
3
6
9
12
Per
cent
%
PHASerum
Untreated
*Significantly increased skin thickness over untreated (p<0.05)
Before
After
Fine LinesSoftened
PHA RegimenStudy
12 weeks
Before After
Smoother, brighter
PHA Regimen Study – 12 weeks
PHA Benefits to Aging Skin
• Anti-aging effects– Smoother, brighter complexion, reduced
appearance of fine lines and wrinkles, increased clarity
• Anti-oxidant/chelator
• Moisturizing
• Gentle enough for sensitive skin
Jan LephartSenior Director of Nu SkinResearch and Development
Tru Targeted Treatments
Tru Targeted TreatmentsEnvironmental
Aging
BiologicalAging
Mechanical Aging
NEW!
Nu Skin
Tru Face Revealing Gel
Nu Skin Tru Face Revealing Gel
• Addresses biological and environmental aging
• Features patented polyhydroxy acid technology
•Lactobionic Acid AND Gluconolactone
• Extremely gentle yet powerful
Nu Skin Tru Face Revealing Gel
• Delivers powerful antioxidants
• Chelates excess iron, reducing potential oxidative damage
• Moisturizes, draws water to skin
• Minimizes appearance of pore size
• Reduces visible effects of photoaging
• Improves skin texture and radiance
• Helps restore youthful cell renewal
• Reveals a smoother, softer complexion
• Perfect for even sensitive, irritable skin
Nu Skin Tru Face Revealing Gel
• Treats mechanical aging
• Features pro-collagen peptide
• Softens and improves the appearance of moderate to deep lines and wrinkles
• Clinical study showed significant wrinkle improvement in 91% of participants
Nu Skin Tru Face Line Corrector
• Combats environmental aging
• Features Kelpadelie, a marine algae extract that is milder to skin than Retinol
• Improves and maintains skin clarity and restores skin radiance
Nu Skin Tru Face Skin Perfecting Gel
Tru Face Revealing Gel - Patented PHA Technology
Tru Face Line Corrector - Pro Collagen Peptide
Tru Face Skin Pefecting Gel - Kelpadelie Algae
Tru Targeted Treatments
Transporting Your Skin Through Time
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