The most important insight from Watson & Crick’s structure for DNA was that genetic information is...
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- Slide 1
- the most important insight from Watson & Cricks structure
for DNA was that genetic information is digitally encoded by lucky
happenstance the genetics revolution has coincided with a
revolution in our ability to process digital information 1953
- Slide 2
- computational algorithms to find and align DNA sequences
Smith-Waterman is the ideal; BLAST is faster but less sensitive;
the compromises continue with nextgen algorithms (e.g. SOAP) Query
554 TGGGGCTGGCAACAACTGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAA
613 ||| || || || ||||||||||| ||||||||||| ||||||||||||||| |||| Sbjct
3095150
TGGAGCCGGGAATAACTGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTC
3095091 Query 614
TGTCCTAGAGGTGGTGAGGCACGAGAGT--GAGAGCTGTGACTGCCTGCAGGGCTTCCAG 671
||||| || ||||||||| | | |||| |||||||||||||| || |||||||||||| Sbjct
3095090
GGTCCTGGATGTGGTGAGG-AAG-GAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAG
3095033 Query 672
ATCG-TCCACTCCCTGGGCGGG-GGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACA 729 |
| |||||| ||||| ||| ||||| || |||||||||||||| |||||||| | || Sbjct
3095032
CT-GACCCACTCTCTGGG-GGGCGGCACGGGGTCCGGGATGGGCACCCTGCTCATCAGCA
3094975 Query 730
AGATTAGAGAGGAGTACCCGGACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCA 789
|||| | || |||||||| ||||| |||||||| |||||||||||||||| || |||| Sbjct
3094974
AGATCCGGGAAGAGTACCCAGACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCA
3094915 Query 790
AGGTGTCGGACACGGTGGTGGAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTG 849
||||||| |||||||||||||||||||||||||| || ||| ||||||||||| | | Sbjct
3094914
AGGTGTCAGACACGGTGGTGGAGCCCTACAACGCCACCCTCTCTGTCCACCAGCTGGTGG
3094855
- Slide 3
- presidential announcement for sequencing of the human genome
one year before its publication 26 Jun 2000: Craig Venter, Bill
Clinton, Francis Collins CeleraIHGSC
- Slide 4
- open access has been official policy since 1996 Bermuda Rules
UCSCs browser (US)
http://genome.ucsc.edu/cgi-bin/hgTracks?org=human Ensembls
contigView (UK)
http://www.ensembl.org/Homo_sapiens/Location/View?r=X:151073054
-151383976 NCBIs mapViewer (US)
http://www.ncbi.nlm.nih.gov/mapview/maps.cgi?taxid=9606&CHR=X&
BEG=151073054&END=151383976 Natures human genome
http://www.nature.com/nature/supplements/collections/humangenome/
index.html
- Slide 5
- 2001: parameters for shotgun sequencing of the human genome
500-bp sequence read