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Continuous health status monitoring of elderlypeople using flexible skin patch sensors
Japan
Prof. Takao Someya (PL)(The University of Tokyo)
Dr. Hiroshi Kajitani(NEC Corporation)
Sweden
Prof. Magnus Berggren (PL)(Linkoping University)
Dr. Tryggve Ljung (AbbVie AB)Dr. Björn Garplind (Invisense AB)
Dr. Göran Gustafsson (RISE Acreo)Dr. Michael Peolsson (RISE SICS)
Swedish-Japanese Joint Symposium
The Future of Skin Electronics
2
Movie
The arrival of super aged society in Japan
3Innovation for healthy longevity society and social system reform are urgently required.
Aging in Japan
Super-aged in 2007Aging rate
27.3% in 2017 >30% in 2025
Super-aged, Worldwide(Moody’s)
13 countries by 202034 countries by 2030
Data: Cabinet Office, Government Of Japan, Ministry of Internal Affairs and Communications, National Institute of Population and Social Security Research, and Ministry of Health, Labor and Welfare, Japan.
0
20
40
60
80
100
120
140
1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 2050 2060
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0
10
15
20
25
30
35
40
45
0 -14 years old
15 - 64 years old
(%)
65 years old and older
Aging rate(>65 years old)
Projection
Popu
latio
n in
100
,000
Accessibility to information
4A safe and comfortable society will be realized when anyone can monitor
biometric information easily, accurately, anytime, and anywhere.
5
Skin electronics
Epidermal electronicsScience 333, 838 (2011).
Human interface
Proc. of the 2016 ACM ISWC, 16 (2016).
Sci. Adv. 2, e1501856 (2016).
Adv. Mater. 29, 1 (2017).
Science 325, 21 (2009).
Adv. Mater. 29, 1703817 (2017).
Imperceptible electronics
Nature 499, 458 (2013).
Physical sensor
Pressure
Nat. Com., 4, 1859 (2013).
Adv. Funct. Mater. 27, 1604465 (2017).
UV
Chemical sensor
Sci. Transl. Med. 8,366ra165 (2016)
Microfluidic
Temperature
Nat. Mater., 12, 938 (2013). Nat. Mater., 11, 795 (2012).
Sweat
Nature, 529, 509 (2016).
Skin battery
Bio-fuel cell
Energy Environ. Sci. 10, 1581 (2017).
Healing
Adv. Healthc. Mater. 3, 1597 (2014).
Memory
ACS Nano 9, 558 (2015).
SensorDisplay Energy
System
Adv. Healt Mater. 4, 506 (2015).PNAS 112, 3920 (2015).
EEG
Nat. Mater., 14, 728-736 (2015).
IEEE Trans. Biomed. Eng., 60, 2848 (2013).
Adv. Mater., 25, 2773 (2013).
EMG ECG
Hydration
Skin modulus
Inorganic LED
OLED
QLED
Micro LED
Sci. Adv. 2, e1501856 (2016).
Sci. Rep., 4, 6074 (2014).
Blood oxygenation
StrainSci. Adv. 2, e1501856 (2016).
A skin display
6We have developed a skin display with stretchability of 45%.
is an array of micro-LEDs embedded in a thin rubber sheet.
Fabrication process and mechanical durability
2.5
2.0
1.5
1.0R
/R0
2000 4000 6000 8000 10000The number of cycles
0
10
8
6
4
2
00 50 100 150 200
New methodConventionalStrain 30%
Cyclic stretching tests
Pre-stretched rubber
Ultrathin substrate
Buckling
Lamination
Micro LEDStretchable Ag wires
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Relaxation of pre-stretch
A skin display attached to the hand
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A skin display can be nicely fitted on the skin due to its stretchability.It exhibits simple graphics with motion including a electrocardiogram
waveform measured with skin sensors.
Nanomesh electrodes on a hand
9It firmly adheres to the shape of the skin. It is ultrathin and lightweight.
A natural skin respiration is realized. There is no sense of fit.
Nanomesh electrodes
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Nanomesh electrodes
Skin
Water
A nanomesh adheres to the skin.
Au
Au
Process flow1. A nanomesh is made of polyvinyl-alcohol (PVA) by an electrospinning method.2. Gold patterns are formed by vacuum evaporation through a shadow mask.3. Nanomesh electrodes are laminated onto the skin with dissolving PVA by spraying water.
Spraying
Nature Nanotechnology (2017). DOI: 10.1038/nnano.2017.125
PVA
11A high level of conformability
Skin sensors with nanomesh electrodesNanomesh electrodes on a fingertip
1 mm
5 μm1 mm
50 μm
Nanomesh electrodes
A sweat pore Sweat & sweat pores
Nanomesh electrodeson a silicone skin
Biocompatibility test
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Dermatitis evaluate different substrates according to the patch test criteria of the ICDRG*. * International Contact Dermatitis Research Group
Three samples were attached to the forearm for a week.
silicone (1 mm thick)
parylene (1 μm thick)
nanomesh conductors
10 mm
forearm
doubtful positive reaction negative reaction(= No inflammation)
silicone (1 mm thick)
parylene (1 μm thick)
nanomesh conductors
Skin sensor to measure electrocardiogram
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Nanomesh electrodes attached on the body
Real-time monitoringby a smartphonep
g
A wireless module for transmitting data to a smartphone
A belly bande-textile
0
1000
0 2 4 6 8 10 12
ECG
Time (s)
0
1000
0.4 0.8 1.2 1.6
ECG
Time (s)
2 4T
1000
Elastic conductor
Electrocardiogram waveform
A health-monitoring system with skin electronics
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Doctor @ hospital
Smart phone
# A waveform stored in memory was exhibited on a skin display in this work.
Skin sensors Skin displays #
FamilyNursing stuff
Patient @ home Patient @ home
A skin sensor system combined with skin display can realize a natural flow from measurement of biometric signals to display of information.
Data collectionsComfortable
AccurateSafe
Real space
Cyberspace
Cloud
AI-assisted diagnosis
FeedbackNaturalIntuitive
Safe
Overview of this project
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Schedule of the projectPromote social implementation by technologies to reduce discomfort in wearable devicesand realize a healthy life for elderly peopleNEC would like to contribute to improving the practicality of physical sensors developed atthe Univ. of Tokyo by providing wireless and packaging technologies.
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SummaryThe new-type wearable sensors with excellentwearing feeling have been developed by using skinelectronics.
A wireless module for skin sensors has beenminiaturized and datacollection platform has been developed.
We will conduct a sensing test integrating withSwedish chemical sensors.
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AcknowledgementsThis research is supported by JST and VINNOVA.
Berggren
Kajitani, NECEndo, NEC
Nakahara, NEC YorozuNEC
Someya, UT
Yokota, UT
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