The Endomembrane System and Peroxisomesclasspages.warnerpacific.edu/BDupriest/BIO 330/Ch 12...

© 2012 Pearson Education, Inc.

Lectures by

Kathleen Fitzpatrick Simon Fraser University

Chapter 12

The

Endomembrane

System and

Peroxisomes

© 2012 Pearson Education, Inc.

How are proteins made?

What do the membrane-bound

organelles do?

© 2012 Pearson Education, Inc.

Figure 12-1

© 2012 Pearson Education, Inc.

Rough ER—other functions

• Rough ER is the site for

– The initial steps of addition of carbohydrates to

glycoproteins

– The folding of polypeptides

– Recognition and removal of misfolded proteins

– Assembly of multimeric protein complexes

© 2012 Pearson Education, Inc.

Figure 12-3

© 2012 Pearson Education, Inc.

Table 12-1

© 2012 Pearson Education, Inc.

Which of these is NOT a part of

the endomembrane system?

• 1) Golgi

• 2) Endosomes

• 3) Rough endoplasmic reticulum

• 4) Mitochondria

© 2012 Pearson Education, Inc.

Which of these is most likely

involved in the inactivation of

birth-control medications by St.

John’s wort?

• 1) Golgi

• 2) Endosomes

• 3) Rough endoplasmic reticulum

• 4) Smooth endoplasmic reticulum

© 2012 Pearson Education, Inc.

What does the Golgi apparatus do

for proteins?

How does it do that?

© 2012 Pearson Education, Inc.

Figure 12-4A

© 2012 Pearson Education, Inc.

Figure 12-4B

© 2012 Pearson Education, Inc.

Figure 12-6

© 2012 Pearson Education, Inc.

How are proteins glycosylated?

© 2012 Pearson Education, Inc.

Figure 12-7

© 2012 Pearson Education, Inc.

How are proteins sent to the right

destination? How do they stay there?

© 2012 Pearson Education, Inc.

Figure 12-8

© 2012 Pearson Education, Inc.

Figure 12-9

© 2012 Pearson Education, Inc.

How do exocytosis and endocytosis

work?

© 2012 Pearson Education, Inc.

Figure 12-12A

© 2012 Pearson Education, Inc.

Figure 12-13

© 2012 Pearson Education, Inc.

How are vesicles formed?

© 2012 Pearson Education, Inc.

Figure 12-15

© 2012 Pearson Education, Inc.

Figure 12-16

© 2012 Pearson Education, Inc.

Figure 12-17A

© 2012 Pearson Education, Inc.

Figure 12-17B, C

© 2012 Pearson Education, Inc.

Figure 12-18A, C

© 2012 Pearson Education, Inc.

Figure 12-18B, D

© 2012 Pearson Education, Inc.

How do vesicles attach to and fuse

with a target membrane?

© 2012 Pearson Education, Inc.

Figure 12-19