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TCA cycle Primary function of this cycle is energy production and final metabolites are CO2 and H 2 O. Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD Pyruvate Acetyl coA +CoA-SH +CO2 +NADH +NAD Primary function of this cycle is energy production and final metabolites are CO2 and H 2 O. Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD Pyruvate Acetyl coA +CoA-SH +CO2 +NADH +NAD
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TCA cycleTCA cycle Tri carboxylic acid cycle : is called so
because several of its metabolites have three carboxyl group (citrate ,cis-aconitate ,isocitrate) .
Also called Kreb-cycle
Cycle of energy production, central cycle in the metabolisim of CHO, fatty acid and amino acid.
TCA cyclePrimary function of this cycle is energy production and final metabolites are CO2 and H2O .
Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD
Pyruvate Acetyl coA +CoA-SH +CO2 +NADH
+NAD
TCA cycleSteps of TCA cycle Citrate synthetase Oxaloacetate Citrate + acetyl CoA CH2COOH | HO-COOH | CH2COOH
TCA cycle Aconitase Citrate Cis-aconitate H2O CH2COOH | C- COOH || CH-
COOH
TCA cycle
Aconitase Cis-aconitate Iso-citrate H2O CH2COOH | CH-COOH | HO-CH-COOH
TCA cycle
Isocitrate dehydrogenase Isocitrate Oxalosuccinate
+ NAD + NADH
TCA cycle
Isocitrate dehydrogenase Oxalosuccinate α-
ketoglutyrate CO2
TCA cycle
α-ketoglutyrate dehydrogenase complex α-ketoglutyrate succinyl CoA + CoA-SH CO2 + NAD + NADH
TCA cycle
Succinate Thiokinase Succinyl CoA Succinate Mg CoA-SH +ADP + ATP
TCA cycle
Succinate dehydrogenase
Succinate Fumerate + FAD + FADH
TCA cycle
Fumarase Fumarate Malate H2O
TCA cycle
Malate dehydrogenase Malate Oxaloacetate + NAD + NADH
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