Sunday 12th February 2017 - Lorne Genome · Sunday 12th February 2017 Conference ... discovery and...

Sunday 12th February 2017 Conference Welcome 2:00PM - 2:10PM Lecture Hall Opening Lecture 2:10PM - 3:00PM Lecture Hall Chair: Kathryn Burdon 2:10 PM Bruce Stillman

The Origin Recognition Complex and Chromosome Duplication: Structure, Function and Human Genetics abs# 1

Afternoon Tea 3:00PM - 4:00PM Exhibition Hall Session 1: Developmental Biology and Gene Regulation 4:00PM - 6:30PM Lecture Hall Chair: Brian Morris 4:00 PM Jing-Dong "Jackie" Han

Integrative Data Analysis for Development and Aging abs# 2 4:35 PM Melissa Little

Directed differentiation to kidney organoids represents a reproducible and developmentally accurate model of human kidney development. abs# 3

5:00 PM Ozren Bogdanovic Embryonic DNA methylation remodelling in the chordate Branchiostoma lanceolatum abs# 4

5:25 PM Josef Penninger Haploid genetics for reproducible cell biology abs# 5

6:00 PM Eva Maria Novoa Pardo Translation-dependent remodeling of the mRNA structure landscape in early-stage vertebrate embryos abs# 6

6:03 PM Christian Pflueger To bind or not to bind – testing transcription factor’s methyl-cytosine tolerance abs# 8

6:06 PM Qiaoping Kevin Wang Funcitonal Validation of Human Obesity GWAS Candidates in vivo abs# 9

6:09 PM Samuel W Lukowski High-throughput single-cell sequencing of 18,787 human IPSCs identifies differentially primed subpopulations. abs# 10

6:12 PM Jian Yan Histone Methyltransferases and H3K4me1 Modulate Long-range Chromatin Interactions at Enhancers abs# 11

6:15 PM Kirsten R McEwen Decoding Molecular Mechanisms of Transcriptional Regulation abs# 12

Welcome BBQ 6:30PM - 8:30PM

Poster Session 1 8:30PM - 11:00PM Exhibition Hall Morana Vitezic The promoter landscape of inflammatory bowel disease (IBD). abs# 100 Herah Hansji Long noncoding RNA ZFAS1 in ribosome regulation: a riddle wrapped in a mystery inside an enigma abs# 101 Debina Ms Sarkar Complexity surrounding multiple isoforms of ANRIL in melanoma abs# 102 Vincent R Harley In fetal testes SOX9 governs transcription and male-specific RNA splicing of target genes via a Sertoli cell genomic signature abs# 103 Philippe Collas 3D human genome modeling reveals impacts of lamin A mutations on genome architecture abs# 104 Andrew Keniry Identifying and characterising novel epigenetic modifiers using X inactivation as a model system abs# 105 Debina Ms Sarkar Complexity surrounding multiple isoforms of ANRIL in melanoma abs# 106 Jincheol Park Impact of data resolution on three-dimensional structure inference methods abs# 107 shadi GHALAMI Prevalence of CYP2D6 Gene and Prostate Cancer Risk in People of Shiraz abs# 109 Hsiao P J Voon A Histone Point Mutation Alters the Chromatin Landscape by Inhibiting a Histone K9/K36 Demethylase abs# 110 Harriet Dashnow Detecting pathogenic STR expansions in next-gen sequencing data abs# 111 Daniel W Thomson The Recycled Human Genome : Ubiquitous neufunctionalisation of pseudogenes via LINE1 mediated intron generation abs# 112 Timothy M. Johanson Lineage-restricted transcription factors regulate genome organisation abs# 113 Namitha Mohandas DNA methylation analysis of neurodevelopmental disorders using disease-discordant monozygotic twins abs# 114 James Miller Targeted sequencing using advanced molecular inversion probes (MIPs) for discovery and validation in Mendelian disease trios abs# 115 Coralie M Reich Polyceraty in Damara Sheep abs# 116 Ira Deveson Mirror images of common, challenging and clinically relevant genetic variants provide spike-in controls for genome sequencing abs# 117 Thomas Preiss The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease abs# 118 Thomas Preiss In planta determination of the mRNA-binding proteome of Arabidopsis etiolated seedlings abs# 119 John Manion A functional genomic approach to identify new synaptic genes and drug targets to prevent neurodegeneration. abs# 120

Helen McRae Chromatin-associated protein regulates haematopoietic stem and progenitor cell activity abs# 122 Zoe L Grant Investigating the role of histone acetylation in angiogenesis abs# 123 Chen Davidovich Short repeats of consecutive guanines provide transcript-specific regulation of the Polycomb repressive complex 2 (PRC2) abs# 124 Heather J Lee Dynamic and heterogeneous DNA methylation in pluripotent cells abs# 125 Richard J Edwards PacBio sequencing, de novo assembly and haplotype phasing of diploid yeast strains abs# 126 Åsa Pérez-Bercoff Investigating the evolution of new biochemical pathways in baker’s yeast Saccharomyces cerevisiae abs# 127 Nazanin Karimnia ASSET (antisense Set7 transcript) is regulated by oxidant redox signaling abs# 128 Natasha Zamudio Chromatin modification in somatic cell reprogramming abs# 129 Anna S Trigos An in silico approach to identify novel treatment options for patients with drug-resistant tuberculosis abs# 130 Alexander J Knights Browning of adipose tissue in mice lacking Krüppel-like factor 3 (KLF3) abs# 131 Elizabeth S Stout The search for disease severity modifiers in patients suffering from blood disorders abs# 132 Tiffany Cole Conserved Transcriptional Architecture of Pain abs# 133 Jinfen J Yik Investigating the roles of KLF, SOX6 and CtBP in regulating globin gene expression abs# 134 Beeke Wienert Introducing a beneficial gain of function mutation suggests a potential gene therapeutic approach for treating β-haemoglobinopathies abs# 135 Dulce B Vargas Landin Epigenomics of Rett Syndrome: the other layer of the story abs# 136 Bong-Seok Jo Alterations of DNA methylation and gene expression detected in the human dilated cardiomyopathy patient samples abs# 137 Bong-Seok Jo Significant numbers of disease-associated SNPs are positioned in introns implicating their functional relevance abs# 138 Tran Quynh Nhu Nguyen Ellis-van Creveld syndrome: Mutation in EFCAB7 changes the EFCAB7-EVC2 interaction in Hedgehog signaling regulation. abs# 139 Sylvia Young Towards Personalized Medicine: Using Bayesian Methods in Genome-enabled Prediction of Complex Human Diseases abs# 140 Jae-Woong Min Analysis of WGS data derived from five paired primary and relapsed acute myeloid leukemia patients abs# 141 Wooi Fang (Catheryn) Lim Assessing the role of functional domains of a family of zinc finger transcription factors in in vivo target specificity abs# 143

Sophia Ying Yii Mah Investigating the KAT6A/B histone lysine acetyltransferase (KAT) complex abs# 144 Luke Hickey Structural Variant Detection in Individuals and Populations with the PacBio Sequel System abs# 146 Leonie M Quinn The essential function of FBP/KSRP proteins in development: Drosophila Psi interacts with Mediator to modulate MYC transcription and tissue growth abs# 147 Lu Yang DNA methylation and transcription factor binding abs# 148 Thomas Quinn propr: A Software Package for Identifying Proportionally Abundant Features using Compositional Data Analysis abs# 150 Paul Marshall ADAR1 dual function as RNA editing and potential DNA binding enzyme in the activity-dependent regulation of adaptive behaviour in the mouse abs# 151 Akira Gokoolparsadh The role of neuronal specific splice factor, RBFOX1, in regulating circular RNA formation abs# 152 Mark Ziemann The ENCODE Gene Set Hub abs# 153 Lingxi JIANG Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model abs# 154 Maria I Bergamasco The histone acetyltransferase KAT6B is essential for cortex development and the maintenance of adult neural stem cells abs# 156 Rhys Allan Examining the conservation of chromatin domains between cell lineages of the same individual abs# 157 Brittany Croft A mutation in FGF9 identified in 46,XY Sex Reversal abs# 158 Hannah Loke Dysregulation of SRY in the male brain: a genetic basis for sex bias in neurological disorders? abs# 159 Alessandro Bonetti Identification and characterization of ncRNAs associated with chromatin in pluripotency abs# 160 Sureshkumar Balasubramanian Alternative splicing coupled with nonsense mediated mRNA decay contributes to thermal induction of floral transition. abs# 162 Gad Abraham Genomic prediction of coronary heart disease abs# 163 Akanksha Srivastava Home: a histogram based machine learning approach to identify differentially methylated regions in a genome abs# 164 Aleisha Symon Identifying novel genes from integrated SOX9 knockout RNAseq/SOX9 ChIPseq datasets abs# 165 Matt A Field Reducing the search space for causal genetic variants in sequenced pedigrees with VASP abs# 166 Brian S Gloss High temporal resolution of gene expression dynamics in developing mouse embryonic stem cells abs# 167

Rachael Turner The mechanisms of alternative 3'UTRs in the control of gene expression abs# 168 Scott C Ritchie NetRep: a scalable permutation approach for assessing replication and preservation of network modules in large datasets abs# 169 Kelan Chen Mechanistic Insight into the Epigenetic Regulator SMCHD1 and its Implication in Diseases abs# 170 Riti Roy Global down-regulation of cellular communication components is a master hallmark of cancer. abs# 171 Linna Guo Deciphering novel transcriptional roles for Argonaute proteins in Drosophila development abs# 172 Cheryl Shoubridge IQSEC2; when two Xs are not better than one. abs# 173 Alice Chin Identifying synthetic lethal drugs for cohesin mutant AML abs# 174 Hannah R Nicholas Homeodomain-interacting protein kinase 1 (HPK-1) regulates stress responses and aging in C. elegans abs# 175 Alexander P Sobinoff BLM and SLX4 play opposing roles in break-induced replication at human telomeres abs# 176 Rachel Woodhouse Investigating the Role of SET-32 and SET-25 in Transgenerational Epigenetic Inheritance in C. elegans abs# 177 Minh Duc Cao Scaffolding and completing genome assemblies in real-time with nanopore sequencing abs# 178 Haloom Rafehi HDAC inhibitor mediated promoter histone deacetylation differs in healthy versus diabetic individuals. abs# 179 Sofia Khan Identifying nonlinear RNAs from single-molecule CAGEscan data abs# 181 Arjun S Chahal From Servant to Master: the Ribosome’s instructive role in cell fate determination abs# 183 Paul Kalitsis Loss of RMI2 destabilises the BLM complex in Bloom-like syndrome abs# 184 May Aung-Htut Novel antisense therapy for multiple sclerosis abs# 185 Mahdi Moradi Marjaneh Genome-wide analysis of allelic expression imbalance detects cis-regulatory effect of breast cancer causal SNPs identified by OncoArray project abs# 186 Stephen Huang Klf1 mutations in the second linker cause congenital non-spherocytic hemolytic anemia due to global reduction of in vivo DNA-binding affinity abs# 187 Gregory Davis F28D1.2 influences meiosis to maintain germline chromosomal integrity in Caenorhabditis elegans abs# 188 Quentin Gouil An epigenomic view of seed germination in Arabidopsis thaliana abs# 189 Tanveer Ahmad RNA processing regulates megakaryocytes and platelet production abs# 190

Aparna Raina Nucleosome positioning as a potential driver of transcriptomic alterations in prostate cancer abs# 191 Kate Brettingham-Moore Methylome profiling in prostate cancer cells following radiotherapy abs# 192 Ingrid Macindoe Mechanism of UBE3A silencing by an antisense transcript abs# 193 Daniele Belluoccio Ultra-high quality DNA synthesis improves representation and fidelity in pooled CRISPR libraries abs# 194 Dong-Mi Shin Hippocampal Transcriptional Networks Altered By Dehydration In Mice abs# 195 Casey Ah-Cann Identification of novel epigenetic regulators of lung development abs# 196 Daniele Belluoccio A Multi-omics Study to Identify Biomarkers of Retinoblastoma abs #197

Monday 13th February 2017 Breakfast workshop – Single Cell Genomics 7:30AM - 8:25AM Lecture Hall

Micro Break 8:25AM - 8:35AM Session 2: Genomics Technologies 8:35AM - 10:10AM Lecture Hall Chairs: Frank Grutzner & Christine Wells 8:35 AM Evan Eichler Long-read sequencing of complex genomes abs# 14 9:10 AM Stephen Turner Enhancer commissioning and decommissioning regulates lineage-

specific transcriptional activation during virus-specific CD8+ T cell differentiation abs# 15

9:30 AM Jacob Corn

Cas9 genome engineering, from mechanism to therapy abs# 16 Morning Tea 10:10AM - 10:45AM Exhibition Hall

Session 3: Julian Wells Medal/Nuclear Organization and Chromosome Structure 10:55AM - 12:30PM Lecture Hall Chairs: Peter Boag & Vincent Harley

10:55 AM Jenny Graves

Australian genomics, weird animals and sex abs# 17 11:30 AM Tommaso Leonardi

Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci abs# 18

11:50 AM JoAnne Engebrecht Sex-specific regulation of meiosis abs# 19

Lunch 12:30PM - 1:30PM Exhibition Hall

Bioinformatics workshop 1:30PM - 3:00PM Heritage Dining Room

Session 4A: Regulation of gene expression 1 3:00PM - 4:00PM Lecture Hall Chairs: Kate Quinlan & Sureshkumar Balasubramanian

3:00 PM Stacey L Edwards

Breast cancer risk at the 12q24 locus is mediated through TBX3 and MED13L regulation. abs# 20

3:15 PM Gretchen Poortinga Targeting ribosomal DNA transcription and nucleolar chromatin in cancer abs# 21

3:30 PM Simon C Barry Mapping regulatory networks and identifying the targets of disease associated genetic risk by chromatin conformation capture in Human Regulatory T cells abs# 22

3:45 PM Garry S. A. Myers Comprehensive definition of the early host cell response to Chlamydia infection by dual RNA-Seq and miRNA-Seq abs# 23

Session 4B: Epigenetics and Epigenomics 3:00PM - 4:00PM Dining Room Chairs: Julia Horsfield & Stephen Turner

3:00 PM Sam Buckberry

Characterising Epigenome Dynamics During the Reprogramming of Somatic Cells to iPS Cells abs# 24

3:15 PM Quentin Gouil Revisiting DNA methylation in plants: moving past CG/CHG/CHH abs# 25

3:30 PM Ruth Pidsley Enduring Epigenetic Landmarks Define the Cancer Microenvironment abs# 26

3:45 PM Natasha Jansz Characterising the Molecular Mechanisms of Transcriptional Control by the Epigenetic Modifier Smchd1 abs# 27

Mini-break 4:00PM - 4:30PM

Session 5: Noncoding RNA and RNA Regulation 4:30PM - 6:30PM Lecture Hall Chairs: Alicia Oshlack & Cameron Bracken

4:30 PM Narry Kim

RNA tails in gene regulation abs# 28 5:05 PM Timothy Bredy

Not available at time of printing abs# 29 5:30 PM Rob Martienssen

Replication, recombination, repair and RNA interference abs# 30 6:05 PM Gurdeep Singh

Embryonic stem cell enhancers conserved among mammals allow the identification of novel transcription factor binding sites abs# 31

6:08 PM Lisa Oyston Functional validation of human Parkinson’s disease GWAS in Drosophila melanogaster. abs# 32

6:11 PM Oscar Luo RNA-Chromatin Interactome Reveals Chromatin-associated RNA Functions for Transcription Regulation in 3D Genome Organization abs# 33

6:14 PM Nikolay E. Shirokikh TCP-seq records the complete cycle of mRNA-ribosome interactions in vivo abs# 34

6:17 PM Artika Nath An interaction map of circulating metabolites, immune-related gene networks and their genetic regulation abs# 35

6:20 PM Noa Lamm An actin-dependent mechanism facilitates nuclear-cytoplasmic cross-talk to guard genome stability abs# 142

Dinner Break 6:30PM - 8:30PM

Poster Session 2 8:30PM - 11:00PM Exhibition Hall Bidyut Roy Searching for therapeutic targets from whole transcriptome of oral cancer abs# 200 Niketa Bhawsinghka Overlapping promoters and operators of Mycobacteriophage D29 ―An insight into the evolution of regulatory elements abs# 201 Fernando J Rossello Molecular Characterisation of Cell Type-Specific Routes to Pluripotency abs# 202 Veronika Kukučková Supervised learning methods for distinction of cattle production type abs# 204 Alison C Testa Understanding the expression of human disease genes using FANTOM5 expression profiles. abs# 205 Chung-Chau Hon An atlas of human long non-coding RNAs reveals their heterogeneity and evidence of their widespread function abs# 206 Olga Zaytseva Elucidating novel mechanisms for growth control and cancer progression: linking RAS and PI3K pathways with MYC transcription via FUBP1 abs# 207 Kin Tung Tam Identification of a Distal Regulatory Element of the Human Neuroglobin Gene abs# 208 Hamid Alinejad-Rokny Gene Prioritization in Novel Copy Number Variants Regions Associated with Autism abs# 209 Gabriella E Martyn The -115 site of the gamma-globin promoter is a critical cis-acting element involved in binding a gamma-globin repressor abs# 210 Scott Cohen Cryo-EM of human telomerase abs# 211 Tim Thomas A novel high affinity, specific inhibitor of the histone acetyltransferases KAT6A (MOZ) and KAT6B (QKF). abs# 212 Timothy Ravasi Rapid transgenerational adaptation of a reef fish to climate change abs# 213 Jeong Park Implication of p400 ATPase and ATM interaction for an efficient DNA damage response abs# 214

Owen Rackham Using Data-driven network biology to understand how to control cell fate abs# 215 Cameron P Bracken MicroRNAs fine-tune transcript abundance in a combinatorial manner during Epithelial-Mesenchymal Transition abs# 216 Amarni Thomas Identifying functional roles for novel cis-regulatory elements predicted to regulate the Runx1 gene. abs# 218 Brian Morris FOXO3 longevity interactome on human chromosome 6 abs# 219 Andrew Pattison Investigating the 3’ untranslated region of mRNA in order to understand the drivers of metastasis in primary triple negative breast tumours abs# 220 Ruth Pidsley Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling abs# 221 Joshua AM allen Visualisation of telomere recombination-directed replication in ALT cancers abs# 223 Tanit Chavalit Identifying WDR5 as a new KLF3 partner protein by co-immunoprecipitation coupled with mass spectrometry abs# 224 Kate GR Quinlan Krüppel-like Factor 3 (KLF3) regulates the expression of the inflammatory modulator Galectin-3 (Lgals3) abs# 225 Rachel Walters Functional genomic identification of new synaptic regulators. abs# 226 Kevin Gillinder Long-range transcriptional regulation of erythropoiesis by KLF1 abs# 227 Melissa Ilsley A mutation in zinc finger domain of human KLF1 causes congenital dyserythropoietic anaemia (CDA) via promiscuous DNA binding and ectopic target gene expression abs# 228 Graham Magor KLF1 is a pioneer transcription factor for erythroid cells abs# 229 Kiran Asplett Identification of Putative Direct Target Genes of IKZF1 (Ikaros) in Erythropoiesis abs# 230 Vinod Benjamin A study into the role of H3.3 Serine 31 phosphorylation in chromatin regulation abs# 231 Christopher G Tomlinson Developing modifiers of the ALT telomere maintenance pathway abs# 232 Jafar S. Jabbari MegaPlex Targeted Amplicon Sequencing for Increased Efficiency on Illumina Systems abs# 234 Craig McIntosh The use of antisense oligonucleotide-mediated exon skipping to treat Spinocerebellar ataxia type 3 abs# 235 Victoria Shenton Functional validation of obesity-associated genes in vivo abs# 236 Pyung Cheon Lee Genome analysis of a new isolate reddish Planococcus faecalis abs# 237 Samantha Barratt-Ross The Burden of Recurrent and Ancestral Mutations in Families with Hypertrophic Cardiomyopathy abs# 238

Jeffrey R Mann Expression of the histone H3.3-K27M mutational driver of paediatric glioblastoma causes dwarfism in mice abs# 239 Chamila I Wanigasuriya Screening for novel epigenetic modifiers and characterizing their molecular role in gene expression control abs# 240 Nathan Harmston Investigating the transcriptional differences between in vivo, subcutaneous and orthotopic models of pancreatic cancer. abs# 241 Kelly M Martinovich Rescuing CFTR expression of mutation specific polymorphisms in Cystic Fibrosis patients abs# 242 Kelly Short Glucocorticoid Receptor-mediated repression of Versican during murine lung development abs# 243 Simon A Hardwick Spliced synthetic genes as internal controls in RNA-seq experiments abs# 244 Sarah R Langley Transcriptional landscape of an hPSC system of Huntington’s Disease abs# 245 Alex Tokolyi 3D Cardiomics: An interactive 3D visualisation of the adult cardiac transcriptome abs# 246 James Blackburn Assessing Cancer Gene Fusions Using Targeted Capture Sequencing abs# 247 Rachael McNally Amplicon-based Diversity Profiling of The Microbiome abs# 248 Christian F Nielsen Condensin I Jumpstarts Essential Transcription after Mitosis abs# 249 Maheshi Udugama Role of ATRX in maintaining ribosomal DNA stability and chromatin assembly abs# 250 Thomas Whitington Identification of structural variants from liquid biopsy ctDNA abs# 251 Yasmin Dijkwel Regulation of H2A.Z localisation during the cell cycle abs# 252 Alexandra L Garnham Using singular value decomposition to alleviate batch effects in RNA sequencing data abs# 253 Megan A. Schischka To barcode them all abs# 254 Ulrike Schumann Understanding the function of 5-methylcytosine in mRNA biology abs# 255 V. Pragathi Masamsetti Genomic DNA replication stress induces parallel mechanisms that alter centromere and telomere structure to induce mitotic cell death abs# 256 Mio Tonouchi Enrichment of unamplified DNA and long-read SMRT Sequencing to unlock repeat expansion disorders abs# 257 Mirana Ramialison Decoding the heart: Mining of the regulatory genome. abs# 258 Ronnie Ren Jie Low Telomere loops regulate activation of the DNA damage response by the chromosome end abs# 259 Jessica Fitch Utilising capture-seq to identify noncoding RNAs in the ribosomal RNA gene repeat intergenic spacer as potential drivers of malignancy abs# 260

Patrick P Stalder Determining how endogenous genomic DNA replication stress translates to ATR inhibitor sensitivity abs# 261 Yuliya V Karpievitch Identification of regions of accessible chromatin from DNA methylome data abs# 262 Michael Lee Development of a whole genome sequencing based classifier to determine telomere maintenance mechanism in tumours abs# 263 Tara K Bartolec Spatio-temporal chromatin dynamics during the DNA damage response abs# 264 Laura Leighton Disrupting the Piwi-interacting RNA pathway in the mouse hippocampus enhances the memory of conditioned fear abs# 265 Qinqin Huang Power, false discovery rate, and Winner's Curse in eQTL studies abs# 266 Alexandra Hackmann A mobile form of TREX-2 like (mTREX-2) complex is involved in the coupling of transcription with mRNA export. abs# 267 Matt Tinning State of the art of single cell transcriptomics. abs# 268 Julian Heng Developmental profiling of RNA expression using PATseq identifies alternative polyadenylation as an important mechanism for the development of cerebral cortex neurons during mouse brain development. abs# 269 James R Torpy Transcriptomic Toolkit for Analysis of Second Generation Sequencing Data in the Cloud abs# 270 Shlomo Yeshurun The Sperm Small RNA Content of Mice is Altered due to Increased Physical Activity abs# 271 Tessa J Sherry Investigating the role of the C-terminal binding protein-1 (CTBP-1) in neuronal development and maintenance in Caenorhabditis elegans abs# 272 Priyanka Toshniwal G-quadruplex DNA formation in the genome and its role in fibrosis. abs# 273 Bhumika Azad The interplay between Heterochromatin- Protein 1 (HP1) and H2A.Z in cancer progression abs# 274 Jinbae Son Dysregulation of rRNA gene chromatin in ovarian cancer abs# 275 Arnold Ou New Class of Small Molecule Multicarbazole Probes for the Targeting Quadraplex DNA. abs# 276 Rui Hou Modelling multi-cellular networks abs# 278 Spencer T Greatorex The human short-chain dehydrogenase/reductase superfamily and their roles in the regulation of endocrine hormone signalling pathways in cancer. abs# 280 Bhupinder Pal Construction of developmental lineage relationships in the mammary gland by single-cell RNA profiling abs# 281 Sarah J Beecroft Searching for the CANVAS disease gene abs# 282 Tracy M Bryan Chromatin remodelling protein ATRX is involved in resolution of G-quadruplexes across the genome abs# 283

Sarah Henrikus A short window of opportunity: DNA polymerase IV is granted limited access to stalled replication forks in Escherichia coli abs# 284 Kaitlin G Scheer The miR-200 family directly regulates mitogen signalling pathways via multiple target genes abs# 286 Andrew Jarratt A whole genome CRISPR/Cas9 screen for regulators of JAK-STAT signaling reveals epigenetic control by Setdb1 abs# 287 Madara Ratnadiwakara SRSF3 facilitates cell proliferation and controls cell cycle in pluripotent cells through the direct regulation of stem cell specific microRNAs abs# 289 Phillippa Taberlay Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations abs# 290 Alexandra Woodworth Non-consensus binding of runx1 in aml abs# 291 Renato Lemgruber dRNA-Seq analysis reveals a fascinating transcriptional architecture in Clostridium autoethanogenum abs# 292 Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch abs# 293 Indeewari Dissanayake Gene regulatory networks controlling root developmental plasticity under nitrate and phosphate deficiency in wheat (Triticum aestivum L.) abs# 294 Alex Pocock Discovering microRNA in complex plant genomes: A comparative bioinformatics analysis of miRNA prediction algorithms in land plants. abs# 295 Jazmine Humphreys Unravelling the dynamic regulation of transcriptional networks by chromatin and transcription factors abs# 296 Nandor Roczo Highly Accurate Genetic Profiling of Circulating Tumor Cells using a Label-free Inertial Microfluidic Approach Coupled with Droplet PCR-based Next-Generation Sequencing abs# 297 Nandor Roczo Size Distribution, Yield, and NGS Library Metrics for cfDNA and cfRNA Extracted from Different Donors, Different Body Fluids, and at Different Time-points abs# 298

Tuesday 14th February 2017

Perkin Elmer BIOO Scientific Reagents Workshop 7:30AM - 8:25AM Lecture Hall Mini Break 8:25AM - 8:35AM Session 6: Disease and Disease Genomics 8:35AM - 10:45AM Lecture Hall Chairs: Andrew Perkins & Leonie Quinn 8:35 AM David Levens

MYC, Topoisomerase, Supercoiling and the FuBPs: Partners in the Control of Global Expression Levels abs# 37

9:10 AM Kathryn North Integrating genomics into clinical practice: the Australian genomics health alliance abs# 38

9:35 AM Irina Voineagu The Role Of The RBFOX1 Splicing Factor In Autism Spectrum Disorders abs# 39

10:00 AM Nissim Benvenisty The Role of Human Parthenogenetic Pluripotent Stem Cells in Imprinting Disorders and Haploidy abs# 40

Morning Tea 10:45AM - 11:15AM Exhibition Hall

Session 7: Evolution and Population Genetics 11:15AM - 12:45PM Lecture Hall Chair: Juliet French

11:15 AM Judith Berman Not available at time of printing abs# 41

11:50 AM David Lambert Ancient and Contemporary Indigenous Genomics of our Region abs# 42

12:15 PM Laura Boykin Cassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistance abs# 43

Lunch 12:45PM - 1:30PM Exhibition Hall Lorne Genome AGM 1:30PM - 2:30PM

Session 8A: Regulation of gene expression 2 2:30PM - 3:30PM Lecture Hall Chairs: & Anne Voss

2:30 PM Ralf Jauch

Programming cell fates with synthetic SOX and OCT transcription factors abs# 44

2:45 PM Benjamin G Gowen Discovery of an autoimmunity-associated IL2RA enhancer by unbiased targeting of transcriptional activation abs# 45

3:00 PM Anja S Knaupp Dissection of the Nanog transcriptional complex by TINC abs# 46

3:15 PM Wei Wei Exploring the role of the epigenetic regulator ING1 in extinction memory abs# 47

Session 8B: RNA Regulation, Disease & Development 2:30PM - 3:30PM Dining Room Chair: Marnie Blewitt

2:30 PM Owen J Marshall

Novel chromatin state transitions occur during neural development abs# 50

2:45 PM Minna-Liisa Anko SRSF3 facilitates reprogramming and coordinates gene expression in pluripotent cells through multiple RNA processing machineries abs# 51

3:00 PM Chikako Ragan Features of biogenesis and function of circular RNAs abs# 49

3:15 PM Leonard Lipovich Primate-specific, estrogen-regulated long non-coding RNA (lncRNA) genes control cell proliferation and cell death in human estrogen receptor positive breast cancer. abs# 48

Mini break 3:30PM - 3:50PM

Session 9: Chromatin and Epigenetics/epigenomics 3:50PM - 5:30PM Lecture Hall Chairs: Alyson Ashe & Phillippa Taberlay

3:50 PM Shelley Berger

Histone acetylation pathways in learning and memory abs# 52 4:25 PM Tamas Fischer

Epigenetic control of pervasive transcription and genomic stability abs# 53

4:50 PM Isabel Bäurle Chromatin regulation of environmental stress memory in plants abs# 54

Mini Break 5:30PM - 5:45PM

Closing Lecture 5:45PM - 6:30PM Lecture Hall Chair: Traude Beilharz

5:45 PM Susan Gasser The essential role of histone H3K9 methylation in stabilizing the genome abs# 55

Announcement of Conference Awards and Conference Close 6:30PM - 7:30PM Lecture Hall

Conference Dinner 7:30PM - 10:30PM