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Strengthening the research and innovative capacities of the Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug discovery
Dr. Pharm. Maija Dambrova, Manager
• Project acronym: InnovaBalt• Type of funding scheme: Coordination
and support actions
• Work programme topics addressed: REGPOT-2012-2013-1
• Total cost: 5.2 million euro
• Contribution of EC: 4.7 million euro
Strategic objective of the project
• to strengthen the multidisciplinary research capacities, management of intellectual property as well as human resources in the innovative drug discovery at Latvian Institute of Organic Synthesis
Short term objectives of the project:• Establishment and strengthening the long-lasting scientific
collaboration and strategic partnership between LIOS and outstanding research institutions in ERA
• Increasing the innovation and improving of management of intellectual property through collaboration and attraction of external professionals
• Upgrading the research infrastructure at LIOS to promote the capacity for the high level research on innovative drug development;
• Increasing the visibility of LIOS in ERA• Ensuring the synergy between research on innovative drug
development and end-users (SMEs, industry, clinics, patients’ organizations)
• Reinforcing the strategic development of LIOS to improve the response to socio-economic needs of Baltic region in health area
Strategic partnering organizationsCentre de RMN à Très Hauts Champs, Ecole Normale Supérieure de Lyon
France
Institute of Biotechnology, Vilnius University Lithuania
Tartu University Estonia
University of Antwerp, Antwerp Drug Discovery Network Belgium
RWTH Aachen University Germany
Uppsala University Sweden
Aalto University Finland
University of Florence Italy
Leiden University The Netherlands
Eurice Ltd Germany
University of Zurich Switzerland
Scientific Steering Committee • Representative from Latvian Ministry of Education and Science
• Professor Raimonds Valters from Latvian Academy of Sciences
• Dr. Andis Slaitas, managing director of Syntagon Baltic
• Professor Ari Koskinen from Aalto University, Finland
• Professor Daumantas Matulis from the Institute of Biotechnology, Lithuania
• Professor Ad IJzerman from Leiden University, the Netherlands
• Professor Claudiu Supuran from University of Florence, Italy
• Dr. Eriks Kupce Bruker Biospin, UK
• Professor Edvards Liepinsh from LIOS
• Professor Gunars Duburs from LIOS
Action plan of InnovaBalt projectCardio
vascular diseases
Cancer Diabetes
and obesity
Infectiousdiseases
Neuro degenerative
diseases
Multidisciplinarity: chemical synthesis, molecular modelling,pharmacological activities,targeted drug delivery forms, green chemistry
Multidisciplinarity: chemical synthesis, molecular modelling,pharmacological activities,targeted drug delivery forms, green chemistry
Advanced IP management and protection, innovation capacity buildingAdvanced IP management and protection, innovation capacity building
Training of young and experienced researchersTraining of young and experienced researchers
Collaboration with stakeholders (policy makers, SMEs, industry, universities,hospitals, patient organizations, society)
Collaboration with stakeholders (policy makers, SMEs, industry, universities,hospitals, patient organizations, society)
Integration in European research area to contribute in the solution of currentsocio-economical needs in health area
Integration in European research area to contribute in the solution of currentsocio-economical needs in health area
Organizational structure
Steering Committee for Research Strategy
Steering Committee for Research Strategy
Project coordinatorIvars Kalvins
Project coordinatorIvars Kalvins
WP8 ManagementProject manager Maija Dambrova
WP8 ManagementProject manager Maija Dambrova
ECEC
EU PartnersEU Partners
WP1A.Sobolevs
WP1A.Sobolevs
WP2L.Ignatovich
WP2L.Ignatovich
WP3O.Pugovics
WP3O.Pugovics
WP4P.Trapencieris
WP4P.Trapencieris
WP5D.Tirzite
WP5D.Tirzite
WP6I.Kalvins
WP6I.Kalvins
WP7G.Veinbergs
WP7G.Veinbergs
Work packages• WP1. Exchange of experience and know-how (via international
two-way secondments of experienced and young researchers of LIOS with researchers from excellent and complementary European research centres)
• WP2. Strengthening of the research potential of human resources • WP3. Renewal of research equipment• WP4. Organization of seminars and conferences• WP5. Improving the management of Intellectual Property and
enhancement of innovation potential• WP6. Dissemination and promotional activities• WP7. External Assessment of LIOS• WP8. Management
WP1 Exchange of experience and know-how
Exchange of know-how and experience via international two-way secondments of experienced scientists and young scientists between the LIOS and leading scientific institutions in the ERA– to explore the opportunities for building of lasting
networks – to gain the access to complementary equipment, data
observations and ideas.
WP1 leader: Dr. chem. Arkadij SobolevTask leaders: Dr.chem. Kristaps Jaudzems, Dr. pharm. Edgars Liepiņš, Dr. chem. Aiva Plotniece, Dr. pharm. Maija Dambrova
WP2 Strengthening of the research
potential of human resources
Objectives:• To increase the LIOS research capacity and experience in
new directions of drug discovery by recruitment of experienced researchers
• To increase the international-level transfer process of accumulated knowledge and technologies through the reintegration of experienced researchers from abroad
• To increase the research potential of existing laboratories by recruitment of post-doctoral researchers
The project foresees the recruitment of 8 experienced researchers and 6 post-doctoral researchers
WP2 leader Dr.hab,chem. Lubova Ignatovich
WP3 leader: Dr.chem. Osvalds PugovičsTask leaders: Dr.chem. Kristaps Jaudzems, Dr. pharm. Edgars Liepiņš,
Dr. chem. Aiva Plotniece
WP3 Renewal of research equipment
Objectives :1. Acquisition of modern
equipment and tools necessary for innovative drug development
2. Upgrading the research equipment
WP 4 Organization of conferences, seminars, trainings
WP leader Dr. Chem. Pēteris TrapencierisTask leaders: Dr. Aiva Plotniece, Dr. Maija Dambrova, Dr. Arkādijs
Soboļevs, Dr. Kristaps Jaudzems, Dr. Raivis Žalubovskis, Dr. Osvalds Pugovičs, Ieva Jaunzeme
Objectives: • To facilitate the knowledge transfer at the national, regional and
international levels
• To increase the visibility of LIOS by dissemination of the results of Latvian scientists in organic chemistry, medicinal chemistry of heterocycles, structure-activity relationships, experimental chemotherapy and pharmacology to the international scientific community.
• To strengthen the long-lasting scientific collaboration between LIOS and partnering organisations in ERA.
WP4 Events• Workshop “Ready for Horizon 2020” (Winter 2013/2014)• Seminar “Advanced antiinfective drug design” (Spring 2014)• Workshop on publication writing for scientific journals and on
popular science (Autumn 2013)• Seminar „Biophysical methods in drug discovery” (Spring 2014)• Seminar „Protein production techniques” (Spring 2014)• BOS-2014 pre-conference roundtable (June 2014)• Workshop „Competitive proposal preparation for Horizon 2020”
(Autumn 2014)• Gustavs Vanags memorial conference ( Autumn 2014)• Conference “BaltDrug” (May 2015)• Conference “Paul Walden 9th Symposium” ( Autumn 2015)• BOS-2016 pre-conference roundtable (June 2016)• BOS-2016 conference (June 2016)• Participation of LIOS researchers in transnational events
WP5 Improving the management of Intellectual Property and enhancement of innovation potential
WP leader Prof.I.KalvinsThe strategy of this WP is based on 3 principles:• development – by providing the strategic Intellectual Property
development plan for the effective management of IPR and efficient technology transfer process
• collaboration –with governmental institutions, research, academia, industry, technology transfer centres and other stakeholders on the issues of innovation and IPR; by networking with partnering organizations
• awareness – by training and education of experienced and early stage researchers as well as entrepreneurs on the IPR and technology transfer issues
WP6 Dissemination and promotional activities
WP leader Dr. Biol.Dace TirzīteTeam: Edīte Mētere, Dr. Antons Ļebedevs, Dr. Aigars
Jirgensons, Dr. Raivis Žalubovskis, Dr. Ronalds Zemribo
Objectives: • Promotion of InnovaBalt within the scientific community
of Europe
• Dissemination of information on advanced innovative medicine development to the industry sector and other stakeholders
• Providing the information for society on topicalities in innovative drug development and results of InnovaBalt
WP8 Assessment of research and innovative potential of LIOS
WP leader Dr.chem Grigorijs VeinbergThe evaluation of LIOS’ overall research quality and
capability by high-level independent experts, nominated by European Commission.
The evaluation will give essential contribution in the definition of the further Strategic plan to strengthen LIOS research and innovation capacities essential for the regional economical and social development as well as promoting the integration of LIOS in the ERA activities.
WP7 Management of projectWP leader Dr.pharm Maija Dambrova
Management board: financial director of LIOS Dace Karkle
Dr. Edgars Suna, Dr. A. Jirgensons, Dr. Edgars Liepinsh
Objectives:• Setting up the appropriate monitoring, coordination and
communication procedures in order to ensure that project is implemented in a timely and cost effective manner in accordance with applicable EC guidelines and national legislation rules
• Ensuring that EC financial and administrative procedures are respected and reports and cost statements are provided in time
Ove
rall
orga
niza
tion
T8.1 Network managementstructure procedures
T8.1 Network managementstructure procedures
T8.2 Administrative and financial management
T8.2 Administrative and financial management
T8.3 Project technical co-ordination and
quality policies
T8.3 Project technical co-ordination and
quality policies
WP2Reinforcing
human potential
WP2Reinforcing
human potential
WP3Renewal of
research equipment
WP3Renewal of
research equipment
WP4Organization
of seminars and conferences
WP4Organization
of seminars and conferences
WP5Improving the management
of IP and enhancement of innovation
potential
WP5Improving the management
of IP and enhancement of innovation
potentialT2.1 Recruitmentof experienced
researchers
T2.1 Recruitmentof experienced
researchers
T2.2 post-doctoralresearchers
T2.2 post-doctoralresearchers
T4.1 Organization of conferences
T4.1 Organization of conferences
T5.1 Recruitment of experiencedIP manager
T5.1 Recruitment of experiencedIP manager
T5.2 Development of IP policy
T5.2 Development of IP policy
T5.3 Staff exchange and training
T5.3 Staff exchange and training
T3.1 Ccomputercluster
T3.1 Ccomputercluster
T3.2 Crystallizationrobot
T3.2 Crystallizationrobot
T3.4 New imagingTechnologies
T3.4 New imagingTechnologies
WP6Dissemination and promotional activities
WP6Dissemination and promotional activities
WP7Assessment of LIOS
WP7Assessment of LIOS
WP8ProjectManagement
T6.1 Elaboration of dissemination strategyT6.1 Elaboration of
dissemination strategy
T6.2 Exploitation of InnovaBalt
results
T6.2 Exploitation of InnovaBalt
results
T6.3 ProvidingInformation to
industry and SMEs
T6.3 ProvidingInformation to
industry and SMEs
InnovaBaltthe leading centre for drug discovery
in Baltic region
InnovaBaltthe leading centre for drug discovery
in Baltic region
T7.1 Kick-offmeeting of theExperts group
T7.1 Kick-offmeeting of theExperts group
T7.1 Communication and interaction
with Expert group
T7.1 Communication and interaction
with Expert group
T7.3 Evaluation report and recommendations
for Strategic Plan
T7.3 Evaluation report and recommendations
for Strategic Plan
T7.4 Workshopon evaluation
results
T7.4 Workshopon evaluation
results
WP1Exchange of experience
and know-how
WP1Exchange of experience
and know-how
T1.1 Staff exchange planning
T1.1 Staff exchange planning
T1.2 Implementationof outgoing visits
T1.2 Implementationof outgoing visits
T1.3 Implementationof incoming visits
T1.3 Implementationof incoming visits
T3.3 Zetasizer Nano
T3.3 Zetasizer Nano
T4.2 Participation in conferences
T4.2 Participation in conferences
Measure Impact on innovation
Upgrading of LIOS infrastructure
•Increasing the possibilities to use contemporary methods in the research and technology development;•Possibility to use upgraded infrastructure to regional research and industry community.
Recruitment researchers experienced in technology transfer issues
•Increasing the innovation capacity;•Organization of optimal environment for technology transfer and innovation.
Recruitment of specialist in Intellectual property management issues
•Strengthening the technology transfer unit;•Providing the optimal management of Intellectual Property, including rights.
Staff echange in the area of knowledge transfer and IP issues
•Obtaining the best experience in innovation and technology transfer issues
Elaboration of Strategic Intellectual Property development plan for LIOS
•Providing the optimal exploitation of existing innovation capacity of LIOS.
Trainings on Intellectual property management issues
•Increasing the capacity of regional research and industry institutions on protection of Intellectual Property, including rights.
Networking with industry (joint research, activities, dissemination of knowledge, exploitation of results)
•Providing the long-lasting capacity of innovation.
Conferences, workshops, seminars •Providing the knowledge on topicalities in the area of innovative medicine discovery.
The main strategic impacts • Contribution to the research, technology and innovation capacity
building in Baltic region: – by strengthening human capacity – improvement of technology environment and – management of intellectual property– promotion of collaboration between research centres – facilitating of cooperation with industry.
• Strong integration in ERA: through long-lasting partnership with selected European research centres
• Improved participation in FP Horizon 2020 and other European research programmes’ activities:
– increasing the skills and awareness about the preparation of competitive proposals and – improving the management skills– networking with other research centres and industry – establishing new partnerships.
Future expectations
• The implementation of InnovaBalt project will result in 1.5 times increase in number of SCI publications co-authored by LOSI personnel and 1.2 times increase in number of registered international patents
• Reinforced IPR culture is expected to facilitate the collaboration with business sector and improve the score of Latvia and Baltic region in the Global Innovatin index.
• LIOS will become the distinguished centre of research and innovation in the Baltic region in the field of medicinal chemistry and pharmacology and will provide the contribution in the solving of socio-economic needs of European society.
Thank you for attention!
Paldies par uzmanību!
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