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Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A. 4000. 3000. Slamf1 -/- [ BALB/c.129]. 2000. wt BALB/c. 1000. IgM IgG1 IgG2a IgG2b IgG3 IgA. 1000. Slamf2 -/- [ BALB/c.129]. 750. wt BALB/c. 500. 250. IgM IgG1 IgG2a IgG2b IgG3 IgA. - PowerPoint PPT Presentation
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Slamf1-/- [BALB/c.129]wt BALB/c
1000
2000
3000
4000
IgM IgG1 IgG2a IgG2b IgG3 IgA
250
500
750
1000
IgM IgG1 IgG2a IgG2b IgG3 IgA
Slamf2-/- [BALB/c.129]wt BALB/c
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A
Slamf1-/- [B6.129]wt B6
500
1000
1500
2000
1 mo 2 mo 3 mo 6 mo
IgM
250
500
750
1000
1 mo 2 mo 3 mo 6 mo
IgG1
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1B
F M0
25
50
75
100
% a
utoa
ntibo
dy +
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S2
B6
CD244
SlamfHaplotype 1
SlamfHaplotype 2
Sle1bSlamf2-/- [B6.129]
Slamf1/- [B6.129]
1.2598.8
72.627.4
1.0399
93.66.42
0.7199.3
7129
84.415.6
0.399.7
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S3
CD4-PE+
PNA-FITC
CD4-PE+
B220-FITC
wt BALB/c
Slamf2-/- [BALB/c.129]
Slamf1-/- [BALB/c.129]
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S4
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5A
p < 0.001
3 months 6 months
Slamf2-/- [B6.129]
Slamf2-/- [B6.129]
B6 B6
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5B
3 months 6 months
Slamf2-/- [B6.129]
Slamf2-/- [B6.129]
B6 B6
B6.129chr1b (26)
B6.Sle1b (13)
129/NZW allele
B6 allele
Slamf2-/- [B6.129]
recombinant region
10Mb
Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S6
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