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Seminar on Food and Feed AdditivesTokyo, JAPAN 2 July 2013
Innovative Biotechnology in Feed Additives: Improvements for a Sustainable Environment, Animal Welfare and Productivity Enhancement
Dr. Gerhard GansSenior Director Global Regulatory Affairs DSM Nutritional Products
Challenge IProtein - a mounting global concern
World demand for quality protein from animal sources is increasing - driven by 2 major factors:
More peopleBefore 2050 the human population is expected to reach 9 billion people
More disposable incomeFamilies with higher income will eat more meat
More animal protein = increased demand for feed ingredients, increased cost and more pressure on the environment
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Soybeans US Soybean meal 44%
Challenge IIRegulatory & Consumer Pressure Increase
Regulators seek to protect consumer, animals and environment
Decision making criteria of consumer are changing
Increasing pressure on broiler producers to:
Improve animal welfare
Reduce use of antibiotics
Protect the environment
Improve food safety
More efficient utilization of protein can help meet all these criteria
Crop
Proventriculus
Gizzard
Duodenum
Pancreas
Diet proteins
Polypeptides
Oligopeptides+ free AAs
Free AAs
Proteolytic enzymes
Pepsin (+ HCl)
TrypsinChymotrypsinElastase
AminopeptidasesCarboxypeptidasesDipeptidases
One Potential Solution:Improve Protein Digestion in Poultry
Characteristics of RONOZYME® ProAct
Is a preparation of serine protease, with broad specificity and high stability at low pH
Is produced by fermentation of a genetically modified Bacillus licheniformis strain containing a synthetic gene mimetic to the gene coding for a serine protease.
The production strain does not contain genes coding for antibiotic resistance
Absence of toxin formation in Bacillus licheniformis was shown by genome analysis and in vitro cytotoxicity studies
The production strain is absent in the preparation and the level of recombinant DNA is below the limit of detection of the PCR method
Extensive safety data package provides evidence on the safe use for consumer, workers and target animals
Decrease quantity of excreta
Decrease excreta moisture
Decrease of water intake
Decrease litter moisture/nitrogen content
Reduce levels in the diet
Decrease nitrogen excretion
Improve digestibility
Environmental Impact: Mode of action Dietary protein: water intake and litter quality
Dietary crude protein
-1% of crudeprotein in the
diet will reducewater in-take
by 2.7%
Animal Welfare Impact
Improved litter dry matter and nitrogen level can help decrease incidence of footpad dermatitis, breast blisters and hock burns
Lower protein diets supplemented with RONOZYME ProAct allow improved welfare without loss in animal performance
Improve litter quality
Improve animal welfare
AID 75.6%
AID82.6%
N input22.5% CP
WithoutProAct
WithProAct
Consumpt. of feed
N input 20.5% CP
N output
N content of manure
N output
Feed Manure
35% Reduction
AID = Apparent Ileal Digestibility of CP
Environmental Impact:Reduction of N excretion
Nitrogen is a major pollutant
Global warming
Nutrient enrichment
Algal bloomsoxygen depletion
Acidification
Acid rain
Emission of Greenhouse Gases:• CO2 - from fertilizer production from use of energy• N2O - from application of N-fertilizers and manure• CH4 - from ruminants, from paddies
Agriculture is responsible for 60% of global N2O emissions and 50% of global methane emissions
Emission of Greenhouse Gases:• CO2 - from fertilizer production from use of energy• N2O - from application of N-fertilizers and manure• CH4 - from ruminants, from paddies
Agriculture is responsible for 60% of global N2O emissions and 50% of global methane emissions
Emission of nitrate: NO3÷:
• from use of fertilizers• from manure
Agriculture is main source of nitrate pollutionNitrate pollution of ground water is also a health issue
Emission of nitrate: NO3÷:
• from use of fertilizers• from manure
Agriculture is main source of nitrate pollutionNitrate pollution of ground water is also a health issue
Emission of ammonia: NH3+:
• from use of fertilizers• from manure
In W Europe 92% of ammonia emissions are agriculturalAmmonia is also an animal health issue
Emission of ammonia: NH3+:
• from use of fertilizers• from manure
In W Europe 92% of ammonia emissions are agriculturalAmmonia is also an animal health issue
Minimise environmental impact, maximise profitability
Europe:
6.357 billion broilers or~ 15.9 mil ton broilers
NH3 emission reduction:
Per ton broilers: -1.68 kg NH3
Total potential: -26712 ton NH3
Reduced N-excretion:
Per ton broilers: - 2.79 kg N
Total potential: - 44018 t N
which means*:
157,500ha less land is needed for manure application
612M more broilers can be reared without need for extra land
Source: Food and Agriculture Organization of the United Nations* Assumes maximum application of 17kg N/ha
RONOZYM ® ProAct Regulatory Approval Times
BRAZIL•4 months for approval
AUSTRALIA•13 months for approval
EU-27•18 months for approval in EFSA & EU
USA•19 month for approval by CVM
CANADA•29 month for approval
CANADA
BRAZIL
AUS
EU-27USA
7
Innovative Product Development Needs:
Convergence in the National Approaches for Premarket Approval
Acceptance of OECD test guidelines instead of national specific test guidelines
Respect and utilize the evaluation results of the counterpart (FSC / EFSA) to accelerate the evaluation process
Rigid and transparent evaluation lead times
Number of expert groups with frequent meetings
Timelines for evaluation process
Active dialogue between authority/expert group and industry to develop further the current approval process.
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