S. ABDC PPT/country paper SRR.pdf · Status : Allinstitutions registered and operationalAll...

Promotion of excellence 

innovation and technology development

Status of Patents , Publication & Technologies in 12th Plan (2007-2012)

Total Cost Number of Projects (%)

Status : Status :  All institutions registered  and operational All institutions registered and operationalinterim facilities setup and interim facilities setup and Directors  appointed  and in position Directors  appointed  and in position Research Activities  started Research Activities  started Construction  in progressConstruction  in progressKey Faculty Recruited and other  process is Key Faculty Recruited and other  process is ongoingongoing

DBTDBT

Biotech Science Cluster, Faridabad

DBTDDDDDDDDDDDDDDDDDDDDDDBBBBBBBBBBBBBBBBBBBBBBBDBDBBBBTTTTTTTTTTTTTTT

Plat form Technology Centre

Centre for Animal Model for Clinical 

Advances

Clinical Research Centre for Paediatric

Diseases (AIIMS)

Clinical Research Centre for Neurological Disorder

with NBRC & Gurgaon Civil Hospital

UNESCO Regional Centre for Biotechnology (RCB)

IncubatorBiotech Park

Cancer Nano Centre

Molecular Breeding (NIPGR)

Drug Discovery Centre

POLICY UNITPOLICY UNITPOLICY UNIT

Paediatrics Biology Centre 

(PBC)

DBTDBT

INDIAN INSTITUTE OFINDIAN INSTITUTE OFSCIENCE EDUCATION SCIENCE EDUCATION

AND RESEARCHAND RESEARCHMinistry of HRDMinistry of HRD

NATIONAL NATIONAL INSTITUTE OFINSTITUTE OF

NANOTECHNOLOGYNANOTECHNOLOGYDSTDST

MANAGEMENT INSTITUTEGovt of Punjab

NationalNationalAgriAgri--food food

BiotechnologyBiotechnologyInstituteInstitute

35 acres 35 acres

Bioprocess Unit15 acres

AgriAgri--food food ParkPark80 acres80 acres

PUNJAB KNOWLEDGE CITY, MOHALIPUNJAB KNOWLEDGE CITY, MOHALI(350 acres)(350 acres)

AGRI‐FOOD CLUSTER

130 acres

Sharing of BM14 beam line on cost vs time basis among ESRF, France MRC,U.K. Government of India and

EMBL,EU

VaccinesS. 

No. 

Vaccine for  Current Status

1. Leprosy  Commercial 

2. Swine Flu (H1N1)  Commercial 

3. Rabies  Approved for use in animals 

4. Japanese 

encephalitis

approved for commercial 

use

5. Rota viral Diarrhoea  Phase III

6. Cholera  Phase III

7. Malaria  Phase I 

8. Anthrax  Phase I 

9. Dengue Pre‐clinical

10. Typhoid  Pre‐clinical

11. HPV Preclinical

DIAGNOSTICSTransferred to the Industries & Launched in the Market

Western Blot for HIV-I & II -HIV/AIDS

Naked Eye Agglutination System (NEVA) -HIV/AIDS

Shantest for detection of Alpha-feto Protein

in Pregnant Women.

JEV-CHEX for Japanese encephalitis

SIGNAL – KA for Leishmania.

Signal MF - Filaria

ELISA- Hepatitis ‘C’

Transferred, yet to be launched:

- IgM Mac ELISA -DengueJapanese encephalitisWest Nile

- IgM – ELISA - Hepatitis ‘A’

DBT

DIAGNOSTICS

Ready for Commercial Launch:•

PCR based assay for M.tuberculosis (CDRI, Lucknow) By M/s. Biotron Health Care Ltd., Mumbai

•

HPV –

Screen Test: A DNA Chip for HPV genotyping from Cervical samples (Xcyton, Bangalore)

•

PCR based assay for STDs (C.trachomatis & N.gonorrhoe (ACBR, New Delhi).

Commercialized Dengue NS1 Antigen Microlisa: J. Mitra & Co.

DEVELOPED IN COLLABORATION WITHINTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND

BIOTECHNOLOGY

Supported by Department of Biotechnology

Commercialized Dengue NS1 Ag & Ab Combi test

J. Mitra & Co.DEVELOPED IN COLLABORATION WITH

INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

Supported by Department of Biotechnology

National Biodesign Alliance: partnering institutions 

An effective and consistent way to deliver chest compressions to sudden cardiac

arrest victims

A better way to gain intra-osseous access in emergency patients.

Non-invasive, rapid and definitive way of airway

management.

Stanford-India Biodesign ProgrammeCreating Entrepreneurs

A low cost, disposable device to manage fecal incontinence in non-ambulatory patients across all

care facilities- Transferred to industry

Food and Nutrition Low cost technologies for Public health

and nutrition

RUTF for severe acute malnutrition

Ultra rice – Iron and Zinc fortified

Designer Crops

Neutraceuticals for wellness

Zinc for acute diarrhea

Zinc for neonetal sepsis

Transgenic crops developed in public sector in regulatory field trials

Crop Organisation TraitBrinjal IARI, New Delhi Insect Resistance

Castor Directorate of Oilseeds Research (DOR), Rajendranagar, Hyderabad

Insect resistance

Sorghum National Research Centre for Sorghum (NRCS),Hyderbad

Insect resistance

Groundnut ICRISAT, Hyderabad Fungal disease resistance

Potato Central Potato Research Institute (CPRI), Shimla

Leaf blight disease resistance

Rice IARI, New DelhiTamil Nadu Agricultural UniversityMahyco, Mumbai

Fungal diseases resistance and drought tolerance

Tomato IARI, New Delhi Virus disease and insect resistance

0.001.002.003.004.005.006.007.008.009.00

CONTROLODC 22ODC 27ODC 32

SAM

DC 22SA

MDC 24

SAM

DC 56SA

MDC 70

ADC 25ADC 93

Line no.

Lyco

pene

(mg/

100g

)

Tomato with improve quality parameters and shelf life

70 R&D projects in 15 crops for development of GM crop varieties in public sector institutions/ universities for improvement of productivity, quality, pest and disease

resistance, water use efficiency and salinity

Rice with water use efficiency Groundnut with virus disease resistance

Back cross derived lines in Swarna background using GR2-R event as donor ready for regulatory testing

Swarna Golden Swarna

40 gram/day to meet to supplement current dietary intake for meeting

Simultaneous Transfer of Insect Resistance Chickpea Transgenic Technology from public sector to private seed

company and Agriculture University forcommercial and public good development

Molecular Breeding of Crops

Molecular breeding and Release of QPM hybrid Maize

QPM hybrid contains:

40% higher tryptophan

30% higher lysine

Hybrids/ Yield (q/ha)* CVRC (Identified for Zone I)

SVT (Uttarakhand)Released

Vivek 9 61.18 39.27

QPM Version of Vivek-9 63.60 42.75

*Yield difference non-significant

Some success stories from SAUs and ICAR of Molecular breeding crops jointly with DBT

Crop Trait considered Institute Name of cvRice Bacterial Blight DRR & CCMB Samba Mahsuri

Rice Bacterial Blight NRCPB, IARI Improved Pusa Basmati-1

Rice Root and Blast resistance

UAS, Bangalore MAS914

Maize Quality protein VPKAS, Almora Hybrid-9

Maize Turcicum leaf blight

IARI

Wheat Leaf rust PAU, Ludhiana

Rice Bacterial Blight PAU, Ludhiana Local variety

Rice BLB, Gall Midge CRRI

Rice Bacterial Blight resistant basmati rice

IARI Pusa 1526-04-25

Crop biofortification for enhanced Iron and Zinc contents and reduced phytates, in wheat, rice and maize through marker assisted breeding/ transgenic approaches.

High and stable β-carotene durum cultivar HI 8663 (Poshan) evolved widely adapted genotype having 1.4 % to 28.4 % higher yield over checks.

High and stable β-carotene (~ 6.5 ppm), high protein content (11.6 %) and high levels of micronutrients.

Can be used as an excellent “dual quality” durum for preparation of “nutritive chapati” and good quality pasta as well.

Food and Nutrition

Proposed implementation --12th planGenomics based Molecular Breeding Platform design contd..

NABI Mohali

NIPGR, New Delhi

Molecular Breeding Technology Platform and Facilities for tools and marker development

9 crops specific regional marker validation and breeding centres; 6 phenotype centres in ICAR institutions, SAUs

Indian private sector companies an non-profit foundations can also participate

DBT ICAR

Biopesticide Products developed through DBT’s support already in the Market

Name of the Company Biocontrol agents/Biopesticides

Trade Name with formulation

Crop Health Product Ltd.Ghaziabad

Trichoderma virideTrichogramma chilonisHaNPV

FunginilEgynilHelionil

MPKV, Rahuri HaNPVSlNPVSoNPV

Trichogramma chilonisT. harzianum

HeliokillMagicSpilocidePhuleTrichocardsPhule Trichoderma

Asthagiri Herbal Research Foundation Chennai

Anti-fungal Botanical Geran

*M/s Prathista Industries Ltd.Secundrabad, A.P.

Trichoderma viride(1.15% wp)

“Protect” (Biofungicides)

Agro Biotech Research Centre

Pseudomonas fluorescence B. bassiana

ABTECH PseudoABTECH Beauveria

Increase in yields average 18per cent in

wheat , rice and legumes

Increases Zinc, Ironand micronutrient

contents in grains

Biofertiliser Technology Development: Mycorrhiza Mass Production - a New generation Broad spectrum biofertilizer

Industries received TERI- DBT technologyCadilla Pharmaceuticals Ltd.Majestic Agronomics (P) Ltd.Sarita Ganga farm (P) Ltd.Cosme Pharma KCP Sugar and IndustriesSymbiotic Life Science (P) Ltd

3500 Tones

Total biofertiliser production of all types is 35000 tones – this product occupies 10 Per cent of market

Bioethanol

Algal Biofuel

Biodiesel

Energy Energy Bioscience Bioscience

CentreCentre

Capacity Building

• Re-engineered feed stock

• Re-engineered microorganisms

• Process optimization • Collection and characterization

• Establishment of repositories

• Development of production system

• Quality planting material

• Improved feed stock

• Process optimization • Biohydrogen

• Biobutanol

National Programme on Energy BiosciencesNational Programme on Energy Biosciences

More than 53 research institutes, universities and industries involved

• Energy Bioscience Chairs

• Energy Bioscience Overseas Fellowships

Next generation 

Biofuels

1500 Lts Pilot scale facility for bioremediation of polluted sites through “Oil Zapper” of petroleum industry

Before 

After 

Total 600 tonnes of oil zapper supplied to oil companies. Bioremediation of oil contaminated soil in operation area of ONGC, IOCL, BPCL and HPCL is completed and the sites were restored after bioremediation

11th Five Year Plan11th Five Year Plan

Programmes for North Eastern States and Sikkim

Programmes for North Eastern States and Sikkim

International Collaboration for International Collaboration for Affordable InnovationAffordable Innovation

DBTDBT

Small Business Innovation Research Initiative (SBIRI)

• To support early stage, • pre-proof-of-concept research• To take up leads towards

commercialization

MISSIONNurture innovative and emerging

technologies / entrepreneurs.

Nitrifying bioreactor- i naquaculture systems formanagement of water quality in shrimp hatchery

RBC phenotyping kit- an affordable import substitute as a blood grouping reagent kit through indigenous production of monoclonals.

RBC phenotyping kit- affordable import substitute as a blood grouping reagent kit through indigenous production of monoclonals.

Automated dispenser–The dispenser can be used to aliquot media and other reagents for assay

Recombinant follicle- stimulating hormone –a subcutaneous injectable preparation used in infertility treatment regimen.

SOME PRODUCTS COMMERCIALIZED IN SMALL BUSINESS INNOVATIVE RESEARCH INITIATIVES SCHEMES BY SMES – MORE IN PIPELINE

Scheme Launched: November 2008

Total Proposals Received: 450 Approved Projects: 60

Biotechnology Industry Research Assistance Council (BIRAC)- End-to-end Services

Started as a pilot project and EFC and cabinet approvedTo be operational as Section 25 company 2012-2013

3X

In Summary