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Regionally Specific Atrophy Following Traumatic Brain Injury. DG MCLAREN , BB BENDLIN, and SC JOHNSON University of Wisconsin—Madison & GRECC, Madison VA Hospital. Background. Identifying longitudinal changes are essential in understanding plasticity and predicting future outcomes - PowerPoint PPT Presentation
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Regionally Specific Atrophy Regionally Specific Atrophy Following Traumatic Brain InjuryFollowing Traumatic Brain Injury
DG MCLAREN, BB BENDLIN, and SC JOHNSON
University of Wisconsin—Madison &GRECC, Madison VA Hospital
Background
• Identifying longitudinal changes are essential in understanding plasticity and predicting future outcomes
• Surface-based approaches have been used in functional and structural analyses
Using the Cortical Surface
McLaren et al. 2007, Van Essen et al. 2005 & 2006
Background
• Identifying longitudinal changes are essential in understanding plasticity and predicting future outcomes
• Surface-based approaches have been used in functional and structural analyses
• Can Surface-based approaches be Can Surface-based approaches be used in longitudinal analyses?used in longitudinal analyses?
Study Parameters
• T1-weighted SPGRs were collected at ~79 days and ~409 days post injury
• Standard Axial SPGR sequence with .9375x.9375x1.2mm voxel dimensions
Processing Steps
2 x Original T1
Align Brains via Skull;Compute Flow
SIENA
Global Results Using SIENA
N=30 N=36
P<.0001
Trivedi et al. 2006
Processing Steps
2 x Original T1
Align Brains via Skull;Compute Flow
Bias Corrected T1(Brain Only)
Normalize & Surface AnalysisSIENA
Surface Creation and Registration
Van Essen 2005
Within Subject Surface Co-registration
• Registration to PALS of the same surface produces identical results
• Registration of an image to itself doesn’t produce the same results
Within Subject Surface Co-registration
• T-statistic of time 2 minus time 1 scans
Percent Brain Volume Change: -.048
P<.0001 corrected
Within Subject Surface Co-registration
TBI Patient Cross-section (time 1)
1028
P<.0001 corrected
TBI Patient Cross-section (time 2)
P<.0001 corrected
TBI Patient Longitudinal
Percent Brain Volume Change: -.8276
P<.0001 corrected
Conclusions
• Surface registration is stable• Normal Controls show little or no
changes consistent with SIENA • Method is sensitive to changes over
time (and errors in segmentation)
• One of the first illustrations of longitudinal changes using the cortical surface
Future Directions
• Improve segmentation to increase accuracy
• More automated and stable procedure• Create study specific averages• Compare against SIENAr• Other patient populations
Acknowledgements
• UW Institute of Aging• Collaborators on the project
Trivedi MA, Ward MA, Hess TM, Gale SD, Dempsey RJ, Rowley HA
• Funding Support:– NIH: T32 AG20013– NIH: RO1 MH65723– NIH: T32 GM007507 – Merit Review Grant from the Department of Veterans Affairs
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