Regeneration of Heart?

Regeneration of Heart?In all ones life, the blood, hair and skin cells can be continuously regenerated, but the heartcells lose proliferative capacity soon after birth. UCL researchers first clarified the reasons!hy adult heart can not regenerate. "he study, published in a recently #ournal of Cell $iology,could help people reprogra% the patient&s heart, so that Cardio%yocytes cells can regain theability to repair itself.In the first !eek after birth, the %a%%alian heart can be regenerated, but this capability !illsoon be lost. Ho!ever, perhaps !e can %ake the heart regain this ability, the senior author ofthe article 'r. Robb (acLellan said.Intheprocessof hu%andevelop%ent, theproliferationof cardio%yocytesgeneratedbyprecursor ste% cells for% the heart. )nce the heart is for%ed, %yocardial cells !ill change itsstatus for% i%%ature cells into %ature cells that can not be proliferated. Ho!ever, the ne!theart cells can change back and forth bet!een the t!o states, to repair heart da%age in ti%e.(acLellan noted that the reason for adult cardiac cells can not regenerating is si%ple. *hen%yocardialcells are in the i%%ature state they do not shrink !ell, !hile shrink capacity is+uiteessential forheart function. "hehu%anbodyislargerthanthene!t, and!eneedstronger systolic to %aintain blood pressure and blood circulation. ,In order to achieve %oreefficient and%orepo!erful cardiacheart, !ehavetogiveuptheabilityof %yocardialregeneration in evolution.- (acLellan said..tudieshavesho!nthat transient knockdo!nblockcell cycleproteins, can%akeadultcardiaccellsre/enter thecell cycle, andthen%akethe%changeintoastatethat canproliferate. Ho!ever, this therapy %ust be reversible, and the effect should disappear after therepair, avoiding cardio%yocytes be %ature again. Currently, (acLellan along !ith his tea%%e%bersaretryingtosendsiR0intotheheart !ithnanoparticles, knockingdo!ntheproteins that %ake cardio%yocytes %aintained the state of %ature.'uring the heart attack, cardiac cells !ill die and for% scar tissue. $y reprogra%%ing, *e caneasily locate the da%aged place and let the cardio%yocytes re1uvenate, and back into thestate !hen they have the ability to regenerate.Recent years,e%bryonic ste% cellsor pluripotent ste% cells are used fre+uently for cardiacregeneration. ,I think, it is possible to push %yocardial cells regeneration right in the body.-(acLellan co%%ented.