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Cross-Linking: Interaction between
• Riboflavin and UVA in order to produce O- (singulet oxigen) with oxidative dexaminhation and carbo-amidic bonds production
• This reaction require three elements:– Riboflavin
– UVA
– Collagen
INDEPENDENTLY FROM RIBOFLAVIN TRANS-EPITHELIAL DELIVERY SYSTEM the epithelium leaved in situ and soaked by
riboflavin, induces a «shielding» effect absorbing over 90% of UV-A radiation, confining CXL penetration in a surface level under 100 µm
The Epithelium should be always removed to ensure a deep and sufficient interaction between UV A, Riboflavin
and collagen molecules, maximizing the CXL effect !!!
UV A photons “In situ” Epithelium , without Riboflavin, induces a “shield” effect
Absorbing about 30 % of UV A radiation !
Corneal Epithelium
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