View
216
Download
2
Category
Preview:
Citation preview
Post Mortem Changes
Jaroslava DuškováInst. Pathol. ,1st Med. Faculty,
Charles Univ., Prague
http://www1.lf1.cuni.cz/~jdusk/
General Pathology – Seminary 1a
irreversible arrest irreversible arrest
of integrated of integrated
organism functionsorganism functions
Death
Post Mortem Changes
physical : algor, pallor (paleness), hypostasis, diffusion of fluids & gases
chemical (enzymatic): rigor, blood coagulation, autolysis
biological: putrefaction
Post Mortem Changes – physical -1
algor – the body temperature levelled out with the surroundings
Post Mortem Changes – physical -2
pallor (paleness) circulation stop,
contraction of the vessels, esp. arteries
Post Mortem Changes – physical -3
hypostasis – gravitation effect
– cadaverous spots
Post Mortem Changes – physical -4
diffusion of fluids & gases – maceration
pseudomelanosis (Hb+ Hydrogen sulfid)
-verdohaemoglobin
Post Mortem Changes - chemical
(enzymatic) -1
rigor (stiffness, cadaverous rigidity)
consumption of macroergic compounds (ATP)
Post Mortem Changes - chemical
(enzymatic) -2
blood coagulation – tissue trombokinases, endothelium
autolysis
Post Mortem Changes - chemical
(enzymatic) -3
Autolysis – disruption of membranes, lost
compartmentalizationCell changes in autolysis:
loss of cytoplasm basophilia cytoplasm swelling, vacuolisation loss of nuclear stainability
(pyknosis, karyorrhexis, karyolysis)
Putrefaction & further cadaverous decompositions
putrefactive bacteriaputrefactive bacteria insectsinsectsworms etc.worms etc.
Post Mortem Changes - Meaning & Consequences
physicalphysical – important in medicojudical – important in medicojudical practice eg. algor practice eg. algor
time of deathtime of death
chemical chemical – interfering– interfering & limiting all & limiting all
special methods special methods biological biological – limiting even the – limiting even the
macroscopy examination macroscopy examination
Recommended