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Pharmacy 483: QI and DUE in Pharmacy Practice. Steve Riddle, BS Pharm, BCPS QI and Medication Utilization Lead HMC Pharmacy February 24, 2004. Acute Myocardial Infarction. HA, 52yo male admitted via ER with severe, “crushing chest pain”, ST elevation with positive enzyme elevations. - PowerPoint PPT Presentation
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Pharmacy 483:
QI and DUE in QI and DUE in Pharmacy PracticePharmacy Practice
Steve Riddle, BS Pharm, BCPS
QI and Medication Utilization Lead
HMC Pharmacy
February 24, 2004
Acute Myocardial Infarction
• HA, 52yo male admitted via ER with severe, “crushing chest pain”, ST elevation with positive enzyme elevations.
• What should be done for this patient?
Why do we need QI in pharmacy or in healthcare
How do we assess quality?How do we assess quality?
• Quality Assurance (QA): quality assurance is any systematic process of checking to see whether a product or service is meeting specified requirements– Implies “maintenance of standard”
• Quality Improvement (QI)– Focus is on improvement of product or service
or process
Continuous Quality Continuous Quality Improvement (CQI)Improvement (CQI)
“Doing things right first time" • Implies that there is only one way to do
something and that good quality care is static and unchanging.
• It is essential to strive for continuous quality improvement and not to assume that because things are "done right first time" they cannot be done better.
Three Categories of Quality Three Categories of Quality ImprovementImprovement
• Eliminating quality problems– Remove unsafe on ineffective agents from formulary– Facilitating use of most appropriate agent – Reducing order-drug turnaround times (ie, automation)
• Reducing costs while maintaining or improving quality– Optimize drug acquisition cost: contract negotiations,
Group Purchasing Organizations (GPOs)– Therapeutic substitution initiatives (ex., PPIs)– Generic utilization
• Expanding customer expectations– Development of innovative products and services to
attract customers (ie, CDTM, mail order)
QI MethodologyQI MethodologyMany QI theories or methods.
Most share key steps….
•Identify What are you improving?
•Analyze Understand the problem(s)
•Develop Hypothesize solutions/changes
•Test or Implement Put it into practice
•Assess Outcomes What worked?
•Sustain Hold the gains
•Spread Broaden scope of gains
AMI Treatment:AMI Treatment:3 QI Examples In Pharmacy3 QI Examples In Pharmacy
.
#1 Disease State Management
#2 Pharmacologic Class Review
#3 Drug Use Evaluation (DUE)
AMI Drug Treatment:AMI Drug Treatment:Assessing Quality IndicatorsAssessing Quality Indicators• What are goals?
– Current Clinical Recommendations (AHA & NCEP Guidelines)
– Benchmarking (CMS Data, UHC)• Review patient data for EBM drug indicators
– Retrospective: Disch Dx (ICD-9 Codes),– Prospective (”Real Time”)
• Identify areas for improvement– Where are major deficiencies?
Quality of Care for AMI:Quality of Care for AMI:Disease State Management Disease State Management
Focus on provision of key elements of carethat optimize outcomes
• Interventions (Arteriogram, PCTA, CABG)• Labs and Diagnostic Eval. (ECG, enzymes, Echo, EF)• Messages (Life Style Modification, Smoking Cessation,
Medication Adherence)• Drug Therapy (Thrombolytics, Heparin, GP-2B3A
inhibitors, ASA, ACEIs, Beta-Blockers, Statins)• Timeliness of therapy (door-to-drug)
HMC Care Goals for AMIHMC Care Goals for AMIMeasure Goal Sampling Plan
AMI patient discharged on ASA
100% Chart Review
AMI patient discharged on ACEI
100% Chart Review
AMI patient discharged on Beta Blocker
100% Chart Review
AMI patient discharged on Statin (if LDL > 130)
100% Chart Review
Smokers with CV Condition will have
documented cessation advice/counseling
75% Chart and CIS documentation
review
HMC Rx Rates : HMC Rx Rates : Secondary Prevention in AMISecondary Prevention in AMI
Report from 10/2000, UHC Benchmarks
86 86
64
50
18
ASA Beta blocker ACEI Statin Smoking0
20
40
60
80
100
Per
cen
t o
f P
atie
nts
Cessation
AMI Treatment: AMI Treatment: Indicated Drugs Under Utilized?Indicated Drugs Under Utilized?
Problems Solutions• Provider lack of
awareness of benefits• Inconsistencies in
prescribing habits• Lack of use of current
prescribing aids• Complex processes
education/awareness of providers
• Simplify processes order sets, clinical pathways
• Designate specific responsibilities
• Clinical Care Coordinator or pharmacist on clinical team
• Use data (ie, daily admit printouts)
Pharmacist RolePharmacist Role• Collaborate in development of practice guidelines
– Committee involvement– Standing order and clinical pathway development
• Influence prescribing patterns– Daily rounding or clinic interactions– Conduct educational programs for residents– Provide feedback to prescribers around specific drugs– “Counter-detailing”
• Perform direct patient care roles– Anticoagulation service– Collaborative disease management protocols– Patient education programs
HMC Rates for Secondary HMC Rates for Secondary Prevention in AMIPrevention in AMI
Data from HMC Dsch Diagnosis Coding for AMI and CIS reviews 10/2002
94 9486 100
74
ASA Beta blocker ACEI Statin Smoking0
20
40
60
80
100
Per
cen
t o
f P
atie
nts
Cessation
ACEI Class Review ACEI Class Review • Clinical Efficacy
– Numerous agents– Varying degrees of literature support– FDA approved indications– Theoretical differences vs. hard outcomes vs.
missing data– “Class Effect”?
• Cost– Low-cost generics vs. brand– Pharmaceutical company detailing
• Convenience– Once daily vs. BID dosing
Drug: Market Share and Annual Cost: Drug: Market Share and Annual Cost: Jan – Dec 01Jan – Dec 01
ACEI Agent Market Share on Utilization
(%)
Market Share on Cost (%)
Annual Cost ($)
#1 Benazepril 36 47.5 119,000
#2 Lisinopril 40 41.0 103,000
#3 Enalapril 23 10.1 25,000
#4 Ramipril 0.1 0.5 1,500
#5 Captopril 1 0.3 700
TTL $249,200
Drug Use Evaluation (DUE)Drug Use Evaluation (DUE)• Definition: Authorized, structured, ongoing review
of practitioner prescribing, pharmacist dispensing and patient use of medications.
• Purpose: To ensure drugs are used appropriately, safely, and effectively to– Improve patient care– Lower the overall cost of care– Foster more efficient use of health care resources
• Process – Comprehensive review of medication use data– Identify patterns of prescribing
DUE TargetsDUE Targets
• Therapeutic appropriateness
• Appropriate generic or FLA utilization
• Inappropriate dose and/or duration
• Over and underutilization
• Compliance with polices/guidelines
DUE: RamiprilDUE: Ramipril
• Restrictions: – Limited Indications: HOPE Criteria– Cost: Trade name vs. generic alternatives
• Appropriate Use– Chart reviews of users– Compare actual use to restriction criteria– Percent compliance rate
• Assessment
Ramipril DUE Results # of Patients
Receiving Ramipril
# Patients that met HOPE
Criteria
# of Patients not meeting HOPE
Criteria
Total 40 33 6*
HMC 34 28 5*
UWMC 6 5 1
Overall, a 82.5% compliance rate for appropriate use.Of the 6 patients not meeting the HOPE criteria for ramipril use:-3 had only 1 identified risk factor (hypertension).-3 had documented EF < 40% secondary to MI or CHF along with numerous other risk factors and would have been eligible for treatment with 1st –line formulary agents.
QUESTIONS?QUESTIONS?
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