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Pharmacology designing experiment. Effects of Diazepam by oral administration with water, milk, grapefruit juice, alcohol, tea. Group member: Christine Tiffany Terry Homer Tutor: Professor lv, Professor Xiong. Presentation Outline. 1. Introduction 1.1 case 1.2 questions - PowerPoint PPT Presentation
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Pharmacology designing experiment
Effects of Diazepam
by oral administration with water, milk, grapefruit juice, alcohol, tea
Group member: Christine Tiffany Terry HomerTutor: Professor lv, Professor Xiong
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Presentation Outline
1. Introduction
1.1 case
1.2 questions2. Experiment Procedure3. Results (Data Analyses and Statistics)
aaa3.1. Sleeping latency
3.2. Sleeping duration
3.3. Open-field4. Conclusion
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Case
Alcohol +hypnotics=toxin?
Introduction
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Questions about administration of hypnotics are raised up
Why dose hypnotics with alcohol will produce toxin?
Isn’t it better to dose hypnotics with milk than with water?
Why it’s not proper to dose hypnotics with tea?
It’s reported that Grapefruit juice will sufficiently increase the hypnotic potency, true?
alcohol
tea
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Experiment procedures
1.grouping 5 groups
5 mice each group
2.giving drug
0.1ml/10g solvent water grapefruit juice alcohol tea milk
0.2ml/10g drugdiazepa
mdiazepam
diazepam
diazepam
diazepam
3.observationawake
spontaneously
sleeping latency
sleeping duration
Open-field
giving caffeine
sleeping latency
sleeping duration
open-field
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3.Results
3.1. Sleeping latency
20
5
25
25
8
0 5 10 15 20 25 30
water
al cohol
mi l k
tea
grapef rui t j ui ce
sl eepi ng l atency(mi ns)
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3.2. Sleeping duration
50
20
50
72
48
0 15 30 45 60 75
water
al cohol
mi l k
tea
j ui ce
sl eepi ng durati on(mi ns)
3.Results
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States Water Milk Tea Alcohol Grapefruit Juice
Aftergiving Diazepam
More and more sedative in 20mins
LongerSleepinglatency thanwater group
Longer sleepinglatency thanwater group
One of themis dead.Others fallasleep verysoon
Very active!Even doinggymnastics.
Sleepingcondition
Non—rapideyes-movement
No sufficientmovement
No sufficientmovement
unconscious Sleep like a log;
Very longlatency
Open FieldCondition
Walkingnormally
Walkingnormally
Walkingnormally
Very exciting;Walking fast
Stay still,Sometimeswalk slowly
Observation of mice’s action
3.Results
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3.3. Open-field
open-fi el d
23
66
99
33
49
166
1620
1
14
24
17
2 80102030405060708090
100
1 2 3record t i me(mi n)
grid
s
water al cohol mi l k tea grapef rui t j ui ce
Water vs. alcohol
Grapefruit juice,water and alcohol
3.Results
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4.Conclusions
(1)Oral administration with milk will lower the drug potency (2)Oral administration with Grapefruit juice will sufficiently increase the
hypnotic potency and cause adverse effect.
(3)Oral administration with tea will lower the hypnotic potency.
(4)Oral administration with alcohol will sufficiently increase the hypnotic potency and cause severe adverse effect.
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