Pedigrees and Karyotyping Analyzing Inheritance Patterns and Chromosomes
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- Pedigrees and Karyotyping Analyzing Inheritance Patterns and
Chromosomes
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- Pedigree Karyotype Pedigree Karyotype
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- Engage Sex-Linked Recessive Hemophilia The Royal Disease Read
the short story Alexis: The Prince Who Had Hemophilia by:-Kelley,
Laureen A. Set in the early 1900s, this is the story of the
youngest child of Tsar Nicholas II of Russia, last Tsar of Russia.
The story includes how Alexis's hemophilia influenced the course of
events in Russia that led to the Russian Revolution
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- Some History Hemophilia has played an important role in
Europe's history Hemophilia has played an important role in
Europe's history The disease began to crop up in Great Britain's
Queen Victorias children The disease began to crop up in Great
Britain's Queen Victorias children It became known as the "Royal
disease" because it spread to the royal families of Europe through
Victoria's descendants It became known as the "Royal disease"
because it spread to the royal families of Europe through
Victoria's descendants
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- How it Spread it spread through the Royal Houses of Europe as
monarchs arranged marriages to consolidate political alliances. it
spread through the Royal Houses of Europe as monarchs arranged
marriages to consolidate political alliances. We can trace the
appearance of hemophilia as it popped up in Spain, Russia, and
Prussia by looking at the family tree. We can trace the appearance
of hemophilia as it popped up in Spain, Russia, and Prussia by
looking at the family tree.
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- The Royal Family Tree
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- Queen Victoria's son Leopold's Family His daughter, Alice of
Athlone, had one hemophilic son (Rupert) and two other children --
a boy and a girl -- whose status is unknown. What is the chance
that her other son was hemophilic? What is the probability that her
daughter was a carrier? hemophiliac?
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- The Spanish Connection Now for the Spanish connection:
Victoria's youngest child, Beatrice, gave birth to one daughter,
one normal son, and two hemophilic sons. Now for the Spanish
connection: Victoria's youngest child, Beatrice, gave birth to one
daughter, one normal son, and two hemophilic sons. Looking at the
pedigree of the royal family, identify which of Beatrice's children
received the hemophilic gene; why can you make this conclusion?
Notice that Beatrice's daughter, Eugenie, married King Alfonso XIII
of Spain and had six children, one of whom was the father of Juan
Carlos, the current King of Spain. Looking at the pedigree of the
royal family, identify which of Beatrice's children received the
hemophilic gene; why can you make this conclusion? Notice that
Beatrice's daughter, Eugenie, married King Alfonso XIII of Spain
and had six children, one of whom was the father of Juan Carlos,
the current King of Spain. Would you predict that Juan Carlos was
normal, a carrier, or a hemophilic? Would you predict that Juan
Carlos was normal, a carrier, or a hemophilic?
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- German and Russian Influences
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- Explore Explore 1 Explore 1 Sex-Linked Inheritance Sex-Linked
Inheritance Explore 2 Explore 2 What Do You Know About Diabetes?
What Do You Know About Diabetes?
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- Karyotyping Analyzing Chromosomes Analyzing Chromosomes
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- Engage Genetic Disorders Patau Syndrome Patau Syndrome Edward
Syndrome Edward Syndrome Klinfelters Syndrome Klinfelters Syndrome
Turner Syndrome Turner Syndrome Super Male Syndrome Super Male
Syndrome Super Female Syndrome Super Female Syndrome
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- 47, XX or XY, +13 serious eye, brain, circulatory defects as
well as cleft palate. 1:5000 live births. Children rarely live more
than a few months. serious eye, brain, circulatory defects as well
as cleft palate. 1:5000 live births. Children rarely live more than
a few months. Patau Syndrome Patau Syndrome
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- Cleft Palate
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- Edward Syndrome almost every organ system affected 1:10,000
live births. Children with full Trisomy 18 generally do not live
more than a few months. almost every organ system affected 1:10,000
live births. Children with full Trisomy 18 generally do not live
more than a few months.
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- Klinefelters Syndrome Male sex organs; unusually small testes,
sterile. Breast enlargement and other feminine body
characteristics. Normal intelligence. Male sex organs; unusually
small testes, sterile. Breast enlargement and other feminine body
characteristics. Normal intelligence.
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- Turner Syndrome the ONLY viable monosomy the ONLY viable
monosomy
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- Super Male and Super Female - Has an XXX - Fertile females with
normal intelligence - Has an XXX - Fertile females with normal
intelligence Has an XYY - Tall male with heavy acne - Some tendency
to mental retardation Has an XYY - Tall male with heavy acne - Some
tendency to mental retardation Aggressive tendency Aggressive
tendency
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- Explore 2 Analyzing chromosomes of a normal male or female
Analyzing chromosomes of a normal male or female
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- Normal Female
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- Normal Male
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- Explain
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- Questions How many chromosomes come from your Father? How many
chromosomes come from your Father? How many chromosomes come from
your Mother? How many chromosomes come from your Mother? What are
chromosome pairs 1-22 called? What are chromosome pairs 1-22
called? What is chromosome pair 23 called? What is chromosome pair
23 called?
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- Parts of a chromosome All human chromosomes have two arms the
short arm is referred to as the ____ arm (petite) the long arm as
the ___ arm P Q
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- Disorders Name 3-4 diseases caused by a chromosomal
abnormality. Name 3-4 diseases caused by a chromosomal abnormality.
What most often causes this abnormal number of chromosomes? What
most often causes this abnormal number of chromosomes?
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- Nondisjunction
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- Terms to Know If either of these gametes unites with another
during fertilization, the result is ________________ (any abnormal
chromosome number) If either of these gametes unites with another
during fertilization, the result is ________________ (any abnormal
chromosome number) A _____________cell has one extra chromosome (2n
+1). A _____________cell has one extra chromosome (2n +1). A
___________ cell has one missing chromosome (2n - 1) A ___________
cell has one missing chromosome (2n - 1) Aneuploidy Trisomy
Monosomy
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- Elaborate Draw pedigrees from the given problems. Draw
pedigrees from the given problems.
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- The Royal Family Tree
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- Elaborate 2 Clues From the Karyotype Clues From the Karyotype
You will become a geneticists by identifying, organizing and
studying human chromosomes to determine if any chromosomal disorder
is present in your patient.
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- Evaluate Without any assistance, identify 4 of the 6 karyotypes
with the correct disorder, male or female, and normal or abnormal.
Without any assistance, identify 4 of the 6 karyotypes with the
correct disorder, male or female, and normal or abnormal.
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