Patients Treated with Leksell Gamma Knife ® 1968-2014

Patients Treated with Leksell Gamma Knife®

1968-2014

• Global Statistics Slide Number

Cumulative volume3

Indications treated annually 4 2014 regional volume

5 Average regional volume

6 Global case mix by year

7 Cumulative regional case mix 8 2014 case mix

9 Cumulative case mix

10 Cumulative indications treated 11 Indications treated 2014

12 Case mix by country

13 Indications fractionated 2014 43

• Indication-Specific Statistics

Vascular Disorders16

Functional Disorders21

Ocular Disorders 26 Benign Tumors

30 Malignant Tumors

• Region & Country Statistics

Asia (excluding Japan) Cumulative volume

46 Indications treated annually 47 Cumulative case mix

48 Cumulative indications treated 49 2014 volume

50 China cumulative volume

51 China case mix

52 South Korea cumulative volume 53 South Korea case mix

54 Taiwan cumulative volume

55 Taiwan case mix

TABLE OF CONTENTS North America Cumulative volume

62 United States cumulative volume 63 United States case mix

Japan Cumulative volume

Latin America Cumulative volume

Europe Cumulative volume

82 Turkey cumulative volume

83 Turkey case mix

84 United Kingdom cumulative volume

85 United Kingdom case mix

Middle East & Africa Cumulative volume

• Please note that making detailed year over year comparisons is not advised due to the annual variability in number of centers reporting. The percent of centers reporting has ranged from 68% to 100%. The rate for 2014 is 95%.

• Data for specific countries is only provided for those countries with 7 or more Gamma Knives.

• The Society has increasingly improved the specificity of indication-specific reporting to allow for a more refined representation of clinical practice. For example, Essential Tremor treatments were reported within 'Other Functional Disorders' prior to 2012, but separately for the past three years.

• Please reference the Leksell Gamma Knife® Society when using or distributing the data in this presentation and do not hesitate to contact the Secretariat for any questions regarding the data.

CAVEATS

Leksell Gamma Knife®

OVER 884,000 PATIENTS TREATED THROUGH 2014, WORLDWIDE

68-100% centers reporting1991 reflects cumulative numbers

INDICATIONS TREATED ANNUALLY THROUGH 2014, WORLDWIDE

TOTAL NUMBER OF TREATMENTS BY REGION 2014

95% centers reporting

17.6321.070

21.536

12.448

18.608

AVERAGE NUMBER OF PERFEXION TREATMENTS PER REGION AND CENTER 2014

AVERAGE NUMBER OF TREATMENTS PER CENTER WORLDWIDE:

US: 183Canada: 316

GLOBAL CASE MIX BY YEAR

36%34%

40% 42% 45%48% 46

46% 43

47% 43

31%38%

42% 41%42%

39%35%37%

34% 31% 33% 32% 33% 35% 35% 35% 35% 38% 39% 39% 39% 39% 40%51%

27%22% 19% 18% 16% 14% 13% 12% 11% 11% 10% 11% 11% 11% 10% 10% 10% 11% 10% 10% 10% 10%

3% 1% 2%1%

2% 3%1%

4% 6% 8% 9% 8% 9% 9% 9% 9% 8% 8% 8% 8% 7%

1%7% 7% 7% 7% 7%

CASE MIX FOR 1991 – 2014 BY REGION

CASE MIX FOR 2014 BY REGION

24% 17

12% 4%

TREATMENTS BY INDICATION 1991 – 2014, WORLDWIDE

325.009

386.895

64.995

103.991

INDICATIONS TREATED 1991 – 2014, WORLDWIDE

*Essential Tremor treatments reported as Other Functional Disorders prior to 2012

INDICATIONS TREATED 2014, WORLDWIDE

CASE MIX BY COUNTRY 2014

CHINA JAPAN SOUTH KOREA

TAIWAN UNITED KINGDOM

UNITED STATES TURKEY

VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

86.987

10.136

VASCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE

VASCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

268172

ARTERIOVENOUS MALFORMATIONS, CUMULATIVE PATIENTS TREATED WORLDWIDE

FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

56.617

787475

267105

FUNCTIONAL DISORDERS TREATED ANNUALLY, WORLDWIDE

FUNCTIONAL DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

1623834

TRIGEMINAL NEURALGIA, CUMULATIVE PATIENTS TREATED WORLDWIDE

OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE

OCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE

OCULAR DISORDERS, PATIENTS TREATED 2014 WORLDWIDE

BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE

125.760

85.32463.692

5.5275.194

3.9123.341

3.3112.869

BENIGN TUMORS TREATED ANNUALLY, WORLDWIDE

BENIGN TUMORS, PATIENTS TREATED 2014 WORLDWIDE

13.031

512422

396306

251237

164158

917045

MENINGIOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE

VESTIBULAR SCHWANNOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE

PITUITARY ADENOMAS, CUMULATIVE PATIENTS TREATED WORLDWIDE

MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE

386.895

250334

1.0792.032

13.055

35.141

MALIGNANT TUMORS TREATED ANNUALLY, WORLDWIDE

MALIGNANT TUMORS, PATIENTS TREATED 2014 WORLDWIDE

29.405

135184

METASTATIC TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE

GLIAL TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE

INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™

51 centers reporting

INDICATIONS FRACTIONATED 2014, USING THE LEKSELL FRAME OR WITH EXTEND™

51 centers reporting

Asia excluding Japan1990 - 2014

PATIENTS TREATEDWITH LEKSELL GAMMA KNIFE®

OVER 235,000 PATIENTS TREATED THROUGH 2014ASIA (excluding Japan)

INDICATIONS TREATED ANNUALLYASIA (excluding Japan)

CASE MIX 1991 - 2014ASIA (excluding Japan)

12.412

39.02364.698

120.246

INDICATIONS TREATED 1991 – 2014, ASIA (excluding Japan)

CASE MIX 2014ASIA (excluding Japan)

1.120 11.103

OVER 157,000 PATIENTS TREATED THROUGH 2014CHINA

CASE MIX 1991 - 2014CHINA

82.592

42.368

23.362

OVER 42,000 PATIENTS TREATED THROUGH 2014SOUTH KOREA

CASE MIX 1991 - 2014SOUTH KOREA

16.302

17.991

OVER 13,000 PATIENTS TREATED THROUGH 2014TAIWAN

68-100% centers reporting

CASE MIX 1993 - 2014TAIWAN

North America1987 - 2014

OVER 225,000 PATIENTS TREATED THROUGH 2014NORTH AMERICA

INDICATIONS TREATED ANNUALLYNORTH AMERICA

CASE MIX 1991 - 2014NORTH AMERICA

63.547

35.604

16.703109.738

INDICATIONS TREATED 1991 – 2014, NORTH AMERICA

CASE MIX 2014NORTH AMERICA

10.03515

OVER 215,000 PATIENTS TREATED THROUGH 2014UNITED STATES

CASE MIX 1991 - 2014UNITED STATES

59.999

34.002

106.26015.813

Japan1990 - 2014

OVER 210,000 PATIENTS TREATED THROUGH 2014JAPAN

INDICATIONS TREATED ANNUALLYJAPAN

CASE MIX 1991 - 2014JAPAN

15.366

41.423

150.456

INDICATIONS TREATED 1991 – 2014, JAPAN

CASE MIX 2014JAPAN

Latin America1985 - 2014

OVER 5,500 PATIENTS TREATED THROUGH 2014LATIN AMERICA

INDICATIONS TREATED ANNUALLYLATIN AMERICA

CASE MIX 1991 - 2014LATIN AMERICA

INDICATIONS TREATED 1991 – 2014, LATIN AMERICA

CASE MIX 2014LATIN AMERICA 261

Europe1968 - 2014

OVER 180,000 PATIENTS TREATED THROUGH 2014EUROPE

INDICATIONS TREATED ANNUALLYEUROPE

CASE MIX 1991 - 2014EUROPE

28.507

10.940

85.375

58.392

INDICATIONS TREATED 1991 – 2014, EUROPE

CASE MIX 2014EUROPE

OVER 22,000 PATIENTS TREATED THROUGH 2014TURKEY

CASE MIX 1997 - 2014TURKEY

12.419

OVER 22,000 PATIENTS TREATED THROUGH 2014UNITED KINGDOM

CASE MIX 1991 - 2014UNITED KINGDOM

Middle East & Africa1996 - 2014

OVER 17,000 PATIENTS TREATED THROUGH 2014MIDDLE EAST & AFRICA

INDICATIONS TREATED ANNUALLYMIDDLE EAST & AFRICA

CASE MIX 1996 - 2014MIDDLE EAST & AFRICA 2.648

2512.042

CUMULATIVE INDICATIONS 1996 – 2014, MIDDLE EAST & AFRICA

68-100% centers reporting*Essential Tremor treatments reported as Other Functional Disorders prior to 2012

CASE MIX 2014MIDDLE EAST & AFRICA 494

Patients Treated with Leksell Gamma Knife ® 1968-2014

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