Pathology of the gastrointestinal tract II (liver,...

Pathology of the

gastrointestinal tract II

(liver, pancreas).

X. practical training

3rd year Dentistry

Congestion of the liver

Congestion of the liver

Congestion of the liver (hepar moschatum)

1 Portobilial spaces

2 Ways of congestion (congestion with

necrosis of hepatocytes)

Pseudolobulus from residues of 3 lobuli, in

centre is portobilium

1

1

1

2

2

Congestion of the liver (hepar moschatum), detail

1

3

2

3

1 Portobilium- dilatated branch of v. portae

2 Pseudolobulus from residues of 3 lobuli, in centre is

portobilium

3 Ways of congestion (congestion with necrosis of

hepatocytes)

4 Biliary duct

5 Branch of a. hepatica

4

5

Liver steatosis

Viral hepatitis

HAV RNA hepatovirus

HBV DNA hepadnavirus

HDV RNA defektní virus

non A non B (NANB)

HCV RNA flavi a pestivirus-like

HEV RNA kalicivirus

HFV RNA togavirus

HGV RNA flavivirus

others: herpesvirus, cytomegalovirus, paramyxovirus, ...

Acute stage of

viral hepatitis

Viral hepatitis

subacute fatal

Chronic viral

hepatis

Liver – chronic viral hepatis

1

2

3 1 Portobiliar space with chronic inflammatory infiltrate

2 „piece-meal necroses“

3 Central part of lobulus with mixed steatosis

Liver – chronic viral hepatis

1

2

1 Chronic inflammatory

infiltrate in portobiliar space

2 Biliary duct

Cirrhosis of the liver

etiology morphology

alcohol 60-70% mikronodular

CAH 10% makronodular

kryptogenic 10-15% mixed

biliáry primary

secondary

pigment haemochromatosis primary

secondary

Congenital metabolic disorders (tyrosinemia,galaktosemia ...)

Cirrhosis of the liver

Cirrhosis of the liver

Cavernous haemangioma – liver

kopie

Primary liver

carcinoma

Hepatocellular carcinoma

Hepatocellular carcinoma

Hepatocellular carcinoma

Cholangiocarcinoma of the liver

Acute haemorrhagic necrosis of pancreas

Cystic fibrosis of the pancreas

Cystic fibrosis of the pancreas