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Vitamin C can be a main stream dermatologic drug if topically delivered to the Dermis
Outstanding Benefits of Vitabrid C12
Vitamin C
Whitening, Photo-Damage
Recovery by decreasingmelanin
formation
Hair-GrowthPromotion
by inducing growth factors: IGF-1, etc.
Anti-Oxidant Efficacy
scavenging free radicals
Anti-Wrinkle,Healthier Skin
by collagen synthesis promotion
Anti-Hair Lossby collagen synthesis promotion
Anti-Inflammatory, Anti-Histamine, Wound Healing
Pumori Saokar Telang, Vitamin C in dermatology,
Indian Dermatology Online Journal, 2013 Apr-Jun; 4(2): 143-146
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/)
Vitabrid C12 – Brand New Vitamin C
LDH Technology – Problem Solved!
Easily oxidized once exposed to air, sun or moisture and loses its “antioxi-dant” properties. Due to its water-soluble nature, hard to penetrate through lipid membrane
Quickly oxidized once topically appliedVery limited and ineffective permeabilityIrritation and pain due to acidity of vitamin C
Vitabrid CG, the main ingredient of Vitabrid C12 products, stores and preserves active Vitamin C within skin-friendly mineral layers; once it is applied to the skin, it releases active vitamin C continuously for over 12 hours permeating through the skin layers down to dermis.
Vitamin C
Excellent skin efficacy,but highly unstable
compounds
Mineral
Bio-compatible andskin-friendly mineral
Vitabrid CG
Stabilization, effective skin delivery,
sustained release, excellent efficacy
Time (Hour)
LDH-Vitamin C powder
100
80
60
40
20
02 4 6 8 10 12
Accu
mul
ated
relea
se am
ount
rate
of vi
tamin
C (%
)
Accumulated Amount of Vitamin C Released
Unstable Vitamin C
LDH Technology
Weakness of existing topical Vitamin C products
Limitations of Vitamin C
Basic Technology of Vitabrid C12
12-hour Transdermal Vitamin C
Vitamin C Absorption Via Ion-Exchange Mechanism
Vitabrid CG POWDER
Vitabrid CG POWDER
STRATUMCORNEUM
VITAMIN C
EPIDERMIS
DERMIS
SKIN WASTES VITAMIN C SWEAT CO2
Joint Research Institute of New Materials, Seoul National University
1hr 2hr 4hr 24hr Magnified image
LDH Technology
0 week 1%
1 week 4%
4 weeks 9%
6 weeks 10%
8 weeks 12%
Participants: 22 females with age between 18-52Evaluation Method: Measuring melanin index and its color after UV-induced pigmentationTesting Agency: DermaPro Corp / Skin Science Institute
Vitabrid CG inhibited 80% of UV-induced melanin formation in HMV-II cell at 43% or 10% lower concentration than APPS
or vitamin C, respectively.Nobuhiko MIWA, Emeritus Prof. Pref. Univ. Hiroshima
Conc. (mg/L)
Inhi
bitio
n(%
)
9876543210
65
67
69
71
73
75
77
79
81
83
85Vitabrid CG
APPS
12% reduction in melanin within 8 weeks of use in comparison to the controlled group.
DermaPro Corp / Skin Science Institute
Vitabrid C12 FACE SolutionBrand new introduction of the revolutionized Vitamin C
Vitabrid C12 Skin Brightening EffectMelanin Inhibition by Vitabrid CG
0 week 0.55
4 weeks 0.47
12 weeks 0.42
8 weeks 0.45
Participants : 22 females with age over 30Evaluation Method : Measuring wrinkle improvement by using skin visiometerTesting Agency : DermaPro Corp / Skin Science Institute
Vitabrid CG had an antioxidant capacity that was 200 times higher compared to AA2G (Vitamin C Derivative) and over 13 times more than
VC-100 (Vitamin C Derivative) in RAW 264.7 cell.Hoseo Toxicoligical Research Center
24% reduction in skin roughness within 12 weeks of use.
DermaPro Corp / Skin Science Institute
61.6
0.3
4.8
Antioxidant capacity
Vitabrid CG
VC-100
AA2G
Inhibition (%)
Vitabrid C12 FACE Solution
Vitabrid C12 Anti-wrinkle EffectAntioxidant Effect of Vitabrid CG
Vitabrid C12 FACE Solution
Direct Correlation between Increase in Collagen Levels vs. Increase in Vitabrid CG Concentration in Human Dermal Fibroblasts
Korea Institute of Permatological Seciences
It was confirmed that CO-
L1A1 mRNA expression was
increased after treatment of
human dermal fibroblasts with
Vitabrid CG. Especially, at 100
ppm treatment, about 2 times
increase compared with Con-
trol. (*P < 0.05)
The expression of COL3A1
mRNA was increased after
treatment with Vitabrid CG in
human dermal fibroblasts. Es-
pecially, at 100 ppm treatment,
about 3 times increase com-
pared with Control. (*P < 0.05)
**
400
350
300
250
200
150
100
50
00 10 50 100
Relat
ive ex
pres
sion
level
ofCO
L1A1
mRN
A
Vitabrid CG (ppm)
Relat
ive ex
pres
sion
level
ofCO
L3A1
mRN
A
Vitabrid CG (ppm)
350
300
250
200
150
100
50
00 10 50 100
*
***
400
350
300
250
200
150
100
50
00 10 50 100
Relat
ive ex
pres
sion
level
ofCO
L1A1
mRN
A
Vitabrid CG (ppm)
Relat
ive ex
pres
sion
level
ofCO
L3A1
mRN
A
Vitabrid CG (ppm)
350
300
250
200
150
100
50
00 10 50 100
*
*
Vitabrid C¹² FACE
Transdermal vitamin C powder for anti-aging and skin rejuvenation. Highly potent Vitamin C compound helps brighten the skin and minimize fine lines and wrinkles through collagen synthesis, making your skin bright, nour-ished and glowing with natural radiance.
1. Key Benefits- Skin brightening- Improves skin tone / texture- Skin rejuvenation - Reduce fine lines / wrinkles
2. Main Features- Strong anti-oxidation benefit - Vitamin C makes skin healthy and radiant by neutralizing the damaging effects of free radical activity from sun, stress, and pollution helping prevent and repair visible signs of aging.- Skin rejuvenation and anti-aging - Vitamin C is one of the most essential substances to promote collagen production, helping maintain vibrant and firm skin texture.- Skin brightening - Vitamin C, a powerful brightening ingredient with antioxidant benefits that reduces the look of melanin for a perfectly bright and even complexion.
3. How to Use1. Shake before using to loosen the powder.2. Mix an appropriate amount of the powder (equivalent of 2 spoonfuls) with daily skin care product of choice (serum or moisturizer) in the palm of the hand.3. Smooth the mixture onto clean face and neck. For best results, apply twice a day (morning and evening).
4. Ingredients- Vitabrid CG - ascorbic acid, zinc oxide, glyceryl monostearate- niacindamide - Help to brighten the appearance of discoloration- allantoin - Helps soothe, hydrate and calm the skin. - adenosine - helps prevent skin damage from UV-B and promotes collagen synthesis, improving visible signs of aging- hydrolyzed collagen - Helps improve skin tone, thickness and moisturization
* Trusted quality vitamin C from the U.K. Quality raw materials are essential for quality skin care. Vitabrid C12 values skin by using Vitamin C imported from the U.K. supplier.
Vitabrid C12
FACE BRIGHTENING PowderState-of-the art 12-hour transdermal Vitamin C powder for your face!
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