Osteogenesis imperfecta (compression fractures). OI-blue sclera

Osteogenesis imperfecta (compression fractures)

OI-blue sclera

Osteopetrosis(Albers-Schonberg)-osteoclast defect, Inc. bone mass but still brittle

Osteochondromatosis

Risk for malignancy?

Chondrosarcoma

Osteochondromatosis

Osteochondromatosis

Osteochondromatosis

Osteochondromatosis w/ cartilage cap

TB in the spine (eponym)? Pott’s Dz

TB-granulomas, giant cells

Calcium stain-Normal Bone

Ca stain-Osteoporosis (Loss of Bone density)

Thick skull? Paget’sHearing loss, Inc. serum Alk Phos, Inc. urine hydroxyproline

Sxs?

At Risk?

osteosarcoma,

CHF

Fibrous dysplasia of the rib

Polyostotic FD + Café au Lait & Early Puberty?McCune-Albright

Fibrous Dysplasia-too much stroma

Osteoid osteoma

Osteoid osteoma

Osteoblastoma

Osteosarcoma-Codman’s Triangle #1 primary mal bone

Osteosarcoma-kids with Rb at risk, Chr 13 del

Adults with previous radiation or Paget’s

Osteosarcoma

Telangiotic type

Osteosarcoma-Telangiotic type

Osteosarcoma-appendicular bones

Chondroma

Oiler’s-multi (one side

Of the body)

Mafucci’s-multi & hemangioma

Chondroma

Chondrosarcoma-axial bones

Chondrosarcoma-#2 primary mal bone

Chondrosarcoma

Chondrosarcoma-single mitosis is Dx

Ewing’s sarcoma-t(11,22)

(PAS+ ) Ewing’s

Liposarcoma-cell type?

Flouret cell (multinucleated lipoblast)

Liposarcoma type? Well-diff/low grade

Liposarcoma type? Myxoid most common t12,16

Liposarcoma-myxoid signet ring cells

Liposarcoma-Pleomorphic w/ Giant lipoblast

Liposarcoma-Round cell

Liposarcoma-ugly looking isn’t it?

Mal Fibrous Histiocytoma-#1 soft tissue mal

Mal Fibrous Histiocytoma-giant cells

Mal Fibrous Histiocytoma

Mal Fibrous Histiocytoma

Synovial Sarcoma-biphasic epitheloid and spindle cell

Synovial Sarcoma-biphasic epitheloid and spindle cell

Synovial Sarcoma-not synovial tissue

Synovial Sarcoma