OSCE Answer 02/2015 TMH AED 1. Question 1 M/69 Known history of HT, IHD, PVD Sudden onset of...

OSCE Answer 02/2015

TMH AED

1

Question 1

• M/69• Known history of HT, IHD, PVD• Sudden onset of constant low back pain• BP 162/85mmHg• P 78/min

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Question 1

• Suggest 5 differential diagnosis of acute low back pain– Mechanical spinal disease– Non-mechanical spinal disease– Visceral disease

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Mechanical Spinal Disease

• Lumbar strain• Degenerative spine• Spondylolisthesis• Spinal stenosis• Prolapsed intervertebral disc• Osteoporosis• Fracture or facet joint dislocation

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Non-Mechanical Spinal Disease

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Visceral Disease

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Red Flag Symptoms

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Question 1

• Bedside abdominal USG was performed

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Question 1

• What’s the sonographic diagnosis?– 7cm in diameter abdominal aortic aneurysm with

concentric hyperechoic lesion signifying thrombus

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Question 1

• How to measure the size of the lesion?– Outer to Outer wall– Longitudinal view– Perpendicular to the

long axis of aorta

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Question 1

• How to classify the type of the lesion using ultrasound?– Identify the origin of the SMA, 2cm below should be

the origin of renal arteries– Classify according to the location of the aortic

aneurysm• Suprarenal• Juxtarenal• Infrarenal

(Ultrasound Clin 2 (2007) 437–453)

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Question 1

• State the microbe that is most commonly associated with this condition?– A study in southern Taiwan from 1996 to 2006 on

mycotic aneurysm• Salmonella (34.6%)• Klebsiella (11.5%)• Staphylococcus aureus (11.5%)

(J Microbiol Immunol Infect 2008;41(4): 318-324)

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Question 2

• F/40• Good past health• Sudden onset of right sided weakness 1 hour

before• BP 180/93 mmHg• P 104/min• GCS 15/15

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Question 2

• Urgent CT brain was performed

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Question 2

• Described the CT finding– Loss of insular ribbon

sign– A loss of definition of the

gray-white interface in the lateral margin of the insular cortex

(Radiology. 1990;176(3):801)

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Question 2

• Suggest 3 more hyperacute stroke CT signs

– Hypodensity of basal ganglia

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Question 2

• Dense MCA sign

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Question 2

• Cortical Sulcal Effacement

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Question 2

• Outline subsequent management plan for this patient– Stabilization, history taking and physical examination– Baseline investigations like blood tests, ECG, CXR– Consult neurologist for assessment– Stroke management– Reperfusion therapy and anti-platelet agent

Emerg Med Clin North Am. 2012 Aug;30(3):713-44

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Stroke Management

• Fluid– Hypovolemia reduce cerebral perfusion– Hypervolemia cerebral edema– Look for SIADH with hyponatremia

• Glucose– Hypoglycemia stroke mimics– Hyperglycemiapoor functional outcome– (Stroke. 2001;32(10):2426)

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Stroke Management

• Head position– Lying flat would increase mean flow velocity of

cerebral artery by 20% in one study(Neurology. 2005;64(8):1354)

– Prop up 30° in patients with• Raised intracranial pressure• Risk of aspirations• Cardiopulmonary disease or oxygen desaturation

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Stroke Management

• Blood pressure control– Blood pressure control within 7 – 10 days post

stroke leads to increase 30 days mortality (The Lancet. 22/10/2014 open access)

(http://dx.doi.org/10.1016/S0140-6736(14)61121-1) – Goals of blood pressure control• Thrombolytic therapy: SBP < 185mmHg, DBP <

110mmHg• No thrombolytic therapy: SBP <220mmHg, DBP <

120mmHg22

Reperfusion Therapy

• Intravenous alteplase (tPA) within 4.5 hours from onset

• Intra-arterial alteplase (tPA) within 6 hours from onset

• Mechanical thrombolysis

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Antiplatelet treatment

• Aspirin 160 to 320mg daily within 48 hours would decrease recurrent of stroke within 14 days and death within 28 days (International Stroke Trial (IST) and Chinese Acute Stroke Trial (CAST))

• ?Dual antiplatelet treatment with aspirin and clopidogrel (300mg loading, then 75mg daily) for high risk patient (ABCD2 score ≥ 4) (CHANCE trial)

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Question 2

• State 3 etiologies for young onset stroke– Cardiac• Congenital heart disease• Endocarditis, cardiomyopathy, prosthetic valve

replacement

– Haematologic• sickle cell disease• Prothrombolic conditions like antiphospholipid

syndrome, protein C deficiency, protein S deficiency etc

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Question 2

• State 3 etiologies for young onset stroke– Vasculopathy• Moyamoya disease (primary or secondary)• Dissection• Vasculitis

– Substance abuse

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Question 2

• Cerebral angiogram was performed after stabilization

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Question 2

• Describe the finding– Puff of smoke appearance– Due to collateral vasculature

• What is the diagnosis?– Moyamoya disease

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Moyamoya Disease

• Bilateral stenosis or occlusion of vessels around circle of Willis with prominent collateral circulation

• Moyamoya is Japanese, meaning hazy like a puff of smoke in the air

• Can lead to both ischemic and haemorrhagic stroke

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Question 3

• F/56• Good past health• Vehicle-pedestrian collision with left knee

injury• BP 153/79mmHg• P 95/min

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Question 3

• Left knee X-ray was taken

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Question 3

• Describe the X-ray finding– Fracture over lateral tibial plateau of the left knee– No depression

• What is the classification of the above condition?– Schatzker classification

• Which type this patient belonged to?– Type I

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Schatzker Classification

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Question 3

• What is the mechanism of the injury?– Valgus force with axial loading

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Question 3

• Name 4 potential complications– Early complications• Compartment syndrome• Vascular injury (popliteal artery)• Nerve injury (peroneal nerve)• Infection• Deep vein thrombosis

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Question 3

• Name 4 potential complications– Late complications• Knee stiffness• Knee instability• Osteoarthritis• Malunion, nonunion• Angular deformity• Late collapse

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Question 4

• M/72• History of DM, HT, SSS on pacemaker• Sudden onset of severe chest pain for 3 hours,

only partially relieved by TNG• BP 164/88 mmHg• P 62/min

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Question 4

• ECG was performed

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Question 4

• Describe the ECG findings– Widen QRS complex with heart rate 60/min

(pacemaker beat)– ST elevation in I, aVL, V4-V6– Reciprocal ST depression in III, aVF

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Question 4

• State an ECG criteria for assistance of diagnosis– Sgarbossa criteria

• What is the diagnosis?– Acute anteriolateral ST elevation myocardial

infarction

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Sgarbossa Criteria

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Modified Sgarbossa Criteria

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Sgarbossa Criteria

• ST elevation ≥1 mm in a lead with a positive QRS complex (ie: concordance) - 5 points

• ST depression ≥1 mm in lead V1, V2, or V3 - 3 points

• ST elevation ≥5 mm in a lead with a negative (discordant) QRS complex - 2 points

• ≥3 points, sensitivity 36%, specificity 90%(NEJM 334(8):481-487)

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Modified Sgarbossa Criteria• at least one lead with concordant STE (Sgarbossa

criterion 1) or• at least one lead of V1-V3 with concordant ST

depression (Sgarbossa criterion 2) or• proportionally excessively discordant ST elevation

in V1-V4, as defined by an ST/S ratio of equal to or more than 0.20 and at least 2 mm of STE. (this replaces Sgarbossa criterion 3 which uses an absolute of 5mm)

• Sensitivity 91%, Specificity 90%(Annals of Emergency Medicine 60 (6): 766–776.)

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Question 4

• Outline the management in AED– Recognize emergency condition and manage in

resuscitation room with resuscitation equipments standby

– Monitoring devices– Set up large bore IV access, blood tests, CXR– Consult cardiologist for assessment– MONA– Reperfusion therapy– Antithrombotic therapy and antiplatelet therapy

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Primary PCI• Door to balloon time– 90 minutes in PCI capable hospital– 120 minutes in non-PCI capable hospital

• Patients presented more than 12 hours, with cardiogenic shock, electrical instability or persistent ischemic symptoms

(2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction)

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Thrombolytic therapy

• Symptoms within 12 hours with primary PCI not available within 120 minutes

• Door to needle time less than 30 minutes

• Facilitated PCI is not recommended• Rescue PCI if failed fibrinolysis

(2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction)

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Thrombolytic therapy• First generation fibrinolytic agents (eg

streptokinase) indiscriminately induce activation of circulating plasminogen and clot-associated plasminogen

• Second generation fibrinolytic agents (eg t-PA) preferentially activate plasminogen in the fibrin domain

• Second generation fibrinolytic agents improve 24 hours, 30 days and 1 year mortality rate in GUSTO trial

(Circulation. Oct 10 2000;102(15):1761-5.)

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Antithrombotic therapy

• Enoxaparin 0.5mg/kg significant reduced clinical ischemic outcome compared with unfractionated heparin in STEMI patient undergoing primary PCI

(ATOLL trial. Lancet. Aug 20 2011;378(9792):693-703.)

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Antiplatelet agents

• Aspirin should be given immediately• Adding clopidogrel 300mg (CLARITY-TIMI 28)

is safe and effective• Increase clopidogrel to 600mg in patient with

STEMI prior to primary PCI was associated with a smaller infarct size (ARMYDA-6 MI)(J Am Coll Cardiol. Oct 4 2011;58(15):1592-9.)

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Question 5

• M/62• Repeated vomiting for 1 day, with mild

epigastric pain after an alcohol binge• First vomited out undigested

food and then mild blood streak

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Question 5

• BP 123/59 mmHg• P 84/min• Abdominal examination was unremarkable.

Per rectal examination noted brownish stool.• CXR was normal

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Question 5

• Name 3 clinical prediction rules/scores in upper gastrointestinal bleeding to risk stratification– Glasgow-Blatchford bleeding score– Rockall score– AIMS65

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Question 5

• He asked if his condition could be managed without hospital admission

• State which score is the most relevant in this scenario? What cut-off and associated clinical implication for the score? – Glasgow Blatchford bleeding score– Score 6 or more has more than 50% risk of

needing an intervention

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Glasgow Blatchford Bleeding Score

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Lancet. 2000;356(9238):1318.

Rockall Score

56Lancet. 1996;347(9009):1138.

AIMS65

(Gastrointest Endosc. 2011;74(6):1215.)57

Question 5

• More history was taken and he had known alcoholic with alcoholic liver cirrhosis

• Blood tests result:– Hb 13.4 g/dL– Urea 7.8 mmol/L

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Question 5

• How would you management this patient?– GBS 4– Admit to EMW for observation• NPO• IV fluid• Type and screen, clotting profile

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Question 5

• He developed gross haematemesis during his stay in AED

• BP 96/49 mmHg• P 106/min

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Question 5

• How would you manage this patient in addition to the management you ordered before?– Manage in resuscitation room– Nasogastric tube insertion, suction with airway

protection– IV fluid resuscitation and hemodynamic resuscitation– Consult surgeon for urgent OGD– IV somatostatin analog, vasopressin– Balloon tamponade

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Question 6

• M/69• History of HT, DM, old CVA• Decrease general condition for 1 month

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Question 6

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Question 6

• Describe the CT finding– Hydrocephalus

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Ventriculomegaly vs hydrocephalus

• Enlargement of the recesses of the third ventricle

• Dilation of the temporal horns of the lateral ventricle

• Interstitial edema of the periventricular tissues (seen on MRI)

• Effacement of the cortical sulci

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Ventriculomegaly vs hydrocephalus

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Question 6

• What further investigations would you proceed?– MRI– Lumbar puncture

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Question 6

• If the opening pressure of the lumbar puncture is 12 cm H2O

• What is the condition called?– Normal Pressure Hydrocephalus

• What is the classic triad of this condition?– Gait instability (magnetic gait)– Cognitive impairment– Urinary incontinence

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Question 6

• What is the definitive treatment?– VP shunt

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