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Organic

S y n t h

臼 i s

The Disconnection pproach

日 d Edition

S t u a r t a r r e

Department

Paul Wyatt

choolof of Bristol 瓦

J o h n ì l e y and Sons Ltd Publication

This edition first published 2008

J o h n

飞的 Sons Inc.

Registered

J o h n

i l e y

τ h e

Atrium

Southem Gate.

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，有部

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Kingdom

For details of

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for customer services and for infonnation about how to apply for

permission to 陀 the c o p y r i material in this book please see our website at www.wiley.com.

τ h e right

the author to be identified as the author of this work has been asserted in accordance with the

Copyright D e s i 盯 and Patents Act 1988.

Al\ rights reserved. N0 缸 of this p u b l i c a t i o n 部 be reproduced stored in a retrieval system or transmitted in

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Designs and Patents Act 1 9 8 8

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equipment reagent or device for a r n o 只 other things

any changes in the instructions or índication

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L i b r a 0

Congress

t a l o g i n g - i n - P l b l i c a t i o n

W a r r e n

S t u a r t

Organic synthesís : the disconnection approach I Stuart Warren and Paul

W y a t

t . 一一 ed.

p. cm.

Includes biblíographical references and index.

ISBN 978-0-470-71237-5

c l o t h )

I S B N 9 7 8 0

7 0 7 1 2 3 6 8 (pbk. :

alk. paper)

1 O ~ m i c 百 y a t t PauL 在 t l e .

QD262.W2842008

547 .2-dc22

A catalogue record for this book is available from the British

9 7 8 - 0 - 4 7 0 - 7 1 2 3 7 5

9 7 8 0 4 7 0

1 2 3 6 8

τ y p e s e t in 10 12 Times-Roman by Laserwords Private Limited Chennai India

2008033269

Printed and bound in Great Britain by CPI Antony Rowe Chippenham Wiltshire

arrian

M a r r i a

吕立

Preface

General References

2 Basic and

Strategy

The Order

Events

4. One-Group C X Dìsconnections

5 Strate v II:

Synthesis of Aromatic

7730J553

li2334586

C X DisconnectÎons

III: Reversal of Polarity

8 A r n ì n

生 S t r a t e g y IV: Protecting

10 One Group C

C Disconnections

Alcohols

11 General 栩如 A: a Disconnection

12 S t r a t e V:

Alkynes)

Alkene

Strategy

V I I : of

1 7 . τ w o G r o u p C

C Disconnections : D i e l s A l d 时 R e a c t i o n s

Strate

v VIII: Introduction to

i s c o n n e c t i o n s II:

IX: Control in Condensations

Compounds

Disconnections III: Compounds

Conjugate Michael Addîtion and Robinson Annelation

i t r o

φ r o u p Disconnections IV: Compounds

Disconnections V:

Strategy XII: Reconnection

Two-Group C

C D i s c o n n

c t i o n s

General

Strategy of o n y l Disconnections

29. XIII: Introduction to Synthesis: Saturated

T h r e e

l e r n b e r e d

33. X V τ h e Use of Ketenes n

34. F i v e M e m e r e d

35. Strate v XV I

36. Six Membered Rings

37. General Strategy C:

38. XVII:

39. AromatÍC

40. General

D A v a n c e d

ontents

Special Methods

Synthesis

Preface

In the 26 years s i n c e 有 i l e y publìshed Organic Disconnection p p r o a c h Stuart

W a r r e n

，由自 a p p r o a c h

to the learning

synthesis has become while the book Ìtself

is now dated in content and a p p e a r a n c e 唱 T i l e y published Organic

and ontrol by Paul Wyatt and S t u a r t 轧 T a r r e n Thís m u 柱 ís as a

fourth year 巳 r g r a d u 时 and research workers in universities and industry. The

workbook was published ìn 2 0 0 8 τ new book made

t h ε o l d

one look very dated ín

and content and gaps between what students were

e x p e c t ε d to

understand in the 1980s

and what are

understand now. This second edition

intended

fill some

those gaps.

The of the book is the same in the second edítion.

alternates chapters

new concepts wÌth strategy chapters that put new work in the context

overall planning.

丁 40 chapters have the same titles: some have hardly been changed whíle others

have a revision with considerable amounts of new

e r i a

In most cases

from recent years are included.

One source of new material

the courses the authors in the pharmaceutical

a s i c course is The Disconnection Approach and 削 a t e r i a l we have for this

course has reinforced our attempts to reasons for the

the various compounds

which w

l i e v e

enlivens

and makes it more for students.

a second edítíon of the workbook after the publication of the

edition of t e x t b o o k was in fact t h ε t h i r d in a series on

firs t The an lntroduction t

如 1 9 7 4 is

a book asking for a of interaction with the reader who

was to solve 剖 while rarely use now as the

method 岳阳 s u p l e r s e d t ~ d interactive programmes on computers. Paul Wyatt is w r i t í n

electronic book to replace The

r b o n y l

Group which will a

an electronic

o o k s

with associated workbooks in a uniform format that we hope will prove of

value as students of organic develop their careers.

Stuart a r r e n and aul 研

March 2008.

organicsynthesisthedisconnectionapproachbystuartwarren-100609101301-phpapp02.pdf

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