Off-the-s helfBioengineered HAV · Microsoft PowerPoint - 27 - Sat AM1 - Mishler - Bioengineered...

O ff-the-s helfBioengineered HAV:N ew Kid on the Block

• Segm ent ofcondu it w hich can b e eas ily,rep eatedlycannu lated that is at leas t:

• 6 cm length s traight s egm ent• 6 m m in diam eter• 6 0 0 m l/m in QB• 6 m m or les s b elow s kin s u rface

• AVG (ePTFE)• Throm b os is

• Infection ofthe condu it

• Intim alhy p erp las ia at the v enou s anas tom os is

• AVG (allogenic and x enogeneic)• Hav e b een s tu died for dialy s is acces s

• N one hav e s how n b etter long-term v iab ility or gained w ide accep tance

A

B

Dacronsleeve

Silicone tubeSmooth muscle cell

Engineered vessel

PGA

Polymer scaffold is designed to guide tissue shape ...

... and designed to degrade

* H u b er.JVas cSu rg 2 0 0 3,Katz m an.JAm ColSu rg 2 0 0 5,Lok.Clin JAm Soc N ep h 2 0 0 5

O ff-the-s helfBioengineered HAV:N ew Kid on the Block

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