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*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.
Novocastra HD - DermatopathologyHighly Definitive Antibodies
BOND 7 mL PA0007
Liquid 1 mL NCL-L-CD117-032
Human Gastrointestinal Stromal TumorIntense membrane staining of tumor cells.
CD117 (c-kit Oncoprotein)
Clone EP10
T-Cell Lymphoma, Mycosis FungoidesA skin biopsy, extensively infiltrated by abnormal T lymphocytes which are strongly CD3 positive.
CD3 Clone LN10
BOND 7 mL PA0553
BOND 30 mL PA0122
Liquid 1 mL NCL-L-CD3-565
Human LymphomaMembrane staining of endothelial cells.
CD31 Clone JC70A
BOND 7 mL PA0414
Liquid 1 mL NCL-L-CD31-607
Dermatofibrosarcoma ProtuberansVascular endothelium and dermal spindle cells, within ramified fat, staining with CD34. Lymphoid cells are negative.
CD34 Clone QBEnd/10
BOND 7 mL PA0212
BOND 30 mL PA0354
Liquid 1 mL NCL-L-END
Human Skin, XanthogranulomaSheets of histiocytes showing variable staining. Larger xanthomatous cells are strongly positive.
CD68 Clone 514H12
BOND 7 mL PA0273
Liquid 1 mL NCL-L-CD68
Human Nipple, Paget’s DiseaseMalignant cells show strong cytoplasmic staining. There is no staining in the squamous epithelial cells.
Cytokeratin 7 Clone RN7
BOND 7 mL PA0942
BOND 30 mL PA0138
Liquid 1 mL NCL-L-CK7-560
Trust the HD Difference – Highly Definitive Antibodies for Diagnostic Confidence• Independently benchmarked against leading equivalents by external QA*
• Establishing a new quality standard in IHC; simplifying antibody selection
Novocastra HD - Dermatopathology
Human Skin, Merkel Cell CarcinomaMalignant Merkel cells show moderate to strong cytoplasmic staining.
Cytokeratin 20 Clone Ks20.8
BOND 7 mL PA0022
BOND 30 mL PA0037
Liquid 0.5 mL NCL-L-CK20
Liquid 1 mL NCL-L-CK20
Human Skin, Kaposi’s SarcomaNeoplastic cells show moderate cytoplasmic staining, while normal endothelial cells show strong staining.
Factor VIII related antigen (von Willebrand Factor)
Clone 36B11
BOND 7 mL PA0055 NEW
Liquid 1 mL NCL-L-vWF
Immunoglobulin A Clone N1CLA
Liquid 1 mL NCL-L-IgA
Human AppendixIntense staining of plasma cells and secreted immunoglobulin A.
Human TonsilMembrane staining of peripheral follicular B cells.
Immunoglobulin D Clone DRN1C
Liquid 1 mL NCL-L-IgD
Immunoglobulin G Clone RWP49 Immunoglobulin M Clone
8HC
BOND 7 mL PA0905 NEW
Liquid 1 mL NCL-L-IgG
BOND 7 mL PA0278 NEW
Liquid 1 mL NCL-L-IgM NEW
Human TonsilCytoplasmic staining of the plasma myeloma cells.
Normal Human LarynxIntense membrane staining of lymphocytes.
Human TonsilIntense cytoplasmic and membrane staining of plasma cells.
Kappa Light Chain Clone CH15
Liquid 1 mL NCL-L-KAP-581
Human Skin, MelanomaDispersed cycling neoplastic cells show a distinct nuclear staining reaction.
Ki67 Clone MM1
BOND 7 mL PA0118
BOND 30 mL PA0410
Liquid 1 mL NCL-L-Ki67-MM1
Human TonsilIntense cytoplasmic and membrane staining of plasma cells.
Human Melanoma A melanoma showing cytoplasmic staining of tumor cells.
Lambda Light Chain Clone SHL53
Melan A Clone A103
BOND 7 mL PA0233
BOND 30 mL PA0044
Liquid 1 mL NCL-L-MelanA
Liquid 1 mL NCL-L-LAM-578
Human Skin, MelanomaA melanoma showing strong cytoplasmic staining.
Melanoma Marker (HMB45)
Clone HMB45
BOND 7 mL PA0027
BOND 30 mL PA0625
Liquid 1 mL NCL-L-HMB45
Human Face, MelanomaNuclear and cytoplasmic staining of malignant melanocytes as well as some neural elements.
BOND 7 mL PA0900 NEW
Liquid 1 mL NCL-L-S100p
S100 Clone Polyclonal
LeicaBiosystems.com
Novocastra HDHighly Definitive Antibodies
Benefits of BOND Ready-to-Use antibodies
✓ Optimized for staining performance on BOND
✓ Validated antibody concentrations
✓ Ease of use: just plug and play
✓ Increase standardization through automation
✓ Eliminate variability in antibody preparation
Benefits of concentrated liquid antibodies
✓ Flexibility of use on various platforms1
✓ Adaptable to a variety of detection systems1
✓ Adjustable concentration to suit user’s tissue1
✓ Economical option that retains confidence in clone selection
1. The performance of antibodies should be validated when used with automated platforms or manual staining systems other than stated on Instructions for Use.
Improve workflow efficiency and streamline validation.
95.11738 Rev F · 03/2016 · Copyright©2016 Leica Biosystems Newcastle Ltd. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. Novocastra and BOND are trademarks of Leica Biosystems and its affiliates. Other logos, product and/or company names might be trademarks of their respective owners. The EP clones have been created by Epitomics Inc., using Epitomics’ proprietary rabbit monoclonal antibody technology covered under Patent No.’s 5, 675, 063 and 7, 402, 409.
Independently Evaluated* Specifically SelectedEach antibody in the range has been independently evaluated* by external QA, NordiQC, in comparison with equivalent products from other vendors. The range represents the highest performing antibodies that Leica Biosystems offers for the most commonly performed IHC tests.
*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.
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