Natalia Trayanova, PhD...Natalia Trayanova, PhD Curriculum Vitae Professional Experience...

NataliaTrayanova,PhDCurriculumVitae

ProfessionalExperience9/12-present DepartmentofMedicine, JohnsHopkinsSchoolofMedicine,Baltimore,MD Professor,JointAppointment.4/12-present DepartmentofBiomedicalEngineering JohnsHopkinsUniversity,Baltimore,MD. Professor,MurrayB.SachsEndowedChair8/06-present DepartmentofBiomedicalEngineeringandInstituteforComputational Science,JohnsHopkinsUniversity,Baltimore,MD. Professor.5/02-7/06 DepartmentofBiomedicalEngineering,TulaneUniversity,NewOrleans. Professor.1/02-5/02 LaboratoryofPhysiology,UniversityofOxford,Oxford,UnitedKingdom. DistinguishedFulbrightVisitingProfessor.1/95-5/02 DepartmentofBiomedicalEngineering,TulaneUniversity,NewOrleans. AssociateProfessor.ElectedtoGraduateFaculty,4/97.1/90-12/94 DepartmentofBiomedicalEngineering,DukeUniversity,Durham,NC AssistantResearchProfessor.6/88-12/89 BulgarianAcademyofSciences,Sofia,Bulgaria AssistantProfessor.12/86-5/88 DepartmentofBiomedicalEngineering,DukeUniversity,Durham,NC VisitingResearchFellow.1/86-12/86 BulgarianAcademyofSciences,Sofia,Bulgaria AssistantProfessor

Education

• 1982–6Ph.D.inBiophysicsfromtheCentralLaboratoryofBiophysics(SectionBioengineering),BulgarianAcademyofSciences,Sofia,Bulgaria

• 1980–2M.S.inPhysicsfromtheDepartmentofPhysics,SofiaUniversity,Bulgaria

HonorsandAwards2017 CapitolHillBriefing,UnitedforMedicalResearch,November2017 FellowoftheInternationalAcademyofMedicalandBiologicalEngineering2017 TEDxTalk2015 DiscoveryInnovationAward,JohnsHopkinsSchoolofMedicine2013 NIHDirector’sPioneerAward2012 MurrayBSachsEndowedChair,JohnsHopkinsUniversity2010 FellowoftheBiomedicalEngineeringSociety2010 FellowoftheAmericanHeartAssociation2009 WilliamR.BrodyFacultyScholar(NamedChair),JohnsHopkinsUniversity2009 Chair,GordonResearchConferenceonCardiacArrhythmiaMechanisms2008 FellowoftheHeartRhythmSociety2007 ViceChair,GordonResearchConferenceonCardiacArrhythmiaMechanisms2005 AwardforExcellenceinResearchandScholarship,TulaneUniversity2004 AstorVisitingLectureship,OxfordUniversity,UK2003 Fellow,AmericanInstituteforMedicalandBiologicalEngineering2002 OutstandingResearcherAward,TulaneSchoolofEngineering2002-2006 EstablishedInvestigatorAward,AmericanHeartAssociation2001-2002 FulbrightDistinguishedScholarsResearchAward2000 LeeH.JohnsonAwardforTeachingExcellence,TulaneUniversity2000 AETMBTeachingAward,DepartmentofBiomedicalEngineering,TulaneUniversity1999 AETMBTeachingAward,DepartmentofBiomedicalEngineering,TulaneUniversity

AwardstoMembersofTrayanovaLaboratoryandTraineeCo-authors2017 RheedaAli,postdoctoralfellow,ProvostPostdoctoralFellowshipaward,JHU2017 AlexandraBardeceanu,PhDstudent,secondDavidC.GakenheimerFellowshipaward2017 FarhadPashakhanloo,postdoctoralfellow,winnerYoungInvestigatorAward,44thInternational

CongressonElectrocardiology,Portland,Oregon2017 FarhadPashakhanloo,postdoctoralfellow,winner,NatureReviewsCardiologycompetitionfor

year-longjournalcoverimage2016 MelanieZile,PhDstudent,winner,StudentPosterCompetition,CardiacMechanoelectricCoupling

andArrhythmias,Freiburg,Germany2016 AlexandraBardeceanu,PhDstudent,DavidC.GakenheimerFellowshipaward2015 MelanieZile,PhDstudent,DavidC.GakenheimerFellowshipaward2015 HermenegildArevalo,postdoctoralfellow,winner,YoungInvestigatorAwardCompetition,clinical

category,HeartRhythmSocietyScientificSessions2015 SohailZahid,PhDstudent,awardee,NSFGraduateFellowship2015 EranUkwatta,postdoctoralfellow,winner,ImagingNetworkSymposium,Ontario,Canada2015 SohailZahid,PhDstudent,awardee,ARCSFoundationScholarshipaward2014 EranUkwatta,postdoctoralfellow,BMECentennialFellowshipaward2014 LukasRantner,PhDstudent,first-authorpaperselectedasbestof2013inthejournal

HeartRhythm2014 KellyChang,PhDstudent,ARCSFoundationScholarshipaward2013 HermenegildArevalo,PhDstudent,finalist,YoungInvestigatorAwardCompetition,

ElectrocardiologySociety2013 ThomasOHara,postdoctoralfellow,awardee,NIHpost-doctoralfellowship2013 LukasRantner,PhDstudent,winner,Stefan-SchuyPrizeforbestpaper,AustrianBMESociety2013 KathleenMcDowell,PhDstudent,winner,Bestposterpresentation,GordonResearchConferenceon

CardiacArrhythmiaMechanisms2013 FijoyVadakkumpadan,awardee,SmithCharitableFoundationAward2013 TakashiAshihara,formermemberandco-authorwithDr.Trayanova,winner,Suzuken

MemorialFoundationAwardoftheJapaneseSocietyofElectrocardiologyforpublicationinthejournalCirculationResearchwithDr.Trayanova

2012 FijoyVadakkumpadan,awardee,AHAScientistDevelopmentAward2012 PatrickBoyle,postdoctoralfellow,winner,postercompetition,Physiomemeeting2012 JasonConstantino,PhDstudent,awardee,SiebelScholarship2012 KathleenMcDowell,PhDstudent,awardee,AHApre-doctoralfellowship2012 PatrickBoyle,postdoctoralfellow,finalist,RosaDelganiYoungInvestigatorAward,CinCmeeting2012 KathleenMcDowell,PhDstudent,winner,JosWillemsYoungInvestigatorAward,ISCEmeeting2011 BrentMillare,PhDstudent,awardee,NIHpre-doctoralfellowship2011 HiroshiAshikaga,finalist,YoungInvestigatorAwardCompetition,AHAScientific

Sessions2011 DavidKrummen,finalist,YoungInvestigatorAwardCompetition,AHAScientificSessions2011 HiroshiAshikaga,winner,YoungInvestigatorAwardCompetition,4thAsiaPacificHeartRhythm

SocietyScientificSession2011 JasonConstantino,PhDstudent,andSethWeinberg,co-author,thirdplacesinthetrainee

postercompetition,GordonResearchConferenceonCardiacArrhythmiaMechanisms2010 JasonConstantino,PhDstudent,awardee,NIHpre-doctoralfellowship2010 JasonBayer,PhDstudent,awardee,AHApre-doctoralfellowship2010 JasonBayer,PhDstudent,finalist,YoungInvestigatorAwardCompetition,ISEmeeting2009 HermenegildArevalo,PhDstudent,awardee,NIHpre-doctoralfellowship2009 KathleenMcDowell,PhDstudent,awardee,NSFpre-doctoralfellowship2009 CarolynPark,undergraduatestudent,PURAaward,JohnsHopkinsUniversity2009 GraceTan,undergraduatestudent,winner,traineepostercompetition,Tissue-level

ArrhythmiaMechanisms,GordonConferenceonCardiacArrhythmiaMechanisms2009 Dr.TakashiAshihara,winner,2009YoungInvestigatorAward,JapaneseSocietyof

Electrocardiology,Kyoto,Japan2009 LukasRantner,PhDstudent,awardee,DoctoralFellowship,AustrianAcademyofSciences2008 GraceTan,undergraduatestudent,PURAaward,JohnsHopkinsUniversity2008 Dr.GernotPlank,winner,StefanSchuyAwardoftheAustrianBMESociety2007 MartinBishop,winner,studentpostercompetition,Organ-levelArrhythmiaMechanisms,Gordon

ResearchConferenceonCardiacArrhythmiaMechanisms2006 MollyMaleckar,PhDstudent,winner,OutstandingGraduateStudentAward,TulaneEngineering2006 BrockTice,PhDstudent,winner,OutstandingResearchGraduateStudentAward,Departmentof

BiomedicalEngineering,TulaneUniversity2005 MartinBishop,winner,studentpapercompetition,IEEEEMBCannualmeeting2005 BrockTice,PhDstudent,AHApre-doctoralfellowship2005 MollyMaleckar,PhDstudent,winner,BestPosterPresentation,Organ/TissueCategory,

GordonConferenceonCardiacArrhythmiaMechanisms,St.Ivez,CA2005 WeihuiLi,PhDstudent,winner,OutstandingGraduateStudentAward,Tulane

EngineeringSchool2004 Dr.BlancaRodriguez,postdoctoralfellow,winner,YoungInvestigatorAward,

HeartRhythmSocietyScientificSessions1999 EzanaAzene,MSstudent,winner,RosanaDelganiYoungInvestigatorAward,Computersin

Cardiology1999 JamesWall,undergraduatestudent,finalist,EMBS/BMESStudentCompetition1997 KirillSkouibine,PhDstudent,finalist,EMBSStudentCompetition

ScientificReviewActivities•BookEditor:CardiacDefibrillation:Mechanisms,ChallengesandImplications,InTechPublishing,2011•JournalAssociateEditor:HeartRhythm,January2014–presentFrontiersinComputationalPhysiologyandMedicine,2010–presentIEEETransactionsonBiomedicalEngineering,1997-2006•JournalEditorialBoardMember:HeartRhythmJournal,2005–presentAmericanJournalofPhysiology,HeartandCirculatoryPhysiology,2011–presentInSilicoPharmacology,2012–present•AreaEditor:IEEEReviewsinBiomedicalEngineering,2008–2015•NIHReviewService:NIHDirectorsNewInnovatorAward,2014-presentNIHMABSStudySection,member2011-2012ESTAStudySection,member2005–2009ESTAStudySection,adhocmember2004–2005NIH,Chair,BRPSpecialStudySection(ZRG)2004–2005AHA,ElectrophysiologyStudySection,2003–2004CVAStudySection,adhocmember2000–2003NSF,BioengineeringDirectorate,1999IsraeliNationalScienceFoundation,2014SwedishAcademyofSciences,2013-2014HongKongResearchCouncil,2008SwissNationalAcademyofSciences,1999CornellTheoryCenter,1999

•NIHNHLBIStrategicPlanningCommittee,2006:GrouponBioinformaticsandComputationalBiology

•AbstractReviewer:InternationalSocietyforComputerizedElectrocardiology,HeartRhythmSociety,AHAScientificSessions,WorldCongressofBiomechanics• Reviewer,YoungInvestigatorCompetitions:NorthAmericanSocietyofPacingandElectrophysiology

•Reviewer,Journals(selected):Science Translational Medicine, Nature Communications, Circulation Research, Circulation, CirculationElectrophysiology and Arrhythmias, Biophysical Journal, Journal of the American College of Cardiology,Cardiovascular Research, Heart Rhythm, Journal of the American College of Cardiology, Journal ofCardiovascular Electrophysiology, American Journal of Physiology, Progress in Biophysics andMolecularBiology,IEEETransactionsonBiomedicalEngineering,AnnalsofBiomedicalEngineering,DrugMetabolismand Pharmacokinetics, Chaos, Journal of Electrocardiography, Journal of Mathematical Biology,Mathematical Biosciences, Journal of Theoretical Biology, Medical and Biological Engineering andComputing, CRC Critical Reviews in Biomedical Engineering, Mathematical Biosciences, PhilosophicalTransactionsoftheRoyalSocietyLondon,PhysicalReview,JournalofPhysiology,ExperimentalPhysiology,PLoS One, PLoS Computational Biology, Progress in Biophysics and Molecular Biology, Drug DiscoveryToday:DiseaseModels,JACC,JACCElectrophysiologyandArrhythmias,Frontiers,andothers

OtherProfessionalService2018 SessionChairandOrganizer,WorldCongressofBiomechanics,Dublin,Ireland2018 ScientificandOrganizingCommittee,ForumofArrhythmology,SaintPetersburg,Russia2018 SessionModerator,AtrialFibrillationSymposium,Orlando,Florida2017 SessionChair,ComputinginCardiology,Rennes,France2017 SessionChair,TRMmeeting,Lugano,Switzerland2017 SessionChair,ComputinginCardiology,Rennes,France2017 SessionChair,Asia-PacificHeartRhythmSociety,Yokohama,Japan2016 Mini-symposiumOrganizerandChair,AMiTaNS'17Conference,Albena,Bulagaria2016 SessionChair,JapaneseHeartRhythmSociety,Sapporo,Japan2016 SessionChair,ISC2016,Tokyo,Japan2016 SessionChair,Cardiostimmeeting,Nice,France2016 SessionChair,WesternAtrialFibrillationSymposium,ParkCity,Utah2015 SessionChair,TRMForum,Lugano,Switzerland2015 Charofmultiplesessions,HeartRhythmSocietyScientificSessions2013-present CIPASteeringTeam,FDA2013-present AmericanHeartAssociation,Mid-AtlanticAffiliateResearchCommittee2013-present AIMBEmembershipcommittee2013 SessionChair,TRMForum,Lugano,Switzerland2013 SessionChair,CardiacElectrophysiologySocietymeeting2013 SessionChair,2013IEEEEMBCmeeting2012-present HeartRhythmSocietyPublicationsCommittee2012–2013 TrackChair,2013IEEEEMBCmeeting2012 CardiacElectromechanicsMinisymposiumOrganizer,8thEuropeanSolidMechanics

Conference2011 SessionChair,AmericanHeartAssociationScientificSessions2011 MinisymposiumOrganizer,ICNAAMmeeting2011 ThemeChair,IEEEEMBCmeeting2011 TraineeCompetitionJudge,GordonResearchConferenceonCardiacArrhythmia

Mechanisms2010 SessionChair,CardiacElectrophysiologySocietymeeting2010 SessionChair,ComputinginCardiologymeeting2010 SessionChair,ISCEmeeting2009 SessionChair,BMESAnnualmeeting2007–2009 Chair,GordonConferenceonCardiacArrhythmiaMechanisms2007–2016 Cardiostimmeeting,ProgramCommittee2006–2010 HeartRhythmSocietyScientificSessionsProgramCommittee2008 SessionChair,AmericanHeartAssociationScientificSessions2008 SessionChair,BMESAnnualmeeting2008 SessionChair,HeartRhythmSocietyScientificSessions2008 BreakoutSessionChair,WorkshoponComputerMethodsforCardiovascularDevices2007 ViceChair,GordonConferenceonCardiacArrhythmiaMechanisms

2007 DebateChair,HeartRhythmSocietyScientificSessions2007 SessionOrganizerandChair,ISCEmeeting2007 ProgramCommitteeMember,CardiacMechano-electricFeedbackMeeting2006 SessionChair,HeartRhythmSocietyScientificSessions2005–2006 ThemeandTrackChair,EMBSAnnualmeeting2005 SessionChair,HeartRhythmSocietyScientificSessions2004–2005 ProgramCommitteeMember,IASTEDmeetings2004 SessionChair,MeetingofthePhysiologicalSociety,Oxford2004 SessionChair,IASTEDmeeting2004 SessionChair,FourthInternationalWorkshoponComputerSimulationandExperimental

AssessmentofElectricalCardiacFunction2003 SessionChair,NASPEmeeting2002 SessionChair,ThirdInternationalWorkshoponComputerSimulationand

ExperimentalAssessmentofElectricCardiacFunction2002 CardiopulmonaryThemeChair,EMBS/BMESConference2002 ElectrocardiologyTrackChairandSessionChair,EMBS/BMESConference2002 SessionChair,Mechano-ElectricalFeedbackMeeting2002 SessionChair,NASPEmeeting2001 SessionChair(2sessions),IEEE/EMBSConference2001 PosterSessionModerator,IUPSSatelliteMeeting“TheIntegratedHeart:

CardiacStructureandFunction”2001 ProgramCommittee,SpecialTopicConferenceonMedicalandBiologicalModeling2000 SessionChair,WorkshoponMappingofControlofComplexCardiacArrhythmias2000 SessionChair(3sessions),WorldCongressandIEEEEMBSConference1999 SessionChair,EMBS/BMESmeeting1998 TrackCo-ChairandSessionChair,IEEEEMBSMeeting1997 SessionChair,Workshop“ComputationalBiologyoftheHeart”1997 TrackChairandSessionChair,BMESAnnualMeeting1996 ConferenceAnimatorandSessionChair,IEEE/EMBSConference1994 SessionChair,WorldCongressonMedicalPhysicsandBiomedicalEngineering1992 SessionChair,IEEEEMBSConference

ProfessionalMembershipsFellow:InternationalAcademyofMedicalandBiologicalEngineeringFellow:HeartRhythmSocietyFellow:AmericanHeartAssociationFellow:AmericanInstituteforMedicalandBiologicalEngineeringFellow:BiomedicalEngineeringSocietyIEEEEngineeringinBiologyandMedicineSocietyInternationalSocietyforHeartResearchInternationalSocietyforComputerizedElectrocardiologySocietyforIndustrialandAppliedMathematicsAmericanAssociationforAdvancementofScienceCardiacMuscleSocietyCardiacElectrophysiologySocietyBiophysicalSocietyNewYorkAcademyofSciencesAmericanSocietyforEngineeringEducationSigmaXiResearchSociety

ExternalAdvisoryBoards,ExternalInstitutionalEvaluation2015-present ExternalAdvisoryBoard,SCIInstitute,UniversityofUtah2011 Chairofevaluationpanel,CenterforBiomedicalComputingatSimulaResearchLaboratory,

Oslo,Norway 2010-2014 Member,NationalBiomedicalComputationResourceAdvisoryCommittee,UCSD

JohnsHopkinsUniversityInstitutionalService2018 ProgramCommittee,SchoolofMedicineResearchRetreat2018 Adhoctenurecommittee,WhitingSchoolofEngineering2017-2018 CenterforCellDynamicsFacultySearchCommittee2017 EvaluationCommittee,DepartmentofNeuroscience,SchoolofMedicine2017 HeadofMechanicalEngineeringSearchCommittee2014-2017 ResearchCouncil,SchoolofMedicine,JohnsHopkinsUniversity2014–2015 WhitingSchoolofEngineeringDeanofResearchSearchCommittee2014–2015 TeamLeader,ResearchCouncil,SchoolofMedicine,JohnsHopkinsUniversity2013–2014 MasterMentorProgram,JohnsHopkinsUniversity2013–2014 BMECentennialPostdoctoralFellowshipCommittee,JohnsHopkinsUniversity2012-2013 JohnsHopkinsUniversityProvostSearchCommittee2012-2013 WhitingSchoolofEngineeringCentennialCommittee2011 JHUHighPerformanceComputingCommittee2008 Adhoctenurecommittee,WhitingSchoolofEngineering2007 WhitingSchoolofEngineeringInternationalAffairsAdvisoryCommittee2007 JHUHealthProfessionsCommittee2007 AppliedMathandStatisticsDepartmentReviewCommitteeTulaneUniversityInstitutionalService2005 HonorsCommittee,SchoolofEngineering2005 HonorBoard,TulaneUniversity2003-2005 FacultySearchCommittee,DepartmentofBiomedicalEngineering2005 OutstandingResearcherAwardCommittee,SchoolofEngineering2004 PresidentialEarlyCareerDevelopmentAwardsCommittee,TulaneUniversity2003 GraduateStudiesCommittee,DepartmentofBiomedicalEngineering2003 OutstandingResearcherAwardCommittee(Chair),SchoolofEngineering2003 AssociateDeanofResearchSearchCommittee,SchoolofEngineering2002-2003 PromotionandTenureCommittee,SchoolofEngineering2002-2003 HonorsCommittee,SchoolofEngineering2002-2003 FacultySearchCommittee(5positions),TulaneDepartmentofMechanicalEngineering2000-2001 ABETTaskForce,DepartmentofBiomedicalEngineering2000-2001 AssessmentCommittee,SchoolofEngineering2000 UndergraduateCurriculumTaskForce,DepartmentofBiomedicalEngineering2000 SearchandRatingCommittee,SchoolofEngineering1999-2005 Member,TulaneUniversitySenateCommitteeonTeachingQuality1995-1999 InternationalProgramCommittee,SchoolofEngineering1995-2001 DirectorofUndergraduateStudies,DepartmentofBiomedicalEngineering1996-1998 Interviewer,HealthProfessionsAdvisingCommittee1995-1997 BMESFacultyAdviser,DepartmentofBiomedicalEngineering1995-1998 Member,FacultySearchCommittee,DepartmentofBiomedicalEngineeringCoursesTaughtatJohnHopkinsUniversityBME580.421 SystemsBioengineeringI:CellularandCardiovascularEngineering.Coreundergraduate

courseinBiomedicalEngineering.Taughteveryyearsince2006(except2015),120-140studentsinthecourse.Thehigheststudent-rankedcourseintheDepartmentofBiomedicalEngineeringfor2010and2011

EN.580.739 AdvancedSeminarsinCardiacElectrophysiologyandMechanics,taughteverysemestersince2011

CoursesTaughtatTulaneUniversityBMEN201IntroductiontoBMEDesignMethodsBMEN272Circuits,SystemsandSignals

BMEN278Circuits,SystemsandSignalsLabBMEN310/610ElectrophysiologyBMEN361/761IntroductiontoBioelectricityBMEN490ResearchandProfessionalPracticeIBMEN611CardiacElectrophysiologyBMEN676AdvancedTopicsinExcitableMediaBMEN671BMENDepartmentalSeminarBMEN613/MATH774CardiacModelingAcademicMentorship•PostdoctoralResearchAdvisorDr.RheedaAli,May2017–presentDr.FarhadPashakhanloo,July2016–present

Dr.YasserAboelkassem,January2015–August2017Dr.DongdongDeng,August2013–presentDr.DafangWang,December2012–presentDr.AdityoPrakosa,August2013–September2015Dr.HemenegildArevalo,November2013–September2015Dr.EranUkatta,October2013–January2016Dr.Yong-taeKim,September2012-September2013Dr.TomO’Hara,October2011–2015Dr.PatrickBoyle,August2011–February2014Dr.GeWang,March2012–March2013Dr.XiaozhongChen,January2008–February2012Dr.KimooLim,September2010-September2011Dr.FijoyVadakkumpandan,July2007–June2011Dr.GernotPlank,October2006–April2008Dr.ViatcheslavGurev,November2004–October2011Dr.TakashiAshihara,October2002–April2004Dr.BlancaRodriguez,May2002–August2004Dr.AlexanderKomendantov,June2001–May2004Dr.JamesEason,July2000–September2002Dr.EdwardVigmond,August1999–July2001

•Ph.D.DissertationResearchAdvisor–Director:JulieShade

RyanO’HaraAlexandraBardeceanuThomasKarathanos,graduatedDecember2017JosephYuSohailZahid,graduatedAugust2017MelanieZile,graduatedDecember2017FarhadPashakhanloo,graduatedJune2016KellyChang,graduatedJune2016BrentMillareYuxuanHu,graduatedJanuary2014KathleenMcDowell,graduatedJuly2013LukasRantner,graduatedJune2013JasonConstantino,graduatedJuly2013HermenegildArevalo,graduatedNovember2013JasonBayer,graduatedFebruary2013BrockTice,graduatedSeptember2009XiaoJie,graduatedMarch2009MollyMaleckar,graduatedDecember2008WeihuiLi,graduatedMarch2007SamKuo,lefttheprogram2006

DavidBourn,graduatedMarch2006JasonMeunier,graduatedJanuary2002FelipeAguel,graduatedAugust2001KirillSkouibine,graduatedAugust1998(co-directedwithDr.Moore)

–PhDCommitteeMember:ClaireZhaoMattWalkerBoombinLimpitikulLauraGautier(graduated2013)SarahParks(graduated2012)SethWeiberg(graduated2011)RajeshBabuSekar(graduated2009)MikeTadross(gradauted2008)JoshuaCysyk(graduated2008)ValerieFranz(graduated2007)KathleenRhea(graduated2004)BrettWingier(graduated2003)AdamCates(graduated1999)DelilahHuelsing(graduated1998)GeorgeCao(graduated1999)LoriVidal(graduated1999)

–PhDExternalExaminer:SimoneScacchi,UniversityofPavia,Italy,2007EugeneSeneta,UniversityofTechnology,Sydney,Australia,1997.AmrAlAbed,TheUniversityofNewSouthWales,Australia2011.

•M.S.ThesisResearchAdvising–Director:CarolynPark(graduated2011)ShruthiShankar(graduated2010)YuxuanHu(graduated2010)SammyLong(graduated2009)LinmiaoXu(graduated2009)ClaireLarson(graduated2004)CarlosHaro(graduated2004)MatthewHillebrener(graduated2003)LubomirDragnev(graduated2003)CraigCampbell(graduated2002)AnnetteLindblom(graduated2000)CoryAnderson(graduated2000)GregorySiekas(graduated1999)EzanaAzene(graduated1999)EvanAtkinson(graduated1999)JohnT.Parry(graduated1998)KristenPasnak(graduated1998)IraNemeth(graduated1998)

–CommitteeMember:LeeLovejoy(graduated2000)DarrylOverby(graduated1997)RockShi(graduated1997)XiahongWu(graduated1996)MichaelParis(graduated1996)LouisLit(graduated1996)TateCantrell(graduated1995)LisaMalden(graduated1994)

•SeniorProjectsDirectedatTulaneUniversity(*HonorsThesis)

2006PaulGeorge,DavidSiet2004-2005*JasonConstantino2003-2004*HermenegildArevalo,*BrockTice2002-2003*CarlosHaro2001-2002*ClaireLarson,*AshleySchneider2000-2001*RachelRuckdeschel,*CraigCampbell,*MathewHillebrener1999-2000*JasonGmyrek,CristineGuidry1998-1999*JamesWall,CoryAnderson,*AnnetteLindblom1997-1998AbigailMoore(withDr.Pollard),*EzanaAzene,*EvanAtkinson,1996-1997*PeterNelson,GarrettSipple,DanielMoller,*VipulKapoor,*SuzanneBaker,*MarcellaWoods(withDr.Pollard)1995-1996*MarkBray,*FelipeAguel,KristenPasnak1994-1995*ShrinivasGanesh,DarrenPorras1993-1994*RachelWinokur1992-1993*LisaMalden

•UndergraduateresearchprojectsatJHU2017-2018 MichaelMurphy,WilliamFrancesci,TiffanyHu2016-2017 MichaelMurphy,WilliamFrancesci,JoeHakim2015-2016 KaitlynWhite,EricaWood,MichaelMurphy2014-2015: VigneshRamchandran,KaitlynWhite,EricaWood2013-2014 EricXie,AnishDalal,KristinaLi2012-2014 AlexanderJebb2012-2013 SethHochberg2007-2010 CarolynPark2008-2009 TedLee2007-2009 GraceTan2006-2008 AlexArtaki,LinmiaoXu,FranciscoConjitoch,JosefWang

FundingCurrentSupportSupportingAgency: TEDCO,MIIInnovationCommercializationProgramAward: $90,000Duration: 02/01/18-11/01/19Title: Personalizedpredictionofablationtargetsinpatientswithatrialfibrillationand

fibroticremodelingPI NataliaA.TrayanovaSupportingAgency: LeducqFoundationAward: $898,874toJHUDuration: 01/10/16-01/10/21Title: RHYTHM:RepolarizationHeterogeneitYimagingforpersonalizedTherapyofHeart

arrhythmiaMPIs Haisaguerre,Efimov,Trayanova,Rogers,CoronelSupportingAgency: NIHAward: $1,235,167Duration: 01/01/16-11/30/19Title: ExplorationofArrhythmogenicTriggersandSubstratesinHeartFailurePrincipalInvestigator NataliaA.TrayanovaSupportingAgency: NIHDirector’sPioneerAwardAward: $4,075,000Duration: 9/13-8/18Title: VirtualElectrophysiologyLaboratoryPrincipalInvestigator NataliaA.Trayanova

SupportingAgency: NIHAward: subcontractfromUCDavis,$25,864Duration: 09/01/15-08/31/20Title: PredictiveMultiscaleinSilicoCardio-PharmacologyPrincipalInvestigator ColeenClancyCo-PI NataliaA.TrayanovaCompletedAwardsSupportingAgency: inHealthPilotProjectDiscoveryAwardAward: $75,000Duration: 01/01/16-04/30/17Title: PersonalizedRiskStratificationforSuddenCardiacDeathUsingCardiacMRIand

VirtualHeartElectrophysiologicStudies(PuRSUit-VirtualHeart)PrincipalInvestigator KatherineWuCo-PI NataliaA.TrayanovaSupportingAgency: NIHAward: subcontractfromColumbia,$123,853Duration: 09/15/15-05/31/17Title: EarlyDetectionandMappingofIschemiaUsingMyocardialElastographyPrincipalInvestigator ElisaKonofagouCo-PI NataliaA.TrayanovaSupportingAgency: SOMDiscoveryInnovationAwardAward: $50,000Duration: 07/01/15-06/30/16Title: PersonalizedVirtualHeart:ApplicationtoAblationofPersistentAtrialFibrillationin

PatientswithFibrosisPrincipalInvestigator NataliaA.TrayanovaSupportingAgency: NIHAward: $2,715,000Duration: 6/11-7/16Title: ResynchronizingtheFailingHeart:InsightsfromaMultiscaleCardiacModelPrincipalInvestigator NataliaA.TrayanovaSupportingAgency: NSFAward: $600,000(Trayanovaportion)Duration: 9/11-8/15Title: CDITypeII:CollaborativeResearch:FromIonChannelstoBloodFlowand

HeartSoundsMPIs: Mittal,Trayanova,HuangSupportingAgency: NIHAward: $800,000(Trayanovaportion)Duration: 4/11-12/15Title: RedoxModificationoftheArrhythmicSubstrateinHeartFailureMPIs: Winslow,Trayanova,O’RourkeSupportingAgency NIHAward $300,000(Trayanovaportion)Duration 4/10-3/15Title: RoleofCardiomyocyteMitochondriainHeartDisease:AnIntegratedApproach

MPIs: O‘Rourke,Trayanova,Bers,Blatter,VanEykSupportingAgency: NIH(BRPgrant)Award: $915,120(Trayanovaportion)Duration: 1/10-6/14Title: ImprovedTargetingandAssessmentofElectrophysiologyInterventionPrincipalInvestigator:HenryHalperinSubcontractPI: NataliaA.TrayanovaSupportingAgency: NIHAward: $375,685(Trayanovaportion)Duration: 07/10-06/15Title: LVStructuralPredictorsofSuddenCardiacDeathPrincipalInvestigator:KatherineWuCo-investigator NataliaA.TrayanovaSupportingAgency: NIH(pre-doctoralfellowship)Award: $123,528Duration: 2/10-1/13Title: Image-BasedModelsthatPredictArrhythmiaMorphologyinPost-InfarctionHeartsPrincipalInvestigator:NataliaA.TrayanovaGraduateAssistant: HermenegildArevaloSupportingAgency: NIH(pre-doctoralfellowship)Award: $124,140Duration: 7/10-6/13Title: Image-basedmodelsofelectromechanicsinnormalandfailingheartsPrincipalInvestigator:NataliaA.TrayanovaGraduateAssistant: JasonLanceConstantinoSupportingAgency: NSFAward: $300,000Duration: 1/10-12/12Title: MechanismsofMechanically-InducedArrhythmiasinMyocardialIschemiaPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIHAward: $2,130,611Duration: 1/07-12/11Title: DefibrillationMechanismsinInfarctedHeartsPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIHAward: $165,000(Trayanovaportion)Duration: 7/10-6/12Title: EarlyDetectionandMappingofIschemiausingMyocardialElastographyPrincipalInvestigator:ElisaKonofagou(ColumbiaUniversity)SubcontractPI: NataliaA.TrayanovaSupportingAgency: NIH(R21)Award: $137,333(Trayanovaportion)Duration: 07/10-06/12Title: TerminationofCardiacArrhythmiabyHighFrequencyElectricFieldPrincipalInvestigator:LeslieTungCo-investigator NataliaA.TrayanovaSupportingAgency: NIH

Award: $1,029,219(Trayanovaportion)Duration: 5/07-4/12Title: VirtualElectrodeHypothesisforDefibrillationPrincipalInvestigator:IgorEfimov(WashingtonUniversity)Co-PI/subcontractPI:NataliaA.TrayanovaSupportingAgency: NIH(R21grant)Award: $170,000(Trayanovaportion)Duration: 1/10-12/11Title: NoninvasiveConductionMappingUsingElectromechanicalWaveImagingPrincipalInvestigator:ElisaKonofagou(ColumbiaUniversity)SubcontractPI: NataliaA.TrayanovaSupportingAgency: MedtronicInc(ExternalResearchProgramAward)Award: $95,000Duration: 7/10-6/11Title: ANovelMethodtoPredictQTintervalInstabilityfromIntracardiacElectrogramsPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: FDAAward: $92,500Duration: 1/10-12/11Title: CriticalPathProject:PediatricDefibrillationPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: AmericanHeartAssociation(pre-doctoralfellowship)Award: $52,900Duration: 07/10-06/12Title: MechanismsofT-waveAlternansinHumanHeartFailurePrincipalInvestigator:NataliaA.TrayanovaGraduateAssistant: JasonBayerSupportingAgency: NSFAward: $10,000Duration: 12/08-12/09Title: 2009CardiacArrhythmiaMechanismsGordonResearchConferencePrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIH(R13grant)Award: $15,000Duration: 12/08-12/09Title: 2009CardiacArrhythmiaMechanismsGordonResearchConferencePrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIHAward: $933,388Duration: 9/05-8/09Title: CardiacTissueStructureintheDefibrillationProcessPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NSFAward: $344,098Duration: 9/06-8/09Title: Shock-inducedArrhythmogenesisinRegionalMyocardialIschemiaPrincipalInvestigator:NataliaA.Trayanova

SupportingAgency: NIHAward: $305,735(JHUportion)+$221,888(Tulaneportion)Duration: 09/04-08/08Title: TheroleofelectroporationindefibrillationPrincipalInvestigator:IgorEfimov(WashingtonUniversity)Co-PI: NataliaA.TrayanovaSupportingAgency: AHApost-doctoralfellowshipAward: $70,000Duration: 07/07-06/09Title: Defibrillationmechanismsinventriculardilatation:theroleofactivedeformationPrincipalInvestigator:NataliaA.TrayanovaPost-doctoralfellow: ViatcheslavGurevSupportingAgency: AHApre-doctoralfellowshipAward: $33,538Duration: 07/06-06/08Title: InvestigationintotheMechanismsofDefibrillationFailureusingHigh-Resolution

ModelsofCadiacTissuePrincipalInvestigator:NataliaA.TrayanovaGraduateassistant: BrockTiceSupportingAgency: AHA,EstablishedInvestigatorAwardAward: $310,000Duration: 8/02-7/06Title: AnalysisofdefibrillationmechanismsinacuteischemiaPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: MedtronicInc.Award: $95,000Duration: 7/04-6/06Title: ResearchServicesAgreementPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIHAward: $114,400(Tulaneportion)Duration: 12/02-11/07Title: ElectrophysiologicalimplicationsofcardiacbidomainPrincipalInvestigator:JohnWikswo(VanderbiltUniversity)Investigator: NataliaA.TrayanovaSupportingAgency: NIH,Pre-NPEBCAward: $1,240,887Duration: 5/03–4/06Title:Biocomputing: IntegratingMolecular/Organ-LevelFunctionMPIs: DonaldGaver,LisaJ.FauciInvestigator: NataliaA.TrayanovaSupportingAgency: NIHAward: $792,433Duration: 7/99-6/05Title: CardiacTissueStructureintheDefibrillationProcessPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: TulaneWallFundAward: $150,000

Duration: 6/01–7/04Title: CenterforComputationalSciencePrincipalInvestigator:LisaJ.Fauci,DonaldGaver,RicardoCortezInvestigator: NataliaA.TrayanovaSupportingAgency: WhitakerFoundation(subcontracttoWashington&LeeUniversity)Award: $41,000(Tulaneportion)Duration: 9/02-8/04Title: TheroleofphasesingularitiesindeterminingdefibrillationefficacyPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NSFAward: $220,000Duration: 9/98-2/03Title: ICDTransvenousleadplacement:Anactivebidomainheart/torsosimulationstudy

ofdefibrillationefficacyPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NSFAward: $22,000Duration: 9/98-2/03Title: REUSupplementtoNSFGOALIawardPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: DOEAward: $1,920,000Duration: 5/01–6/03Title: LivingstonDigitalMillenniumCenterforComputationalSciencePrincipalInvestigator:LisaJ.Fauci,DonaldGaver,RicardoCortezInvestigator: NataliaA.TrayanovaSupportingAgency: AmericanHeartAssociationAward: $90,000Duration: 7/01-12/02Title: RolesofStructureandHeterogeneityintheInductionandMaintenanceofAtrial

ReentryPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NIHAward: $15,000(Tulaneportion)Duration: 3/01-2/02Title: MagneticFieldoftheHeartPrincipalInvestigator:JohnWikswo(VanderbiltUniversity)Investigator: NataliaA.TrayanovaSupportingAgency: TulaneACLRTTotalAward: $6740Duration: 1999-2000Title: VirtualBioelectricityLabsinBMEN361/761PrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: LouisianaBoardofRegents(R&DProgram)TotalAward: $109,713plus$12,500matchincashDuration: 9/98-8/01Title: CardiacTissueinanElectricFieldPrincipalInvestigator:NataliaA.Trayanova

SupportingAgency: ACLRT,TulaneUniversityTotalAward: $7,000Duration: 8/99-9/00Title: VirtualBioelectricityLabsPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: AmericanHeartAssociationTotalAward: $25,000Duration: 9/98-8/99Title: Analysisofelectrodeconfigurationsinahigh-resolutionmodelofcardiac

defibrillationPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: Ventritex,adivisionofSt.JudeMedical(researchagreement)TotalAward: $50,000Duration: 9/97-8/98Title: BidomainModeloftheVentriclesPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: Medtronic,Inc.(researchagreement)TotalAward: $17,000Duration: 9/97-8/99Title: DevelopmentofaHumanAtrialModelPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: Medtronic,Inc.(researchagreement)TotalAward: $7,000Duration: 10/97-9/99Title: EffectsofAblationandShocksonAtrialFibrillationPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: TheWhitakerFoundationTotalAward: $179,205Duration: fundingendedAugust1,1996Title: TheBidomainModelwithPeriodicIntracellularJunctions:AStudyofCardiac

StimulationPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: NSF(subcontractfromDukeUniversity)TotalAward: $10,852Duration: summer1995Title: CardiacMembranePolarizationinStrongElectricFieldsInvestigator: NataliaA.TrayanovaSupportingAgency: NSF(subcontractfromDukeUniversity)TotalAward: $11,181Duration: summer1996Title: CardiacMembranePolarizationinStrongElectricFieldsInvestigator:NataliaA.TrayanovaSupportingAgency: TulaneCommitteeonResearchTotalAward: $4,000Duration: summer1996Title: MembraneElectroporationduringtheDefibrillationShockPrincipalInvestigator:NataliaA.Trayanova

SupportingAgency: NSFTotalAward: $1,665Duration: 9/15/96-3/15/96Title: InternationalTraveltoAttendthe18thConferenceoftheIEEEEMBS,Nov.1996,

Amsterdam,TheNetherlandsPrincipalInvestigator:NataliaA.TrayanovaSupportingAgency: LEQSF–EnhancementProgramTotalAward: $126,000Duration: oneyearTitle: BiomedicalEngineeringEnhancement:EstablishinganIntegratedTissue

EngineeringFacilityPrincipalInvestigator:DonaldGaverCo-PI: NataliaA.TrayanovaSupportingAgency: NSF,GroupInfrastructureGrantTotalAward: $528,779Duration: 9/97–8/02Title: ComputationalScienceinBiomedicalSystemsPrincipalInvestigator:LisaJ.FauciCo-PI: NataliaA.TrayanovaPatents

• PatentNumber:EP1761300-A1Title:Implantablecardioverterdefibrillationelectrodesystemfordefibrillationtherapy

• ApplicationNumber:20060020316(filed2004,issued2006)Title:Implantablecardioversionanddefibrillationsystemincludingintramuralmyocardialelectrode

• ApplicationNumber:20120215269(filed2010,issued2012)Title:MethodandDeviceforTreatingCardiacArrhythmias

• ApplicationNumber:20130102912(filed2010,issued2013)Title:NOVELMETHODOLOGYFORARRHYTHMIARISKSTRATIFICATIONBYASSESSINGQTINTERVALINSTABILITY

• ApplicationNumber:20140088943(filed2012,issued2014Title:SYSTEMANDMETHODFORPLANNINGAPATIENT-SPECIFICCARDIACPROCEDURE

• ApplicationNumber:20140122048(filed2012,issued2014)Title:SYSTEMANDMETHODFORPERSONALIZEDCARDIACARRHYTHMIARISKASSESSMENTBYSIMULATINGARRHYTHMIAINDUCIBILITY

• ApplicationPCT/US13/39680(submitted2013)Title:AMETHODFORLOWVOLTAGEDEFIBRILLATIONWITHFAR-FIELDSTIMULIOFVARIABLETIMINGSBASEDONFEEDBACKFROMTHEHEART

• ApplicationPCT/US13/46531(submitted2013)Title:AMETHODFORCOMPUTATIONALLYPREDICTINGOPTIMALPLACEMENTSITESFORINTERNALDEFIBRILLATORSINPEDIATRICANDCONGENITALHEARTDEFECTPATIENTS

• ApplicationC12794(submitted2013)Title:SUDDENCARDIACDEATHRISKASSESSMENTBYANALYSISOFPATIENTSMYOCARDIALWALLSHAPE

• ApplicationFC12602-P12602-01(submitted2013)Title:PERSONALIZEDCOMPUTATIONALMODELINGOFATRIALFIBROSISTOGUIDECATHETERABLATIONOFATRIALFIBRILLATION

• ApplicationC13278-P13278-01;2240-373518(submitted2014)Title:PredictionofTargetsforCatheterAblationofPersistentAtrialFibrillationbasedonAnalysisofPatient-SpecificFibrosisPatterns

• ApplicationC13584(submittedMay2015):Title:SimulationPredictionofTargetsforCatheterAblationofLeftAtrialFlutterinPatientswithAtrialStructuralRemodeling

• ApplicationC13583(submittedMay2015),Title:Patient-SpecificModelingoftheHeartforPredictionofTargetsforCatheterAblationofVentricularTachycardiainPatientswithImplantableCardioverter

Defibrillators• ApplicationC14362(submittedNovember2016),Title:RiskStratificationforVentricularArrhythmiain

PatientswithRepairedTetralogyofFallot(TOF)viaImage-BasedComputationalSimulations• ApplicationC14508(submittedDecember2016),Title:UsingPatient-SpecificModelingoftheHeartfor

RiskStratificationofVentricularArrhythmiainPatientswithHypertrophicCardiomyopathy(HCM)

SelectedInvitedTalks

• Dean’sSymposium,PalmBeach,FL,2018• AFmeeting,Orlando,FL,2018• TRMmeeting,Lugano,Switzerland,2017• AmericanHeartAssociationmeeting,Anaheim,CA,2017• AFIBmeeting,Madrid,November2017• LeducqAnnualmeeting,Bordeaux,France,October2017• PhystechBioMed-2017,Moscow,Russia,September2017• MoscowInstituteofPhysicsandTechnology,September2017• MoscowStateUniversity,Moscow,Russia,September2017• Asia-PacificHeartRhythmSociety,Yokohama,Japan,September2017• SISSASummerSchool,Brashov,Romania,July2017• AMiTaNSsymposium,Albena,Bulgaria,June2017• HeartRhythmScientificSessions,May2017(invitedfaculty,severaltalks)• StanfordBiodesignSymposium,May2017• CMBEmeeting,PittsburgPA,April2017(keynotelecture)• WSEDean’sAlumniLecture,WashingtonDC,March2017• CardiologyGrandRounds,Norfolk,VA,March2017• AtrialFibrillationSymposium,TheHague,TheNetherlands,March2017• Children’sHospital,WashingtonDC,March2017• TEDtalkatTEDxJHU,February2017• BiophysicalSocietymeeting,NewOrleans,LA,February2017• AtrialFibrillationSymposium,OrlandoFL,January2017• Symposium“Cardiomyopathies:alookatthefuture”,Florence,Italy,December2016• AmericaHeartAssociationScientificSessions,NewOrleans,November2016• VTSymposium,NewYork,October2016• InstituteforEngineeringinMedicine,UniversityofMinnesota,Minneapolis,September2016• CardiacMechanoelectricCouplingandArrhythmias,Freiburg,Germany,September2016(keynotelecture

andclosinglecture),September2016• GordonResearchConferenceonHealthcareInformatics,HongKong,July2016• JapaneseHeartRhythmSociety,Sapporo,Japan,July2016(2talks)• ISC2016,Tokyo,Japan,July2016(keynotelecture)• Cardiostimmeeting,Nice,France,June2016• HeartRhythmScientificSessions,May2016(invitedfaculty,severaltalks)• StanfordBiodesignSymposium,May2016• TRMForum,Lugano,Switzerland,December2015• Asia-PacificHeartRhythmScientificSessions,Mebourne,Australia,November2015• OhioStateUniversityDorothyM.DavisHeart&LungResearchInstitute’sAnnualResearchDay(keynote

address)• SummerCourseonImage-basedBiomedicalModeling,ParkCity,UTJuly2015(keynotelecture)• LyricInstitute,UniversityofBordeaux,June2015• HeartRhythmScientificSessions,Boston,May2015(invitedfaculty,severaltalks)• StanfordBiodesignSymposium,Boston,May2015• ArrhythmiaSatelliteSymposium,Physiomemeeting,Auckland,NewZealand,April2015(keynotelecture)• GordonResearchConferenceonCardiacArrhythmiaMechanisms,Barga,Italy,March2015• CellBiologyoftheHeartSymposium,Keystone,CO,March2015• WesternAtrialFibrillationSymposium,ParkCity,Utah,February2015• CardiacMuscleSociety,Baltimore,MD,February2015(keynotelecture)• CenterforBiomedicalImageComputingandAnalytics,UniversityofPennsylvania,Philadelphia,February

2015• ICES,UniversityofAustin,Austin,TX,January2015• AtrialFibrillationSymposium,Orlando,Fl,January2015• FDACiPAWorkshop,WashingtonDC,December2014• AmericanHeartAssociationScientificSessions,Chicago,November2014(invitedfaculty)• CardiacArrhythmias:ChallengesforDiagnosisandTreatment,AsymposiuminhonorofGRMines,McGill

University,Montreal,Canada,November2014• WomeninEPMeeting,Orlando,FL,October2014(invitedfaculty)• LondonVTSymposium,London,UK,September2014• SIAMAnnualMeeting,Chicago,July2014(plenarylecture)• WorkshoponLargeScaleModelingofCardiacElectrophysiology,DalhousieUniversity,Halifax,

Canada,June2014• Cardiostimmeeting,Nice,France,June2014• RadiologyDepartment,JohnsHopkinsSchoolofMedicine,May2014• HeartRhythmScientificSessions,SanFrancisco,May2014(invitedfaculty,fourtalks)• StanfordBiodesignSymposium,PaloAlto,May2014• MedtronicInc.,Minneapolis,MN,April2014• WesternAtrialFibrillationSymposium,ParkCity,UT,March2014• CardiovascularResearchCenter,UniversityofWisconsin-Madison,Madison,WI,January2014• TheTexasAcademyofMedicine,ScienceandEngineering.Austin,TX,January2014(keynotelecture)• TRMForum,Lugano,Switzerland,December2013• AmericanHeartAssociationScientificSessions,Dallas,TX,November2013(invitedfaculty)• MEDICONmeeting,Seville,Spain,September2013• DenisEscandeSymposium,Amsterdam,September2013• IEEEEMBCmeeting,Osaka,Japan,July2013(keynotelecture)• Europace,Athens,Greece,July2013• ModelingPhysiologicalFlowsMeeting,Sardinia,Italy,2013• HeartRhythmScientificSessions,Denver,May2012(invitedfaculty,severaltalks)• StanfordBiodesignSymposium,Denver,May2013• DavidRosenbaumSymposium,MetroHealth,Cleveland,May2013• DepartmentofBiomedicalEngineering,StonyBrookUniversity,NewYork,March2013• SIAMConferenceonComputationalScienceandEngineering,Boston,February2013(plenary• speaker)• WesternAtrialFibrillationSymposium,ParkCity,UT,March2013• FourthChileanWorkshoponNumericalAnalysisofPartialDifferentialEquations,Concepcion,• Chile,January2013(invitedtalk)• ICMDistinguishedSeminarSeries,JohnsHopkinsUniversity,December2012• IMAGConsortium,NIH,November2012• AmericanHeartAssociationScientificSessions,LosAngeles,CA,November2012(invitedtalk)• Physiomemeeting,SanDiego,November2012(plenaryspeaker)• MetroHealthHospital,CWRU,Cleveland,OH,October2012• DepartmentofPhysiology,CWRU,Cleveland,OH,October2012• 4thComputationalPharmacyWorkshop,Krakow,Poland,September2012(keynotespeaker)• 8thEuropeanSolidMechanicsConference,CardiacElectromechanicsMinisymposium,Graz,Austria,July

2012(invitedtalk)• CardiostimMeeting,Nice,France,June2012(2invitedtalks)• CardiovascularResearchRetreat,DepartmentofMedicine,JohnsHopkinsUniversity,June2012(invitedtalk)• HeartRhythmScientificSessions,Boston,May2012(invitedfaculty,3talks)• MurrayB.SachsEndowedChairInstallationPresentation,May,2012• ConferenceonEngineeringFrontiersinPediatricandCongenitalheartDisease,StanfordUniversity,April

2012(keynotespeaker)• BiomedicalEngineeringDepartment,JohnsHopkinsUniversity,April2012• CardiovascularSymposium,UCDavis,CA,March2012• WesternAtrialFibrillationSymposium,ParkCity,Utah,February2012• NationalResearchLaboratoryforMitochondrialSignaling,DepartmentofPhysiology,CollegeofMedicine,

InjeUniversity,Busan,SouthKorea,January2012(COOLLecture)• SeoulMini-WorkshoponrecentProgressinBiosimulation,Seoul,SouthKorea,January2012(keynote

speaker).• ChallengesinComputingConference,Oslo,Norway,December2011(keynotespeaker)• CaMoWorkshop,SimulaLaboratory,Oslo,Norway,December2011.• SixthInternationalWorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiac

Function,Lugano,Switzerland,December2011.

• AmericanHeartAssociationScientificSessions,Orlando,Florida,November2011• CenterforArrhythmiaResearch,UniversityofMichiganSchoolofMedicine,AnnArbor,October2011• Cardiology,UniversityofMichiganSchoolofMedicine,AnnArbor,October2011(FoundersLecture)• Physiomemeeting,Oxford,UK,July2011.• ImperialCollegeLondon,UK,July2011.• St.JudeMedical,Sunnyvale,CA,June2011(ResearchLyceumLecture)• St.JudeMedical,Silmar,CA,June2011(ResearchLyceumLecture)• NFSI&ICBEM2011conference,Banff,Canada,May2011(plenaryspeaker).• HeartRhythmSocietyScientificSessions,SanFrancisco,CA,May2011.• AmericanCongressonPharmacometrics,SanDiegoCA,April2011.• GordonResearchConferenceonCardiacArrhythmiaMechanisms,GalvestonTX,February2011.• DepartmentofBiomedicalEngineering,ColumbiaUniversity,NY,January2011.• NIH,NationalInstituteforAging,January2011.• FDA,SilverSprings,MD,December2010.• BostonScientific,Inc,Minneapolis,MN,July2010.• SimulaResearchLaboratory,Oslo,Norway,June2010.• Cardiostimmeeting,Nice,France,June2010.• HeartRhythmSocietyScientificSessions,Denver,Co,May2010.• ISCEmeeting,Albuquerque,NM,April2010.• DivisionofCardiology,JohnsHopkinsMedicalInstitutions,April2010• DepartmentofElectricalEngineeringandComputerScience,UniversityofCalgary,Canada,March2010.• BethIsraelDeaconessMedicalCenter,Boston,MA,March2010.• UCDavisCardiovascularSymposium,Davis,CA,February2010.• AmericanHeartAssociationmeeting,Orlando,November2009.• NHLBI/VCUworkshop,Richmond,VA,October2009• UniversityofPittsburghSchoolofMedicine,Pittsburgh,October2009• CardiacPhysiomemeeting,Cambridge,July2009• JapaneseSocietyofElectrocardiologyandJapaneseHeartRhythmSocietyJointMeeting,Kyoto,July2009(2

invitedpresentations)• ISHRmeeting,BaltimoreMD,June2009.• HeartRhythmSocietyScientificSessions,Boston,MA,May2008(4invitedpresentations).• MountSinai,NYC,March2009.• AppliedMathDepartment,JHU,November2008.• JointJHU-ThisnguaUniversitymeeting,Beijing,China,October,2008• BMESannualmeeting,St.Louis,MO,October2008.• CARPUser’sMeeting.Banff,Canada,September2008.• Cardiostimmeeting,Nice,France,June2008.• HeartRhythmSocietyScientificSessions,SanFrancisco,CA,May2008.• WorkshoponMulti-scaleModellingoftheHeart,Auckland,NewZealand,March2008(plenaryspeaker).• WorkshoponComputerMethodsforCardiovascularDevices,WashingtonDC,March2008.• DepartmentofVeterinaryMedicine,CornellUniversity,October2007.• BiomedicalEngineeringGraduateProgramRetreat,JohnsHopkinsUniversity,OceanCity,MD,September

2007.• EMBSmeeting,Lyon,France,August2007.• NHLBIworkshop“SystemsApproachtoUnderstandingElectromechanicalActivityintheHumanHeart”,

WashingtonDC,August2007.• DalhousieUniversity,Halifax,NovaScotia,Canada,June2007.• HeartRhythmSocietyMeeting,Denver,CO,May2007(3invitedpresentations).• InternationalSocietyforComputerizedElectrocardiographyMeeting,Cancun,Mexico,April2007.• WhitingSchoolofEngineering,JohnsHopkinsUniversity,April2007.• MechanoelectricFeedbackandArrhythmiasMeeting,OxfordUniversity,April2007• DepartmentofPharmacology,ColumbiaUniversitySchoolofMedicine,March2007• CardiovascularResearchLaboratory,UCLA,February2007.• DepartmentofBioinformaticsandComputationalBiology,GeorgeMasonUniversity,January2007.• InstituteforMolecularCardiobiology,JohnsHopkinsUniversity,January2007.• FifthInternationalWorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiac

Function,Lausanne,Switzerland,December2006.• ThirdTechnion-JohnsHopkinsSymposiuminMedicalScienceandBiomedicalEngineering,JohnsHopkins

University,October2006(FredHittmanDistinguishedLecture).• CardiacElectrophysiologyandArrhythmia,MathematicalBiosciencesInstitute,October2006.• CardiacMechanicsandRemodeling,MathematicalBiosciencesInstitute,September2006.• SymposiumonBiomedicalEngineering,Zurich,Switzerland,September2006(keynoteaddress).• 4thFairbergCardiacWokrship,April2006.• DepartmentofBioengineering,UniversityofUtah,April2006.• DepartmentofBioengineering,UCSD,April2006.• Medtronic,Inc.,April2006.• DepartmentofBiomedicalEngineering,UniversityofMinnesota,April2006.• DepartmentofBiomedicalEngineering,ColumbiaUniversity,March2006.• DepartmentofBiomedicalEngineering,TulaneUniversity,March2006.• DepartmentofBioengineering,UniversityofWashington,February2006.• DepartmentofBiomedicalEngineering,JohnsHopkinsUniversity,January2006.• DepartmentofBiomedicalEngineering,UniversityofFlorida,January2006.• DepartmentofBioengineering,UCSD,December2005.• DepartmentofBiomedicalEngineering,WashingtonUniversity,St.Louis,December2005.• IntegrativeBiologyMeeting,Oxford,UK,October2005(keynoteaddress).• EMBSmeeting,Shanghai,China,September2005.• 82ndAnnualMeetingofthePhysiologicalSocietyofJapan,Sendai,Japan,May2005.• ComputationalPhysiology:FromGenometoPhysiomeConference,SanDiego,March2005.• DepartmentofBiomedicalEngineering,VanderbiltUniversity,December2004.• DepartmentofPhysiology,NagoyaUniversity,Japan,November2004.• InternationalSymposiumon“LeadingProjectforBiosimulation”,Kyoto,Japan,November2004.• DefibrillationWorkshop,MedtronicInc.,Minneapolis,October2004• PhysiologicalSciencesMeeting,Oxford,UK,October2004.• IntegrativeBiologyMeeting,Oxford,UK,September2004.• RussianPhysiomeProjectMeeting,Ekaterinburg,Russia,September2004.• WorkshopCardiacCellularElectrophysiology:FromfunnycurrentstothecurrentPhysiome,Montpelier,

France,September2004.• SIAMAnnualMeeting,Portland,Oregon,July2004.• MedicalSchool,ShigaUniversity,ShigaPrefecture,Japan,July2004.• 31stInternationalCongressonElectrocardiology,Kyoto,Japan,June2004.• LaboratoryofPrecisionBiomedicalEngineering,TokyoUniversity,Tokyo,Japan,June2004.• FourthInternationalWorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiac

Function,CapdAil,France,June2004• Cardiostim2004,Nice,France,June2004• IntegrativeBiologyWorkshop,OxfordUniversity,UK,June2004.• OxfordInstituteforIndustrialandAppliedMathematics,OxfordUniversity,UK,June2004.• DepartmentofPhysiology,OxfordUniversity,UK,June2004.• NASPEHeartRhythmSocietyAnnualMeeting,debate,SanFrancisco,May2004• NASPEHeartRhythmSocietyAnnualMeeting,corecurriculum,SanFrancisco,May2004• WorkshoponMultiscaleComputationalModelsforBiomedicalResearch,UniversityofCaliforniaSanDiego,

March2004• DepartmentofMedicalPhysicsandBiophysics,UniversityofGraz,Austria,February2004• ScientificComputingandImagingInstitute,UniversityofUtah,November2003.• GordonConferenceonCardiacArrhythmiaMechanisms,NewHampshire,August2003.• SIAMAnnualMeeting,Montreal,Canada,June2003.• NorthAmericanSocietyforPacingandElectrophysiologyAnnualMeeting,clinicaltutorial,Washington,DC,

May2003.• IternationalSocietyforComputerizedElectrocardiologyAnnualMeeting,Snowbird,Utah,April2003• DepartmentofBiomedicalEngineering,UniversityofFlorida,April2003• DepartmentofElectricalEngineeringandComputerScience,UniversityofCalgary,March2003.• SIAMConferenceonComputationalScienceandEngineering,SanDiego,February2003.• DepartmentofPharmacology,TulaneSchoolofMedicine,NewOrleans,January2003.

• WorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiacFunction,Lausanne,Switzerland,December2002.

• OutstandingResearchAwardCeremony,TulaneSchoolofEngineering,NewOrleans,November2002• Medtronic,Inc.,October2002.• DepartmentofPhysiology,TulaneSchoolofMedicine,NewOrleans,October2002.• Mechano-ElectricFeedbackMeeting,Oxford,UK,September2002.• AspenInstituteofPhysics,Aspen,Colorado,August2002.• Cardiostimmeeting,Nice,France,June2002(twoinvitedtalks).• DepartmentofMathematics,UniversityofLiverpool,Liverpool,UK,March2002.• DepartamentodeIngenieriaElectronica,UniversidadPolitecnicadeValencia,Valencia,Spain,February2002.• SchoolofBiomedicalSciences,UniversityofLeeds,Leeds,UK,January2002• UniversityLaboratoryofPhysiology,UniversityofOxford,Oxford,UK,January2002.• Theintegratedheart:Cardiacstructureandfunction,Satellitemeetingofthe34thWorldCongressofthe

InternationalUnionofPhysiologicalScience,Queenstown,NewZealand,August2001.• CardiologyGrandRounds,DepartmentofMedicine,DivisionofCardiology,TulaneUniversity,July2001.• LivingStatePhysicsGroup,DepartmentofPhysics,VanderbiltUniversity,April2001.• DepartmentofCardiology,CornellMedicalSchool,April2001.• DepartmentofMathematics,SouthernMethodistUniversity,March2001.• WorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiacFunction,Lausanne,

Switzerland,December2000.• WorkshoponMappingandControlofComplexArrhythmia,Montreal,Oct.2000.• LivingStatePhysicsGroup,DepartmentofPhysics,VanderbiltUniversity,Sept.2000• WorldCongressonMedicalPhysicsandBiomedicalEngineering,Chicago,July2000.• NorthAmericanSocietyforPacingandElectrophysiology,clinicaltutorial,Washington,DC,May2000.• CardiacRhythmManagementLaboratory,UniversityofAlabama,Birmingham,December1999.• BiocomputingSymposium’99,MaunaLani,Hawaii,Jan.1999.• InternationalWorkshoponComputerSimulationandExperimentalAssessmentofElectricalCardiac

Function,Lausanne,Switzerland,Dec.1998.• 20thAnnualInternationalConferenceoftheIEEE/EMBS,HongKong,Oct-Nov,1998.• ClevelandClinicFoundation,Sept.1998.• CardiacRhythmManagementLaboratory,UniversityofAlabama,Birmingham,August1998.• InternationalSocietyforComputerizedElectrocardiology,Keystone,Colorado,April1998.• AnnualMeetingoftheBMES,SanDiego,October1997.• DepartmentofBiomedicalEngineering,UniversityofMemphis,Memphis,TN,July1997.• CardiacRhythmManagementLaboratory,UniversityofAlabama,Birmingham,July1997.• Workshop“ComputationBiologyoftheHeart”,UniversityofCaliforniaatSanDiego,June1997.• Medtronic,Inc.,June1997.• DepartmentofBiomedicalEngineering,UniversityofMemphis,Memphis,TN,February1997.• DepartmentofPhysiology,TulaneUniversityMedicalCenter,February1997.• IEEE/EMBS17thAnnualInternationalConference,Amsterdam,TheNetherlands,November,1996.• AucklandUniversityMedicalCenter,Auckland,NewZealand,July1996.• UniversityofTechnology,Sydney,Australia,July1996.• TasmaniaMedicalCenter,Hobart,Australia,July1996.• DepartmentofEngineeringScience,AucklandUniversity,Auckland,NewZealand,June1996.• FirstInternationalConferenceonBioelectromagnetism,Tampere,Finland,June1996.• DefibrillationWorkshop,Birmingham,Alabama,April1996.• IEEE/EMBS16thAnnualInternationalConference,Montreal,Canada,September,1995(twotalks).• DefibrillationWorkshop,DurhamNC,April1995.• AnnualFallMeetingoftheBMES,Tempe,Arizona,October1994.• DepartmentofBiomedicalEngineering,UniversityofMemphis,Memphis,TN,July1994.• DepartmentofBiomedicalEngineering,TulaneUniversity,NewOrleans,LA,June1994.• DefibrillationWorkshop,DurhamNC,April1994.• DepartmentofBiomedicalEngineering,DukeUniversity,DurhamNC,March1994.• CrayConferenceonHigh-PerformanceComputinginBiomedicalResearch,ResearchTrianglePark,NC,

October,1992.• IEEE/EMBS13thAnnualInternationalConference,Orlando,Fla.,November,1991.

• AnnualMeetingoftheBMES,Charlottesville,Va.,October1991.• ErasmusUniversity,Rotterdam,TheNetherlands,September1991.• CVRTI,TheUniversityofUtah,SaltLakeCity,Utah,August1991.• DepartmentofBiomedicalEngineering,DukeUniversity,Durham,NC,October1990.• DepartmentofPhysiologyTheUniversityofArizona,Tucson,Az.,November,1987.• DepartmentofPhysiology,UniversityofAlberta,Calgary,Canada.June1987.RecentlyintheNewshttps://cardiacrhythmnews.com/imaging-based-simulations-for-predicting-sudden-death-and-guiding-ablation/https://engineering.jhu.edu/magazine/2017/12/so-long-trial-error/#.WiHHqYZOm7ohttps://hub.jhu.edu/2017/11/17/marcc-computer-center-boosts-hopkins-research/https://twitter.com/UMR4NIH/status/930926154537504768(picturesfromCapitolHillbriefing)http://bit.ly/2AKOcZ5ATPvideo(videooftheCapitolHillbriefing)https://www.facebook.com/unitedformedicalresearch/videos/529300827425719/(CapitolHillbriefing)https://www.youtube.com/watch?v=xCYuZcinid4https://engineering.jhu.edu/magazine/2017/05/the-heart-as-art/#.WSRFohMrLMUhttp://www.amazingthingspodcast.com/episodes/2017/3/13/natalia-trayanova-using-a-personalized-virtual-heart-to-prevent-sudden-cardiac-deathhttp://tedxjhu.com/20162017/http://www.hopkinsmedicine.org/news/publications/hopkins_medicine_magazine/features/winter-2017/imaging-and-infastructurehttps://med.stanford.edu/news/all-news/2016/09/newborns-deadly-heart-arrhythmia-caused-by-mosaic-of-mutant-cells.htmlhttp://www.healthcanal.com/blood-heart-circulation/heart-disease/74870-newborn%E2%80%99s-deadly-heart-arrhythmia-caused-by-mosaic-of-mutant-cells.htmlhttp://www.pnas.org/content/113/41/11373.fullhttp://releases.jhu.edu/2016/09/12/light-tames-lethal-heart-disorders-in-mice-and-virtual-humans/http://hub.jhu.edu/2016/09/12/heart-arrhythmia-healing-light/http://finance.yahoo.com/news/optical-defibrillator-shows-promise-less-171040981.htmlhttp://www.digitaltrends.com/cool-tech/optical-defibrillator/http://www.huffingtonpost.co.uk/entry/light-beams-heart-treatment_uk_57d7c7ece4b0a32e2f6c8f32https://www.ivanhoe.com/medical-breakthroughs/cardiovascular/light-puts-hearts-rhythm-medicines-next-big-thing/http://www.wfmz.com/health/health-beat/health-beat-light-puts-hearts-in-rhythm/222704212http://www.wndu.com/content/news/Researchers-looking-to-help-those-with-heart-arrhythmia-407649795.htmlhttp://www.medgadget.com/2016/09/optical-defibrillation-soothe-arrhythmic-hearts.htmlhttps://www.ivanhoe.com/?p=2065&preview=1&_ppp=816514a3e1https://www.dotmed.com/news/story/32907http://www.globalfuturist.org/2016/09/new-breakthrough-restarts-hearts-with-light/http://www.ndtv.com/health/gentle-light-beams-may-treat-lethal-heart-condition-study-1458165https://www.engadget.com/2016/09/14/future-heart-defibrillators-could-save-lives-with-light-pulses/http://www.upi.com/Health_News/2016/09/13/Light-beams-may-replace-electricity-for-heart-disorder-treatment/4031473781431http://www.labroots.com/trending/cardiology/4070/optical-defibrillation-hearthttp://www.futurity.org/arrhythmia-light-optogenetics-1245752-2/http://medicalxpress.com/news/2016-09-termination-lethal-arrhythmia.htmlhttp://www.pubniche.com/papyrus/ZG9pOjoxMC4xMTcyL0pDSTg4OTUw/?utm_content=buffer4b2af&utm_medium=social&utm_source=twitter.com&utm_campaign=bufferhttp://www.technology.org/2016/09/13/light-tames-lethal-heart-disorders-mice-virtual-humans/http://electronics360.globalspec.com/article/7329/scientists-treat-arrhythmias-with-light-beams-instead-of-electrical-shockshttp://newatlas.com/optical-defibrillation/45442/

http://www.massdevice.com/light-based-arrhythmia-treatment-skips-shocks/http://www.valuewalk.com/2016/09/fix-heartbeat-replace-shocks-red-light/http://www.dailymail.co.uk/health/article-3785725/Could-end-defibrillators-Technique-using-gentle-light-waves-instead-electric-shocks-stops-life-threatening-heart-failure.htmlhttp://www.itechpost.com/articles/29233/20160913/light-beams-heart-disease-research.htmhttp://esciencenews.com/articles/2016/09/13/termination.lethal.arrhythmia.with.lighthttp://www.medgadget.com/2016/09/optical-defibrillation-soothe-arrhythmic-hearts.htmlhttps://www.sciencedaily.com/releases/2016/09/160912173836.htmhttp://www.andhravilas.net/en/Gentle-beams-of-light-can-treat-lethal-heart-disordershttp://www.upi.com/Health_News/2016/09/13/Light-beams-may-replace-electricity-for-heart-disorder-treatment/4031473781431http://exceptionmag.com/22073/to-fix-heartbeat-replace-shocks-with-red-light/https://scienceblog.com/487851/light-tames-lethal-heart-disorders-mice-virtual-humans/http://www.sciencecodex.com/light_tames_lethal_heart_disorders_in_mice_and_virtual_humans-190021http://medicalphysicsweb.org/cws/article/research/66540http://blogs.voanews.com/science-world/2016/09/14/light-not-shock-restarts-heart-bees-nest-in-sandstone-5-second-rule/http://www.osa-opn.org/news/defib/http://healthcaretechnology.com/topics/technology-management/light-beams-help-patients-deadly-heart-disorderhttp://www.totalhealth.co.uk/blog/gentle-beams-light-could-replace-electric-shocks-treatment-heart-disordershttp://cardiacrhythmnews.com/pre-clinical-study-indicates-light-could-be-used-to-treat-ventricular-arrhythmias/http://www.osa-opn.org/home/newsroom/2016/september/lighting_the_heart_back_to_normal_rhythm/http://blogs.voanews.com/science-world/2016/09/14/light-not-shock-restarts-heart-bees-nest-in-sandstone-5-second-rule/http://www.cardiovascularbusiness.com/topics/structural-heart/light-therapy-could-offer-same-benefits-electric-shock-defibrillation-after-heart-attackhttp://www.aerzteblatt.de/nachrichten/70485https://www.theguardian.com/science/2016/may/10/virtual-hearts-help-doctors-spot-patients-most-at-risk-from-fatal-arrhythmias?CMP=share_btn_fb#_=_https://thepathologist.com/issues/0716/a-virtual-vision-of-the-future/http://www.nature.com/nrcardio/journal/vaop/ncurrent/full/nrcardio.2016.86.htmlhttp://www.healthcare-in-europe.com/en/article/16978-the-virtual-heart-arrhythmia-risk-predictor.htmlhttp://news.discovery.com/tech/apps/virtual-heart-attack-tech-predicts-death-160510.htmhttp://hub.jhu.edu/2016/05/10/arrhythmia-3-d-imaging-heart/http://spectrum.ieee.org/the-human-os/biomedical/imaging/with-a-patients-virtual-heart-doctors-predict-cardiac-arresthttps://medicalresearch.com/author-interviews/personalized-virtual-map-of-heart-allows-for-better-prediction-of-sudden-death-risk/24264/http://www.mirror.co.uk/news/world-news/fatal-heart-attacks-could-become-7944486http://aimbe.org/college-of-fellows/COF-1001/https://www.dotmed.com/news/story/30835http://medicalxpress.com/news/2016-05-personalized-virtual-heart-sudden-cardiac.htmlhttp://www.medgadget.com/2016/05/computer-model-hearts-taken-from-mri-scans-predict-sudden-cardiac-death.htmlhttp://www.medimaging.net/new-3d-tool-predicts-patients-at-higher-risk-from-lethal-arrhythmias/articles/294764294/new-3d-tool-predicts-patients-at-higher-risk-from-lethal-arrhythmias.htmlhttp://www.techtimes.com/articles/157511/20160511/computer-generated-virtual-heart-may-predict-cardiac-risk-in-patients-with-arrhythmias.htmhttp://www.news-medical.net/news/20160511/Non-invasive-3-D-virtual-heart-assessment-tool-can-help-predict-arrhythmia-risk-in-patients.aspxhttp://computer.expressbpd.com/news/personalized-virtual-heart-predicts-the-risk-of-sudden-cardiac-death/17464/http://www.skynews.com.au/tech/technews/2016/05/11/virtual-heart-can-predict-cardiac-risk.html

http://www.ibtimes.co.uk/virtual-heart-predicts-risk-sudden-cardiac-death-arrhythmia-1559326http://www.newseveryday.com/articles/41554/20160512/virtual-heart-assessment-tool-accurately-pinpoints-fatal-arrhythmia.htmhttp://www.innovationessence.com/personalized-virtual-predicts/http://www.bignewsnetwork.com/news/243962429/3d-virtual-heart-to-predict-sudden-cardiac-death-riskhttp://www.parentherald.com/articles/42614/20160511/3d-virtual-heart-predicts-risk-arrythmia-induced-sudden-cardiac-death.htmhttps://www.sciencedaily.com/releases/2016/05/160510124506.htmhttp://www.express.co.uk/life-style/health/668940/Virtual-3D-hearts-Computer-models-organ-help-surgeons-save-liveshttp://www.pulseheadlines.com/3d-virtual-device-diagnoses-heart-fatal-arrhythmias/30465/http://www.ibtimes.com.au/scientists-develop-virtual-heart-accurately-predicts-risk-sudden-cardiac-death-1515230http://technical.ly/baltimore/2016/05/13/3-ways-jhu-researchers-making-surgery-easier/http://www.natureworldnews.com/articles/22186/20160516/scientists-develop-3-d-virtual-heart-assessment-tool-help-diagnose.htmhttp://www.genengnews.com/gen-news-highlights/personalized-virtual-heart-predicts-deadly-arrhythmias/81252714http://medcitynews.com/2016/05/virtual-heart-risk-arrhythmias/http://www.futurity.org/3d-virtual-heart-1160012/http://www.hngn.com/articles/199174/20160511/3-d-virtual-heart-assessment-tool-pinpoints-patients-risk-fatal-arrhythmia.htmhttp://www.dicardiology.com/content/personalized-virtual-heart-predicts-risk-sudden-cardiac-deathhttp://www.healthimaging.com/topics/cardiovascular/3d-virtual-heart-helps-identify-potentital-defibrillator-implant-patientshttp://healthtechinsider.com/2016/05/13/personalized-virtual-heart-predicts-arrhythmia/http://www.laboratoryequipment.com/news/2016/05/personalized-virtual-heart-predicts-sudden-cardiac-death-riskhttps://healthtimes.com.au/hub/cardiology/5/news/aap/virtual-heart-simulation-can-predict-cardiac-risk/1640/http://www.somersetlive.co.uk/personal-3d-models-patients-hearts-created-help/story-29253646-detail/story.htmlhttp://www.modernreaders.com/3d-heart-simulation-arrhythmias/45906/melissa-taylorhttp://engineering.jhu.edu/magazine/2016/01/the-need-for-speed/#.VqG5DfEds68http://hub.jhu.edu/at-work/2015/12/03/on-sabbatical-trayanovahttp://www.bme.jhu.edu/about/awards-achievements.php?id=71http://wtop.com/health/2015/07/a-new-way-to-fix-a-broken-heart-virtual-reality-revolutionizes-cardiac-care/http://www.hopkinsmedicine.org/news/publications/insight/features/june-2015/high-powered-computing-center-boosts-big-data-analysishttp://www.seas.gwu.edu/dr-natalia-trayanova-discusses-%E2%80%9Cyour-personal-virtual-heart%E2%80%9D-2015-frank-howard-lecturehttps://rising.jhu.edu/computational-hearthttps://www.youtube.com/watch?v=D2CwGCR1c94&feature=youtu.behttp://www.bme.jhu.edu/news-events/news-highlights.php?id=470http://spectrum.ieee.org/biomedical/imaging/custom-cardiology-a-virtual-heart-for-every-patienthttp://www.bme.jhu.edu/news-events/news-highlights.php?id=470http://www.hopkinsmedicine.org/news/publications/pediatric_heart_newshttp://www.bme.jhu.edu/news-events/news-highlights.php?id=446http://www.the-scientist.com/?articles.view/articleNo/38900/title/Opinion--Model-Organ/http://releases.jhu.edu/2013/09/30/high-risk-high-reward-research-grants-from-the-nih-go-to-two-johns-hopkins-scientists/http://www.bme.jhu.edu/news-events/news-highlights.php?id=401http://touch.baltimoresun.com/#section/-1/article/p2p-78204143/http://programs.wypr.org/podcast/illuminating-heart-and-helping-it-beathttp://www.slate.com/blogs/future_tense/2013/08/30/stopping_heart_attacks_with_light_optogenetics_resear

chers_see_opsins_as.htmlhttp://www.tbo.com/health/light-could-replace-shock-to-regulate-hearts-20131207/http://motherboard.vice.com/blog/the-pacemakers-of-the-future-will-keep-your-heart-beating-with-lighthttp://www.hopkinsmedicine.org/news/media/releases/virtual_heart_precision_guides_defibrillator_placement_in_children_with_heart_disease_https://www.hopkinschildrens.org/newsDetail.aspx?id=12488http://www.bme.jhu.edu/news-events/news-highlights.php?id=394http://engineering.jhu.edu/news/2013/08/28/using-light-to-restore-healthy-heartbeats/http://eng.jhu.edu/wse/magazine-summer-13/item/shes-got-the-beat/http://www.hopkinsmedicine.org/news/publications/dome/dome_may_2013/mapping_the_heart_http://connect.siam.org/the-beat-goes-on-modeling-the-human-hearthttp://releases.jhu.edu/2012/11/01/computational-medicine/http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/about_us/scientists/natalia_trayanova.htmlhttp://gazette.jhu.edu/2012/05/07/at-bme\%E2\%80\%99s-50th-trayanova-named-inaugural-sachs-professor/http://engineering.jhu.edu/news/2012/05/07/1924/#.UhlAt7zwH0Uhttp://www.nbcnews.com/id/44704817/ns/health-heart_health/#.Uhk_YLzwH0Uhttp://www.scientificamerican.com/article.cfm?id=computer-heart-simulation-arrhythmia#commentFormhttp://www.icm.jhu.edu/news/files/individual.htmlhttp://www.hopkinsmedicine.org/news/media/releases/instead_of_defibrillators_painful_jolt_there_may_be_a_gentler_way_to_prevent_sudden_death_according_to_hopkins_scientistshttp://eng.jhu.edu/wse/magazine-fall-11/item/data-driven/P2/RecentVideos:https://vimeo.com/johnshopkins/review/182861038/28d775bfd9http://hub.jhu.edu/2016/09/12/heart-arrhythmia-healing-light/https://www.facebook.com/johnshopkinsuniversity/videos/10153932881757217/?pnref=storyhttps://vimeo.com/johnshopkins/review/181951935/720e3cff41https://www.instagram.com/p/BKiv6X_hLFH/https://www.youtube.com/watch?v=i1ySpe_jfjchttp://www.bitelevision.com/dve-balgarki-v-sasht-s-prinos-kam-svetovnata-nauka-i-meditsina/https://www.youtube.com/watch?v=D2CwGCR1c94&feature=youtu.behttps://www.youtube.com/watch?feature=player_embedded&v=caEsQrVVTIUhttp://engineering.jhu.edu/videos/natalia-trayanova-computational-simulations-of-the-heart/#.UhlAkLzwH0Uhttps://www.youtube.com/watch?v=J15rjxBOqHchttps://www.youtube.com/watch?v=T5mrAMQ_AJEhttps://www.youtube.com/watch?v=Uw2csTpAf7shttp://vimeo.com/71735602https://www.youtube.com/watch?v=J15rjxBOqHc&list=PLd_5BzGlfpgoXT_g8mwcsEBdg2tcQ877xhttps://www.youtube.com/watch?v=m7uin5f5T60https://www.youtube.com/watch?v=tXpPyrBsPaUhttps://www.youtube.com/watch?v=D2CwGCR1c94https://vimeo.com/71735602https://www.youtube.com/watch?v=dDjs-yC5mk0https://www.youtube.com/watch?v=caEsQrVVTIUhttps://www.youtube.com/watch?v=RzwZ6Af1v1Uhttps://www.youtube.com/watch?v=Uw2csTpAf7s

BibliographyCurrentH-factor:54BookEditorCardiacDefibrillation:Mechanisms,ChallengesandImplications,InTechPublishing,2011

PopularScience-styleArticlesN.Trayanova.YourPersonalVirtualHeart,IEEESpectrum,Novemberpp.35-40,2014.

Op-edpieces

N.Trayanova.ModelOrgan:Howcomputermodelingcanimprovecardiaccare.TheScientist,articleNo38900,January17,2014

PodcastsN.Trayanova.AmazingThings:UsingaPersonalized,VirtualHearttoPreventSuddenCardiacDeathPeer-ReviewedJournalPublications

1. BoylePM,KarathanosT,TrayanovaN.CardiacOptogenetics:2018,JACC:ClinElectrophys. 2018,DOI:10.1016/j.jacep.2017.12.006

2. CochetH,DuboisR,YamashitaS,AlJefairiN,BerteB,SellalJB,HooksD,FronteraA,AmraouiS,ZemouraA,DenisA,DervalN,SacherF,CorneloupO,LatrabeV,Clément-GuinaudeauS,RelanJ,ZahidS,BoylePM,TrayanovaN,BernusO,MontaudonM,LaurentF,HociniM,HaïssaguerreM,JaïsP,RelationshipBetweenFibrosisDetectedonLateGadolinium-EnhancedCardiacMagneticResonanceandRe-EntrantActivityAssessedWithElectrocardiographicImaginginHumanPersistentAtrialFibrillation,JACC:ClinElectrophys.4,2018,http://dx.doi.org/10.1016/j.jacep.2017.07.019(accompaniedbyaneditorial).

3. BoylePM,MurphyMJ,KarathanosTV,ZahidS,BlakeRC3rd,TrayanovaN.Terminationofre-entrantatrialtachycardiaviaoptogeneticstimulationwithoptimizedspatialtargeting:insightsfromcomputationalmodels,JPhysiol.2018Jan15;596(2):181-196.

4. KangC,BadiceanuA,BrennanJA,GloschatC,QiaoY,TrayanovaN,EfimovIR.β-adrenergicstimulationaugmentstransmuraldispersionofrepolarizationviamodulationofdelayedrectifiercurrentsIKsandIKrinthehumanventricle.SciRep.2017Nov21;7(1):15922.

5. HeikhmakhtiarAK,RyuAJ,ShimEB,SongKS,TrayanovaN,LimKM.InfluenceofLVADfunctiononmechanicalunloadingandelectromechanicaldelay:asimulationstudy.MedBiolEngComput.2017Nov3.doi:10.1007/s11517-017-1730-y.[Epubaheadofprint]

6. KimYS,YuniartiAR,SongKS,TrayanovaN,ShimEB,LimKM.Computationalanalysisoftheeffectofmitralandaorticregurgitationonthefunctionofventricularassistdevicesusing3Dcardiacelectromechanicalmodel.MedBiolEngComput.2017Oct28.doi:10.1007/s11517-017-1727-6.[Epubaheadofprint]

7. KimCH,SongKS,TrayanovaN,LimKM.Computationalpredictionoftheeffectsoftheintra-aorticballoonpumponheartfailurewithvalvularregurgitationusinga3Dcardiacelectromechanicalmodel,MedBiolEngComput.2017Oct23.doi:10.1007/s11517-017-1731-x.[Epubaheadofprint]

8. DengD,MurphyMJ,HakimJB,FranceschiWH,ZahidS,PashakhanlooF,TrayanovaN,BoylePM.Sensitivityofreentrantdriverlocalizationtoelectrophysiologicalparametervariabilityinimage-basedcomputationalmodelsofpersistentatrialfibrillationsustainedbyafibroticsubstrate,Chaos.2017Sep;27(9):093932.doi:10.1063/1.5003340.

9. CerroneM,MontnachJ,LinX,ZhaoYT,ZhangM,Agullo-PascualE,Leo-MaciasA,AlvaradoFJ,DolgalevI,KarathanosTV,MalkaniK,VanOpbergenCJM,vanBavelJJA,YangHQ,VasquezC,TesterD,FowlerS,LiangF,RothenbergE,HeguyA,MorleyGE,CoetzeeWA,TrayanovaN,AckermanMJ,vanVeenTAB,ValdiviaHH,DelmarM.Plakophilin-2isrequiredfortranscriptionofgenesthatcontrolcalciumcyclingandcardiacrhythm,NatureCommunications.2017Jul24;8(1):106.doi:10.1038/s41467-017-00127-0.

10. TrayanovaN,PashakhanlooF,WuKC,HalperinHR.Imaging-BasedSimulationsforPredicting

SuddenDeathandGuidingVentricularTachycardiaAblation.CircArrhythmElectrophysiol.2017Jul;10(7).pii:e004743.doi:10.1161/CIRCEP.117.004743.

11. ZileMA,TrayanovaN.MyofilamentproteindynamicsmodulateEADformationinhumanhypertrophiccardiomyopathy,ProgBiophysMolBiol.2017Nov;130(PtB):418-428.doi:10.1016/j.pbiomolbio.2017.06.015.

12. DhamalaJ,ArevaloHJ,SappJ,HoracekM,WuKC,TrayanovaN,WangL.SpatiallyAdaptiveMulti-ScaleOptimizationforLocalParameterEstimationinCardiacElectrophysiology.IEEETransMedImaging.2017Sep;36(9):1966-1978.doi:10.1109/TMI.2017.2697820.

13. BoylePM,ZahidS,TrayanovaN.Usingpersonalizedcomputermodelstocustom-tailorablationproceduresforatrialfibrillationpatients:arewethereyet?ExpertRevCardiovascTher.2017Apr11.doi:10.1080/14779072.2017.1317593.

14. PashakhanlooF,HerzkaD,MoriS,ZvimanM,HalperinH,GaiN,BluemkeD,TrayanovaN,McVeighE.Submillimeterdiffusiontensorimagingandlategadoliniumenhancementcardiovascularmagneticresonanceofchronicmyocardialinfarction,JournalofCardiovascularMagneticResonance19:9,2017,DOI:10.1186/s12968-016-0317-3

15. BoylePM,ZahidS,TrayanovaN.Towardspersonalizedcomputationalmodellingofthefibroticsubstrateforatrialarrhythmia,Europace18(suppl4):iv136-iv145,2016,doi:10.1093/europace/euw358

16. DengD;ArevaloHJ;PrakosaA;CallansDJ;TrayanovaN,Afeasibilitystudyofarrhythmiariskpredictioninpatientswithmyocardialinfarctionandpreservedejectionfraction,Europace18(suppl4):iv60-iv66,2016,doi:10.1093/europace/euw351

17. RoneyCH,BayerJD,ZahidS,MeoM,BoylePM,TrayanovaN,HaïssaguerreM,DuboisR,CochetH,VigmondEJ,ModellingmethodologyofatrialfibrosisaffectsrotordynamicsandelectrogramsRestrictedAccessEuropace18(suppl4):iv146-iv155,2016,doi:http://dx.doi.org/10.1093/europace/euw365

18. KarathanosTV,BoylePM,TrayanovaN.Light-basedapproachestocardiacarrhythmiaresearch:Frombasicsciencetotranslationalapplications.ClinMedInsightsCardiol.10(Suppl1):47-60,2016.

19. ChangKC,TrayanovaN.Mechanismsofarrhythmogenesisrelatedtocalcium-drivenalternansinamodelofhumanatrialfibrillation.SciRepNov4;6:36395.doi:10.1038/srep36395,2016

20. PriestJR,GawadC,KahligKM,YuJK,O'HaraT,BoylePM,RajamaniS,ClarkMJ,GarciaST,CeresnakS,HarrisJ,BoyleS,DeweyFE,Malloy-WaltonL,DunnK,GroveM,PerezMV,NeffNF,ChenR,MaedaK,DubinA,BelardinelliL,WestJ,AntolikC,MacayaD,QuertermousT,TrayanovaN,QuakeSR,AshleyEA.Earlysomaticmosaicismisararecauseoflong-QTsyndrome,ProcNatlAcadSciUSA.113:11555-11560,2016(accompaniedbyapressrelease;storypickedupbyanumberofnationalandinternationalnewoutlets;featuredvideoonPNASwebpage).

21. BruegmannT,BoylePM,VogtCC,KarathanosTV,ArevaloHJ,FleischmannBK,TrayanovaN,SasseP.Optogeneticdefibrillationterminatesventriculararrhythmiainmouseheartsandhumansimulations,JClinInvest.126:3894-3904,2016(accompaniedbyapressreleaseandavideoonYouTubeandFacebookfromJHU;storypickedupbyanumberofnationalandinternationalnewoutlets,includinganinterviewbytheEconomist,andTVnewsbyanumberofTVchannelsaroundthecountry).

22. Sanchez-AlonsoJL,BhargavaA,O'HaraT,GlukhovAV,SchobesbergerS,BhogalN,SikkelMB,MansfieldC,KorchevYE,LyonAR,PunjabiPP,NikolaevVO,TrayanovaN,GorelikJ.Microdomain-SpecificModulationofL-TypeCalciumChannelsLeadstoTriggeredVentricularArrhythmiainHeartFailure.CircRes.119:944-0955,2016.

23. ZghaibT,IpekEG,ZahidS,BalouchMA,MisraS,AshikagaH,BergerRD,MarineJE,SpraggDD,ZimmermanSL,ZipunnikovV,TrayanovaN,CalkinsH,NazarianS.Associationofleftatrialepicardialadiposetissuewithelectrogrambipolarvoltageandfractionation:Electrophysiologicsubstratesforatrialfibrillation.HeartRhythm.2016Aug19.pii:S1547-5271(16)30673-7.doi:10.1016/j.hrthm.2016.08.030.[Epubaheadofprint]

24. ArevaloHJ,BoylePM,TrayanovaN.Computationalrabbitmodelstoinvestigatetheinitiation,perpetuation,andterminationofventriculararrhythmia,ProgBiophysMolBiol.Jul;121(2):185-194,2016

25. BayerJD,LalaniGG,VigmondEJ,NarayanSM,TrayanovaN.Mechanismslinkingelectricalalternansandclinicalventriculararrhythmiainhumanheartfailure,HeartRhythm.13:1922-1931,2016.

26. HJArevalo,FVadakkumpadan,EGuallar,AJebb,PMalamas,KCWu,NTrayanova.Arrhythmiarisk

stratificationofpatientsaftermyocardialinfarctionusingpersonalizedheartmodels.NatureCommunications.May10;7:11437.doi:10.1038/ncomms11437,2016(accompaniedbyapressreleasefromJHU;storypickedupbyover60nationalandinternationalnewoutlets,includinganarticleintheGuardianandaninterviewonBBC.ChosenasNature’sfeaturedarticle,andaccompaniedbyareviewinNatureReviewsCardiology)

27. ZhangY,BarocasVH,BerceliSA,ClancyCE,EckmannDM,GarbeyM,KassabGS,LochnerDR,McCullochAD,Tran-Son-TayR,TrayanovaN.Multi-scaleModelingoftheCardiovascularSystem:DiseaseDevelopment,Progression,andClinicalIntervention,AnnBiomedEng.44(9):2642-2660,2016.

28. ZahidS,WhyteKN,SchwarzEL,BlakeRC3rd,BoylePM,ChrispinJ,PrakosaA,IpekEG,PashakhanlooF,HalperinHR,CalkinsH,BergerRD,NazarianS,TrayanovaN.Feasibilityofusingpatient-specificmodelsandthe"minimumcut"algorithmtopredictoptimalablationtargetsforleftatrialflutter.HeartRhythm.13:1687-1698,2016

29. FukumotoK,HabibiM,IpekEG,ZahidS,KhurramIM,ZimmermanSL,ZipunnikovV,SpraggD,AshikagaH,TrayanovaN,TomaselliGF,RickardJ,MarineJE,BergerRD,CalkinsH,NazarianS.AssociationofLeftAtrialLocalConductionVelocityWithLateGadoliniumEnhancementonCardiacMagneticResonanceinPatientsWithAtrialFibrillation.CircArrhythmElectrophysiol.2016Mar;9(3):e002897.doi:10.1161/CIRCEP.115.002897.

30. TrayanovaN,ChangKC.Howcomputersimulationsofthehumanheartcanimproveanti-arrhythmiatherapy.JPhysiol.594:2483-2502,2016.

31. PashakhanlooF,HerzkaDA,AshikagaH,MoriS,GaiN,BluemkeDA,TrayanovaN,McVeighER.MyofiberArchitectureoftheHumanAtriaasRevealedbySubmillimeterDiffusionTensorImaging,CircArrhythmElectrophysiol.2016Apr;9(4):e004133.doi:10.1161/CIRCEP.116.004133.

32. ZahidS,CochetH,BoylePM,SchwarzEL,WhyteKN,VigmondEJ,DuboisR,HociniM,HaïssaguerreM,JaïsP,TrayanovaN.Patient-derivedmodelslinkre-entrantdriverlocalizationinatrialfibrillationtofibrosisspatialpattern,CardiovascRes.110(3):443-454,2016

33. KarathanosTV,PMBoyle,JDBayer,DWang,NTrayanova,OpsinSpectralSensitivityDeterminestheEffectivenessofOptogeneticTerminationofVentricularFibrillationintheHumanHeart:ASimulationStudy,JPhysiol2016Mar4.doi:10.1113/JP271739.[Epubaheadofprint]

34. Haissaguerre,M.,Shah,A.J.,Cochet,H.,Hocini,M.,Dubois,R.,Efimov,I.,Vigmond,E.,Bernus,O.,Trayanova,N.Intermittentdriversanchoringtostructuralheterogeneitiesasamajorpathophysiologicmechanismofhumanpersistentatrialfibrillation.JPhysiol.594(9):2387-2398,2016

35. ChrispinJ,GucukIpekE,ZahidS,PrakosaA,HabibiM,SpraggD,MarineJE,AshikagaH,RickardJ,TrayanovaN,ZimmermanSL,ZipunnikovV,BergerRD,CalkinsH,NazarianS.Lackofregionalassociationbetweenatriallategadoliniumenhancementoncardiacmagneticresonanceandatrialfibrillationrotors,HeartRhythm.13(3):654-660,2016

36. UkwattaE,ArevaloH,LiK,YuanJ,QiuW,MalamasP,WuKC,TrayanovaN,VadakkumpadanF.MyocardialInfarctSegmentationfromMagneticResonanceImagesforPersonalizedModelingofCardiacElectrophysiology,IEEETransMedImaging.35:1408-19,2016

37. ZileMA,TrayanovaN.Rate-dependentforce,intracellularcalcium,andactionpotentialvoltagealternansaremodulatedbysarcomerelengthandheartfailureinduced-remodelingofthinfilamentregulationinhumanheartfailure:Amyocytemodelingstudy,ProgBiophysMolBiol.120(1-3):270-280,2016.

38. MolitorisJM,PaliwalS,SekarRB,BlakeR,ParkJ,TrayanovaN,TungL,LevchenkoA.Preciselyparameterizedexperimentalandcomputationalmodelsoftissueorganization,IntegrBiol8:230-242,2016.

39. LandS,GurevV,ArensS,AugustinCM,BaronL,BlakeR,BradleyC,CastroS,CrozierA,FavinoM,FastlTE,FritzT,GaoH,GizziA,GriffithBE,HurtadoDE,KrauseR,LuoX,NashMP,PezzutoS,PlankG,RossiS,RuprechtD,SeemannG,SmithNP,SundnesJ,RiceJJ,TrayanovaN,WangD,JennyWangZ,NiedererSA.Verificationofcardiacmechanicssoftware:benchmarkproblemsandsolutionsfortestingactiveandpassivematerialbehavior,ProcMathPhysEngSci;471(2184):20150641,2015

40. Ukwatta,E.,Arevalo,H.,Rajchl,M.,White,J.,Pashakhanloo,F.,Prakosa,A.,Herzka,D.A.,McVeigh,E.,Lardo,A.C.,Trayanova,N.,Vadakkumpadan,F.(2015).Image-basedreconstructionofthree-dimensionalmyocardialinfarctgeometryforpatient-specificmodelingofcardiacelectrophysiology.MedicalPhysics,42(8),4579-90.

41. UkwattaE,RajchlM,WhiteJ,PashakhanlooF,HerzkaDA,McVeighE,LardoAC,TrayanovaN,VadakkumpadanF.Image-basedReconstructionof3DMyocardialInfarctGeometryforPatientSpecificApplications,ProcSPIEIntSocOptEng.21;9413.pii:94132W,2015

42. AmbrosiCM,BoylePM,ChenK,TrayanovaN,EntchevaE.Optogenetics-enabledassessmentofviralgeneandcelltherapyforrestorationofcardiacexcitability,SciRep.2015;5:17350.doi:10.1038/srep17350.

43. DengD,ArevaloH,PashakhanlooF,PrakosaA,AshikagaH,McVeighE,HalperinH,TrayanovaN.Accuracyofpredictionofinfarct-relatedarrhythmiccircuitsfromimage-basedmodelsreconstructedfromlowandhighresolutionMRI,FrontPhysiol.2015Oct13;6:282.doi:10.3389/fphys.2015.00282.eCollection2015.

44. Deng,D.,Arevalo,H.,Pashakhanloo,F.,Prakosa,A.,Ashikaga,H.,McVeigh,E.,Halperin,H.,Trayanova,N.(2015).Accuracyofpredictionofinfarct-relatedarrhythmiccircuitsfromimage-basedmodelsreconstructedfromlowandhighresolutionMRI.FrontPhysiol,6,282.

45. ChoiYJ,ConstantinoJ,VedulaV,TrayanovaN,MittalR.,ANewMRI-BasedModelofHeartFunctionwithCoupledHemodynamicsandApplicationtoNormalandDiseasedCanineLeftVentricles,FrontBioengBiotechnol.2015Sep23;3:140.doi:10.3389/fbioe.2015.00140.eCollection2015.

46. NSmith,NTrayanova.Computationalmodelsofheartdisease.DrugDiscovToday:DisModel,http://dx.doi.org/10.1016/j.ddmod.2014.12.002,2015

47. UkwattaE,ArevaloH,LiK,YuanJ,QiuW,MalamasP,WuKC,TrayanovaNA,VadakkumpadanF.48. MyocardialInfarctSegmentationfromMagneticResonanceImagesforPersonalizedModelingof

CardiacElectrophysiology,IEEETransMedImaging.2015Dec25.doi:10.1109/TMI.2015.2512711.[Epubaheadofprint]

49. PingP,GustafssonÅB,BersDM,BlatterLA,CaiH,JahangirA,KellyD,MuoioD,O'RourkeB,RabinovitchP,TrayanovaN,VanEykJ,WeissJN,WongR,SchwartzLongacreL.HarnessingthePowerofIntegratedMitochondrialBiologyandPhysiology:ASpecialReportontheNHLBIMitochondriainHeartDiseasesInitiative,CircRes.117(3):234-238,2015

50. PBoyle,TKarathanos,EEntcheva,NTrayanova.Computationalmodelingofcardiacoptogenetics:Methodologyoverviewandreviewoffindingsfromsimulations.ComputBiolMed.65:200-208,2015

51. KhrapkoK,NTrayanova,NattelS.Modelingtheagingheart:fromlocalrespiratorydefectstoglobalrhythmdisturbances.CellMetab21(5):662-663.2015

52. KMcDowell,SZahid,FVadakkumpadan,JBlauer,R.MacLeod,NTrayanova,Virtualelec-trophysiologicalstudyofatrialfibrillationinfibroticremodeling,PLoSONE,10(2):e0117110,2015,doi:10.1371/journal.pone.0117110

53. LimKM,HongSB,LeeBK,ShimEB,NTrayanova.Computationalanalysisoftheeffectofvalvularregurgitationonventricularmechanicsusinga3Delectromechanicsmodel.JPhysiolSci.65:159-164,2015.

54. PBoyle,TKarathanos,NTrayanova:“BeautyisaLightintheHeart”:Thetransformativepotentialofoptogeneticsforclinicalapplicationsincardiovascularmedicine,TrendsinCardiovascularMedicine,25:7381,2015(accompaniedbyaneditorial).

55. EUkwatta,JYuan,WQiu,KCWu,NTrayanova,VadakkumpadanF.Myocardialinfarctsegmentationandreconstructionfrom2Dlate-gadoliniumenhancedmagneticresonanceimages.MedImageComputAssistInterv.17(Pt2):554-61,2014

56. NTrayanova,PBoyle,HArevalo,SZahid,Exploringsusceptibilitytoatrialandventriculararrhythmiasresultingfromremodelingofthepassiveelectricalpropertiesintheheart:asimulationapproach,FrontiersinCardiacElectrophysiology,12;5:435,2014.

57. Ringenberg,J.,Deo,M.,Filgueiras-Rama,D.,Pizarro,G.,Ibañez,B.,Peinado,R.,Trayanova,N.,Miller,M.,Merino,J.L.,Berenfeld,O.,Devabhaktuni,V.(2014).Effectsoffibrosismorphologyonreentrantventriculartachycardiainducibilityandsimulationfidelityinpatient-derivedmodels.ClinMedInsightsCardiol,8(Suppl1),1–13.http://dx.doi.org/10.4137/CMC.S15712

58. APrakosa,PMalamas,SZhang,FPashakhanloo,HArevalo,DHerzka,ALardo,HHalperin,EMcVeigh,NTrayanova,VadakkumpadanF.Methodologyforimage-basedreconstructionofventriculargeometryforpatient-specificmodelingofcardiacelectrophysiology,ProgBiophysMolBiol115:226234,2014

59. KChang,JBayer,NTrayanova:Disruptedcalciumreleaseasamechanismforatrialalternansassociatedwithhumanatrialfibrillation,PLoSComputationalBiology,0(12):e1004011.2014,doi:10.1371/journal.pcbi.1004011

60. TKarathanosT,PBoyle,NTrayanova.Optogenetics-EnabledDynamicModulationofActionPotentialDurationinAtrialTissue:FeasibilityofaNovelTherapeuticApproach.Europace16Suppl4:iv69-iv76,2014

61. FVadakkumpadanF,NTrayanova,KCWu,Image-basedleft-ventricularshapeanalysisforsuddencardiacdeathriskstratification.HeartRhythm,11:1693-700,2014.

62. NTrayanova,Mathematicalapproachestounderstandingandimagingatrialfibrillation:Signif-icanceformechanismsandmanagement,CircRes,14:1516-1531,2014

63. YHu,VGurev,JConstantino,N.Trayanova,OptimizingCRTtominimizeATPconsumptionheterogeneitythroughouttheleftventricle:Asimulationanalysisusingacanineheartfailuremodel,HeartRhythm,11:10631069,2014

64. NTrayanova,LRantner.Newinsightsintodefibrillationoftheheartfromrealisticsimulationstudies.Europace,16:705-713,2014.

65. PWright,VNikolaev,TOHara,IDiakonov,ABhargava,STokar,SSchobesberger,AShevchuk,MSikkel,RWilkinson,N.Trayanova,ALyon,SHarding,JGorelik,Caveolin-3regulatescompartmentationofcardiomyocytebeta2-adrenergicreceptor-mediatedcAMPsignaling,JMolCellCardiol,67:38-48,2014

66. LZhou,SSolhjoo,BMillare,GPlank,MRAbraham,SCortassa,N.Trayanova,BORourke,EffectsofRegionalMitochondrialDepolarizationonElectricalPropagation:ImplicationsforArrhythmogenesis,CircArrh&Electrophys,7:143-151,2014

67. NTrayanova,PMBoyle,Advancesinmodelingventriculararrhythmias:frommechanismstotheclinic,WIREsSystBiolMed6(2):209-24.doi:10.1002/wsbm,2014

68. PBoyle,EEntcheva,NTrayanova.Seethelight:canoptogeneticsrestorehealthyheartbeats?And,ifitcan,isitreallyworththeeffort?ExpertRevCardiovascTher.12:17-20,2014

69. PBoyle,CPark,HArevalo,EVigmond,NTrayanova,Sodiumcurrentreductionunmasksastructure-dependentsubstrateforarrhythmogenesisinthenormalventricles,PLoSONE9(1):e86947,2014doi:10.1371/journal.pone.0086947

70. NTrayanova,Virtual3Dheartmodelstoaidpacemakerimplantationinchildren,FutureCardiol,10:5-8,2014

71. YHu,VGurev,JConstantino,N.Trayanova,Efficientpreloadingoftheventriclesbyaproperlytimedatrialcontractionunderliesstrokeworkimprovementintheacuteresponsetocardiacresynchronizationtherapy,HeartRhythm10:1800-1806,2013

72. J.Constantino,YHu,ALardo,N.Trayanova,MechanisticInsightintoProlongedElectromechanicalDelayinDyssynchronousHeartFailure:AComputationalStudy.AmJPhysiolHeartCircPhysiol.305:H1265-73,2013

73. PBoyle,JWiliams,CAmbrossi,EEntcheva,N.Trayanova,Acomprehensivemultiscaleframeworkforsimulatingoptogeneticsintheheart,NatureCommunications4:2370,DOI:10.1038/ncomms3370,2013(accompaniedbyapressreleasefromJHU;storypickedupby60nationalandinternationalnewoutlets,includinganarticleintheBaltimoreSunandaninterviewonNPR)

74. L.Rantner,FVadakkumpadan,PSpevak,JCrosson,N.Trayanova.Placementofimplantablecardioverter-defibrillatorsinpaediatricandcongenitalheartdefectpatients:apipelineformodelgenerationandsimulationpredictionofoptimalconfigurations,J.Physiol17:43214334,2013(ac-companiedbypressreleasesbyJHUMedicineandJohnHopkinsChildren’sCenter,F1000Rec-ommended)

75. HArevalo,GPlank,PHelm,HHalperin,N.Trayanova,TachycardiainPost-InfarctionHearts:Insightsfrom3DImage-BasedVentricularModels,PLoSONE,8:e68872.doi:10.1371/jour-nal.pone.0068872,2013

76. McDowellKS,VadakkumpadanF,BlakeR,BlauerJ,PlankG,MacleodRS,N.Trayanova,Mechanisticinquiryintotheroleoftissueremodelinginfibroticlesionsinhumanatrialfibrillation,BiophysJ.,104:2764-2773,2013

77. N.Trayanova,Cardiacmodeling:Theroadfromequationstotheclinic,SIAMNews46(6),July-August2013.

78. RantnerLJ,TiceBM,N.Trayanova,Terminatingventriculartachyarrhythmiasusingfar-fieldlow-voltagestimuli:Mechanismsanddeliveryprotocols,HeartRhythm,10:1209-1217,2013(ac-companiedbyaneditorial)

79. AshikagaH,ArevaloH,VadakkumpadanF,BlakeRC3rd,BayerJD,NazarianS,MuzZvimanM,

TandriH,BergerRD,CalkinsH,HerzkaDA,N.Trayanova,HalperinHR,Feasibilityofimage-basedsimulationtoestimateablationtargetinhumanventriculararrhythmia,HeartRhythm,10:1109-1116,2013(coverfigure;accompaniedbyaneditorial)

80. Y.Hu,V.Gurev,J.Constantino,J.D.Bayer,N.Trayanova.EffectsofMechano-ElectricFeedbackonScrollWaveStabilityinHumanVentricularFibrillation.PLoSONE,8:e60287.2013doi:10.1371/journal.pone.0060287

81. X.Chen,L.Tereshchenko,RBerger,N.Trayanova,ArrhythmiaRiskStratificationbasedonQTIntervalInstability:AnIntracardiacElectrocardiogramStudy,HeartRhythm10:875-80,2013(accompaniedbyaneditorial)

82. S.Weinberg,K.Chang,RZhu,HTandri,R.Berger,N.Trayanova,LTung,DefibrillationSuccesswithHighFrequencyElectricFieldsisRelatedtoDegreeandLocationofConductionBlock,HeartRhythm10:740-748,2013(accompaniedbyaneditorial)

83. DKrummen,JBayer,JHo,GHo,MSmetak,N.Trayanova,SNarayan,MechanismsforHumanAtrialFibrillationInitiation:ClinicalandComputationalStudiesofRepolarizationRestitutionandActivationLatency,CirculationElectrophys&Arrhythmias5:1149-1159,2013.

84. Trayanova,N.IntheSpotlight:CardiovascularEngineering,IEEEReviewsBiomedEng6:19-20,2013.

85. Vadakkumpadan,F.,Arevalo,H.,Trayanova,N.Patient-SpecificModelingOfTheHeart:EstimationOfVentricularFiberOrientations.J.Vis.Exp.,e50125,doi:10.3791/50125,2012.

86. N.Trayanova,ComputationalCardiology:TheHeartoftheMatter,ISRNCardiology(SpotlightArticle),vol.2012,ArticleID269680,doi:10.5402/2012/269680,2012.

87. RWinslow,N.Trayanova,DGeman,MMiller,ComputationalMedicine:TranslatingModelstoClinicalCare,ScienceTranslationalMedicine,4,158rv11,2012(accompaniedbyJHUpressrelease;storypickedupbynumerousnewsoutlets;F1000Recommended)

88. K.McDowell,FVadakkumpadan,RBlake,JBlauer,GPlank,RMacLeod,N.Trayanova,Patient-specificmodelingofatrialfibrosisasasubstrateforatrialfibrillation.JElectrocardiol45:640645,2012.

89. N.Trayanova,T.O’Hara,J.D.Bayer,P.M.Boyle,K.S.McDowell,J.Constantino,H.Arevalo,Y.Hu,F.Vadakkumpadan.Computationalcardiology:Howcomputersimulationscouldbeusedtodevelopnewandadvanceexistingtherapies.Europace14:v82v89,2012

90. JConstantino,YHu,NTrayanova.Acomputationalapproachtounderstandingthecardiacelectromechanicalactivationsequenceinthenormalandfailingheart,withtranslationtotheclinicalpracticeofCRT,ProgBiophysMolBiol,110(2-3):372-379,2012.

91. LRantner,HArevalo,JConstantino,IEfimov,GPlank,NTrayanova.Three-DimensionalMechanismsofIncreasedVulnerabilitytoElectricShocksinMyocardialInfarction:AlteredVirtualElectrodePolarizationsandConductionDelayinthePeri-InfarctZone,JPhysiol:590:45374551,2012

92. JDBayer,RCBlake,GPlank,NTrayanova,ANovelRule-BasedAlgorithmforAssigningMyocardialFiberOrientationtoComputationalHeartModels,AnnalsofBiomedicalEngineering40:2243-2254,2012

93. FVadakkumpadan,HArevalo,CCeritoglu,MMiller,NTrayanova,Image-BasedEstimationofVentricularFiberOrientationsforPersonalizedModelingofCardiacElectrophysiology,IEEETransMedImaging31:1051-1060,2012

94. ChenX,TrayanovaN.ANovelMethodologyforAssessingtheBounded-InputBounded-OutputInstabilityinQTIntervalDynamics:ApplicationtoClinicalECGwithVentricularTachycardia,IEEETransBiomedEng.59:2111-21117,2012

95. V.Gurev,K.Tavakolian,J.Constantino,B.Kaminska,A.P.Blaber,NTrayanova,Mechanismsunderlyingisovolumiccontractionandejectionpeaksinseismocardiogrammorphology,JMBE32:103-110,2012.

96. AshiharaT,HaraguchiR,NakazawaK,NambaT,IkedaT,NakazawaY,OzawaT,ItoM,HorieM,TrayanovaN.TheRoleofFibroblastsinComplexFractionatedElectrogramsDuringPersistent/PermanentAtrialFibrillation:ImplicationsforElectrogram-BasedCatheterAblation,CircRes,110:275-284,2012

97. LimKM,ConstantinoJ,GurevV,ZhuR,ShimEB,TrayanovaN.Comparisonoftheeffectsofcontinuousandpulsatileleftventricular-assistdevicesonventricularunloadingusingacardiacelectromechanicsmodel,JPhysiolSci.62:11-19,2012

98. YamazakiM,HonjoH,AshiharaT,HaradaM,SakumaI,NakazawaK,TrayanovaN,HorieM,KalifaJ,JalifeJ,KamiyaK,KodamaI.Regionalcoolingfacilitatesterminationofspiral-wavereentrythroughunpinningofrotorsinrabbithearts,HeartRhythm,9:107-114,2012

99. NTrayanova,JConstantino,TAshihara,GPlank,ModelingDefibrillationoftheHeart:ApproachesandInsights,IEEEReviewsBiomedEng4:89-102,2011.

100. TandriH,WeinbergS,ChangK,ZhuR,TrayanovaN,TungL,BergerR.Reversiblecardiaccon-ductionblockanddefibrillationwithhighfrequencyelectricfield,ScienceTranslationalMedicine,3(102):102ra96,2011(accompaniedbyJHUpressrelease;storypickedupbynumerousnewsoutlets)

101. MorenoJ,ZhuI,YangP-C,BankstonJ,JengM-T,KangC,WangL,BayerJ,ChristiniD,TrayanovaN,RipplingerC,KassR,ClancyC.Acomputationalmodeltopredictantiarrhythmicdrugeffectsoncardiacrhythms.ScienceTranslationalMedicine,3,98ra83,2011(accompaniedbypressreleases;storypickedupbynumerousnewsoutlets)

102. Trayanova,N.IntheSpotlight:CardiovascularEngineering,IEEEReviewsBiomedEng4:1416,2011.

103. XChen,YHu,BFetics,RBerger,NTrayanova.UnstableQTintervaldynamicsprecedesVTonsetinpatientswithacutemyocardialinfarction:AnovelapproachtodetectinstabilityinQTintervaldynamicsfromclinicalECG,CirculationElectrophys&Arrhythmias,4:858-66,2011.

104. KSMcDowell,HJ.Arevalo,MMMaleckar,NTrayanova.Susceptibilitytoarrhythmiaintheinfarctedheartdependsonmyofibroblastdensity.BiophysJ,101:1307-1315.2011.

105. NTrayanova,JJRice.CardiacElectromechanicalModels:FromCelltoOrgan,FrontiersinPhysiology,vol.2,article43,2011.

106. QuinnTA,GraniteS,AllessieMA,AntzelevitchC,BollensdorffC,BubG,BurtonRA,CerbaiE,ChenPS,DelmarM,DifrancescoD,EarmYE,EfimovIR,EggerM,EntchevaE,FinkM,FischmeisterR,FranzMR,GarnyA,GilesWR,HannesT,HardingSE,HunterPJ,IribeG,JalifeJ,JohnsonCR,KassRS,KodamaI,KorenG,LordP,MarkhasinVS,MatsuokaS,McCullochAD,MiramsGR,MorleyGE,NattelS,NobleD,OlesenSP,PanfilovAV,TrayanovaN,RavensU,RichardS,RosenbaumDS,RudyY,SachsF,SachseFB,SaintDA,SchottenU,SolovyovaO,TaggartP,TungL,VarrA,VoldersPG,WangK,WeissJN,WettwerE,WhiteE,WildersR,WinslowRL,KohlP.MinimumInformationaboutaCardiacElectrophysiologyExperiment(MICEE):standardisedreportingformodelreproducibility,interoperability,anddatasharing,ProgBiophysMolBiol.,107:4-10,2011

107. TrayanovaN,JConstantino,VGurev.ElectromechanicalModelsoftheVentricles.AmJPhysiolHeartCircPhysiol301:H279-86,2011.

108. CetingulH,PlankG,TrayanovaN,VidalR.EstimationoflocalorientationsinfibrousstructureswithapplicationstothePurkinjesystem,IEEETransBiomedEng58:1762-1772,2011

109. NTrayanova,Whole-heartmodeling:Applicationstocardiacelectrophysiologyandelectrome-chanics,CircRes,108:113-128,2011

110. ProvostJ,GurevV,TrayanovaN,KonofagouEE,MappingofCardiacElectricalActivationwithElectromechanicalWaveImaging:Aninsilico-invivoReciprocityStudy,HeartRhythm8:752-759,2011(accompaniedbyaneditorial).

111. GurevV,LeeT,ConstantinoJ,ArevaloH,TrayanovaN.Modelsofcardiacelectromechanicsbasedonindividualheartsimagingdata,BiomechModelMechanobiol,10:295-306,2011.

112. N.Trayanova,ConstantinoJ,GurevV.Modelsofstretch-activatedventriculararrhythmias.JElectrocardiol.43:479-85,2010(coverfigure).

113. TrayanovaN.Atrialdefibrillationvoltage:Fallingtoanewlow,HeartRhythm,8:109-110,2011.114. FishmanGI,ChughSS,DimarcoJP,AlbertCM,AndersonME,BonowRO,BuxtonAE,ChenPS,Estes

M,JouvenX,KwongR,LathropDA,MascetteAM,NerbonneJM,O’RourkeB,PageRL,RodenDM,RosenbaumDS,SotoodehniaN,TrayanovaN,ZhengZJ.Suddencardiacdeathpredictionandprevention:ReportfromaNationalHeart,Lung,andBloodInstituteandHeartRhythmSocietyworkshop.Circulation,122:2335-2348,2010

115. N.Trayanova.IntheSpotlight:Cardiovascularengineering.IEEEReviewsinBiomedicalEngineering3:12-14,2010.

116. GurevV,ConstantinoJ,RiceJJ,NTrayanova,Distributionofelectromechanicaldelayintheheart:Insightsfroma3Delectromechanicalmodel,BiophysJ,99:745-754,2010(coverfigure).

117. BayerJD,NarayanSM,LalaniGG,NTrayanova.Rate-dependentactionpotentialalternansinhumanheartfailureimplicateabnormalintracellularcalciumhandling,HeartRhythm7:1093-101,2010

(accompaniedbyaneditorial)118. ConstantinoJ,LongY,AshiharaT,NTrayanova.Tunnelpropagationfollowingdefibrillationwith

ICDshocks:Hiddenpostshockactivationsintheleftventricularwallunderlieisoelectricwindow.HeartRhythm7:953-61,2010(accompaniedbyaneditorialandapodcast)

119. JieX,TrayanovaN.Mechanismsforinitiationofreentryinacuteregionalischemiaphase1B,HeartRhythm7:379386,2010(accompaniedbyaneditorialandapodcast)

120. NTrayanova,BTice.Integrativecomputationalmodelsofcardiacarrhythmias:simulatingthestructurallyrealisticheart.DrugDiscoveryToday:DiseaseModels6:85-91,2010.

121. VadakkumpadanF,ArevaloH,PrasslA,ChenJ,KickingerF,KohlP,PlankG,TrayanovaN.Image-basedmodelsofcardiacstructureinhealthanddisease.WileyInterdisciplinaryReviews:SystemsBiologyandMedicine,2:489-506,2010(namedTop10WSBMArticle2012)

122. JieX,GurevV,TrayanovaN.Mechanismsofmechanicallyinducedspontaneousarrhythmiasinacuteregionalischemia,CircRes,106:185-192,2010.

123. N.Trayanova.IntheSpotlight:Cardiovascularengineering.IEEEReviewsinBiomedicalEngineering2:12-14,2009.

124. M.Maleckar,J.Greenstein,W.Giles,N.Trayanova.Electrotoniccouplingbetweenhumanatrialmyocytesandfibroblastsaltersmyocyteexcitabilityandrepolarization,BiophysJ97:217990,2009.

125. M.Maleckar,J.Greenstein,W.Giles,N.Trayanova.K+currentchangesaccountfortheratedependenceoftheactionpotentialinthehumanatrialmyocyte,AmJPhysiol,297:1398-1410,2009.

126. VigmondE,VadakkumpadanF,ArevaloH,GurevV,DeoM,PlankG,N.Trayanova.Towardspredictivemodelingoftheelectrophysiologyoftheheart,ExperimentalPhysiology94:563-77,2009.

127. F.Vadakkumpadan,L.Rantner,BTice,PBoyle,A.Prassl,EVigmond,GPlank,NTrayanova,Image-basedmodelsofcardiacstructurewithapplicationsinarrhythmiaanddefibrillationstudies,JElectrocardiol,42:157,e1-10,2009.

128. A.J.Prassl,F.Kickinger,H.Ahammer,V.Grau,E.Hofer,E.J.Vigmond,N.Trayanova,G.Plank.Automaticallygenerated,anatomicallyaccuratemeshesforcardiacelectrophysiologyproblems,IEEETransBME56:1318-1330,2009.

129. MMaleckar,JGreenstein,NTrayanova,WGiles,Mathematicalsimulationsofligand-gatedandcell-typespecificeffectsontheactionpotentialofhumanatrium,ProgBiophysMolBiol(2-3):161-70,2008.

130. N.Trayanova.IntheSpotlight:CardiovascularEngineering.IEEEReviewsinBiomedicalEngineering1:12-14,2008.

131. MMaleckar,M.C.Woods,V.Y.Sidorov,M.R.Holcomb,D.N.Mashburn,J.PWikswo,N.Trayanova,Polarityreversallowersactivationtimeduringdiastolicfieldstimulationoftherabbitventricles:Insightsintomechanisms,AmJPhysiolHeartCircPhysiol295:H1626-1633,2008.

132. S.M.Narayan,J.Bayer,G.Lalani,N.Trayanova.AlternansinphaseIIofhumanventricularactionpotentialspredictslong-termoutcomes:Amechanismlinkingfailingmyocardiumwitharrhythmias,JACC,52:1782-1792,2008.

133. Y.Rudy,M.J.Ackerman,D.M.Bers,C.Clancy,S.R.Houser,B.London,A.D.McCulloch,D.A.Przywara,R.L.Rasmusson,R.J.Solaro,N.Trayanova,D.VanWagoner,A.Varro,J.N.Weiss,D.A.Lathrop,Systemsapproachtounderstandingelectromechanicalactivityinthehumanheart:ANationalHeart,Lung,andBloodInstituteWorkshopsummary,Circulation118:1202-1211,2008.

134. G.Plank,L.Zhou,J.Greenstein,S.Cortassa,R.Winslow,B.ORourke,N.Trayanova.Frommitochondrialionchannelstoarrhythmiasintheheart:Computationaltechniquestobridgethespatio-temporalscales.PhilTransRoyalSoc.London366:3381-409,2008(coverfigure).

135. W.Li,V.Gurev,A.McCulloch,N.Trayanova.Theroleofmechanoelectricfeedbackinvulnerabilitytoelectricshocks,Prog.Biophys.&Mol.Biol.(2-3):461-478,2008.

136. X.Jie,B.Rodrguez,J.R.deGroot,R.Coronel,N.Trayanova.Reentryinsurvivedsubepicardiumcoupledtodepolarizedmidmyocardium:Insightsintoarrhythmogenesisinischemiaphase1B,HeartRhythm5:10361044,2008(accompaniedbyaneditorial)

137. N.Trayanova.Thelongandtheshortoflongandshortdurationventricularfibrillation,CircRes102:1151-1152,2008.

138. T.Ashihara,J.Constantino,N.Trayanova.Tunnelpropagationofpostshockactivationsasahypothesisforfibrillationinductionandisoelectricwindow,CircRes102:737-745,2008.

139. TMaharaj,B.Rodrguez,RBlake,N.Trayanova,DGavaghan.Theroleoftransmuralventricularheterogeneitiesincardiacvulnerabilitytoelectricshocks,Prog.Biophys.&Mol.Biol.96:321-338,

2008.140. GPlank,APrassl,EHofer,NTrayanova,Evaluatingintramuralvirtualelectrodesinthemyocardial

wedgepreparation:Simulationsofexperimentalconditions.Biophys.J94:1904-1915,2008.141. M.Bishop,B.Rodriguez,F.Qu,I.R.Efimov,D.Gavaghan,NTrayanova.Theroleofphotonscattering

inopticalsignaldistortionduringarrhythmiaanddefibrillation.BiophysJ.93:3714-26,2007.142. M.Bishop,D.Gavaghan,N.Trayanova,B.Rodriguez.Photonscatteringeffectsinopticalmappingof

propagationandarrhythmogenesisintheheart,J.Electrocardiol.40:S75-S80,2007.143. B.Tice,B.Rodrguez,J.Eason,N.Trayanova,Mechanisticinvestigationintothearrhythmogenicrole

oftransmuralheterogeneitiesinregionalischemiaphase1A,Europace9:46-58,2007.144. EstesNA3rd,PageR,BoydenP,CappatoR,Chiu-ManC,DayJ,DimarcoJ,FerrickA,HamdanM,

HamiltonR,HohnloserS,JungW,KanterR,KnightB,LindsayB,NataleA,ReynoldsD,RosenbaumD,SaxonL,ShenWK,TrayanovaN,WilkoffB.HeartRhythmSocietyScientificProgramCommittee,HeartRhythm,4:e1-e9,2007.

145. N.Trayanova.Drawingthecurtainontheisoelectricwindow?HeartRhythm,4:766-767,2007.146. A.Komendantov,N.Trayanova,J.Tasker.Somato-dendriticmechanismsunderlyingtheelec-

trophysiologicalpropertiesofhypothalamicmagnocellularneuroendocrinecells:Amulticompart-mentalmodelstudy,JComputNeuroscience,23:143-168,2007.

147. H.Arevalo,B.Rodrguez,N.Trayanova.Arrhythmogenesisintheheart:Multiscalemodelingoftheeffectsofdefibrillationshocksandtheroleofelectrophysiologicalheterogeneity,Chaos17:015103-1–015103-13,2007.

148. M.Bishop,B.Rodriguez,N.Trayanova,D.Gavaghan.InferenceofintramuralwavefrontorientationfromopticalrecordingsinrealisticwholeheartmodelsBiophysJ.91:3957-3958,2006.

149. N.Trayanova,B.Rodriguez,G.Plank.Whathavewelearnedfrommathematicalmodelsofdefibrillationandpostshockarrhythmogenesis?Applicationsofbidomainsimulations,HeartRhythm3:1232-1235,2006.

150. V.Gurev,M.Maleckar,N.Trayanova.Cardiacdefibrillationandtheroleofmechano-electricfeedbackinpostshockarrhythmogenesis,AnnalsNYAcadSci1080:320-333,2006.

151. R.Burton,G.Plank,J.Schneider,V.Grau,H.Ahammer,S.Keeling,J.Lee,N.Smith,D.Gavaghan,N.Trayanova,P.Kohl.Three-dimensionalmodelsofindividualcardiachisto-anatomy:Toolsandchallenges,AnnalsNYAcadSci1080:301-319,2006.

152. B.Rodrguez,N.Trayanova,D.Noble.Modelingcardiacischemia,AnnalsNYAcadSci1080:395414,2006.

153. D.Bourn,R.Gray,N.Trayanova,Characterizationoftherelationshipbetweenpre-shockstateandvirtualelectrodepolarization-inducedpropagatedgradedresponsesresultinginarrhythmiainduction,HeartRhythm,3:583-595,2006(accompaniedbyaneditorial).

154. D.Bourn,M.Maleckar,B.Rodrguez,N.Trayanova.Mechanisticenquiryintotheeffectofpre-fibrillatoryconditionsontheupperlimitofvulnerability,PhilosophicalTrans.RoyalSocietyA,346:1349-1366,2006.

155. S.Kuo,N.Trayanova.Actionpotentialmorphologyheterogeneityintheatriumanditseffectonatrialreentry,PhilosophicalTrans.RoyalSocietyA,346:1333-1348,2006.

156. M.Bishop,B.Rodriguez,J.Eason,J.Whiteley,N.Trayanova,D.Gavaghan.Synthesisofvoltage-sensitiveopticalsignals:Applicationtopanoramicopticalmapping,Biophys.J.80:29382045,2006.

157. N.Trayanova.Defibrillationoftheheart:Insightsintomechanismsfrommodelingstudies,Exper.Physiol.91:323-337,2006.

158. W.Li,P.Kohl,N.Trayanova.Myocardialischemialowersprecordialthumpefficacy:Aninquiryintomechanismsusing3Dsimulations.HeartRhythm3:179186,2006(coverpagefigure;articleaccompaniedbyaneditorial).

159. B.Rodrguez,J.Eason,N.Trayanova.Differencesbetweenleftandrightventricularanatomydeterminethetypesofreentrantcircuitsinducedbyanexternalelectricshock.Arabbitheartsimulationstudy,Prog.Biophys.&Mol.Biol.90:399-413,2006.

160. B.Rodrguez,L.Li,J.Eason,I.Efimov,N.Trayanova.Differencesbetweenleftandrightventricularchambergeometryaffectcardiacvulnerabilitytoelectricshocks.Circ.Res.97:168175,2005(coverpagefigure).

161. TAshihara,NTrayanova.Cellandtissueresponsestoelectricshocks.Europace7:S155-S165,2005.162. N.Trayanova.Inpursuitoftheelusiveculprit.HearthRhythm,2:629-703,2005.163. B.Rodrguez,B.Tice,J.Eason,F.Aguel,N.Trayanova.Cardiacvulnerabilitytoelectricshocksduring

phase1Aofacuteglobalischemia,HearthRhythm,1:695-703,2004.164. T.Ashihara,N.Trayanova.Asymmetryinmembraneresponsestoelectricshocks:Insightsfrom

bidomainsimulations.Biophys.J.87:2271-2282,2004.165. E.Vigmond,V.Tsoi,S.Kuo,J.Kneller,S.Nattel,N.Trayanova.Theeffectofvagallyinducedaction

potentialdispersiononatrialarrhythmogenesis,HearthRhythm,1:334-344,2004.166. RodrguezB,TiceBM,EasonJC,AguelF,FerreroJMJr,N.Trayanova.Effectofacuteglobalischemia

ontheupperlimitofvulnerability:asimulationstudy.AmJPhysiol,286:H2078H2088,2004.167. N.Trayanova,W.Li,J.Eason,P.Kohl.Theeffectofstretch-activatedchannelsondefibrillation

efficacy:Asimulationstudy,HeartRhythm1:67-77,2004.168. W.Li,P.Kohl,N.Trayanova.Inductionofventriculararrhythmiasfollowingmechanicalimpact:A

simulationstudyin3D.J.MolecularHistology,35:679-686,2004.169. M.Hillebrener,J.Eason,N.Trayanova.Mechanisticinquiryintodecreaseinprobabilityof

defibrillationsuccesswithincreaseincomplexityofpreshockreentrantactivity,AmJPhysiol286:H909-H917,2004.

170. T.Ashihara,T.Namba,T.Ikeda,M.Ito,K.Nakazawa,N.Trayanova.Mechanismsofmyocardialcaptureandtemporalexcitablegapduringspiralwavereentryinabidomainmodel,Circulation109:920-925,2004.

171. T.Ashihara,T.Namba,M.Ito,T.Ikeda,K.Nakazawa,N.Trayanova.Spiralwavecontrolbyalocalizedstimulus:AbidomainmodelstudyJ.Cardiovasc.Electrophys.15:226-233,2004

172. B.Rodriguez,N.Trayanova.Upperlimitofvulnerabilityinadefibrillationmodeloftherabbitventricles,J.Electrocardiol.36(Suppl.):51-57,2003.

173. F.Aguel,J.Eason,N.Trayanova.Advancesinmodelingcardiacdefibrillation,Int.J.Bifurcations&Chaos,13:3791-3805,2003.

174. M.Hillebrener,J.Eason,N.Trayanova.Postshockarrhythmogenesisinasliceofthecanineheart,J.Cardiovasc.Electrophys.14:S249-S256,2003(coverfigure).

175. J.Eason,N.Trayanova.Thecriterionforventriculardefibrillation:Anerrorornot(ReplytotheEditor),J.Cardiovasc.Electrophys.14:556-557,2003.

176. N.Trayanova,R.Gray,D.Bourn,J.Eason.Virtualelectrodeinducedpositiveandnegativegradedresponse:NewinsightsintofibrillationinductionanddefibrillationJ.Cardiovasc.Electrophys.14:756-763,2003.

177. C.Larson,L.Dragnev,N.Trayanova.Analysisofelectrically-inducedreentrantcircuitsinasheetofmyocardium,AnnalsBiomed.Eng.,31:768-780,2003(coverfigure).

178. E.Atkinson,N.Trayanova,ContactprobesforMAPrecording:Acomputationalstudy,JournalofBiologicalSystems,11:139-160,2003.

179. N.Trayanova.Areweclosertounderstandingdefibrillationinthewholeheart?J.Cardiovasc.Electrophys.13:1128-1130,2003.

180. J.Meunier,J.Eason,N.Trayanova.Terminationofreentrybyalong-lastingACshockinasliceofthecanineheart:Acomputationalstudy,J.Cardiovasc.Electrophys.13:1253-1262,2002.

181. E.Vigmond,F.Aguel,N.Trayanova.Computationaltechniquesforsolvingthebidomainequationsinthreedimensions,IEEETrans.Biomed.Eng.,49:1260-1269,2002.

182. N.Trayanova,J.Eason.Shock-inducedArrhythmogenesisintheMyocardium,Chaos12:962972,2002.

183. J.Eason,N.Trayanova.Phasesingularitiesandterminationofspiralwavereentry,J.Cardiovasc.Electrophys.13:672-679,2002.

184. N.Trayanova,J.Eason,F.Aguel.Cardiacdefibrillation:Alookinsidetheheart,ComputingandVisualizationinScience,4:259-270,2002,2002.

185. K.Skouibine,J.Wall,W.Krassowska,N.Trayanova.Modelinginductionofarotorbyperpendicularelectricshocks,Med&BiolEng&Comput40:47-55,2002.

186. C.Anderson,N.Trayanova.Successandfailureofbiphasicshocks:Resultsofbidomainsimulations,MathBiosci174:91-109,2001.

187. J.Meunier,N.Trayanova,R.Gray.Entrainmentbyanextracellularstimulusinacomputationalmodelofcardiactissue,J.Cardiovasc.Electrophys.12:1176-1184,2001.

188. E.Vigmond,N.Trayanova,R.Malkin.Excitationofacardiacmusclefiberbyextracellularlyappliedsinusoidalcurrent,J.Cardiovasc.Electrophys.12:1145-1153,2001.

189. R.Gray,D.Huelsing,F.Aguel,N.Trayanova,Effectofstrengthandtimingoftransmembranecurrentpulsesonisolatedrabbitventricularmyocytes,J.Cardiovasc.Electrophys.12:1129-1137,2001.

190. E.Vigmond,R.Ruckdeschel,N.Trayanova,Reentryinamorphologicallyrealisticatrialmodel,J.Cardiovasc.Electrophys.12:1046-1054,2001.

191. A.Lindblom,F.Aguel,N.Trayanova.Virtualelectrodepolarizationleadstoreentryinthefarfield,J.Cardiovasc.Electrophys.12:946-956,2001.

192. N.Trayanova.Conceptsofventriculardefibrillation,PhilosophicalTrans.RoyalSocietyLondon,359:1327-1337,2001

193. E.Azene,N.Trayanova,E.Warman.Wavefront-obstacleinteractionsincardiactissue:Acomputationalstudy,AnnalsBiomedEng,29:35-46,2001.

194. C.Anderson,N.Trayanova,K.Skouibine.Terminationofspiralwaveswithbiphasicshocks:Theroleofvirtualelectrodepolarization,JCardiovasc.Electrophys.11:1386-1396,2000.

195. K.Skouibine,N.Trayanova,P.Moore.Anumericallyefficientmethodforsimulationofdefibrillationinanactivebidomainsheetofmyocardium,Math.Biosci.166:85-100,2000.

196. K.Skouibine,N.Trayanova,P.Moore.Successandfailureofthedefibrillationshock:Insightsfromasimulationstudy,JCardiovascElectrophys,11:785-796,2000.

197. I.Efimov,F.Aguel,Y.Cheng,B.Wollenzier,N.Trayanova.Virtualelectrodepolarizationinthefarfield:implicationsforexternaldefibrillation,Am.J.Physiol.279:H1055-H1070,2000.

198. A.Lindblom,B.Roth,N.Trayanova.Theroleofvirtualelectrodesinarrhythmogenesis:Pinwheelexperimentrevisited,J.Cardiovasc.Electrophys.11:274-285,2000..

199. J.Meunier,N.Trayanova,R.Gray.Sinusoidalstimulationofmyocardialtissue:Effectsonsinglecells,J.Cardiovasc.Electrophys.10:1619-1630,1999.

200. S.Knisley,N.Trayanova,F.Aguel.Rolesofelectricfieldandfiberstructureincardiacelectricalstimulation,BiophysJ,77:1404-1417,1999.

201. K.Skouibine,N.Trayanova,P.Moore:Anode/cathodemakeandbreakphenomenainamodelofdefibrillation,IEEETrans.Biomed.Eng.46:769-777,1999.

202. N.Trayanova.Far-fieldstimulationofcardiactissue,Herzschrittmacher-Therapie&Electro-physiologie10:137-148,1999

203. F.Aguel,K.DeBruin,W.Krassowska,N.Trayanova.Effectsofelectroporationonthetrans-membranepotentialdistributioninatwo-dimensionalbidomainmodelofcardiactissue.J.Car-diovasc.Electrophys.10:701-714,1999.

204. E.Entcheva,N.Trayanova,F.Claydon.Patternsofandmechanismsforpolarizationoftheheart:Abidomainanalysis,IEEETrans.Biomed.Eng.46:260-270,1999.

205. F.Aguel,J.Eason,N.Trayanova,G.Siekas,M.Fishler.Impactoftransvenousleadpositiononactive-canICDdefibrillation:AcomputationalStudy,PACE,22[pt.II]:158-164,1999.

206. TrayanovaN.,F.Aguel,K.Skouibine.Extensionofrefractorinessinamodelofcardiacdefibrillation.in:PacificSymposiumonBiocomputing’99,Eds.Altman,Dunker,Hunter,KleinandLauderdale,WorldScientific,pp.240-251,1999.

207. TrayanovaN.,K.Skouibine.ModelingDefibrillation:EffectsofFiberCurvature,J.Electrocardiol.,31:23-29,1998.

208. TrayanovaN.,K.Skouibine,P.Moore.Virtualelectrodesindefibrillation,ProgBiophysMolBiol,69:387-403,1998.

209. TrayanovaN.,K.Skouibine,F.Aguel.Theroleofcardiactissuestructureindefibrillation,Chaos,8:221-233,1998.

210. J.Eason,J.Schmidt,A.Dabasinskas,G.Siekas,F.Aguel,N.Trayanova,Theinfluenceofanisotropyonlocalandglobalestimatesofelectricalgradientincomputermodelsofinternaldefibrillation,AnnalsBiomed.Eng.,26:840-849,1998.

211. TrayanovaN.,M.-A.Bray.Membranerefractorinessandexcitationinducedincardiacfibersbymonophasicandbiphasicshocks,J.Cardiovasc.Electrophys.,8:745-757,1997.

212. TrayanovaN.Effectsoftissue-bathinterfaceontheinducedtransmembranepotential:amodelingstudyincardiacstimulation,AnnalsBiomed.Eng.25:783-792,1997.

213. TrayanovaN.Discreteversussyncytialtissuebehaviorinamodelofcardiacstimulation–I:Mathematicalformulation.IEEETrans.Biomed.Eng.,43:1129-1140,1996.

214. TrayanovaN.Discreteversussyncytialtissuebehaviorinamodelofcardiacstimulation–II:Resultsofsimulation.IEEETrans.Biomed.Eng.,43:1141-1150,1996.

215. TrayanovaN.Abidomainmodelforringstimulationofacardiacstrand.IEEETrans.Biomed.Eng.,40:393-397,1994.

216. TrayanovaN.Anapproximatesolutiontothe“periodic”bidomainequationsinonedimension.

Math.Biosci.,120:189-210,1994217. TrayanovaN.,T.Pilkington.Abidomainmodelwithperiodicintracellularjunctions.Aone-

dimensionalanalysis.IEEETrans.Biomed.Eng.,40,pp.424-433,1993218. TrayanovaN.,B.J.Roth,L.J.Malden.Theresponseofasphericalhearttoauniformelectricfield:A

bidomainanalysisofcardiacstimulation.IEEETrans.Biomed.Eng.,40:899-908,1993219. TrayanovaN.,T.Pilkington.Theuseofspectralmethodsinbidomainstudies,In:High-Performance

ComputinginBiomedicalEngineering,CRCPress,403-426,1993,re-printedinCRCCrit.Revs.Biomed.Eng.20(3,4):255-277.

220. TrayanovaN.,C.S.Henriquez.Examinationofthechoiceofmodelsforcomputingtheextracellularpotentialofasinglefiberinarestrictedvolumeconductor.Med.&Biol.Eng.&Comput.29:103-108,1992.

221. R.Enoka,N.Trayanova,Y.Laouris,L.Bevan,R.Reinking,D.Stuart,Fatigue-relatedchangesinmotorunitactionpotentialsofadultcats,Muscle&Nerve14:138-150,1992.

222. PopivanovD,GavrilenkoT,GanchevGN,TrayanovaN.Spatio-temporalcharacteristicsofSEPtotibialnervestimuation.ActaPhysiolPharmaclBulg,1792-3):32-39

223. TrayanovaN.,C.S.Henriquez.Modificationofacylindricalbidomainmodelforcardiactissue.Math.Biosci.104:59-72,1991.

224. Trayanova,N.,C.S.Henriquez,R.Plonsey,Limitationsofapproximatesolutionsforcomputingtheextracellularpotentialsofsinglefibersandbundleequivalents,IEEETrans.Biomed.Eng.37:22-35,1990.

225. Henriquez,C.S.,N.Trayanova,R.Plonsey,Aplanarslabbidomainmodelforcardiactissue,AnnalsBiomed.Eng.18:367-376,1990.

226. Trayanova,N.,C.S.Henriquez,R.Plonsey,Extracellularpotentialsandcurrentsofasingleactivefiberinarestrictedvolumeconductor,AnnalsBiomed.Eng.18:219-238,1990.

227. TrayanovaN.,Electricalbehaviorofaskeletalmusclefiberinavolumeconductoroffiniteextent,Biol.Cybern.63:121-125,1990.

228. Genchev,T.,T.Yanev,A.Gydikov,N.Trayanova,Locationofthemotorunitelectricalaxisanddeterminationofthemuscleanisotropyratio,Biol.Cybern.63:229-236,1990.

229. GydikovA.,A.Kossev,N.Trayanova,D.Stephanova,Electrotonicpotentialsofmyelinatednervefibers,Electromyogr.Clin.Neurophysiol.30:47-51,1990.

230. GydikovA.,N.Trayanova,Avolumeconductorstudyofelectrotonicpotentialsofunmyelinatedexcitablefibers,Electromyogr.Clin.Neurophysiol.30:227-231,1990.

231. Stephanova,D.,N.Trayanova,A.Gydikov,A.Kossev,Extracellularpotentialsofasinglemyelinatednervefiberinanunboundedvolumeconductor,Biol.Cybern.61:205-210,1989.

232. Plonsey,R.,C.S.Henriquez,N.Trayanova,Extracellular(volumeconductor)effectonadjoiningcardiacmuscleelectrophysiology,Med.&Biol.Eng.&Comput.,26:126-129,1988.

233. Henriquez,C.S.,N.Trayanova,R.Plonsey,Potentialandcurrentdistributionsinacylindricalbundleofcardiactissue,Biophys.J.,53:907-918,1988.

234. Kossev,A.,A.Gydikov,N.Trayanova,N.Radicheva,ConfigurationandselectivityofbranchedEMG-electrodes,Electromyogr.clin.Neurophysiol.,28:397-404,1988.

235. N.Trayanova,A.Gydikov.Extracellularpotentialfieldcausedbytherestingpotentialofamyelinatednervefiber,Electromyogr.clin.Neurophysiol.,27:203-207,1987.

236. Gydikov,A.,N.Trayanova,Extracellularpotentialsofsingleactivemusclefibres:Effectsoffinitefiberlength,Biol.Cybern.,53:363-372,1986.

237. RadichevaN,N.Trayanova,GydikovA,GerilovskyL.Extracellularpotentialfieldofunmyelinatedactiveaxons,ActaPhysiolPharmacyBulg,13:22-29,1987

238. Gydikov,A.,L.Gerilovsky,N.Radicheva,N.Trayanova,Influenceofthemusclefibreendgeometryontheextracellularpotentials,Biol.Cybern.,54:1-8,1986.

239. Gydikov,A.,A.Kossev,A.Trayanova,N.Radicheva,Selectiverecordingofmotorunitpotentials,Electromyogr.clin.Neurophysiol.,26:273-281,1986.

240. Trayanova,N.,A.Gydikov,Somefeaturesoftheextracellularpotentialfieldofactivesinglemusclefibres.Amodelinvestigation,Electromyogr.clin.Neurophysiol.,26:613-622,1986.

241. Gydikov,A.,D.Kosarov,A.Kossev,K.Kostov,N.Trayanova,N.Radicheva.Motorunitpotentialsathighmuscleactivityrecordedbyselectiveelectrodes,Biomed.Biochim.Acta,45:6368,1986.

242. TrayanovaN.,Influenceofthefiberendonthecalculatedextracellularpotentialsofsinglemusclefibers,Electromyogr.clin.Neurophysiol.,25:443-451,1985.

243. TrayanovaN.,G.Dimitrov,Mathematicalmodelsoftheextracellularpotentialsgeneratedbyexcitablefibersinavolumeconductor,Electromyogr.clin.Neurophysiol.,23:123-137,1983.

244. Trayanova,N.,G.Dimitrov,Extracellularpotentialsintheproximityoftheexcitablefibers,Electromyogr.clin.Neurophysiol.,22:291-301,1982.

245. TrayanovaN.,Equivalentsourcesfortheextracellularpotentialsofsinglefibersandbundles,ActaPhysiol.Pharmacol.Bulg.16:3-7,1990.

246. TrayanovaN.,Separationofthesodiumandpotassiumcurrentsfromanactionpotentialofasingleactivefiber,ActaPhysiol.Pharmacol.Bulg.15:53-58,1989.

247. TrayanovaN.,Amethodforcalculationtheextracellularpotentialsfromexperimentallyrecordedintracellularpotentialsofsinglemusclefibers,ActaPhysiol.Pharmacol.Bulg.14:83-91,1988.

248. Kossev,A.,A.Gydikov,N.Trayanova,Comparisonofthedifferentversionsofthecurrentsourcedensityanalysismethodinneurophysiologicalstudies,ActaPhysiolPharmacolBulg14:75-82,1988.

249. Trayanova,N.,A.Gydikov,A.Kossev,Optimizationofthesourcederivationsfromthescalpsurface,ActaPhysiol.Pharmacol.Bulg.13:60-68,1987.

250. Radicheva,N.,N.Trayanova,A.Gydikov,L.Gerilovsky,Extracellularpotentialfieldofunmyelinatedactiveaxons,ActaPhysiol.Pharmacol.Bulg.13:22-29,1987.

251. TrayanovaN.,N.Radicheva,A.Gydikov,A.KossevandI.Iliev,Dependenceofthetotalioniccurrentonthetemperatureduringactionpotentialofafrogmusclefibre,Comp.Rend.Acad.Bulg.Sci.,38:1235-1238,1985.

252. Gydikov,A,LGerilovsky,NRadicheva,NTrayanova,Relationsbetweentheshapesofdifferentmusclepotentials.Experimentalandmodelinvestigations,ActaPhysiolPharmacolBulg,11:33-41,1985.

253. Radicheva,N.,N.Trayanova,A.Gydikov,K.Kostov,A.Kossev,Changesinthetotalioniccurrentoffrogmusclefibreactionpotentialundercontinuousactivity,Comp.Rend.Acad.Bulg.Sci.,38:1081-1084,1985.

PeerReviewedBookChapters

1. NTrayanova,PMBoyle,ModelingtheAgingHeart,inDZipes,JJalife,W.Stevenson(Eds.),CardiacElectrophysiology:FromCelltoBedside},7e,Saunders,(inpress).

2. NTrayanova,PMBoyle,CardiacArrhythmias:MechanisticKnowledgeandInnovationFromComputerModels,inAQuarteroni(Ed.),TheCardio-CirculatorySystem:fromModelingtoClinicalApplications,SpringerInternationalPublishing,ISBN978-3-319-05229-8,2015

3. TrayanovaN.PrinciplesandApplicationsofComputerModelinginDevicePatients,inClinicalCardiacPacing,Defibrillation,andResynchronizationTherapy,5thEdition,Eds.Ellenbogen,Wilkoff,Lau,Auricchio,Elsevier(inpress).

4. TrayanovaN.Defibrillation,inComprehensiveBiomedicalPhysics,vol.10,Ed.A.Brahme,Elsevier,p.255-268,2014

5. TrayanovaN,ConstantinoJ,HuY.CardiacElectromechanicalModels,inCardiacElectrophysiology:FromCelltoBedside,Eds.ZipesandJalife,6thEdition,ElsevierPublishingCompany,p.361-369,2013.

6. TrayanovaN.ModelingofVentricularArrhythmias,in:CardiacMapping,4thEdition,Eds.Shenasa,Hindricks,Borggrefe,BreithardtJosephson,Wiley-Blackwell,p.14–150,2013.

7. AshiharaT,ConstantinoJ,TrayanovaN.Mechanismsofdefibrillationfailure,in:CardiacDefibrillation:Mechanisms,ChallengesandImplications,Ed.N.Trayanova,InTechPublishing,pp.3-10,2011.

8. PlankG,TrayanovaN.Modelingdefibrillation,in:CardiacDefibrillation:Mechanisms,ChallengesandImplications,InTechPublishing,Ed.N.Trayanova,pp.39-58,2011.

9. JConstantino,V.Gurev,NTrayanova.Electromechanicalmodelinganditsapplicationtocardiacresynchronizationtherapy,in:CardiacMultimodalImageGuidedDiagnosisandTherapy,McGraw-Hill,Eds.WagnerandPahlm,pp.222-232,2011(coverfigure)

10. M.J.Bishop,HArevalo,PBoyle,NTrayanova,E.Vigmond,G.Plank,Computationalcardiacelectrophysiology:Modelingtissueandorgan,in:CardiacMultimodalImageGuidedDiagnosisandTherapy,McGraw-Hill,Eds.WagnerandPahlm,pp.233-265,2011

11. N.Trayanova,VGurev,JConstantino,YHu,Mathematicalmodelsofventricularmechanoelectric

couplingandarrhythmia,in:CardiacMechano-ElectricCouplingandArrhythmias,2ndedition,Eds.Kohl,Franz,pp258-268,2011.

12. R.Coronel,M.J.Janse.,N.Trayanova,X.Jie,Stretch-inducedarrhythmiasinischaemia,in:CardiacMechano-ElectricCouplingandArrhythmias,2ndedition,Eds.Kohl,Franz,pp.352-360,2011.

13. K.McDowell,N.Trayanova,PKohl,Fibroblastsandcardiacelectrophysiology,inTheCardiacFibroblast,Ed.N.Turner,ResearchSignpost,pp.9-27,2011

14. Vadakkumpadan,F,Gurev,V,Constantino,J,Arevalo,H,N.Trayanova.Modelingofwhole-heartelectrophysiologyandmechanics:Towardspatient-specificsimulations.in:Patient-SpecificModelingoftheCardio-VascularSystem:Technology-DrivenPersonalizedMedicine,RoyKerckhoffs(Eds.),Springer,pp.145-165,2010(coverfigure).

15. N.Trayanova,G.Plank.Modelingcardiacdefibrillation,inCardiacElectrophysiology:FromCelltoBedside,Eds.ZipesandJalife,5thEdition,ElsevierPublishingCompany,2009.

16. N.Trayanova,G.Plank.BidomainModelofDefibrillation,in:CardiacBioelectricTherapy:MechanismsandPracticalImplications,Eds.Efimov,Kroll,Tchou,Springer,2008.

17. AshiharaT,N.Trayanova:Shock-inducedchangesintransmembranepotential:Whatistheasymmetrydueto?Insightsfrombidomainsimulations.In:HiraokaM,OgawaS,KodamaI,InoueH,KasanukiH,KatohT(eds):AdvancesinElectrocardiology2004:Proceedingofthe31stInternationalCongressonElectrocardiology.WorldScientific,Singapore,pp.143-147,2005.

18. AshiharaT,N.Trayanova:Mechanismsofshock-inducedarrhythmogenesis:Roleoftissuediscontinuityandelectroporationintheinitiationoffocalrepetitivepostshockactivations.In:HiraokaM,OgawaS,KodamaI,InoueH,KasanukiH,KatohT(eds):AdvancesinElectrocardiology2004:Proceedingofthe31stInternationalCongressonElectrocardiology.WorldScientific,Singapore,pp.832-836,2005.

19. TrayanovaN.,RodriguezB:Changesinrabbitheartvulnerabilityduringphase1Aofacuteglobalischemia.InHiraokaM,OgawaS,KodamaI,InoueH,KasanukiH,KatohT(eds):AdvancesinElectrocardiology2004:Proceedingofthe31stInternationalCongressonElectrocardiology.WorldScientific,Singapore,pp.818-826,2005.

20. N.Trayanova,F.Aguel,C.Larson,C.Haro.Modelingcardiacdefibrillation:Aninquiryintopost-shockdynamics,in:“CardiacElectrophysiology:FromCelltoBedside”,Eds.ZipesandJalife,4theditionpp.282-291,2004.

21. N.Trayanova,J.Eason,C.Anderson,F.Aguel.ComputermodelingofdefibrillationII:Whydoestheshockfail?in:QuantitativeCardiacElectrophysiology,eds.C.CaboandD.Rosenbaum,MarcelDekker,NewYork,NY,pp.235-256,2002

22. N.Trayanova.Inductionofreentryanddefibrillation:Theroleofvirtualelectrodes.In:ComputerSimulationandExperimentalAssessmentofCardiacFunction,Eds.Virag,Blanc,Kappenberger,FuturaPublishingCo,pp.165-172,2001,

23. TrayanovaN.,L.Malden,E.Atkinson.ComputermodelofMAPgenesis,in:MonophasicActionPotentials,editedbyM.Franz,pp.47-69,1999.

ProceedingsPublications

1. FVadakkumpadan,HArevalo,FPashakhanloo,AAlers,FDawoud,KSchuleri,EMcVeigh,ALardo,N.Trayanova,EstimationofVentricularFiberOrientationsinInfarctedHeartsforPatient-SpecificSimulations,InternationalSymposiumonBiomedicalImaging,April7-11,SanFrancisco,CA,pp.636-639,2013.

2. FVadakkumpadan,N.Trayanova,LYounes,KWu,Left-VentricularShapeAnalysisforPredictingSuddenCardiacDeathRisk,Proceedingsofthe34thAnnualInternationalIEEEEMBSConferencepp.4067-4070,2012

3. PMBoyle,JCWilliams,EEntcheva,NTrayanova.AComputationalFrameworkforSimulatingCardiacOptogenetics,ComputinginCardiology2012;39:5-8.

4. VadakkumpadanF,ArevaloH,CeritogluC,MillerM,N.Trayanova.Image-basedestimationofventricularfiberorientationsforpatient-specificsimulations,ConfProcIEEEEngMedBiolSoc.2011,1672-1675,2011

5. AAkhbardeh,KTavakolian,ViGurev,WNew,BKaminska,N.Trayanova,ComparativeAnalysisofThreeDifferentModalitiesforCharacterizationoftheSeismocardiogram,ConfProcIEEEEngMedBiolSoc,2899-2903,2009.

6. H.E.Cetingul,G.Plank,N.Trayanova,R.Vidal.EstimationofmultimodalorientationdistributionfunctionsfromcardiacMRIfortrackingPurkinjefibersthroughbranching.ProceedingsoftheIEEEInt.SymposiumonBiomedicalImaging(ISBI09),2009

7. AAkhbardeh,F.Vadakkumpadan,JBayer,N.Trayanova.Locallyhomogenizedandde-noisedvectorfieldsforcardiacfibertrackinginDT-MRIimages,ProceedingsoftheSPIE,Volume7261,pp.72611R-72611R-10,2009.

8. H.E.Cetingl,R.Vidal,G.Plank,N.Trayanova,NonlinearFilteringforExtractingOrientationandTracingTubularStructuresin2DMedicalImages,IEEEInt.SymposiumonBiomedicalImaging(ISBI08),pp.260263,Paris,France,May2008.

9. HArevalo,PHelm,NTrayanova,Developmentofamodeloftheinfarctedcanineheartthatpredictsarrhythmiagenerationfromspecificcardiacgeometryandscardistribution”,ComputersinCardiologyProceedings,2008.

10. N.Trayanova,G.Plank.Arrhythmogenesisresearch:Aperspectivefromcomputationalelec-trophysiologyviewpoint.ConfProcIEEEEngMedBiolSoc.1:406-409,2007.

11. XJie,BRodrguez,RBlake,N.Trayanova,Roleofcellularuncouplinginarrhythmogenesisinischemiaphase1B.ConfProcIEEEEngMedBiolSoc.1:2272-2275.2006.

12. H.Arevalo,N.Trayanova.MaintenanceofVentricularFibrillationinHeterogeneousVentricle.ConfProcIEEEEngMedBiolSoc.;1:3950-3953,2006.

13. BRodrguez,BTice,RBlake,DGavaghan,NTrayanova.Vulnerabilitytoelectricshocksintheregionally-ischemicventricles.ConfProcIEEEEngMedBiolSoc.1:2280-2283,2006.

14. M.J.Bishop,B.Rodriguez,N.Trayanova,D.J.Gavaghan.Modulationofshock-endvirtualelectrodepolarizationasadirectresultof3Dfluorescentphotonscattering.ConfProcIEEEEngMedBiolSoc.1:1556-1559,2006.

15. T.Maharaj,B.Rodriguez,R.Blake,N.Trayanova,D.J.Gavaghan.Transmuralelectrophysiologicalheterogeneitiesinactionpotentialdurationincreasetheupperlimitofvulnerability.ConfProcIEEEEngMedBiolSoc.1:4043-4046,2006.

16. B.Rodrguez,N.Trayanova,D.Gavaghan.Roleofshocktimingincardiacvulnerabilitytoelectricshocks,in:Anaesthesia,Pain,IntensiveCareandEmergencyMedicine-A.P.I.C.E.Proceedingsofthe20thPostgraduateCourseinCriticalCareMedicine,Trieste,Italy-November18-21,2005Gullo,A.(Ed.),pp.134-145,2006.

17. X.Jie,B.Rodrguez,N.Trayanova.Theischemicheart:whatcausesectopicbeating?Proc.25AnnualIEEE/EMBSConf.pp.276-280,2005.

18. N.Trayanova,J.Eason,M.Hillebrenner.Defibrillationofarrhythmiasofincreasedcomplexity,IASTEDInternationalConferenceonBiomedicalEngineering,2004.

19. B.Rodrguez,J.Eason,B.Tice,J.M.Ferrero,N.Trayanova.Effectofacuteglobalischemiaoncardiacvulnerabilitytoelectricalshocks,Proc.24AnnualIEEE/EMBSConf,pp.151-152,2003.

20. N.Trayanova,J.Eason.Post-shockelectricalbehaviorintheheart,Proceedingsofthe2ndEuropeanMedical&BiologicalEngineeringConferenceEMBEC’02,pp.732-733,2002.

21. F.Aguel,C.Campbell,N.Trayanova,Biphasicdefibrillationinamodeloftherabbitheart,Proc.23AnnualIEEE/EMBSConf,(CD-ROM),2002.

22. J.Eason,M.Hillebrenner,C.Campbell,N.Trayanova,Assessingshockefficacyasafunctionofarrhythmiacomplexityinaslabofthecanineheart,Proc.23AnnualIEEE/EMBSConf,(CD-ROM),2002.

23. W.Li,J.Eason,P.Kohl,N.Trayanova.Theinfluenceofstretch-activatedchannelsondefibrillation,Proc.23AnnualIEEE/EMBSConf,(CD-ROM),2002.

24. C.Larson,L.Dragnev,J.Eason,N.Trayanova,Analysisofelectrically-inducedreentrantcircuitsusingnon-lineardynamicstools.Proc.23AnnualIEEE/EMBSConf,(CD-ROM),2002.

25. N.Trayanova,R.Ideker,W.Li,J.Newman,J,Eason,P.Kohl.Effectsofmechano-electricfeedbackondefibrillationthreshold,Proceedingsofthe3rdInternationalWorkshoponCardiacMechano-electricfeedbackandarrhythmias,pp.50-51,2002.

26. E.Vigmond,S.Kuo,N.Trayanova.Theroleofvagalstimulationonatrialarrhythmogenesis,Proc.23AnnualIEEE/EMBSConf,(CD-ROM),2002.

27. E.Vigmond,S.Kuo,N.Trayanova.Actionpotentialdurationheterogeneityinacomputermodeloftheatria.InternationalJournalofBioelectromagnetism,vol.4,pp.15–16,2002.

28. E.Vigmond,F.Aguel,N.Trayanova.Computationallyefficientmethodforsolvingthebidomainequationsin3D.Proc.22AnnualIEEE/EMBSConf,(CD-ROM)2001.

29. J.Eason,N.Trayanova.Phasesingularitiesandterminationofspiralwavereentry,Proc.22AnnualIEEE/EMBSConf,(CD-ROM)2001.

30. E.Azene,N.Trayanova.Wavefront-obstacleinteractions:Acomputationalstudy.ComputersinCardiology,pp.1-5,1999.

31. B.JRoth,A.Lindblom,N.Trayanova.Criticalpointtheoryversusthebidomainmodelforreentryinduction,Proc.21thAnnualIEEE/EMBSConf.,1999

32. F.Aguel,N.Trayanova,G.Siekas,J.C.Eason,M.G.Fishler,A.Street.VirtualelectrodesinducedthroughoutbulkmyocardiumbyICDdefibrillation,Proc.21thAnnualIEEE/EMBSConf.,1999

33. J.Wall,N.Trayanova,K.Skouibine,W.Krassowska.ModelinginductionofreentrywitharealisticS2stimulus,Proc.21thAnnualIEEE/EMBSConf.,1999

34. N.Trayanova.TheRoleofVirtualSourcesinDefibrillation.Proc.InternationalWorkshoponComputerSimulationandExperimantalAssessmentofElectricalCardiacFunction,p.113-117,1998

35. E.Azene,N.Trayanova,E.Warman.Fibrillationinatwo-dimensionalsheetofatrialmyocardium:Acomputationalstudyofwavefront-obstacleinteractions.ComputersinCardiology1998,IEEEPress,pp.185-189,1998

36. N.Trayanova,K.Skouibine.Terminationofreentrantactivationswithdefibrillationshocks:Amodelstudy,in:Electrocardiology’98,225-228,1998

37. K.Skouibine,N.Trayanova,P.Moore.Successandfailureofthedefibrillationshock:Doesitdependonthefiberfield?,Proc.20thAnnualIEEE/EMBSConf.,HongKong,pp.428-431,1998

38. F.Aguel,N.Trayanova,JEason,G.Siekas,M.Fishler,R.Malkin.Impactofendocardialleadpositionontransvenousdefibrillationefficacy:Asimulationstudy,ComputersinCardiology,1997.

39. J.T.Parry,N.Trayanova,Defibrillation-shockexcitationinasinglecardiacfiber,Proc19thEMBSConf,1997.

40. K.Skouibine,N.Trayanova,P.Moore,Reorganizationandterminationofaspiralwavereentryfollowingadefibrillationshock,Proc19thAnnualIEEE/EMBSConf,1997.

41. TrayanovaN.Theroleofcardiactissueanisotropyintheprocessofdefibrillation.Med.&Biol.Eng.&Comput.,Vol.34,Suppl.1,pp.75-76,1996.

42. TrayanovaN.andM.-B.Bray.WavefrontterminationwithmonophasicandbiphasicShocks:Asimulationstudy,Proc.18thAnnualIEEE/EMBSConf.,1996.

43. TrayanovaN.,J.C.EasonandC.S.Henriquez.Electrodepolarityeffectsontheshock-inducedtransmembranepotentialdistributioninthecanineheart.Proc.17thAnnualIEEE/EMBSConf.,1995.

44. TrayanovaN.andW.Krassowska,Virtualelectrodeeffectsinabidomainmodelwithelectroporatingmembrane.Proc.17thAnnualIEEE/EMBSConf.,1995.

45. TrayanovaN.Virtualelectrodeeffectsinamodelofcardiacstimulation.Proc.16thAnnualIEEE/EMBSConf.,61-62,1994.

46. TrayanovaN.Transmembranepotentialchangesduringstimulationinabidomainmodelofthemyocardium.In:ComputersinCardiology1993,LosAlamitos:IEEEComputerSocietyPress,253-256,1993.

47. TrayanovaN.andB.J.Roth.Mechanismsforcardiacstimulation.Proc.15thAnnualIEEE/EMBSConf.,817-818,1993.

48. B.J.RothandN.Trayanova.Electricalstimulationinatime-dependent,passivebidomain.Proc.15thAnnualIEEE/EMBSConf.,857-858,1993.

49. J.EasonandN.Trayanova.Theeffectsoffibercurvatureinabidomaintissuewithirregularboundaries.Proc.15thAnnualIEEE/EMBSConf.,744-745,1993.

50. TrayanovaN.andB.J.Roth.Cardiactissueinanelectricfield:Astudyofelectricalstimulation.In:ComputersinCardiology1993,LosAlamitos:IEEEComputerSocietyPress,695-698,1992.

51. TrayanovaN.andT.Pilkington.Theperiodicbidomainmodel:Anapplicationtocardiacstimulation.Proc.14thAnnualIEEE/EMBSConf.,2346-2348,1992.

52. PollardA.,N.TrayanovaandC.S.Henriquez.AComparisonofiterativemethodsforthedeterminationoftheinterstitialpotentialdistributionwiththebidomainmodel.Proc.14thAnnualIEEE/EMBSConf.,602-603,1992.

53. TrayanovaN.,T.PilkingtonandC.S.Henriquez.Aperiodicbidomainmodelforcardiactissue.Proc.13thAnnualIEEE/EMBSConf.,502-503,1991.

54. HenriquezC.S.,N.Trayanova.Aplanarslabpropagationmodelforcardiactissue.Proc.12thAnnualIEEE/EMBSConf.,p.617,1990.

55. SchmidtJ.,N.Trayanova,T.Pilkington.Theeffectofvariablethicknessskeletalmuscleonbodysurfacepotentialsusinganeccentricspheresmodel.Proc.12thAnnualIEEE/EMBSConf.,p.628,1990.

56. HenriquezC.S.,N.Trayanova,R.Plonsey,Sourcedistributioninmulticellularpreparations,Proc.10thAnnualIEEE/EMBSConf.,948-949,1988.

57. Radicheva,N.,N.Trayanova,A.GydikovandV.Kolev,Dependenceoftheextracellularactionpotentialsontheextracellularionicconcentration,in:LifeSciences:BirkhauserCongressReports,Proc.4thInternationalConferenceonWaterandIonsinBiologicalSystems,91-98,1986.

SelectedAbstracts1. PrakosaA,NikolovPP,ZahidS,IpekEG,NazarianS,TrayanovaNA.FeasibilityofSimulation-Based

PredictionofOptimalVentricularTachycardia(VT)AblationTargetsinPatientsWithICDArtifactBurden.Circulation.2016,134(Suppl1),A19049

2. Cartoski,M.J.,Prakosa,A.,Nikolov,P.,Boyle,P.M.,Spevak,P.J.,&Trayanova,N.(2016).RiskStratificationforVentricularArrhythmiainPatientsWithRepairedTetralogyofFallot(TOF)viaImage-BasedComputationalSimulations:APilotStudy.Circulation,134(Suppl1),A11921.

3. Nikolov,P.,Prakosa,A.,Arevalo,H.J.,Wu,K.C.,&Trayanova,N.(2016).ANovelApproachtoArrhythmiaRiskStratificationinPatientsWithNon-ischemicCardiomyopathy.Circulation,134(Suppl1),A20903.

4. AboelkassemY,TrayanovaNA.TropomyosinDynamicsduringCardiacThinFilamentActivationasGovernedbyaMulti-WellEnergyLandscape.BiophysicalJournal.2016;110(3):524a.

5. BoylePM,MurphyMJ,BlakeRC,3rd,etal.OptogeneticTerminationOfReentrantAtrialArrhythmiaCouldBeEnabledByLocalized,Long-Duration,LowEnergyLightPulsesAppliedEndocardially:AComputationalStudy.HeartRhythm.2016;13(5Suppl):S176-177.

6. BoylePM,MurphyMJ,KarathanosTV,etal.PulseDurationDeterminesEfficacyofArrhythmiaTerminationviaTargetedOptogeneticStimulation.BiophysicalJournal.2016;110(3):585a.

7. BoylePM,ZahidS,SchwarzEL,etal.CellAndTissue-LevelChangesResultingFromFibrosisNeedToBeRepresentedInPersonalizedAtrialModelsToCorrectlyReproduceClinicalOutcomesInAFPatients.HeartRhythm.2016;13(5Suppl):S541-542.

8. BoylePM,ZahidS,SchwarzEL,etal.EmergentMechanismsOfAFSustenanceAfterFailedReentrantDriver(RD)Ablation:InsightsFromMRI-BasedPersonalizedAtrialModels.HeartRhythm.2016;13(5Suppl):S405-406.

9. ChangKC,TrayanovaNA.RoleOfAlternansAssociatedWithHumanAtrialFibrillationInArrhythmiaInitiationAndMaintenance.HeartRhythm.2016;13(Suppl5):S368-369.

10. IpekEG,FukumotoK,ZahidS,etal.AssociationofLeftAtrialLateGadoliniumEnhancementWithRegionalElectrogramFractionationDuringSinusRhythm.HeartRhythm.2016;13(Suppl5):S297-298.

11. MillareBM,TrayanovaNA.ClustersOfVentricularTissueWithMetabolicallyInducedDelayedExcitabilityCanInitiateAReentrantWave.HeartRhythm.2016;13(Suppl5):S193.

12. NikolovPP,PrakosaA,ArevaloHJ,WuKC,TrayanovaNA.ANovelApproachtoArrhythmiaRiskStratificationinPatientsWithNon-ischemicCardiomyopathy.Circulation.2016;accepted.

13. PashakhanlooF,ArevaloHJ,HerzkaDA,etal.NovelSub-MillimeterResolutionSwineHeartModelRevealsTheContributionOfInfarct3DMicrostructureToTheFormationAndMaintenanceOfPost-InfarctReentry.HeartRhythm.2016;13(Suppl5):S542.

14. PashakhanlooF,HerzkaDA,AshikagaH,etal.Sub-MillimeterResolutionDiffusionTensorImagingReveals3DOrganizationofMyofiberArchitectureInTheHumanAtria.HeartRhythm.2016;13(Suppl5):S457.

15. Millare,B.O'Rourke,B.andN.A.Trayanova(2014)."Cell-WideCoordinationofROS-InducedROSReleasebyHydrogenPeroxideinMitochondrialNetworks."BiophysicalJournal106(2):183a,2016

16. PrakosaA,NikolovPP,ZahidS,IpekEG,NazarianS,TrayanovaNA.FeasibilityofSimulation-BasedPredictionofOptimalVentricularTachycardia(VT)AblationTargetsinPatientsWithICDArtifactBurden.Circulation.2016,134(Suppl1),A19049

17. UkwattaE,NikolovP,HannaG,etal.VirtualElectrophysiologicalStudyUsingT1MappingTechniquesImprovesSensitivityInPredictingAdverseArrhtyhmicEventsInPost-InfarctionPatients.HeartRhythm.2016;13(5Suppl):S506-507.

18. YuJK,BoylePM,O'HaraT,PriestJR,AshleyE,TrayanovaNA.SomaticMosaicismofNovelSCN5AMutationinPurkinjeSystem(PS)mayUnderlie2:1BlockinanInfantwithLongQTSyndrome(LQTS).BiophysicalJournal.2016;110(3):527a.

19. YuJK,O'HaraT,BoylePM,etal.MosaicExpressionOfANovelSCN5AMutation(V1762L)InPurkinjeCellsMayUnderlie2:1AVBlockAndLeftBundleBrandBlockObservedInAnInfantWithLQTS.HeartRhythm.2016;13(5Suppl):S455.

20. ZahidS,BoylePM,SchwarzEL,etal.MachineLearningIdentifiesRelationshipbetweenReentrantDriverLocationsandFibrosisSpatialPatternsinPatient-SpecificModelsofHumanAtria.HeartRhythm.2016;13(Suppl5):S370.

21. ZahidS,BoylePM,SchwarzEL,etal.ReentrantDriverssimulatedfromMRI-basedpatient-specificmodelscorrelatetodriversmappedclinicallywithECGI.HeartRhythm.2016;13(Suppl5):S297-298.

22. ZahidS,WhyteKN,SchwarzEL,etal.PredictionofOptimalAblationTargetsforLeftAtrialFlutterinPatient-SpecificModelsusingthe‘MinimumCut’Algorithm.HeartRhythm.2016;13(5Suppl):S121-122.

23. BoylePM,ZahidS,SchwarzE,etal.LocalComplexityoftheFibrosisSpatialPatternDeterminestheLocationsofStableReentrantSourcesinPersistentAtrialFibrillation:AnalysisfromPatient-SpecificModels.HeartRhythm.2015;12(5Suppl):S7.

24. BoylePM,ZahidS,SchwarzE,etal.PrevalenceofRegionswithHighlyIntermingledFibroticandNon-FibroticTissueisaBetterPredictorofArrhythmiaInducibilityThanTotalFibrosisBurden:AnalysisofPatient-SpecificModelsofPersistentAtrialFibrillation.HeartRhythm.2015;12(5Suppl):S80.

25. BoylePM,KarathanosTV,WangD,etal.SpatialDistributionofLight-SensitiveCellsandDensityofIlluminationSourcesDetermineEffectivenessofOptogenetics-BasedTerminationofAtrialFibrillationinaSimulationStudy.HeartRhythm.2015;12(5Suppl):S407-408.

26. ZahidS,BoylePM,SchwarzE,etal.StabilityofReentrantSourcesandAblationTargetinginFibroticHumanAtriawithPersistentAtrialFibrillation.HeartRhythm.2015;12(5Suppl):S116.

27. ZahidS,WhyteKN,SchwarzEL,etal.FeasibilityofUsingMRI-based,Patient-SpecificSimulationstoPredictAblationTargetsinHumanLeftAtrialFlutter.HeartRhythm.2015;12(5Suppl):S113.

28. CochetH,DuboisR,RelanJ,etal.Relationshipbetweenrotoractivityandfibrosisinpersistentatrialfibrillation:acombinednoninvasivemappingandMRIstudy.HeartRhythm.2015;12(5Suppl):S512.

29. ZahidS,BoylePM,MalamasP,etal.ReentrantSourcesinPersistentAFAreLocatedinRegionswithSpecificSpatialPatternsofFibrosis.Circulation.2014;130(Suppl2):A13235.

30. ArevaloH,VadakkumpadanF,JebbA,MalamasP,WuK,andTrayanovaN,VirtualElectrophysiologicalStudyImprovesRiskPredictionofAdverseCardiacEventsinPost-InfarctionPatients,HeartRhythm,12(5):S545-S546,2015.

31. A.Prakosa,H.J.Arevalo,S.Zahid,E.Ukwatta,J.Chrispin,E.G.Ipek,K.Fukumoto,S.Nazarian,andN.A.Trayanova.OvercomingICDImageArtifact:MRI-BasedHeartModelPredictsOptimalAblationSitesforInfarct-RelatedVentricularTachycardia.HeartRhythm,12(5):S374,2015.

32. PMBoyle,SZahid,ELSchwarz,KNWhyte,EJVigmond,RDubois,MHaïssaguerre,MHocini,PJaïs,HCochet,NATrayanova,LocalComplexityoftheFibrosisSpatialPatternDeterminestheLocationsofStableReentrantSourcesinPersistentAtrialFibrillation:AnalysisfromPatient-SpecificModels,HeartRhythm12(5Suppl):S7,2015.

33. PMBoyle,SZahid,ELSchwarz,KNWhyte,EJVigmond,RDubois,MHaïssaguerre,MHocini,PJaïs,HCochet,NTrayanova,PrevalenceofRegionswithHighlyIntermingledFibroticandNon-FibroticTissueisaBetterPredictorofArrhythmiaInducibilityThanTotalFibrosisBurden:AnalysisofPatient-SpecificModelsofPersistentAtrialFibrillation,HeartRhythm12(5Suppl):S80,2015.

34. SZahid,KNWhyte,ELSchwarz,APrakosa,PMBoyle,BBarcelon,KFukumoto,JChrispin,EGIpek,MHabibi,TSuzuki,HRHalperin,HCalkins,RDBerger,SNazarian,NATrayanova,FeasibilityofUsingMRI-based,Patient-SpecificSimulationstoPredictAblationTargetsinHumanLeftAtrialFlutter,HeartRhythm12(5Suppl):S113,2015.

35. SZahid,PMBoyle,ELSchwarz,KNWhyte,EJVigmond,RDubois,MHaïssaguerre,MHocini,PJaïs,HCochet,NATrayanova,StabilityofReentrantSourcesandAblationTargetinginFibroticHumanAtriawithPersistentAtrialFibrillation,HeartRhythm12(5Suppl):S116,2015.

36. PMBoyle,TVKarathanos,DWang,SZahid,Whyte,ELSchwarz,HCalkins,SNazarian.EEntcheva,NATrayanova,SpatialDistributionofLight-SensitiveCellsandDensityofIlluminationSourcesDetermineEffectivenessofOptogenetics-BasedTerminationofAtrialFibrillation(AF)ina

SimulationStudy,HeartRhythm12(5Suppl):S407-8,2015.37. HCochet,RDubois,JRelan,SZahid,NAljefairi,SYamashita,JSellal,BBerte,SAmraoui,ADenis,N

Derval,PMBoyle,NATrayanova,FSacher,MHocini,P.Jaïs,Relationshipbetweenrotoractivityandfibrosisinpersistentatrialfibrillation:acombinednoninvasivemappingandMRIstudy,HeartRhythm12(5Suppl):S512,2015.

38. TVKarathanos,PMBoyle,JDBayer,DWang,NATrayanova,"WavelengthofLightStimulusDeterminesEffectivenessofOptogenetics-BasedVentricularDefibrillationinaComputationalModeloftheHumanHeart"BMES2015.

39. MZile,NTrayanova,LargeAmplitudeRate-DependentMechanicalAlternansmayPrecedeArrhythmogenesisinHumanHeartFailureandareLinkedtoElectricalAlternansviaAbnormalCalciumHandling,BiophysJ,108(2),503a-504a,2015

40. TKarathanos,PMBoyle,JBayer,DWang,NTrayanova,OpsinSpectralSensitivityDeterminestheEffectivenessofOptogenetics-BasedDefibrillation,BiophysJ,108(2),148a,2015

41. VRamchandran,TOHara,YMarkandeya,RBalijepalli,TKamp,NTrayanova,IonicMechanismsthatUnderlieVentricularActionPotentialProlongationfollowingLossofCaveolin-3inAdultTransgenicMice,BiophysJ,108(2),195a,2015

42. KChang,NTrayanova,DependencyofCa2+AlternansonIonChannelLocalizationinHumanAtrialCellsBiophysJ,108(2),267a-268a,2015

43. TO’Hara,A.Glukhov,PWright,PhD,ABhargava,JGorelik,NTrayanova,MechanisticConnectionsBetweenCaveolin-3LossandArrhythmia,HeartRhythm11:S417-S418,2014

44. FPashakhanloo,HArevalo,FVadakkumpadan,RBeinart,MZviman,DHerzka,HHalperin,EMcVeigh,NTrayanova,Novelhighresolutionwholeheartmodelofinfarctiondemonstratesthatscarcomplexityissufficientforinducingarrhythmiaintheabsenceofioniccurrentremodeling,HeartRhythm11:S251-S252,2014

45. K.Chang,JBayer,NTrayanova,DisruptionofRyanodineReceptorKineticsDrivesAlternansinHumanAtrialFibrillation,HeartRhythm11:S167,2014

46. HArevalo,FPashakhanloo,RBeinart,FVadakkumpadan,MZviman,DHerzka,EMcVeigh,HHalperin,NTrayanova,Predictionofinfarct-relatedreentrantcircuits:usingin-vivovs.ex-vivoMRIwholeheartmodels,HeartRhythm11:S250,2014

47. BrentMillare,BO’Rourke,NTrayanova,Cell-wideCoordinationofROS-inducedROSReleasebyHydrogenPeroxideinMitochondrialNetworks,BiophysJ(inpress),2014

48. FVadakkumpadan,HArevalo,AJebb,KWu,NTrayanova,Image-BasedPatient-SpecificSimulationsofVentricularElectrophysiologyforSuddenArrhythmicDeathRiskStratification,Circulation128:A18014,2013

49. JYu,PMBoyle,CMAmbrosi,NTrayanova,EEntcheva,High-ThroughputContactlessOptogeneticAssayforCellularCoupling:IllustrationbyChR2-Light-SensitizedCardiacFibroblastsandCardiomyocytes,Circulation128:A14943,2013

50. TO’Hara,PTWright,VONikolaev,JGorelik,NTrayanova,Caveolin-3RestoresLocalcAMPSignalingWithoutRestoringT-TubulesinResponsetoss2AdrenergicReceptorStimulationinHeartFailure,Circulation128:A10586,2013

51. FVadakkumpadan,LYounes,NTrayanova,KWu,Image-BasedLeftVentricularShapeAnalysisforSuddenCardiacDeathRiskStratification,HeartRhythm,10(11):1753,2013.

52. MZile,JBayer,NTrayanova,Largeamplituderate-dependentmechanicalalternansmayprecedearrhythmogenesisinhumanheartfailureandarelinkedtoelectricalalternansviaabnormalcalciumhandling,Physiomemeeting,BarHarbor,Oct.2013(abstractavailableonlineatcar-diacphysiome.phys.mcw.edu)

53. BMillare,BO’Rourke,NTrayanova,Cell-wideCoordinationofROS-inducedROSReleasebyHydrogenPeroxideinMitochondrialNetworks,Physiomemeeting,BarHarbor,Oct.2013(abstractavailableonlineatcardiacphysiome.phys.mcw.edu)

54. PBoyle,CPark,HArevalo,EVigmond,NTrayanova,INareductioncreatesastructure-dependentarrhythmogenesissubstrateinnormalventricles,Physiomemeeting,BarHarbor,Oct.2013(abstractavailableonlineatcardiacphysiome.phys.mcw.edu)

55. ArevaloH,VadakkumpadanF,JebbA,WuK,NTrayanova,PatientspecificMRI-basedmodelsofinfarctedheartscanpredictriskofsuddencardiacdeath,JournalofElectrocardiology46:e19e20,2013.

56. JBayer,S.Narayan,GLalani,NTrayanova,Ca-drivenlow-amplitudeactionpotentialvoltage

alternansprecedesarrhythmogenicspatiallydiscordantalternansinhumanheartfailure,HeartRhythm10(5):S6,2013u

57. HArevalo,HEstner,CPark,HHalperin,NTrayanova,Image-basedcomputationalmodelofinfarctedheartscannon-invasivelypredictoptimalablationsite,HeartRhythm10(5):S327-S328,2013.

58. HArevalo,FVadakkumpadan,AJebb,KWu,NTrayanova,Patient-specificMRI-basedmodelsofinfarctedheartscanpredictriskofsuddencardiacdeath,HeartRhythm10(5):S327,2013.

59. LRantner,FVadakkumpadan,J.Crosson,PSpevak,NTrayanova,PredictionofoptimalICDplacementinapatient-specificmodelofpediatriccongenitalheartdefect,HeartRhythm10(5):S254,2013

60. KMcDowell,FVadakkumpadan,JBlauer,GPlank,RMacLeod,NTrayanova,Patient-SpecificAtrialModelingUncoversLinkBetweenFibrosisandAtrialFibrillation,HeartRhythm10(5):S180,2013.

61. SHegde,SShea,LPan,PKarmarkar,JBarbot,KJKirchberg,FVadakkumpadan,JMaurer,JCook,NTrayanova,MSolaiyappan,PVJohnston,DLKraitchman,Transendocardialtherapeutic-deliveryusingreal-timeMRIguidance,InternationalSocietyforMagneticResonanceinMedicine(ISMRM)AnnualMeeting,SaltLakeCity,p.4314,2013.

62. SHegde,SShea,LPan,PKarmarkar,JBarbot,KJKirchberg,FVadakkumpadan,JMaurer,JCook,NTrayanova,MSolaiyappan,PVJohnston,DLKraitchman,Transmyocardialtherapeuticsdeliveryusingreal-timeMRIguidance,JournalofCardiovascularMagneticResonance15(Suppl1):p15,2013.

63. TAshihara,RHaraguchi,KNakazawa,TIkeda,TOzawa,MIto,MHorie,NTrayanova,FunctionalPropertiesofComplexFractionatedAtrialElectrogramsDuringAtrialFibrillationCanbeExplainedbyStructuralRemodeling:AComputationalStudy,Circulation126(S21):A10039,2012.

64. ABhargava,TO’Hara,MBSikkel,ARLyon,NTrayanova,JGorelik,NanoscaleMovementofL-TypeCalciumChannelsintheCardiomyocyteMembraneCanContributetoArrhythmiaDuringHeartFailure.Circulation126(S21):A11953,2012.

65. TO’Hara,NTrayanova,Globalizationofbeta2-AdrenergicResponseFollowingT-tubularDegra-dationisArrhythmogenic.Circulation126(S21):A13454,2012.

66. DKrummen,JBayer,JHo,GHo,MSmetak,N.Trayanova,MechanismsforHumanAtrialFibrillationInitiation:ComputationalStudiesofRepolarizationRestitutionandActivationLatency,Proceedingsofthe34thAnnualInternationalIEEEEMBSConference(minisymposium),2012

67. TAshihara,RHaraguchi,SInada,KNakazawa,TIjeda,TOzawa,MIto,MHorie,NTrayanova,TheoreticalbasisofoptimalstrategyforCFAE-targetedablationduringchronicatrialfibrilation,HeartRhythm9(5):S197,2012

68. YHu,VGurev,NTrayanova,Efficientatrialfillingunderliesstrokeworkimprovementintheacuteresponsetocardiacresynchronizationtherapy(CRT),HeartRhythm9(5):S254,2012

69. PMBoyle,JCWilliams,EEntcheva,andNTrayanova,SpatialDistributionofChannelrhodopsin2AffectsOpticalStimulationEfficiencyinCardiactissue,HeartRhythm9(5):S182,2012.

70. RantnerLJ,TrayanovaN.Lowvoltagedefibrillationismostsuccessfulnearthefibrillationcyclelength.HeartRhythm9(5):S254,2012

71. TO’Hara,TrayanovaN,BlockofEnhancedLateNa+CurrentinHumanHeartFailurePreventsActionPotentialProlongationandbAdrenergicStimulationInducedEarlyAfterdepolarizations,HeartRhythm9(5):S10,2012

72. KCChang,SHWeinberg,RZhu,HTandri,RD.Berger,TrayanovaN,DegreeofInducedRefractorinessPredictsSuccessofDefibrillationbyHighFrequencyElectricField,HeartRhythm;9(5):S257,2012.

73. McDowellK,BlauerJ,VadakkumpadanF,PlankG,MacLeodR,TrayanovaN,FibrosisUnderliestheBreakupofPulmonaryVeinEctopicWavesinPatient-SpecificAtrialModels,HeartRhythm;9(5):S253,2012.

74. ArevaloH,EstnerH,ParkC,HalperinH,TrayanovaN,In-vivoMRI-basedmodelsofinfarct-relatedventriculartachycardiasuccessfullypredictoptimalablationsite,HeartRhythm,9(5):S181,2012.

75. GurevV,ConstantinoJ,HuY,TrayanovaN.RegionalHeterogeneityofVentricularContractilityEnhancesEfficacyofCardiacResynchronization.Circulation;124Supp:A16506,2011.

76. AshikagaH,ArevaloH,VadakkumpadanF,BlakeR,BergerR,CalkinsH,TrayanovaN,HalperinH,MRI-BasedPatient-SpecificVirtualElectrophysiologyLaboratoryforScar-RelatedVentricularTachycardia,Circulation,124Supp:A541,2011.

77. ChenX,BergerRD,TrayanovaN.DevelopmentofInstabilityinQTIntervalDynamicsBeforetheOnsetofVentricularFibrillation.Circulation;124Supp:A15428,2011.

78. DEKrummen,JDBayer,JHo,GHo,MRMollerus,N.Trayanova,S.M.Narayan..MechanismsforHumanAtrialFibrillationInitiation:ClinicalandComputationalStudiesImplicatingRepolarizationRestitution.Circulation.124Supp:A553,2011.

79. LGTereshchenko,R.Kim,L.Han,D.Das,K.Cheng,E.Robinson,S.Schulman,J.Brinker,R.Berger,N.Trayanova,MechanicalAlternansStronglyCorrelateswithT-waveAlternansandPredictsDeathinMildandModerate,butnotEnd-StageHeartFailurePatients,HeartRhythm,8,:1825,2011

80. ArevaloH,ParkC,BlakeR,HalperinH,TrayanovaN,In-VivoMRI-BasedModelsOfInfarctedHeartsSuccessfullyPredictOptimalAblationSite,BMES2011AnnualFallMeeting,Hartford,CT,2011.

81. ConstantinoJ,GurevV,TrayanovaN.ProlongedElectromechanicalDelayInDyssynchronousHeartFailureArisesFromReducedContractility.HeartRhythm,8(5):S18,2011

82. ParkC,ArevaloH,TrayanovaN.SafetyFactorPredictsConductionBlockAndArrhythmogenesisInBrugadaSyndrome.HeartRhythm,8(5):S395,2011.

83. HuY,GurevV,TrayanovaN.TheCardiacResynchronizationTherapy(CRT)PacingSiteThatResultsInMostHomogeneousEnergyConsumptionIsDifferentFromThatBasedOnStrokeWorkImprovement.HeartRhythm8(5):S324-325,2011.

84. J.D.Bayer,D.E.Krummen,S.M.Narayan,TrayanovaN.IsoproterenolAltersPotassiumandSodiumCurrentKineticstoSteepenActionPotentialDurationRestitutionandShortenActivationLatencyinHumanAtrialFibrillation.HeartRhythm,8(5):S258,2011.

85. D.E.Krummen.,J.D.Bayer,J.Ho,G.Ho,M.R.Mollerus,TrayanovaN,S.MNarayan.MechanismsofAtrialFibrillationInitiationbyClinicalInductionMethods:ClinicalandComputationalModelingStudiesofAtrialActivationandRepolarizationRestitution.HeartRhythm,8(5):S305,2011.

86. J.D.Bayer,D.E.Krummen,S.M.Narayan,TrayanovaN.Beta-AdrenergicStimulationAltersbothIonChannelCurrentsandFunctionalRefractoryPeriodtoSteepenActionPotentialDurationRestitutioninPersistentAtrialFibrillation.BiophysJ.,100(suppl1):434a-435a,2011.

87. ChenX,TereshchenkoL,BergerRD,TrayanovaN.ArrhythmiaRiskStratificationbyAssessingQTintervalInstabilityinPatientswithStructuralHeartDisease.HeartRhythm,8(5):S295,2011

88. RantnerLJ,TiceBM,TrayanovaN.Virtualelectrode-inducedearlierpropagationisresponsibleforterminatingventriculartachycardiaafterlowvoltagefieldstimuli.HeartRhythm,8(5):S107,2011.

89. ParkCJ,ArevaloHJ,TrayanovaN.ArrhythmogenesisinBrugadaSyndrome:RoleofVentricularStructure,BiophysJ.,100(suppl.1):435a,2011.

90. TrayanovaN,Electromechanicalmodeloftheheart,SIAM,CSE2011,p.211.91. McDowellK,ArevaloH,MaleckarM,BlakeR,TrayanovaN,Fibroblast-myocytecouplinginduces

alterationsinpotassiumcurrentsthattriggerregionalactionpotentialdurationprolongationininfarctedmyocardium.HeartRhythm,7:S163-164,2010.

92. WeinbergSH,TandriH,ChangKC,TrayanovaN,BergerRD,TungL.HighFrequencyFieldStimulationTerminatesReentryandBlocksCardiacConduction.HeartRhythm,7:S291,2010.

93. Y.Hu,X.Chen,V.Gurev,R.Blake,J.Bayer,TrayanovaN,QTIntervalInstabilityCorrelateswithRepolarizationInstability,HeartRhythm,7:S351,2010.

94. ParkCJ,ArevaloHJ,TrayanovaN.RightventricularstructurepredisposestoarrhythmogenesisinBrugadasyndrome,HeartRhythm.7:S226-S227,2010.

95. RantnerLJ,ArevaloHJ,ConstantinoJL,VadakkumpadanF,BlakeRC,TrayanovaN.Shockinducedscrollwaveformationispromotedinitiallyintheperi-infarctzone,thenatthescar.HeartRhythm,7:S91,2010.

96. ArevaloH,VadakkumpadanF,andTrayanovaN,Fiberarchitectureininfarctedheartsdoesnotsignificantlyaffectlocationofreentryisthmusoroptimalablationsite,HeartRhythm,7:S163,2010

97. ConstantinoJ,GurevV,TrayanovaN.OptimalCardiacResynchronizationTherapyisAchievedbyPacingfromtheLVRegionWiththeLongestElectromechanicalDelay,HeartRhythm,7:S164S165,2010

98. ProvostJ,GurevV,TrayanovaN,KonofagouEE.ValidationofElectromechanicalWaveImagingforMappingoftheRegionalCardiacElectricalActivityNoninvasivelyInVivo.IEEEInternationalUltrasonicsSymposium,SanDiego,CA,Oct,2010.

99. BayerJ.,NarayanS.,LalaniG.,TrayanovaN.SpatiallydiscordantalternansinactionpotentialvoltageunderlieT-wavealternansinhumanheartfailure.The37thInternationalCongressonElectrocardiology,Lund,Sweden,June2010.

100. ConstantinoJ,GurevV,TrayanovaN,ElectromechanicalDelayisheterogeneousinthefailingcanineventriclesbothduringleftbundlebranchblockandfollowingbiventricularpacing.HeartRhythm,

6:1685,2009.101. BayerJD,NarayanSM,LalaniGG,TrayanovaN.Rate-DependentActionPotentialAlternansin

HumanHeartFailureImplicateAbnormalitiesinIntracellularCalciumHandling.HeartRhythm,6(11):1685,2009.

102. HuY,GurevV,ConstantinoJ,TrayanovaN,Degenerationofventriculartachycardiaintoventricularfibrillationfollowingrightventriculardilation.Circulation,120:S698,2009.

103. KTavakolian,VGurev,AAkhbardeh,BKaminska,N.Trayanova,Seismogramcapturesdecreaseinleftventricularstrokevolumeduringinspiration,BMESAnnualMeeting2009.

104. Y.Hu,JConstantino,VGurev,N.Trayanova.DegenerationofVentricularTachycardiaintoVentricularFibrillationFollowingRightVentricularDilation,BMESAnnualMeeting2009.

105. JConstantino,VGurev,N.Trayanova.Image-BasedElectromechanicalModelRevealsProlongedElectromechanicalDelayinHeartFailure,BMESAnnualMeeting2009.

106. ChenX,BayerJ,TiceB,VadakkumpadanF,TrayanovaN,TheEffectofCardiacTissueArchitectureontheSpatialDistributionofConductionVelocityanditsRestitution,BMESAnnualMeeting2009

107. L.Zhou,N.Trayanova,B.O’Rourke.Effectofmitochondrialdepolarizationoncardiacarrhythmia:insightsfromamultiscalemathematicalmodelofthemyocardium,ISHRNorthAmericanSectionMeeting2009.

108. Rantner,LJ,Arevalo,HJ,Constantino,JL,Vadakkumpadan,F,Blake,RC,Plank,G,Trayanova,N,Slowedconductionintheperi-infarctzoneandtransmuralanchoringtothescarunderlieincreasedvulnerabilitytoshocksininfarctedhearts.HeartRhythm.6:S169,2009.

109. ArevaloH,PlankG,HelmP,HalperinH,TrayanovaN,VolumeofPeri-InfarctZoneDeterminesArrhythmogenesisinInfarctedHeart.HeartRhythm,6:S232-233,May,2009.

110. BayerJD,NarayanSM,LalaniGG,PlankG,TrayanovaN.ReducedCaUptakeLowerstheThresholdforActionPotentialandT-waveAlternansatFastRates:aClinicalandModelingStudy.HeartRhythm,6:S231-S232,May,2009.

111. GurevV,ProvostJ,KonofagouE,TrayanovaN,Insilicocharacterizationofventricularactivationpatternsbyelectromechanicalwaveimaging.HeartRhythm,6:S357,May,2009.

112. F.Vadakkumpadan,H.Arevalo,CCeritoglu,MMiller,NTrayanova,Image-BasedEstimationofMyocardialFiberOrientationsforPatient-SpecificModelsofCardiacElectrophysiology.HeartRhythm,6:S1688,2009.

113. ChenX,AkhbardehA,AzarAA,BergerRD,TrayanovaN.NovelQTStabilityMonitoringAlgorithmInClinicalECGRecordings.HeartRhythm,6:S332,May,2009

114. McDowellK,ArevaloH,MaleckarM,BlakeR,PlankG,TrayanovaN,Fibroblastmyocytecouplingcausesactionpotentialdispersionintheinfarctedheart.HeartRhythm,6:S295-296,2009.

115. H.Arevalo,M.Bishop,B.Rodriguez,N.Trayanova.PhotonscatteringduringopticalmappingdistortsthespatiotemporalorganizationinVF.HeartRhythm5:S359,2008

116. L.Zhou,G.Plank,S.Cortassa,J.Greenstein,R.Winslow,N.Trayanova,B.O’Rourke.Effectsofmitochondrialdepolarizationonelectricalpropagationinanintegratedmultiscalemodelofthemyocardium,HeartRhythm5:S109,2008

117. M.Maleckar,J.Greenstein,W.Giles,N.Trayanova.Couplingofhumanatrialmyocytesandmyofibroblastscanleadtoconductiondisturbances,HeartRhythm5:S57,2008

118. G.Plank,A.Prassl,J.Wang,G.Seemann,D.Scherr,D.Sanchez-Quintana,MD,H.Calkins,N.Trayanova.Atrialfibrosispromotesthetransitionofpulmonaryveinectopyintoreentrantarrhythmias,HeartRhythm5:S78,2008

119. H.Arevalo,A,Prassl,G.Plank,P.Helm,H.Helprin,N.Trayanova.Modeloftheinfarctedcanineheartpredictsarrhythmiagenerationfromspecificcardiacgeometryandscardistribution,HeartRhythm5:S162-163,2008

120. X.Jie,V.Gurev,N.Trayanova.Mechanismsofmechanically-inducedspontaneousarrhythmiasinacuteregionalischemia,HeartRhythmS58-S59,2008

121. J.Bayer,S.Narayan,T.Ashihara,G.Lalani,N.Trayanova.ReducedcalciumuptakeleadstohumanacionpotentialphaseIIandT-wavealternans:Acomputersimulationstudy,HeartRhythm5:S109,2008

122. F.Vadakkumpadan,H.Arevalo,A.Prassl,J.Chen,F.Kickinger,P.Kohl,G.Plank,N.Trayanova,Image-basedmodelsofcardiacstructureinhealthanddisease,BMESAnnualMeeting2008.

123. J.Constantino,V.Gurev,N.Trayanova,HeterogeneityinContractilePropertiesDoesNotExplainTransmuralDelayinMyofiberShortening”BMESAnnualMeeting2008.

124. Y.Long,J.Constantino,N.Trayanova.ReducedExcitableAreaattheLeftVentricularAnteriorWallLowerstheDefibrillationThreshold,BMESAnnualMeeting2008

125. CPark,HArevalo,NTrayanova,Roleoffiberorientation,tissuethickness,andInaexpressioninventricularepicardialactivation,BMES2008AnnualMeeting,267,2008.

126. V.Gurev,J.Constantino,N.Trayanova.TransmuralDyssynchronyofMyofiberShorteningisDeterminedbyDepolarizationSequencewithinMyocardialLayers,Circulation,118:S349-S350,2008.

127. ArevaloH,HelmP,TrayanovaN,Developmentofamodeloftheinfarctedcanineheartthatpredictsarrhythmiagenerationfromspecificcardiacgeometryandscardistribution,ComputersinCardiology,5:S73,2008.

128. JProvost,V.Gurev,J.Luo,N.Trayanova,E.Konofagou.CharacterizationofWaveOriginsinElectromechanicalWaveImaging,2008IEEEInternationalUltrasonicsSymposium,Beijing,China,Nov2-5,2008

129. L.Xu,M.Chang,R.Blake,U.Farooq,N.Trayanova.Investigatingfaileddefibrillationinacomputationalmodelofcalciumoverload,BMESAnnualMeeting,2007.

130. T.Ashihara,T.Yao,M.Ito,M.Horie,R.Haraguchi,K.Nakazawa,T.Namba,T.Ikeda,N.Trayanova.SteepAPDrestitutioncurveisnotessentialformicrovoltT-wavealternans:Insightsfromcomputersimulations.HeartRhythm4:S92,2007.

131. T.Maharaj,B.Rodriguez,G.Plank,A.J.Prassl,T.Mansoori,V.Grau,P.Kohl,D.Gavaghan,N.Trayanova.Shockinducedvirtualelectrodesinamicro-anatomicallyaccuratewedgemodel.HeartRhythm4:S110-S111,2007.

132. LiW.,A.McCulloch,N.Trayanova.Effectofmechanoelectricfeedbackonshock-inducedarrhythmogenesisindilatedventricles.HeartRhythm4:S160,2007.

133. TiceB,RipplingerC,PlankG,PrasslA,EfimovI,TrayanovaN.Modelsofendocardialmicrostructurefromopticalcoherencetomographyimaging.HeartRhythm4:S158,2007.

134. X.Jie,B.Rodrguez,J.DeGroot,R.Coronel,N.Trayanova.Ventriculararrhythmiasinregionalischemiaphase1B.HeartRhythm,4:S157,2007.

135. VFedorov,JConstantino,VNikolski,NTrayanova,I.Efimov,Structuraldeterminantsofshock-inducedelectroporationintheventricles,BiophysicalSocietyAnnualMeeting,Baltimore,March2007.

136. BRodriguez,BTice,RBlake,JEason,DGavaghan,NTrayanova.Vulnerabilitytoelectricshocksinregionalischemia.HeartRhythm,3:S226,2006.

137. MMaleckar,RBlake,NTrayanova.Fibrosisdecreasesactivationtimeduringdefibrillationshocks.HeartRhythm,3:S187,2006.

138. MWoods,MMaleckar,VSidorov,MHolcomb,DMashburn,NTrayanova,JWikswo.Negativevirtualelectrodepolarizationintherabbitleftventricledelaysactivationduringdiastolicfieldstimulation.HeartRhythm,3:S181,2006.

139. TMaharaj,BRodriguez,RBlake,NTrayanova,DGavaghan.Roleoftransmuralheterogeneitiesinvulnerabilitytoelectricshocks.HeartRhythm,3:S225,2006.

140. DBourn,RGray,NTrayanova.Virtualelectrode-inducedpropagatedgradedresponsesandarrhythmogenesis.HeartRhythm,3:S262-S263,2006.

141. MYamazaki,HHonjo,TAshihara,MHarada,ISakuma,KNakazawa,MHorie,NTrayanova,KKamiya,IKodama.Regionalcoolingfacilitatesterminationofspiralwavereentrythroughunpinningofrotorsin2-dimensionalrabbitventricularmyocardium.HeartRhythm,3:S110,2006.

142. XJie,BRodriguez,RBlake,JDeGroot,RCoronel,NTrayanova.Reentryinsurvivingepicardiumcoupledtodepolarizedmidmyocardialtissue:asimulationofarrhythmogenesisduringischemiaphase1B.HeartRhythm,3:S267-S268,2006.

143. VGurev,NTrayanova.Stretch-inducedreentrantarrhythmiasduringacuteregionalischemia.HeartRhythm,3:S267,2006.

144. TArafune,TAshihara,KNakazawa,NTrayanova,MYamazaki,HHonjo,KKamiya,IKodama,ISakuma.Analysisofshockinducedvirtualelectrodepolarizationinvarioushypothermiaandcapturemechanisms.HeartRhythm,S263,2006.

145. GPlank,APrassl,EVigmond,RBurton,JSchneider,NTrayanova,PKohl.Developmentofamicroanatomicallyaccuraterabbitventricularwedgemodel.HeartRhythm,3:S111,2006.

146. JConstantino,RBlake,MMarshall,NTrayanova.DecreasingLVpostshockexcitablegaplowerstheupperlimitofvulnerability.HeartRhythm,3:S225-S226,2006.

147. SKuo,NNiwa,TAshihara,VNikolski,VFedorov,IEfimov,NTrayanova.RoleofElectroporationinInitiationofSpontaneousEctopicPostshockActivations.HeartRhythm,3:S222,2006.

148. VGurev,RBlake,NTrayanova.MyocardialStretchAltersthePatternofPost-shockActivity.HeartRhythm,in3:S310-S311,2006.

149. TiceB,RodrguezB,TrayanovaN.Arrthythmogenicityoftransmuralheterogeneitiesinarealisticmodelofregionalischemia.HeartRhythm,2(5):S261,2005.

150. BishopMJ,RodrguezB,EasonJC,WhiteleyJP,NobleJA,TrayanovaN,GavaghanDJ.Directopticalmappingsignalsynthesisoverageometricallyaccurateventricularmodel.HeartRhythm,2(5):S220,2005.

151. RodrguezB,LiL,EasonJ,EfimovIR,TrayanovaN.Roleofventricularanatomyinvulnerabilitytoelectricshocks.HeartRhythm,2(5):S257,2005.

152. MaleckarMM,BournDW,RodrguezB,TrayanovaN.Mechanisticinsightintotheincreaseintheupperlimitofvulnerabilitytoelectricshocksfollowingrapidpacing.HeartRhythm,2(5):S219,2005.

153. AshiharaT,TrayanovaNA,YaoT,OzawaT,ItoM,HorieM:MechanismsunderlyingAndersensyndromeinahumanventricularmodel.HeartRhythm,2(5):S181-S182,2005.

154. AshiharaT,TrayanovaNA,NakazawaK,YamazakiM,HonjoH,SakumaI,KamiyaK,KodamaI:Spiralwavecontrolbyregionalcoolinginabidomainmodel.HeartRhythm.2(6):S220,2005.

155. HonjoH,YamazakiM,AshiharaT,SakumaI,NakazawaK,TrayanovaNA,KamiyaK,KodamaI:Controloffunctionalreentrybyregionalcoolinginanepicardiallayerofrabbitventricularmyocardium.HeartRhythm.2(6):S140,2005.

156. VigmondE.,V.Tsoi,S.Kuo,Y.Yin,N.Trayanova,andP.Page,Usingatrialelectrogramstoestimatevagalinfluence,HeartRhythm,2(5):S179,2005.

157. LiW.,P.Kohl,N.Trayanova,Myocardialischemialowersprecordialthumpefficacy:aninquiryintomechanismsusing3Dsimulations,HeartRhythm2(5):S219,2005.

158. AshiharaT,NakazawaK,YamazakiM,HonjoH,SakumaI,KamiyaK,KodamaI,TrayanovaN:Cardiactissueresponsestoelectricalstimulationunderregionalcooling.JpnJPhysiol,55:S88,2005.

159. TiceB,RodrguezB,TrayanovaN.Characterizationofregionalischemiaphase1Aasanar-rhythmogenicsubstrate,SIAMAnnualmeeting,NewOrleans,July2005.

160. TrayanovaN.Mechanismsofdefibrillationbyexternalshocks,InternationalCongressofPhysi-ologicalSciences,SanDiego,S94,2005.

161. AshiharaT,TrayanovaN,NakazawaK,YamazakiM,HonjoH,SakumaI,KamiyaK,KodamaI:Fibrillationcontrolbyregionalcoolinginabidomainventricularmodel.TransactionsoftheJapaneseSocietyforMedicalandBiologicalEngineering,43(Suppl.1):452,2005.(InJapanese)

162. AshiharaT,TrayanovaN,NakazawaK,YamagazkiM,HonjoH,SakumaI,KamiyaK,KodamaI:Lowenergydefibrillationwithregionalcoolingofmyocardium:Theoreticalstudyusingabidomainmodel.JournalofArrhythmia.21(2):246,2005.(InJapanese)

163. N.Trayanova.Arrhythmogenesisfollowingelectricalandmechanicalstimulation.InternationalSymposiumon“LeadingProjectforBiosimulation”,Kyoto,Japan,November2004.

164. N.Trayanova,BMTice,B.Rodrguz,Arrhythmogenesisinregionalischemia:InsightsfromComputerSimulations,MeetingofthePhysiologicalSociety,Oxford,Oct.1-3,2004.

165. KomendantovA.O.,TrayanovaN.A.andTaskerJ.G.Synapticbackgroundactivitycontrolsfiringpatterninhypothalamicmagnocellularneurons:modelstudy.Soc.Neurosci.33thAnnualMeeting,Oct.23-27,2004,SanDiego,CA,(CD-ROM).

166. KomendantovA.O.,TrayanovaN.A.andTaskerJ.G.Rolesofsynapticinputsandretrogradesignalinginburstfiringinamodelofhypothalamicvasopressin-secretingneurons.16thAnnualRetreatoftheNeuroscienceCenterofExcellence.March1,2003,NewOrleans,Louisiana,p.80.

167. T.Ashihara,N.Trayanova.MechanismofShock-InducedArrhythmogenesis:RoleofTissueDiscontinuityandElectroporationintheInitiationofFocalRepetitivePostshockActivations,31stInternationalCongressonElectrocardiology,Kyoto,Japan,June27-July1,2004.

168. T.Ashihara,N.Trayanova.PhysiologicalAsymmetryofShock-InducedChangesinTransmembranePotentialinaBidomainModel,31stInternationalCongressonElectrocardiology,Kyoto,Japan,June27-July1,2004.

169. RodrguezB,N.Trayanova,Cardiacvulnerabilitytoelectricshocksduringphase1Aofacuteglobalischemia,31stInternationalCongressonElectrocardiology,Kyoto,Japan,June27-July1,2004.

170. RodrguezB,TiceB,EasonJ,AguelF,TrayanovaN.Cardiacvulnerabilitytoelectricshocksduring

phase1Aofacuteglobalischemia.HeartRhythm1(1):S90,2004.171. M.MaleckarandN.Trayanova.NegativeVEPAffectsActivationDuringDiastolicStimulationinthe

RabbitVentricles,HeartRhythm,1(1S):S225,2004.172. W.Li,P.Kohl,N.Trayanova.Mechanismsofmechanicallyinducedventriculararrhythmia:A

simulationstudy,HeartRhythm,1(1S):S256,2004.173. B.Rodrguez,TrayanovaN.Modelingcardiacdefibrillationundernormalandischemicconditions,

SIAMConferenceonLifeSciences,PortlandJuly11-16,2004.174. KohlP,A.Garny,N.Trayanova.(How)docomputermodelshelpusunderstandarrhythmias?,J.

MolecularandCellularElectrophysiology,36:740,2004.175. W.Li,L.Fauci,N.Trayanova.SimulationofMechano-electricFeedbackinCardiacTissue,Multiscale

ModelingWorkshop,UCSD,March25-27,2004.176. BMTice,B.Rodrguz,JCEason,FAguel,N.Trayanova,ComputationalStudyoftheRegionally

IschemicHeart,MultiscaleModelingWorkshop,UCSD,March25-27,2004.177. M.Maleckar,N.Trayanova.Paradoxicalactivationtimeduringdiastolicstimulationintherabbit

ventricles,AnnalsBiomed.Eng.,31(BMESAnnualMeetingabstracts),2003.178. T.Ashihara,T.Yao,T.Namba,A.Kawase,T.Ikeda,M.Ito,M.Horie,K.Nakazawa,N.Trayanova.

Temporalexcitablegapduringfibrillationisdependentonfiberorientationduetoanode-breakexcitation.PACE,26:1026,2003.

179. D.Bourn,N.Trayanova,R.Gray.IsoelectricWindowasaFunctionofCouplingInterval,PACE,26:1044,2003.

180. J.Eason,M.Hillebrenner,N.Trayanova.ArelationshipbetweenDFT,arrhythmiacomplexity,andtheisoelectricwindow.PACE,26:1109,2003.

181. C.Haro,C.Larson,F.Aguel,N.Trayanova.Post-shockvortexfilamentdynamicsintherabbitventricles.PACE,26:997,2003.

182. S.Kuo,N.Trayanova.ActionPotentialDurationHeterogeneityintheAtriumanditsEffectonAtrialReentry,PACE,26:985,2003.

183. B.Rodriguez,C.Campbell,L.Li,J,Eason,I.Efimov,N.Trayanova.Effectofelectrodepolarityonshock-inducedarrhythmogenesis,PACE,26:978,2003.

184. E.Vigmond,V.,S.Kuo,N.Trayanova.RoleofVagalStimulationinAtrialFibrillationPACE,26:1026,2003.

185. N.Trayanova.Electricalinductionofarrhythmias,ProceedingsoftheSIAMannualmeeting,2003.186. N.Trayanova.Simulationofshock-inducedelectricalbehaviorintheheart,ProceedingsoftheSIAM

ConferenceonComputationalScienceandEngineering,p.105,2003.187. KomendantovA.O.,TrayanovaN.A.andTaskerJ.G.Rolesofsynapticinputsandretrogradesignalling

inburstfiringinamodelofhypothalamicvasopressinneurons.Soc.Neurosci.33rdAnnualMeeting,Nov.8-12,2003,NewOrleans,LA,(CD-ROM).

188. Komendantov,A.O.,Trayanova,N.A.andTasker,J.G.Computationalmodelsuggeststheputativemechanismsofburstingactivityinmagnocellularhypothalamicneurons.15thAnnualRetreatoftheNeuroscienceCenterofExcellence.March1,2003,NewOrleans,Louisiana,p.87.

189. N.Trayanova,F.Aguel.Transmuralshock-inducedscroll-wavefilamentsfollowingunsuccessfulshocksintherabbitheart,Circulation,106:II-192,2002.

190. D.Bourn,N.Trayanova,R.Gray,Shock-Inducedarrhythmogenesisandisoelectricwindow,PACE25(partII):604,2002.

191. F.Aguel,C.Campbell,N.Trayanova,DefibrillationmodelofLangendorfperfusedrabbitheartexhibitsnotransmuralreentry,PACE25(partII):628,2002.

192. E.Kalu,N.Trayanova,Modelingelectricfieldstimulationofsinglecardiaccell:electrodiffusivemodelapproach,21stMeetingoftheElectrochemicalSocietyinPhiladelphia,PA,May2002.

193. Komendantov,A.O.,Trayanova,N.A.andTasker,J.G.Rolesofintrinsicioniccurrentsandexcitatorysynapticinputsinburstgenerationinoxytocin-secretingneurons:acomputationalstudy.Soc.Neurosci.32ndAnnualMeeting,Nov.2-7,2002,Orlando,FL,ProgramNo.273.4.2002(AbstractViewer/ItineraryPlanner.Washington,DC:SocietyforNeuroscience,2002.CDROM).

194. E.Vigmond,S.Kuo;N.Trayanova.EffectsofAPDrestitutiononatrialreentry,BulletinoftheAmericanPhysicalSociety,47(partII):949,2002

195. F.Aguel,C.Campbell,N.Trayanova.Activebidomainsimulationofdefibrillationinwholerabbitventricleswithrealfiberorientation,ProceedingsoftheBMESmeeting,AnnalsBiomed.Eng.,29(Suppl.1):S48,2001.

196. J.Meunier,N.Trayanova,R.Gray.ACDefibrillationinanAnatomicalModeloftheCanineHeart.,ProceedingsoftheBMESmeeting,AnnalsBiomed.Eng.,29(Suppl.1):S49,2001.

197. F.Aguel,A.Lindblom,N.Trayanova.Vulnerabilitytofar-fieldstimulation:Criticalpointhypothesisrevisited,PACE24(partII):670,2001.

198. N.Trayanova,M.Hillebrener,F.Aguel,C.Campbell,J.Eason.Transmuralpost-shockar-rhythmogenesisinthecanineheart,PACE24(partII):670,2001.

199. T.Baynham,N.Trayanova,R.Ideker,S.Knisley.Linestimulationacrossfibersproducesarrhythmiasviabreakexcitationthatdependsonvirtualelectrodes,ProceedingsoftheAHAmeeting,Circulation,102:1674,2000

200. N.Trayanova.Shock-inducedArrhythmogenesis:AModelingApproach,WorldCongress2000(CD-ROM).

201. E.Vigmond,N.Trayanova,P.Moore.Ananatomicallyaccuratemodelforthestudyofatrialreentry,WorldCongress2000(CD-ROM).

202. J.Meunier,N.Trayanova,R.Gray.SinusoidalStimulationofMyocardialTissue:EffectsonaTwo-DimensionalGrid.WorldCongress2000(CD-ROM).

203. EVigmond,N.Trayanova.IsolatedCableApproachforSimulationsofCardiacElectricalActivity,SIAMAnnualMeeting,p.89,July2000.

204. F.Aguel,N.Trayanova,I.Efimov.Externaldefibrillationmodelofanatomicallyaccuraterabbitventricles,in:PACE,vol.23,p.616,21stScientificSessionsofNASPE,2000.

205. A.Lindblom,N.Trayanova,B.Roth.Theroleofvirtualelectrodesinarrhythmogenesis,18thAnnualHoustonConferenceonBiomedicalEngineeringResearch,p.120,Feb.2000.

206. C.Anderson,N.Trayanova,K.Skouibine.Terminationofaspiralwaveswithmonophasicandbiphasicshocks:Theroleofshocktiming,18thAnnualHoustonConferenceonBiomedicalEngineeringResearch,p.121,Feb.2000.

207. N.Trayanova,F.Aguel.Virtualelectrodepolarizationintherabbitventricles,5thInternationalDeadSeaSymposiumonCardiacArrhythmiasandDeviceTherapy,Europace1:A7,2000.

208. F.Aguel,N.Trayanova,S.Knisley.Effectofmyocardialfibrousstructureonshock-inducedtransmembranepotential,17thAnnualHoustonConferenceonBiomedicalEngineeringResearch,Feb.1999.

209. J.Meunier,N.Trayanova,R.Gray.Sinewavestimulationofmyocardialtissue:effectsonsinglecells.17thAnnualHoustonConferenceonBiomedicalEngineeringResearch,Feb.1999.

210. N.Trayanova,F.Aguel,J.Eason,G.Siekas,M.Fishler,A.Street.VirtualelectrodesinducedthroughouttheheartbyICDdefibrillation,PACE,22:A67,1999.

211. E.Entcheva,N.Trayanova,F.Claydon.Uniformelectricfieldcaninducevirtualelectrodesthroughcardiacfibercurvature,PACE,21:961,1998.

212. F.Aguel,N.Trayanova,S.Knisley.Shockextracellularfieldsandtheirimpactontransmembranepotentialsinthemyocardium.AnnalsBiomedEng.26(suppl.1):S-22,1998.

213. N.Trayanova,F.Aguel,J.Eason,M.Fishler,G.Siekas,Impactoftransvenousleadpositiononactive-canICDdefibrillation,In:Deasmaladiesdecoeretdesvaisseaux,vol.91,Cardiostim,1998,181.

214. K.Skouibine,N.Trayanova,F.Aguel.Far-fieldstimulationofcardiactissue.AnnalsBiomedEng.26(suppl.1):S-22,1998.

215. TrayanovaN.F.Aguel,J.C.Eason,M.Fishler,G.Siekas.Myocardialfiberarchitectureaffectstransvenousdefibrillationthresholdsinahumanthoraxmodel,AnnalsBiomed.Eng.,25:S60,1997.

216. TrayanovaN.,J.C.Eason.Shock-inducedtransmembranepotentialdistributioninthecanineheart:EffectsofelectrodelocationandpolarityPACE17:331,1995.

217. TrayanovaN.Cardiacstimulationinthepresenceofaperfusingbath.Proc.oftheWorldCongressonMedicalPhysicsandBiomedicalEngineering,p.404,1994.

218. TrayanovaN.Cardiactissueinanelectricfield,AnnalsBiomed.Eng.,22:28,1994.219. TrayanovaN.Subthresholdstimulationinclassicalandperiodicmodelsforcardiactissue.Annals

Biomed.Eng.,19:621,1991.