Multi-Compartment Pharmacokinetics

Multi-Compartment Pharmacokinetics

Chapters 19 and 20http://www.boomer.org/c/p4/

One versus Two Compartment

• Rapid Equilibrium versus Slower Equilibrium

http://www.boomer.org/c/p4/c19/c1901.html

Multi-Compartment Pharmacokinetic Model

• Deviation from One Compartment Model• Models and Parameters• Equations• Parameter Estimation• Effect of Changing Parameters• Apparent Volumes of Distribution• Dosage Calculations• Oral Administration

Multi-Compartment Pharmacokinetic Model

This Equation is

A. The integrated equation for concentration after an IV bolus

B. The differential equation for concentration after an IV bolus

C. The integrated equation for concentration after an oral dose

A Two Compartment Model becomes One when

A. k12 and k21 are fastB. k21 is faster than

k12C. CLD is fastD. All of the above

Varea is Calculated using

A. The dose and the intercept values (A and B)

B. The dose, AUC and beta

C. V1 and the microconstants

Achieving and maintaining a specified Cp is

easier with a 2C drug

A. TrueB. False

Non Compartmental Analysis

• Linear (First-order) Kinetics• No Model ‘Requirement’• New Parameters – AUMC, MRT, MAT• Faster Calculation with Spreadsheet or SAS

Non Compartmental Analysis

The mean residence time can be calculated as

A. AUMC/AUCB. AUC/AUMCC. AUMC2

D. Dose/AUC

An estimate of ka can be calculated from

A. AUCB. AUMCC. MRTD. MAT

Do you usually have your laptop AND

phone connected to WiFi in this room?

A. TrueB. False

Have you had problems connecting to the WiFi in this room?

A. NeverB. OccasionallyC. Often

Have you had problems

connecting to the WiFi in this room

during in-class Quiz or Exams

A. TrueB. False