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Connections from the substantia nigra: (a) normal and (b) in Parkinson’s disease
Excitatory paths are shown in green; inhibitory are in red.
People with Parkinson’s disease show decreased initiation of movement, slow and inaccurate movement, and psychological depression.
Parkinson’s Disease
Symptoms-rigidity, muscle tremors, slow movement, difficulty initiating movement
Brain Changes-Selective loss of cells in substantia nigra and amygdala/decrease in dopamine
Possible Causesgeneticsexposure to toxins (MPTP)
Parkinson’s Disease
L-Dopa Treatmentprecursor for dopaminedemonstrates individual effectivenessdoes not stop progression of the diseasenumerous side effects (nausea, restlessness, sleep problems, low
blood pressure, hallucinations, and delusions)Therapies Other Than L-Dopa
Pallidotomy Cell transplantsDeep brain stimulation
Connections from the substantia nigra: (a) normal and (b) in Parkinson’s disease
Excitatory paths are shown in green; inhibitory are in red.
People with Parkinson’s disease show decreased initiation of movement, slow and inaccurate movement, and psychological depression.
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