Modified Histone Maprockland-inc.com/uploadedFiles/Support/Pathways/histone...Histone H4 L P c e G...

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Modified Histone MapModified Histone Map

Featured Modified Histone Antibodies

www.rockland-inc.com orders@rockland-inc.com

Histone H3 [Dimethyl Lys4]

Epi-PlusTM is a jointly owned trademark of Novus Biologicals, LLC and Rockland Immunochemicals, Inc. Modified Histone Map © Novus Biologicals, LLC 2011. All Rights Reserved.

H4

H4

H2B

H2B

H3

H3

H2A

H2A

H2A

H2B

H3

H2B

H4

H4

H2B

H2A

RT K Q A

GG

AP

QA T

AP

TG

GV

H RR P G

VA

LR

EI

RR

YQ

ST

EL

L I R L P F QR

LV

RE

IAQ

DF

D L R FQ

SS/A

A

ALQ

EA

C/S

EA

YL V G L F E

D

NL

CA

IH

A

V

I MP

DIQLA

RR

IR G E

RA

A

T

ST

K

RK

K AA

RK

S

KK

YT

K

K

KT

T

KR

TK

P

AcP

P

P

Ac

Me

Me

Ac Me

Ac

MeP

Ac

Me

P

P

Ac

Me

Ac

Me

P

P

Ac

P

Ac

Me

2

34

6

10

11

14

17

18

23

26

27

28

36

37

4145

56

64

79

80

107

115

118122

Histone H3

GG

G GG L

G

GG

A

RH

R

VL R DD N I Q

T

PA

I

RR

LA

RR

GG V

R I G L I

EE

TR

GV

L

VF

L EN V I R D A V T Y T

HE

A

R

TV

TA M D V V

AL

QG

RT

L Y GF

G

SR

K K

K

K

K K

SY

KK

K

Y

KR

P

Ac

Ac

Me

Ac

Ac

P

P

Me

Ac

Ac

Me

P

Ac

Me1

35 8

12

16

20 31

47

51

5977

79

88

91

92

Histone H4

L

P

Ac

Me

G

CitR8

MeCit

KAc

9

Cit

Ac

A/S31

Ac

Me

87

V/I89M/G90

96

Cit

I

K44

G

Legend

Me

P

Ac Acetylation

Methylation

Phosphorylation

A - AlanineC - CysteineD - Aspartic acidE - Glutamic acidF- PhenylalanineG - GlycineH - Histidine

I - IsoleucineK - LysineL - LeucineM - MethionineN - AsparagineP - ProlineQ - Glutamine

R - ArginineS - SerineT - ThreonineV - ValineW - TryptophanY - Tyrosine

Modi�cations:

Residues:

Cit Citrullination

Me1

Me2

Me3

Monomethylation

Dimethylation

Trimethylation

Me2

Me1

Me2

Me1

Me3

Me2

Me1

Me3

P

Me2

Me1

Me3

Me2

Me1

Me2

Me1

Me2

Me1

Me2

Me1

Me3

Me2

Me1Ac

Me

Isoform Residue Changes:Histone H3.2 C96 S96Histone H3.3 A31 S31 S87 A87 V89 I89

M90 G90 C96 S96

Ac

Histone H3 [Trimethyl Lys4] Histone H3 [Dimethyl Lys36]Histone H3 [Phospho Thr6] Histone H3 [Dimethyl Lys18] Histone H3 [Monomethyl Lys36]Histone H3 [Trimethyl Lys4] 600-401-I58 600-401-I59 600-401-I59 600-401-I63 600-401-I79 600-401-I87 600-401-I86

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