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The relationship between gut microbiota and weight gain in
humansEmmanouil Angelakis, Fabrice Armougom, Matthieu Million, Didier Raoult
PPT By: Andrea Bonde
Overview• Article is a review of the actual experiments• Gut microbes may be a cause of obesity
• Associated with a number of disease states that include allergy, inflammatory bowel disease, cancer,
and diabetes.• Gut flora contribute enzymes that are absent in
humans for food digestion• 95% of total organisms in intestine and colon
+ =
Obesity• Affects 400 million individuals
• Associated with severe disorders
• Influenced by a mixture of environmental, genetic, neural,
and endocrine factors.• Infectious agents have been
proposed to be a cause• 32 genes are linked to BMI
(body mass index)• Availability of inexpensive,
calorically dense foods
Gut Microbiota• Approx. 1011-12 microorganisms per gram of human
content in the GI tract.• Gut flora have variations among different populations.
• Gut flora also varies due to age
• Bacteroids• Eubacterium• Bifidobacterium• Peptostreptoccocus• Fusobacterium• Ruminococcus• Clostridium• Lactobacillus
Microbes Per Year of LifeNewborn 3wk-1yr 1-7yrs 2-18yrs Adult
Bifidobacteria BacteriodeStaphlococcusLactobacillus
BifidobacteriaClostridium
Starts to resemble the
adult microflora
Stable level of Bifidobacteria
and Lactobacillus
Stable over time
• Dietary habits are considered to be one of the main factors that contribute to the diversity of the human
gut microbiota.• With a high-fat/low-fiber or low-fat/high-fiber diet
microbe composition has detectable change in 24hours.
Obese VS. Lean
Higher levels of certain
bacteria due to body type.
Conclusion•Obese and lean individuals have
different levels of bacteria populations.
•Diet significantly changed gut microbiota.
• The manipulation of gut microbes with probiotics, prebiotics, antibiotics and other interventions were factors
for weight gain and obesity, and should be investigated further!
Further Perspective• Increasing number of studies• Shifts in abundances of bacterial
communities• Interpretation of the results might
have been biased, thus far.•Food = Source for viruses and Bacteria• Little effort in standardizing research•Ask how and MAKE IT MANDITORY!
Works Cited
"Search." Earn Reward Points and Redeem Them For Free Stuff at
Swagbucks.com. N.p., n.d. Web. 22 Jan. 2013.
<http://www.swagbucks.com>.
"The relationship between gut microbiota and weight gain in
humans." Future Medicine. N.p., n.d. Web. 22 Jan. 2013.
<http://www.furutremedicine.com/>.
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