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Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Mentoring the MentorMentoring the Mentor
Stuart White, DC, DACBN
Whole Health Associates
1406 Vermont
Houston, Texas 77006
713/522-6336
stuartwhite@wholehealthassoc.com
www.wholehealthassoc.com
www.doctorofthefuture.org
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Mentor goals:
� To declare what is possible and establish a commitment to that possibility
� Address personal and professional barriers limiting the ability to serve
� Evolution of vision/mission/ethics that drive success
� Create immediate action steps to apply learning and growth
� Construct the round table of applied trophologists
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Mentoring the mentor:
� Who are the mentors? – Practitioners
� Who are we mentoring? – Patients and GAP
� What’s the purpose? – Optimized life
� How does it work? – Whatever you learn you teach someone else (anyone else)
� Who’s is included? – Self selection, you pick yourself
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Mentoring the mentor:
� Each participant attends monthly teleconferences (1 hour in duration, 4th Thursday of every 2nd month) creating a round table discussion/exploration of the dynamics and details of a nutrition-based holistic practice
� Each participant chooses how to convey the notes and information to their world and community – no information squandering
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Review - Distinguish yourself
• It is more apparent why people are choosing alternative
health care professionals who specialize in a functional
approach
• No matter you specialty or technique you must distinguish
yourself as an expert – people are just seeking to
understand and they need you to do so
• Typically in the healthcare industry people are receiving
shallow answers that leave them puzzled with the mystery
of “Why is this happening to me?” and “ What can I do
about it?”
• Trends research over 10 years ago identified a number of
factors essential to being successful in the nutritional field –
one of those was establishing yourself as an expert
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Review - Explanation as hope
• The practitioner’s ability to explain health issues and therapeutic outcomes creates an inflation of understanding in the patient which feels like hope• Today in the professional world there is so much avoidance of ‘giving false hope’ that often we end up offering little hope at all• I propose another model that bolsters hope and expectation and subsequently practices accountability as to whether the therapeutic endeavors are achieved or not• As long as the hope that has been instilled is revisited and acknowledged as being accomplished or not the betrayal of false hope can be avoided• So as an example, if a practitioner was describing the potential for nutritional intervention through supplements and diet modification to improve the lipid profile, then s/he would need to revisit to success or failure of the experiment within a reasonable period of time • Our community is starving for legitimate hope, as a starting place, as empowerment to begin, as an idea to act upon• There is genius in hope
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Mentor Considerations
Micro Circulation concepts as a primary health issue
Infection as the primary microvascular burden
Enabling Strategies – Kerry Bone
1 – Micro Circulation
2 – Mitochondrial Function
3 – Dysbiosis
4 – Detox
5 – Stealth pathogens & Persistent Virus
(6 – Nrf2 activation)
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Seven Pillars
Unified Mechanisms
of Health
Promoting Physiology
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7 Pillars of Healing7 Unified Mechanisms of Health
�Endocrine/Hormonal
�Glycemic Management
�pH Bioterrain
�Immuno-Inflammatory
�Circulatory Status
�Digestive Potency
�Cellular Vitality
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Normal
Miracle
Endocrine
Hormonal
Glycemic
Management
pH
Bioterrain
Minerals
Immune
Inflammatory
Circulatory
Status
Digestive
Potency
Cellular
Vitality
MethylationMethylation
Control of Genetic expressionControl of Genetic expression
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
MTHFR Gene -
• The MTHFR gene encodes the production of a protein that helps to convert folic acid into its biological active form methyltetrahydrofolate • In sequencing the gene researchers discovered that some individuals had a cytosine (C) at base pair position 677 (most commonly) and others had Thymidine (T) at that position• This is referred to as MTHFR C677T and causes an alanine to valine change in the protein sequence at position 222 of the protein –this small change results in less efficient synthesis of active folate compounds• Most Americans are homoxygous for the nomal variant of 677CC, but up to 10% of the population may be homozygous for the other variant 677TT, which means noticably less efficient methylation accounting for higher risks for certain disease• These individuals need more dietary folate/folic acid consumption
The MTHFR polymorphism as example
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
The MTHFR polymorphism as example
Variable pathways -
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Nutrient Influence -
Downstream Effects -
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Predicting SNP Effects -
Predicting SNP Effects -
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Predicting SNP Effects -
Wheels within wheels -
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
SNP means outcome -
Beginning to undertsand -
Imagination is everything.
It is the preview of life’s
coming attractions.Albert Einstein
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Mentoring the Mentors
Phase I & II detoxification occur principally in the liver, while Phase I, II, & III occur in every cell – the liver determines the foundational capacity to cleanse
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The secret formula for encouraging a healthy 2 to 16 ratio� 1-O-FERULOYL-BETA-D-GLUCOSE Leaf: � 1-O-P-COUMAROYL-BETA-D-GLUCOSE Leaf: � 1-O-P-SINAPOYL-BETA-D-GLUCOSE Leaf: � 2-HYDROXY-BUT-3-ENYL-GLUCOSINOLATE Leaf: � 4-METHOXY-INDOL-3-YL-METHYL-GLUCOSINOLATE Leaf: � ALLYL-ISOTHIOCYANATE Seed: � ALPHA-LINOLENIC-ACID Leaf 990 - 7,069 ppm� ALPHA-TOCOPHEROL Leaf 4 - 63 ppm� ANTEISO-HEPTACOSAN-1-OL Flower: � ANTEISO-MONTANYL-ALCOHOL Leaf: � ANTEPENTACOSAN-1-OL Leaf: � ARACHIDONIC-ACID Leaf 10 - 71 ppm� ARGININE Leaf 2,030 - 14,494 ppm� ASCORBIC-ACID Leaf 720 - 6,069 ppm� ASH Leaf 13,700 - 97,818 ppm� BETA-CAROTENE Leaf 5 - 41 ppm� BORON Leaf 57 ppm; Stem 21 ppm; � CAFFEIC-ACID Leaf 34 ppm; � CALCIUM Leaf 395 - 3,177 ppm� CARBOHYDRATES Leaf 89,600 - 639,744 ppm� CITRIC-ACID Leaf: � COPPER Leaf 1 - 5 ppm� COUMESTROL Shoot 400 ppm; � CYSTINE Leaf 220 - 1,571 ppm� FAT Leaf 2,000 - 28,560 ppm� FERULIC-ACID Leaf 10 ppm; � FIBER Leaf 15,100 - 107,814 ppm� FOLACIN Leaf 0.56 - 4 ppm� FUMARIC-ACID Leaf: � HEPTACOSAN-1-OL Flower: � HEXACOSAN-1-OL Leaf: � HISTIDINE Leaf 760 - 5,426 ppm� INDOLE-3-ACETONITRILE Shoot:
� INDOLE-3-CARBINOL Shoot:� INDOLE-3-CARBOXALDEHYDE Shoot: � INDOLE-3-CARBOXYLIC-ACID Shoot: � INDOYL-3,3'-DIMETHANE-CARBOXYLIC-ACID Shoot: � IRON Leaf 9 - 136 ppm� ISOHEXACOSAN-1-OL Leaf: � ISOLEUCINE Leaf 1,320 - 9,425 ppm� ISOOCTACOSAN-1-OL Leaf: � KILOCALORIES Leaf 430 - 3,070 /kg� LEUCINE Leaf 1,520 - 10,853 ppm� LINOLEIC-ACID Leaf 450 - 3,213 ppm� LYSINE Leaf 1,540 - 10,996 ppm
ISOHEXACOSAN-1-OL Leaf: ISOLEUCINE Leaf 1,320 - 9,425 ppmISOOCTACOSAN-1-OL Leaf: KILOCALORIES Leaf 430 - 3,070 /kgLEUCINE Leaf 1,520 - 10,853 ppmLINOLEIC-ACID Leaf 450 - 3,213 ppmLYSINE Leaf 1,540 - 10,996 ppmMAGNESIUM Leaf 230 - 1,642 ppmMALIC-ACID Leaf: MANGANESE Leaf 3 - 24 ppmMETHIONINE Leaf 320 - 2,285 ppmMOLYBDENUM Leaf 0.9 ppm; Stem 0.36 ppm; MONTANYL-ALCOHOL Leaf: NIACIN Leaf 6 - 64 ppmOCTACOSAN-1-OL Leaf: OLEIC-ACID Leaf 190 - 1,357 ppmOXALATE Leaf 3,600 - 25,704 ppmP-COUMARIC-ACID Leaf 12 ppm;PALMITIC-ACID Leaf 530 - 3,784 ppmPALMITOLEIC-ACID Leaf 20 - 142 ppmPANTOTHENIC-ACID Leaf 3.1 - 22 ppmPENTACOSAN-1-OL Leaf: PHENYLALANINE Leaf 980 - 6,997 ppmPHOSPHORUS Leaf 690 - 4,927 ppmPHYTOSTEROLS Leaf 240 - 1,710 ppmPOTASSIUM Leaf 3,670 - 29,343 ppmPROP-2-ENYL-GLUCOSINOLATE Leaf: PROTEIN Leaf 32,580 - 250,000 ppmQUERCETIN Sprout Seedling 25 ppm; QUINIC-ACID Leaf: RIBOFLAVIN Leaf 0.4 - 10 ppmRUTIN Shoot 20 ppm; SEC-BUTYL-ISOTHIOCYANATE Seed: SELENIUM Leaf 0.024 ppm; Stem 0.012 ppm; SINAPIC-ACID Leaf 107 ppm; SODIUM Leaf 221 - 1,990 ppmSTEARIC-ACID Leaf 30 - 214 ppmSUCCINIC-ACID Leaf: TETRACOSAN-1-OL Leaf: THIAMIN Leaf 1.3 - 11 ppmTHREONINE Leaf 1,200 - 8,568 ppmTRIACONTAN-1-OL Leaf: TRYPTOPHAN Leaf 370 - 2,642 ppmVALINE Leaf 1,550 - 11,067 ppmVIT-B-6 Leaf 2.2 - 16 ppmWATER Leaf 846,000 - 945,500 ppmZINC Leaf 10 - 157 ppm
Brussel Sprouts
Cruciferous Complete
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Detox – Phase I & II
Textbook of Functional Medicine: David S. Jones, Institute for Functional Medicine: Gig Harbor, WA.: Page 278
Needs Homocysteine
support, B2, B3, B6, Glutathione, AA, Flavonoids, Phospholipids
Needs Homocysteine
support, Glycine, Taurine,
Glutamine, NAC, Cysteine,
Methionine
Learning wisdom -
It is highly dishonorable for a
reasonable soul to live in so
divinely built a mansion as the
body she resides in – altogether
unacquainted with the exquisite
structure of it.
Robert Boyle (1627-1691)
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
MTHFR Influence -
• Because the MTHFr genetic defect is so common, supplementing around/bypassing the defect
with L-5-MTHF has almost miraculous panacea like qualities in resolving a whole host of diseases
and ailments.
• Methylation is the key to human life and optimal well being. It does the following:
Turn on and off genes (Epigenetics – gene regulation)
Process chemicals and toxins (biotransformation)
Build neurotransmitters (dopamine, serotonin, epinephrine)
Process hormones (estrogen)
Build immune cells (T cells, NK cells)
DNA and RNA synthesis (Thymine aka 5-methyluracil)
Produce energy (CoQ10, carnitine, ATP)
Produce protective coating on nerves (myelination)
• Under methylation is now known to be of the primary root causes of the following conditions:
Autism, Cancer, Fibromyalgia, Chronic Fatigue Syndrome, Diabetes, Pulmonary
Embolisms, Cleft Palette, Spina Bifida, Parkinson’s, Neural Tube Defects
Atherosclerosis, Immune Deficiency, ADD/ADHD, Multiple
Sclerosis, Alzheimer’s, Dementia, Chemical Sensitivity, Congenital Heart
Defects, Depression, Alcoholism,Addictive Behaviors, Insomnia, Down’s
Syndrome, Chronic Viral Infection, Thyroid Dysfunction, Neuropathy, Recurrent
Miscarriages, Infertility, Anxiety, Schizophrenia, Bipolar, Allergies
Over or Under Methylation
• We must become familiar with the signs of over and under methylation
•Undermethylation - Elevated histamine and/or elevated basophils indicate undermethylation
•Review of symptoms and medical history can bolster the diagnosis•Most undermethylated persons exhibit seasonal allergies, perfectionism, strong wills, slenderness, OCD tendencies, high libido, depression
• Overmethylation –•Overmethylated persons generally exhibit anxiety, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI‘s
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
More than MTHFR -
•Now there is a lot more to the methylation cycle than just the MTHFr gene that has a real verifiable impact on health.
•COMT and MAO A: processes neurotransmitter catabolism and estrogens•CBS: processes homocysteine and if upregulated, depletes methyl groups, increases taurine•MTR/MTRR: recycles B12 and processes B12 for methionine production GSTM1 and SOD: major detoxification enzymes•GAD: transforms glutamate to GABA•HNMT: processes histamine (secondary enzyme for histamine; primary is DAO)•QDPR: recycles BH4•NOS: processes ammonia, forms nitric oxide from arginine•SUOX: process sulfites/sulfur and this mutation is made worse from CBS upregulation
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Genomic Tools
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
©2014 Standard Process Inc. All rights reserved.
THE
GENETIC
ASSESSMENT
©2014 Standard Process Inc. All rights reserved.
Pauline Gee, PhDChief Scientific Officer/Co-Founding Investor; BodySync, Inc., is a genetic Health
and Wellness company that provides a personal approach to wellness to
empower healthcare professionals to tailor their care specifically for each
individual patient. Pauline oversees BodySync’s CLIA-certified laboratory
including related information technology activities and is responsible for the
Company’s quality assurance and regulatory affairs. She comes to BodySync with
over fifteen years of commercial experience in genomics and its healthcare
applications. Pauline earned a doctorate in the Faculty of Interdisciplinary Studies
specializing in neurochemistry and a Bachelor of Science degree in Kinesiology
and Biology from Simon Fraser University, in British Columbia, Canada. As a
Medical Research Council Fellow, she studied oxidized DNA bases and patented
DNA base-specific Ames strains at the University of California Berkeley. Her
postdoctoral work at Stanford University focused on DNA repair in differentiated
neurons.
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
©2014 Standard Process Inc. All rights reserved.
What is NutriSync?
� Measures 45 genetic variations in each
patient.
� Variations were chosen because nutrition
choices can be made to address them
� Analyzes each patient’s nutrition and
lifestyle status from self-reporting survey
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©2014 Standard Process Inc. All rights reserved.
NutriSync Provides –� To Healthcare Professional Summary
– Standard Process recommendations for
to meet the difference in Daily Goals
– Standard Process recommendations for
lifelong fundamental health
– Genetic results
� Patient’s NutriSync Action Plan
– >20 page full report
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Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
©2014 Standard Process Inc. All rights reserved.
Why NutriSync?NutriSync establishes new
behaviors that work:
� Genetically guided group were about
5 times more likely to maintain their
BMI
� Twice as many people in the
genetically guided group lowered
fasting glucose levels after 90 days
� Evidence that compliance is
maintained longer in light of one’s
own genetics
©2014 Standard Process Inc. All rights reserved.
Me versus Everyone Else
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
©2014 Standard Process Inc. All rights reserved.
Vitamin B genes in NutriSync
MTR
MTRR
MTHFR
1996-2013 Humpath.com http://www.humpath.com/spip.php?article1228
CBS
©2014 Standard Process Inc. All rights reserved.
Nutritional Intervention Works
0
2
4
6
8
10
12
14
16
CC TT
Baseline
Exclusion diet
Folate-rich diet
Supplement
� 75% of people with “TT” surveyed
reported dietary folate levels <<DRI
Ho
mo
cyst
ein
e
(µm
ol/
L)
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
©2014 Standard Process Inc. All rights reserved.
NutriSync Metabolic Network
©2014 Standard Process Inc. All rights reserved.
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Genomic Tools
Nutrisync Practitioner report
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
Nutrisync Patient report
Genetic Reference Guide
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Principles at work
• Sufficient clinical observation allows mechanisms to be
revealed that will remove the idiopathic mystery of
hypertension and return it to a simple physiological
modulation and resultant augmentation in function, balance,
tissue fortification and promotes healthy genetic expression
• This allows the symptom resolution to occur as a result of
system ‘mosaic’ change, and then of course the downstream
events occur
• The longing in the public is for this sort of detective work to
find the cause and make the correction – increasingly food is
seen as medicine and people are asking more and more for
what foods will change their health patterns
Sequential Intervention� By giving hope through discussion of therapeutic rationale and then
accountably determine if the therapy had efficacy it is possible to initiate activity that may assist a person to make the changes that result in healing
� Sequential intervention and accountable follow-up can show what has worked and what may still need to be employed
� Promote an understanding of intervention that creates evolutions in individual physiology and show the effect of that intervention
� See the concept of micro circulation dynamics as a unified mechanism of disease and a source to health
� Allow every condition to become a strategic consideration of possible etiology and therapeutic rationale – people are in search of experts – reveal yourself
� The comprehensive nature of nutritional therapy means there is always more physiology to optimize and support leaving an individual constantly refining as long as they wish to further improve their status
� If the practitioner is accountable s/he will be allowed to experiment with reasonable ideas
Dr. Stuart White Nov. 20, 2014
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Mentoring the Mentors
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Change the world
It wants to
Change the world
It wants to
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