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Mateusz SkowronPaweł Ślusarczyk
Supervisor: Joanna Deperas-Standyło
Higher-order structure of chromosomes
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0/G1 have formof long and screwed strings
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
Theory Human lymphocyte cell nucleus – filled with 23 pairsof chromosomes containing DNA
Chromosomes in phase G0 / G1 have formof long and screwed strings
Firstly believed to form a chaotic spaghetti-like structure
1990’s – chromosomes prefer to rest in some particuliar regions of the nucleus, called domains or territories
Nucleus – sphere
Chromosomal domain – sphere
Domains can overlap each other
Nucleus model
Chromosomal domains in the
nucleus
Model chromosome – a chain of connectedspheres
CHROMOSOME MODEL
Chromosomal territories in the nucleus
Spheres in each chromosome cannot overlap each other
A real chromosome
Cпасибо for your attention!
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