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MagetteEudora High School
Volume and Composition
• Varies due to:– Size– Hydration– Body composition
• 8% of body weight
• About 5 Liters
MagetteEudora High School
Erythrocytes
• “Red Cells”• 95% of cellular blood• Bi-Concave disc• Non-nucleated• Hemoglobin
– 1/3 of volume
• 4-7 million/mm3
MagetteEudora High School
How Much Did You Give?
• 4-7 million RBC’s /mm3 of blood
• 1 mm3 = 100 mL
• You gave 1 pint
MagetteEudora High School
How Much Did You Give?
• 4-7 million RBC’s /mm3 of blood
• 1 mm3 = 100 mL
• You gave 1 pint
• 1 pint = 473.2 mL
MagetteEudora High School
How Much Did You Give?
• 4-7 million RBC’s /mm3 of blood• 1 mm3 = 100 mL• You gave 1 pint• 1 pint = 473.2 mL• 4,000,000 x 100 x 473.2 = 189,280,000,000• 7,000,000 x 100 x 473.2 = 331,240,000,000
MagetteEudora High School
How Much Did You Give?
• 4-7 million RBC’s /mm3 of blood• 1 mm3 = 100 mL• You gave 1 pint• 1 pint = 473.2 mL• 4,000,000 x 100 x 473.2 = 189,280,000,000• 7,000,000 x 100 x 473.2 = 331,240,000,000
• You gave 190-330 Billion erythrocytes!
MagetteEudora High School
Hemoglobin
• 1/3 of RBC volume• Globular protein• “Heme” groups
containing iron
MagetteEudora High School
Hemoglobin
• 1/3 of RBC volume• Globular protein• “Heme” groups
containing iron
MagetteEudora High School
Hemoglobin
• 1/3 of RBC volume• Globular protein• “Heme” groups
containing iron
MagetteEudora High School
Hemoglobin
• 1/3 of RBC volume• Globular protein• “Heme” groups
containing iron• Carries oxygen• Similar to myoglobin• Responsible for red
color of blood
MagetteEudora High School
Questions:
• Is blood sometimes blue?
• How does this relate to what we know about iron-deficiency anemia?
MagetteEudora High School
Questions:
• Is blood sometimes blue?
• How does this relate to what we know about iron-deficiency anemia?
• How do the CSI people get DNA from blood?
MagetteEudora High School
RBC Production
• “Erythropoiesis”
• Red Bone Marrow
• Erythropoietin: hormone released from kidneys and liver that stimulates production of RBC’s
MagetteEudora High School
Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
MagetteEudora High School
Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
4.Inhibition
MagetteEudora High School
Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
4.Inhibition
MagetteEudora High School
RBC Breakdown
• Liver and spleen• RBC is destroyed by
macrophages• Hemoglobin is broken
down into “heme” groups and globular proteins
• Proteins are broken down to amino acids and metabolized
MagetteEudora High School
RBC Breakdown
• Heme group is broken down into iron and biliverdin
• Iron is stored and/or reused
• Biliverdin is converted to orange pigment (bilirubin)
• “Bilis-” are secreted in bile
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