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Lecture 08 – Second Messengers II – Calcium signaling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. CSB Fig 02:01 Cell signalling pathways . Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 . - PowerPoint PPT Presentation
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Lecture 08 – Second Messengers II – Calcium signaling
BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy
Last modified -13F
CSB Fig 02:01 Cell signalling pathways
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
Transducers Second Messengers II
1. Calcium signaling • 1. Cyclic ADPribose
• 2. Inositol phosphate & other lipid signaling
• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:14 Basic Ca2+ signalling mechanism
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:15 Ca2+ signalling dynamics
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:17 Ca2+ signalling toolkit
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:10 Ca2+ entry mechanisms
ROCs
• Cysteine-loop receptors• Nicotinic acetylcholine receptors (nAChRs)• 5-Hydroxytryptamine 3 (5-HT3) receptors• γ-Aminobutyric acid (GABA) receptors• Glycine receptors (GlyRs)
• Glutamate receptors• α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)
receptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors
• ATP-sensitive P2X receptors
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:11 Nicotinic acetylcholine receptor
ROCs
• Cysteine-loop receptors• Nicotinic acetylcholine receptors (nAChRs)• 5-Hydroxytryptamine 3 (5-HT3) receptors• γ-Aminobutyric acid (GABA) receptors• Glycine receptors (GlyRs)
• Glutamate receptor • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) rec
eptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors
• ATP-sensitive P2X receptors
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:13 Ionotropic glutamate receptor
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:14 AMPA receptor phosphorylation
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:15 NMDA receptor
ROCs
• Cysteine-loop receptors• Nicotinic acetylcholine receptors (nAChRs)• 5-Hydroxytryptamine 3 (5-HT3) receptors• γ-Aminobutyric acid (GABA) receptors• Glycine receptors (GlyRs)
• Glutamate receptors• α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)
receptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors
• ATP-sensitive P2X receptors
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:16 P2X receptor structure
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:10 Ca2+ entry mechanisms
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3: Cyclic nucleotide-gated channels
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:10 Ca2+ entry mechanisms
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:07 CaV2 channel family
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:10 Ca2+ entry mechanisms
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:19 Conformational coupling hypothesis
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:22 STIM-induced Ca2+ entry
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:46 Ryanodine receptor structure
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 3:47 InsP3R regulation
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:19 Ca2+-induced Ca2+ release
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:20 Ca2+ transient mechanisms
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
CSB Fig 2:21 Temporal aspects
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