LECTURE 05: CHROMOSOMAL BASIS OF INHERITANCE II FCH3 key concepts Fhistorical development of the...

LECTURE 05: CHROMOSOMAL BASIS OF INHERITANCE II

CH3 key concepts historical development of

the chromosome theory... genetics + cell biology

chromosomes mitosis & meiosis chromosome behavior &

inheritance patterns organelle chromosomes*

MENDELIAN ANALYSIS: 2 GENES

MENDELIAN ANALYSIS: 2 GENES

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

cell cycle

INTERPHASE

MITOSIS & MEIOSIS

sisterchromatids

MITOSIS & MEIOSIS

microtubule attachment to the kinetochore

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

sister chromatidsseparate poles

nuclear spindle prominentchromosomes equatorial plane

sister chromatidscluster poles

chromosomesuncoil;

nuclear membranereappears

visible sister chromatids;

nuclear membranebreak down

chromosomescondense

MITOSIS & MEIOSIS

I: reduction division: 2n n

sisterchromatids

non-sisterchromatids

tetrads, orbivalents

homologous chromosomes or homologues

MITOSIS & MEIOSIS

centromeresdivide

II: mitotic division: n n

no pairing(with what?)

MITOSIS & MEIOSIS

Prophase I

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

bivalent pairing due to synaptonemal complex proteins associated with chromatid crossing over @ chiasmata

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

MITOSIS & MEIOSIS

CHROMOSOMES & INHERITANCE

DIPLOIDLIFE CYCLE

CHROMOSOMES & INHERITANCE

HAPLOIDLIFE CYCLE

CHROMOSOMES & INHERITANCE

ALTERNATINGLIFE CYCLE

(PLANTS)

CHROMOSOMES & INHERITANCE

ALTERNATINGLIFE CYCLE

OF CORN

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE+

+

–

–

Neurospora

crassa

haploidfungus

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

wild type mutant pink x albino al+ al

that’s better ... centromeres illustrated correctly...

equivalent daughter cells

CHROMOSOMES & INHERITANCE

mitosis in diploid cell dihybrid A/a ; B/b ... centromeres illustrated

incorrectly... (text books do this sometimes)

meiosis in diploid cell dihybrid A/a ; B/b segregation independent assortment 1:1:1:1 gametic ratio

CHROMOSOMES & INHERITANCE

CHROMOSOMES & INHERITANCE

CHROMOSOMAL BASIS OF INHERITANCE: PROBLEMS

in Griffiths chapter 3, beginning on page 109, you should be able to do questions 1, 2, 5-10, 12, 16, 18-20, 22, 25-30, 32, 33, 40

begin with the solved problems on page 108 if you are having difficulty

try Schaum’s Outline questions in chapter 1