Janeway’s Immunobiology Seventh Edition Janeway’s Immunobiology Seventh Edition Chapter 10...

Janeway’s Immunobiology

Seventh Edition

Janeway’s Immunobiology

Seventh Edition

Chapter 10Dynamics of Adaptive Immunity

Chapter 10Dynamics of Adaptive Immunity

Steffen Thiel

st@microbiology.au.dk

ca.1 uge

DC CD4 T cell

TH1TH2TH17Treg

Inhibition af andre CD4 T celler

Parasit infektion

TH1 response

TH2 response

Nye adhesionsmolekyler

Nye muligheder

Effect T

Effect T

TNF-

VCAM/ICAM

Effect T

Macrophag

Movie – lymphocyte migration

Ingen IL-12

Ingen egne T celler- men IL-12

IL-12 holder gang i TH1 celler

Memory

Memory T-cells

Hvordan ser overfladen af enmemory T cell ud

Ingen CD4 T cells Ingen memory

Godt CD8 T celle respons

Published online 26 September 2007 | Nature 449, 390 (2007)HIV vaccine failure prompts Merck to halt trial

----------------------------

The Thai-trial – publiceret oktober 2009:

Hvad pressen og producenterne skrev:

"Although the level of protection was modest, we think the study is a major scientific advance,“ said Colonel Jerome Kim, HIV vaccines product manager for the U.S. Army.

The controversial $105 million trial, the largest and most expensive AIDS vaccine study ever conducted, took 6 years and involved more than 16,000 volunteers at eight sites in Thailand

Rent faktisk:

51 vaccinated people had become infected within 3 years of receiving their last shot,as compared with 74 people in the placebo group.

Immunity. 2010 Oct 29;33(4):542-54.Induction of immunity to human immunodeficiency virus type-1 by vaccination.McElrath MJ, Haynes BF.A recent vaccine regimen has shown modest efficacy against HIV-1 acquisition.