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Teaching Program on Principles of Pathology. Chapter 2
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Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 1
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 2
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 3
• Cell membranes • ATP prod
Autophagosome DNA • Plasma membrane • Lysosome
No Yes Yes Yes
No Yes Yes Yes
• Yes • Neutrophils
Minimal No No
• Cell groups • Cell swelling • Picnosis
• Single cells • Lysis
• Single cells • Cell shrinkage • Picnosis
• Single cells • Cell-‐in-‐cell
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 4
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 5
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 6
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 7
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 8
O
R-‐C-‐O-‐CH + lipase + Ca++ = (3) RCOO-‐Ca++ (soap)
O
Triglyceride – (fat)
R-‐C-‐O-‐CH2
O
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 9
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 10
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 11
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 12
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 13
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 14
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 15
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 16
Principles of Pathology h2p://www.interpathology.org
Irreversible Cell Injury 17
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