Interaksi Alel Dan Rekombinasi

Interaksi Alel dan

Rekombinasi

UIN Maulana Malik Ibrahim Malang

Andik Wijayanto M.Si

TIK: Memahami proses interaksi alel, rekombinasi, dapat

membuat linkage map dan analisisnya

Interaksi Alel

The phenotype and

genotype ratios are

the same (1:2:1) like

codominant but this

is due to incomplate

dominant (the

dominant allel does

not fully contribute

the phenotype in a

heterozygote

(weakened or

diluted)

Dominance

Epistasis

Involves intra-allelic gene interaction.

Involves inter-allelic gene interaction.

One allele hides the effect of other allele at the same gene pair.

One gene hides the effect of other gene at different gene loci.

Epistasis

Interaction between alleles at different loci

Epistatic

alleles

Hypostatic

alleles

Phenotypic

Expression

aa bb b

aa BB, Bb B

AA, Aa Bb, Bb, bb A

Penghitungan Interaksi Alel

• Diperoleh data biji Pisum sativum: O E

Kuning halus 315 9/16X556 313

Hijau halus 108 3/16X556 104

Kuning keriput 101 3/16X556 104

Kuning keriput 32 1/16X556 35

total 556

X2 = (315-313)2 + (108-104)2 + (101-104)2 + (32-35)2

313 104 104 35

= 0.013 + 0.154 + 0.087 + 0.257

= 0.511

• Ho : P1 = P2 = P3 . . . . Pn

• H1 : P1 ≠ P2 , P3 . . . . Pn

dF = n-1 = 4-1 = 3, selang kepercayaan 95%

Xtabel = 7.82, X2hitung ≤ X2

tabel

maka H0 diterima (sesuai dg hukum Mendel)

Penghitungan Interaksi Alel

B. Diperoleh data pasien CAD (hubungan gen p53 terhadap penyakit CAD):

Gen p53 COD Jumlah

Ya Tidak

Aktif 20 50 70

Tidak Aktif 10 40 50

Jumlah 30 90 120

X2 = (20-17.5)2 + (50-52.5)2 + (10-12.5)2 + (40-37.5)2

17.5 52.5 12.5 37.5

= 1.143

• Ho : P1 = P2 = P3 . . . . Pn

• H1 : P1 ≠ P2 , P3 . . . . Pn

dF = n-1 = 2-1 = 1, selang kepercayaan 95%

X2tabel = 3.84, X2

hitung ≤ X2tabel

maka H0 diterima (aktif tidaknya gen p53 tidak berpengaruh terhadap ekspresi penyakit CAD)

In 1931, Harriet Creighton and Barbara McClintock were studying two

genes of corn that they knew were both located on chromosome 9. One

affected seed color (C, colored; c, colorless) and the other affected

endosperm composition (Wx, waxy; wx, starchy)

Your ALTITUDE does not depend on your

APTITUDE, but depend on your

ATTITUDE, so you can MAGNITUDE

Ketinggian atau harga diri Anda tidak

ditentukan oleh bakat, posisi, jabatan

atau harta Anda, tapi terletak pada SIKAP

Anda. Sehingga dengan itu Anda bisa

membuat perubahan-perubahan yang

bermakna dalam kehidupan