Innate + adaptive immunity

Echinodermata

Urochordata

Vertebrata

ChondrichtyesMammalia

Chordata

MHC +TCR +NK cells +Complement system +Complement receptors (SCR) +

MHC -TCR -NK cell receptors +Complement (Bf,C3, C6-C9) +Complement receptors (SCR) +

Agnatha

CionaBotryllusHalocynthia

Petromyzon

innate+ adaptiveimmunity

innate immunity only

Cephalochordata

MHC

NK receptors-570 myr

-525 myr

Innate + adaptive immunity

Innate immunity only

From Thomas C. G. Bosch (Kiel)

« Pathogens »« Pathogens »

Innate ImmunityInnate Immunity(NK cells, DC, Neutrophils, Monocytes/Macrophages)(NK cells, DC, Neutrophils, Monocytes/Macrophages)

Adaptive Immunity Adaptive Immunity (T and B Lymphocytes )(T and B Lymphocytes )

Effector Functions

Initiation of Ag-specific response

Figure 2-1

Toll-like Receptors (TLR):innate immune sensors

Toll and TLRs

Nat Rev Immunol. 2004 Jul;4(7):521-7.

The road to Toll.Lemaitre B.

Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette, France.

lemaitre@cgm.cnrs-gif.fr

1

PG, LPLP

2 3 4 5 6 7 8 9 10

dsRNALPS

Flagellin

Zym, LP

ssRNA IMQ IMQ CpG

Toll-like receptors

Figure 2-16 part 1 of 2

Figure 2-16 part 2 of 2

Figure 2-17

Mannose Rec. (MR, Endo180, DEC205, PLA2R)C-typeLectins

Others(LRR, CARD,…)

Ig-SF

TLR

h LIR (ILT)m PIR

NCRTREMhKIR

NKRP-1

mLY49

NKG2D

DC-SIGN receptorsDectin-2 (NCCL)Langerin

BDCA-2 (DLEC)

NOD moleculesTLR

Figure 2-5