Importance of Preventive Dental Care in Patients Taking Bisphosphonate Therapy

ORAL AND MAXILLOFACIAL PATHOLOGY OOOO

e196 Abstracts February 2014

MIGUEL, BÁRBARA VANESSA DE BRITO MONTEIRO,LUÍZ CARLOS ALVES JÚNIOR, MARIA ALICE RAMALHODE SÁ LEITE, ÉRICKA JANINE DANTAS DA SILVEIRA,CASSIANO FRANCISCO WEEGE NONAKA. UNI-VERSIDADE FEDERAL DO RIO GRANDE DO NORTE.

Oral lichen planus (OLP) is a common immunologicallymediated mucocutaneous disease that usually manifests in areticular and erosive form. TGF-b regulates cell proliferation anddifferentiation. IL-6 is a multifunctional cytokine capable ofstimulating inflammatory and various biological processes. Ma-terials and Methods: Analysis of the immunoexpression of IL-6and TGF-b was done in 40 cases of OLP and 10 cases of in-flammatory fibrous hyperplasia (HFI). The analysis was semi-quantitative and used to verify the percentage, the stainingpattern, the immunoreactive epithelial layers, and the sub-epithelial types of immunostained inflammatory cells. Results:The OLP group showed a higher percentage of epithelial im-munostaining for IL-6 than HFIs (p ¼ 0.001). There were nostatistical differences in the immunoexpression of TGF-b betweenthe clinical forms of OLP and HFIs. Conclusion: The results ofthis study suggest an important role for IL-6 in the pathogenesisof OLP.

PE-332 - ORAL LICHEN PLANUS: AN EPIDEMIOLOG-ICAL STUDY. JOANA DOURADO MARTINS, JULIANAARAUJO LIMA DA SILVA, ALESSANDRA LAIS PINHOVALENTE, LAIZE NASCIMENTO SOUZA, MARIORUBENS FEITOSA DE SOUSA, JAMILLE RIOS MOURA,VALÉRIA SOUZA FREITAS. UNIVERSIDADE ESTADUALDE FEIRA DE SANTANA.

Lichen planus is a chronic inflammatory disease of unknownetiology. When it affects the oral mucosa, it is called oral lichenplanus (OLP). This study surveyed the clinicopathological casesof OLP diagnosed in the Oral Cancer Center at UEFS between1998 and 2010. Materials and Methods: The sample consisted of112 adults with a clinical and histopathological diagnosis of OLP.Results: The disease most commonly affects women in the fourthdecade of life. Erosive lesions were predominant, and the tonguesuffered a higher occurrence of OLP. Topical corticosteroids werethe most frequently prescribed medication to control symptomaticlesions. From the systemic conditions studied, menopause wasone of the most frequent found. Conclusion: The subjects of thisstudy must remain under regular follow-up, especially becausethe erosive form of lichen planus presents the greatest risk ofmalignant transformation.

PE-333 - IMPACT OF HSV 1/2, EBV, AND CMVINFECTION ON CHEMOTHERAPY-INDUCED ORALMUCOSITIS IN ACUTE LYMPHOBLASTIC LEUKEMIAPATIENTS. ANDREZA BARKOKEBAS SANTOS DEFARIA, DÉBORAH FONSECA, IGOR HENRIQUEMORAIS, TEREZA GUSMAO, LUIZ ALCINO GUEIROS,ALESSANDRA CARVALHO, JAIR CARNEIRO LEÃO.UFPE.

Objective: This study evaluated the influence of HSV1/2,EBV, and CMV infections in chemotherapy-induced oral mucosi-tis. Methods: Ninety-two patients diagnosed with acute lympho-blastic leukemia who had undergone chemotherapy were selected.Results: Serology using an ELISA test showed that 65 individuals(70.7%) developed mucositis after the seventh day of chemo-therapy. Of these 60% were grade I and 40% grade II; 64% hadHSV-1; 62% EBV; 81% and 22% were, respectively, CMV-IgG

and CMV-IgM positive; and almost 10% were concomitantlypositive for all the viruses studied. The results showed no corre-lation between oral mucositis and herpesvirus infection: HSV-1(p ¼ 0.469), EBV (p ¼ 0.454), CMV-IgG (p ¼ 0.192), and CMV-IgM (p ¼ 0.069). However, using a logistic regression model itwas observed that the severity of oral mucositis was influenced bythe presence of HSV-1 (p¼ 0.03).Conclusion: Based on the resultsof the present study, it can be concluded that herpesvirus is anubiquitous infection in the target population. Also, HSV-1 exac-erbates the severity of mucositis in patients with leukemia.

PE-334 - IMPORTANCE OF PREVENTIVE DENTAL CAREIN PATIENTS TAKING BISPHOSPHONATE THERAPY.LILIANE CRISTINE FERREIRA DE SOUZA BORGES,JULIANA FERREIRA DE SOUZA, PERLA PORTO LEITESHITARA, HALBERT VILLABA, DAIANE TENOR LOPES,MARCO VINICIUS CHAUD. UNIVERSIDADE DE SOR-OCABA UNISO.

Bisphosphonates (BPs) are used in bone pathologies. Since2003, there have been reports of osteonecrosis of the jawsinduced by the use of BPs. This study highlights the importanceof dental care before therapy with BPs. Methods: The experimentwas conducted in vivo. Animals were divided into 3 groups thatunderwent administrations of zoledronic acid or saline solution.One of the treated groups underwent tooth extraction. Alveolarchanges were investigated by histologic analysis. Results: Ani-mals treated with BPs and undergoing extraction showed osteo-necrosis. Dental surgical procedures present risk factors forosteonecrosis related to delay healing and the presence of bac-terial colonies. Conclusion: The results indicate that for patientsundergoing treatment with BPs, dental extraction is a risk factorthat induces osteonecrosis. This reinforces the importance ofdental care before rather than during treatment.

PE-335 - CROSS-SECTIONAL STUDY OF 609 SALIVARYGLAND LESIONS IN A BRAZILIAN POPULATION.PAULO GOBERLÂNIO DE BARROS SILVA, FRANCISCOARTUR FORTE OLIVEIRA, THALES SALLES ANGELIMVIANA, FÁBIO WILDSON GURGEL COSTA, ANA LARYSSAFERREIRA GOMES PORTO, MÁRIO ROGÉRIO LIMAMOTA, FABRÍCIO BITÚ SOUSA. UNIVERSIDADE FED-ERAL DO CEARÁ.

Salivary gland tissues are distributed widely in the stoma-thognathic system and may be affected by diverse conditions,including neoplastic and non-neoplastic lesions. This studydescribed the pathologic features of salivary gland lesions (SGL)seen in a Brazilian outpatient service. Data from 609 samples ofSGL were retrieved from five anatomic pathology services inFortaleza, Brazil, over a 5-year period. From this total, the ratio ofmales to females was 1:1.5. Benign conditions (93.76%) weremore frequent than malignant lesions (6.24%). Mucocele (n ¼420), pleomorphic adenoma (n ¼ 49), and sialoadenitis (n ¼ 27)were the most common benign lesions. Mucoepidermoid carci-noma (n ¼ 10), adenocarcinoma (n ¼ 10), and adenoid cysticcarcinoma (n ¼ 10) were the main malignant lesions diagnosed.This study adds to the worldwide literature the pathologic featuresof a sample of SGL in a Brazilian population.

PE-336 - DOSE RESPONSE STUDY OF LASER THERAPYON NITRIC OXIDE PRODUCTION IN MACRO-PHAGES. SAMANTHA CARDOSO DE ANDRADE, IGORHENRIQUE MORAIS SILVA, WYLLA TATIANA FERREIRA