Http://mri.med.cornell.edu Magnetic Resonance Imaging Yi Wang, PhD Imaging Physics Hardware/Software...

http://mri.med.cornell.edu

Magnetic Resonance Imaging Yi Wang, PhD

Imaging Physics Hardware/Software

Clinical/Biological Application

Nguyen, Spincemaille, de Rochefort, Brown, Kressler, Codella, Singh, Lee, Wang, Zabih

Prince, Kent, Weinsaft, Cheng, Morrisett, Cham….

Imaging Physics Study

Spin Dynamics– interaction of body tissue (p)

with magnetic field (B)– B pulses for probing tissue e

pB

kz

ky

kx

Image Formation– spatial encoding (Fourier k)

in signal detection– k-space sampling– pulse sequences for tissue

morphology & function

Technology Development - hardware

• RF coils: cardiac coil, bilateral peripheral coil

• High performance computing: 34 node cluster

Technology Development - software

• Fast imaging sequences: time resolved 4D spiral, fgre, ssfp, fse

• Navigator motion suppression: diaphragm navigator, cardiac fat navigator

Carotid MRA

Navigator Cardiac MRI

4D Cardiac MRI

Peripheral MRA

4D MRA

Functional peripheral MRI - perfusion

1st pass perfusion quantifies ischemia

Delayed enhancement predicts ulcer

Perfusion/DE characterizes wound healing?

Functional peripheral MRI – vessel wall

TOF T1 T2 PD

Rich tissue contrast to characterize plaque and monitor statin therapy.

Magnetization/susceptibility MRI

Cunningham et al

MR-SQUID: Magnetic resonance susceptibility quantification using inversion of dipole fields.

In vivo imaging of biochemical reaction?

Quantification of magnetically labeled cellular MRI?

Thank You!